High ER stress in β-cells stimulates intracellular degradation of misfolded insulin

Biochemical and Biophysical Research Communications

Volumn 324, Issue 1, 2004, Pages 166-170

  Allen, Jenny R ^a   Nguyen, Linh X ^a   Sargent, Karen E G ^a   Lipson, Kathryn L ^a   Hackett, Anthony ^a   Urano, Fumihiko ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Diabetes; Endoplasmic reticulum stress; Endoplasmic reticulum associated protein degradation; Unfolded protein response

Indexed keywords

HRD1 PROTEIN; INSULIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL STIMULATION; CONTROLLED STUDY; DIABETES MELLITUS; ENDOPLASMIC RETICULUM; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; STRESS;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED STRAINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SUBUNITS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 4744374044     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.09.035     Document Type: Article

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