How insulin engages its primary binding site on the insulin receptor

Nature

Volumn 493, Issue 7431, 2013, Pages 241-245

  Menting, John G ^a   Whittaker, Jonathan ^b   Margetts, Mai B ^a   Whittaker, Linda J ^b   Kong, Geoffrey K W ^a   Smith, Brian J ^a,c   Watson, Christopher J ^d   Žáková, Lenka ^e   Kletvíková, Emília ^e   Jiráček, Jiří ^e   Chan, Shu Jin ^f   Steiner, Donald F ^d   Dodson, Guy G ^d   Brzozowski, Andrzej M ^d   Weiss, Michael A ^b   Ward, Colin W ^a   Lawrence, Michael C ^a,g  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LA TROBE UNIVERSITY   (Australia)

^d UNIVERSITY OF YORK   (United Kingdom)

^e INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^f UNIVERSITY OF CHICAGO   (United States)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR;

BIOCHEMISTRY; CANCER; CRYSTAL STRUCTURE; DIABETES; DISEASE TREATMENT; HORMONE; MAMMAL; PATHOGENICITY; PROTEIN;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; HORMONE RECEPTOR INTERACTION; INSULIN BINDING; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION;

ANIMALS; BINDING SITES; CALORIMETRY; CATTLE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INSULIN; LEUCINE; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, INSULIN; REPRODUCIBILITY OF RESULTS;

MAMMALIA;

EID: 84872162672     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11781     Document Type: Article

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