Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation

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Volumn 12, Issue 3, 2011, Pages 330-348

  Viswanathan, Jayashree ^a,b   Haapasalo, Annakaisa ^a,b   Böttcher, Claudia ^c   Miettinen, Riitta ^a,b,d   Kurkinen, Kaisa M A ^a,b   Lu, Alice ^e   Thomas, Anne ^e   Maynard, Christa J ^c   Romano, Donna ^e   Hyman, Bradley T ^e   Berezovska, Oksana ^e   Bertram, Lars ^f   Soininen, Hilkka ^a,b   Dantuma, Nico P ^c   Tanzi, Rudolph E ^e   Hiltunen, Mikko ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d CNServices Ltd   (Finland)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

amyloid precursor protein; High molecular weight forms; PEN 2; Proteasomal degradation; Transcript variant

Indexed keywords

GAMMA SECRETASE; MEMBRANE PROTEIN; PRESENILIN 1; PROTEASOME; PROTEIN UBIQUILIN 1 TV1; PROTEIN UBIQUILIN 1 TV3; UNCLASSIFIED DRUG;

AGGRESOME; ALZHEIMER DISEASE; ARTICLE; CELLULAR DISTRIBUTION; ELECTRON MICROSCOPY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; REGULATORY MECHANISM;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELLS, CULTURED; GENE EXPRESSION; HEK293 CELLS; HUMANS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PHAGOSOMES; PRESENILIN-1; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY;

EID: 79751480230     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/j.1600-0854.2010.01149.x     Document Type: Article

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