Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 50, 2007, Pages 19989-19994

  Datta, Rupak ^a   Waheed, Abdul ^a   Shah, Gul N ^a   Sly, William S ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4 phenylbutyric acid; Endoplasmic reticulum stress; Parathyroid hormone; Unfolded protein response

Indexed keywords

4 PHENYLBUTYRIC ACID; COMPLEMENTARY DNA; PARATHYROID HORMONE; RNA; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL STRAIN HEK293; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FAMILIAL DISEASE; GENE MUTATION; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HYPOPARATHYROIDISM; IMMUNOHISTOCHEMISTRY; PARATHYROID GLAND; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL LINE; CYSTEINE; ENDOPLASMIC RETICULUM; GENES, DOMINANT; HUMANS; HYPOPARATHYROIDISM; MOLECULAR SEQUENCE DATA; MUTATION; PARATHYROID HORMONE; PHENYLBUTYRATES; PROTEIN FOLDING; PROTEIN PRECURSORS; PROTEIN SORTING SIGNALS;

EID: 38049180869     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708725104     Document Type: Article

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