Pronounced cytosolic aggregation of cellular prion protein in pancreatic β-cells in response to hyperglycemia

Laboratory Investigation

Volumn 87, Issue 2, 2007, Pages 139-149

  Strom, Alexander ^a   Wang, Gen Sheng ^a   Reimer, Rudolph ^b   Finegood, Diane T ^c   Scott, Fraser W ^a,d  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c SIMON FRASER UNIVERSITY   (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

Author keywords

cells; Diabetes; Hyperglycemia; Inclusions; Islets; Prion protein

Indexed keywords

CELL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOBREEDING RAT; CELL SPECIFICITY; CELL TYPE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE MODEL; ENDOCRINE CELL; FLUORESCENCE MICROSCOPY; GLUCOSE INFUSION; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NERVE CELL; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; STAINING;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; CYTOSOL; DIABETES MELLITUS, TYPE 1; GLUCOSE; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; MICROSCOPY, FLUORESCENCE; PRPC PROTEINS; RATS; RATS, INBRED WF; RATS, SPRAGUE-DAWLEY;

EID: 33847232980     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700500     Document Type: Article

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