Mutant INS-Gene induced diabetes of youth: Proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Liu, Ming ^a   Haataja, Leena ^a   Wright, Jordan ^a   Wickramasinghe, Nalinda P ^b   Hua, Qing Xin ^b   Phillips, Nelson F ^b   Barbetti, Fabrizio ^c,d   Weiss, Michael A ^b   Arvan, Peter ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; INSULIN; PROINSULIN;

ANIMAL CELL; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DISULFIDE BOND; EMBRYO; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; GENETIC ASSOCIATION; HORMONE PROTEIN COMPLEX; HORMONE SYNTHESIS; HORMONE TRANSPORT; HUMAN; HUMAN CELL; MOUSE; MUTANT INSULIN GENE INDUCED DIABETES OF YOUTH; MUTATIONAL ANALYSIS; NONHUMAN; PATHOGENESIS; PROTEIN FOLDING; PROTEIN STRUCTURE; RAT; STRUCTURE ANALYSIS; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; DOMINANT GENE; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; TRANSPORT AT THE CELLULAR LEVEL;

MUS;

AMINO ACID SEQUENCE; BIOLOGICAL TRANSPORT; ENDOPLASMIC RETICULUM; GENES, DOMINANT; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROINSULIN;

EID: 78149445119     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013333     Document Type: Article

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