Deciphering the hidden informational content of protein sequences: Foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormone

Journal of Biological Chemistry

Volumn 285, Issue 40, 2010, Pages 30989-31001

  Liu, Ming ^a   Hua, Qing Xin ^b   Hu, Shi Quan ^b   Jia, Wenhua ^b   Yang, Yanwu ^b   Saith, Sunil Evan ^a   Whittaker, Jonathan ^b   Arvan, Peter ^a   Weiss, Michael A ^b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; HYDROPHOBICITY; ISOMERS; MAMMALS;

ALANINE-SCANNING MUTAGENESIS; CELL DYSFUNCTION; DIABETES MELLITUS; FLEXIBLE ARM; HYDROPHOBIC RESIDUES; INSULIN CHAIN; LONG RANGE INTERACTIONS; N-TERMINALS; NATIVE STATE; NON-NATIVE; PLACENTAL MAMMALS; PROINSULIN; PROTEIN SEQUENCES; SIDE CHAINS;

INSULIN;

ALANINE; DISULFIDE; PHENYLALANINE; PROINSULIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIABETES MELLITUS; EMBRYO; HORMONE ACTION; HORMONE STRUCTURE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MUTAGENESIS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN FOLDING; PROTEIN SECRETION; THERMODYNAMICS; AMINO ACID SUBSTITUTION; CHEMICAL MODEL; CHEMICAL PHENOMENA; CHEMISTRY; GENETICS; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MISSENSE MUTATION; NUCLEAR MAGNETIC RESONANCE; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

EUTHERIA;

AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 1; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, CHEMICAL; MUTATION, MISSENSE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROINSULIN; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY;

EID: 77957262631     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.152645     Document Type: Article

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