Contribution of residue B5 to the folding and function of insulin and IGF-I: Constraints and fine-tuning in the evolution of a protein family

Journal of Biological Chemistry

Volumn 285, Issue 7, 2010, Pages 5040-5055

  Sohma, Youhei ^a   Hua, Qing Xin ^b   Liu, Ming ^c   Phillips, Nelson B ^b   Hu, Shi Quan ^b   Whittaker, Jonathan ^b   Whittaker, Linda J ^b   Ng, Aubree ^d   Roberts Jr , Charles T ^d,e   Arvan, Peter ^c   Kent, Stephen B H ^a   Weiss, Michael A ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR SECRETION; CHEMICAL DENATURATION; DISULFIDE EXCHANGE; DOMAIN MODEL; GROWTH FACTOR; IGF-BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR; NUCLEAR OVERHAUSER EFFECTS; PROINSULIN; PROTEIN FAMILY; RECEPTOR SIGNALING; SINGLE STRUCTURE; STRUCTURAL AMBIGUITY; WILD TYPES;

BIOACTIVITY; BIOCHEMISTRY; ISOMERS; NUCLEAR MAGNETIC RESONANCE; PEPTIDES; SIGNAL TRANSDUCTION; SULFUR COMPOUNDS; TUNING;

INSULIN;

DISULFIDE; HISTIDINE; INSULIN; PROINSULIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DENATURATION; HORMONE ACTION; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; THERMODYNAMICS; WILD TYPE;

ANIMALS; CELL LINE; CIRCULAR DICHROISM; DISULFIDES; GLYCOSYLATION; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MAGNETIC RESONANCE SPECTROSCOPY; MICE; PHOSPHORYLATION; PROINSULIN; PROTEIN FOLDING; PROTEIN STABILITY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77951191473     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.062992     Document Type: Article

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