Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathway

Molecular Biology of the Cell

Volumn 12, Issue 3, 2001, Pages 577-588

  Mutka, S C ^a   Walter, P ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HEAT SHOCK PROTEIN; SIGNAL RECOGNITION PARTICLE;

ADAPTATION; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CYTOSOL; GENE EXPRESSION; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TARGETING; PROTEIN TRANSPORT; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; STRESS; YEAST;

EID: 0035173051     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.3.577     Document Type: Article

References (41)

1. Two novel related yeast nucleoporins Nup170p and Nup157p: Complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p
2. The stress response to loss of signal recognition particle function in Saccharomyces cerevisiae
3. Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex
4. Model for signal sequence recognition from amino-acid sequence of 54k subunit of signal recognition particle
5. Translocation of proteins across the endoplasmic reticulum membrane
6. Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression
7. YDJIp facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism
8. 70K Heat shock related proteins stimulate protein translocation into microsomes
9. The yeast proteome database (YPD) and Caenorhabditis elegans proteome database (WormPD): Comprehensive resources for the organization and comparison of model organism protein information
10. Multicopy suppression of cold-sensitive sec mutations in Escherichia coli
11. Exploring the metabolic and genetic control of gene expression on a genomic scale
12. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
13. Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex
14. SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum
15. Mutant in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae
16. The signal recognition particle in S. cerevisiae
17. Perk is essential for translational regulation and cell survival during the unfolded protein response
18. The translocon: A dynamic gateway at the ER membrane
19. Rapid and efficient site-specific mutagenesis without phenotypic selection
20. Suppression of growth and protein secretion defects in Escherichia coli secA mutants by decreasing protein synthesis
21. Targeting of proteins to mitochondria
22. Continued functioning of the secretory pathway is essential for ribosome synthesis
23. Signal sequences specify the targeting route to the endoplasmic reticulum membrane
24. ER membrane protein complex required for nuclear fusion
25. Protein kinase C enables the regulatory circuit that connects membrane synthesis to ribosome synthesis in Saccharomyces cerevisiae
26. A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit
27. The signal recognition particle receptor is important for growth and protein secretion in Saccharomyces cerevisiae
28. SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation
29. Identification of five new essential genes involved in the synthesis of a secreted protein in Escherichia coli
30. Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p
31. Regulation of ribosome detachment from the mammalian endoplasmic reticulum membrane
32. Protein translocation across the endoplasmic reticulum requires a functional GTP binding site in the α-subunit of the signal recognition particle receptor
33. Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes
34. Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation
35. Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast
36. The fate of membrane-bound ribosomes following the termination of protein synthesis
37. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
38. Yeast heat shock factor contains separable transient and sustained response transcriptional activators
39. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation
40. Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane