Proinsulin maturation, misfolding, and proteotoxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 40, 2007, Pages 15841-15846

  Liu, Ming ^a   Hodish, Israel ^a   Rhodes, Christopher J ^b   Arvan, Peter ^a,c  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Diabetes mellitus; Endoplasmic reticulum storage disease; Insulin secretion; Proinsulin disulfide isomers

Indexed keywords

C PEPTIDE; GENE PRODUCT; PROINSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; ENDOPLASMIC RETICULUM; GENE EXPRESSION; HUMAN; HUMAN CELL; INSULIN RELEASE; MOUSE; MUTANT; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROCESSING; SECRETORY CELL;

CELL LINE; DNA, COMPLEMENTARY; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; KIDNEY; MUTANT CHIMERIC PROTEINS; PROINSULIN; PROTEIN FOLDING; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SECRETORY VESICLES;

MUS;

EID: 35648957233     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702697104     Document Type: Article

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