EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

Science

Volumn 299, Issue 5611, 2003, Pages 1394-1397

  Oda, Yukako ^a   Hosokawa, Nobuko ^a   Wada, Ikuo ^b,c   Nagata, Kazuhiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; SUBSTRATES;

CYTOPLASM;

PROTEINS;

CALNEXIN; CALRETICULIN; GLYCOPROTEIN; MANNOSE BINDING PROTEIN; MEMBRANE PROTEIN; PROTEIN EDEM; UNCLASSIFIED DRUG;

BIOCHEMISTRY; PROTEIN;

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FUNCTIONAL ASSESSMENT; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MEMBRANE BINDING; ONSET AGE; PRIORITY JOURNAL; PRODUCT RECOVERY; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN SECRETION; STRESS;

ACETYLCYSTEINE; ALPHA 1-ANTITRYPSIN; CALNEXIN; CALRETICULIN; CELL LINE; ENDOPLASMIC RETICULUM; GLYCOPROTEINS; HUMANS; INDOLIZINES; MEMBRANE PROTEINS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0037470515     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079181     Document Type: Article

References (28)

1. S. W. Fewell, K. J. Travers, J. S. Weissman, J. L. Brodsky, Annu. Rev. Genet. 35, 149 (2001).
2. R. K. Plemper, D. H. Wolf, Trends. Biochem. Sci. 24, 266 (1999).
3. R. R. Kopito, R. Sitia, EMBO Rep. 1, 225 (2000).
4. C. M. Carbral, Y. Liu, R. N. Sifers, Trends Biochem. Sci. 26, 619 (2001).
5. N. Hosokawa et al., EMBO Rep. 2, 415 (2001).
6. C. A. Jakob, P. Bruda, J. Roth, M. Aebi, J. Cell. Biol. 142, 1223 (1998).
7. C. A. Jakob et al., EMBO Rep. 2, 423 (2001).
8. K. Nakatsukasa, S. Nishikawa, N. Hosokawa, K. Nagata, T. Endo, J. Biol. Chem. 276, 8635 (2001).
9. I. Braakman, EMBO Rep. 2, 666 (2001).
10. Y. Liu, P. Choudhury, C. M. Cabral, R. N. Sifers, J. Biol. Chem. 274, 5861 (1999).
11. A. A. McCracken, J. L. Brodsky, J. Cell. Biol. 132, 291 (1996).
12. S. W. Pipe, J. A. Morris, J. Shah, R. J. Kaufman, J. Biol. Chem. 273, 8537 (1998).
13. L. Ellgard, A. Helenius, Curr. Opin. Cell. Biol. 11, 120 (2001).
14. A. Parodi, Annu. Rev. Biochem. 69, 69 (2000).
15. B. Tsai, Y. Ye, T. A. Rapoport, Nature Rev. Mol. Cell. Biol. 3, 246 (2002).
16. A. Helenius, M. Aebi, Science 291, 2364 (2001).
17. E. Chevet, P. H. Cameron, M. F. Pelletier, D. Y. Thomas, J. J. M. Bergeron, Curr. Opin. Struct. Biol. 11, 120 (2001).
18. R. N. Sifers, S. Brashears-Macatee, V. J. Kidd, H. Muensch, S. L. C. Woo, J. Biol. Chem. 263, 7330 (1988).
19. K. S. Cannon, A. Helenius, J. Biol. Chem. 274, 7537 (1999).
20. Y. Oda et al., unpublished data.
21. F. Tokunaga, C. Brostrom, T. Koide, P. Arvan, J. Biol. Chem. 275, 40757 (2000).
22. C. Fagioli, R. Sitia, J. Biol. Chem. 276, 12885 (2001).
23. C. M. Wilson, M. R. Farmery, N. J. Bulleid, J. Biol. Chem. 275, 21224 (2000).
24. C. M. Carbral, Y. Liu, K. W. Moremen, R. N. Sifers, Mol. Biol. Cell. 13, 2639 (2002).
25. H. Yoshida et al., Dev. Cell 4, 265 (2003).
26. I. Wada, S. Imai, M. Kai, F. Sakane, H. Kanoh, J. Biol. Chem. 270, 20298 (1995).
27. U. G. Danilczk, M. F. Cohen-Doyle, D. B. Williams, J. Biol. Chem. 275, 13089 (2000).
28. We thank K. Kohno for the gift of HA/pAT, D. B. Williams for the soluble CNX construct and B. H. Toyama for editorial contribution. Supported by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.