Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe β-cell loss in Munich Ins2C95S mutant mice

Diabetes

Volumn 56, Issue 5, 2007, Pages 1268-1276

  Herbach, Nadja ^a,d   Rathkolb, Birgit ^a   Kemter, Elisabeth ^a   Pichl, Lisa ^a   Klaften, Matthias ^b   De Angelis, Martin Hrabé ^b   Halban, Philippe A ^c   Wolf, Eckhard ^a   Aigner, Bernhard ^a   Wanke, Ruediger ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d Institute of Veterinary Pathology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BODY WEIGHT; CELL DENSITY; CELL LOSS; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; FEMALE; GENE; GENE INS2; GENE MUTATION; GENETIC LINKAGE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HOMOZYGOSITY; HYPOGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; JUVENILE DIABETES MELLITUS; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; BLOOD GLUCOSE; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 1; DNA; HETEROZYGOTE DETECTION; HOMOZYGOTE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C3H; PANCREAS; PREVALENCE;

EID: 34248187585     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0658     Document Type: Article

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