Proinsulin and the genetics of diabetes mellitus

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19159-19163

  Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SECRETION; DIABETES MELLITUS; ER STRESS; GLOBULAR PROTEINS; HUMAN GENETICS; INSULIN GENE; MISFOLDING; MOUSE MODELS; PROINSULIN; PROTEIN EVOLUTION; STRUCTURAL BASIS; TWO CHAINS; WILD TYPES;

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CELL DEATH; CELL MEMBRANES; CHROMOSOMES; MEDICAL PROBLEMS; PHYSIOLOGY;

INSULIN;

INSULIN RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PREPROINSULIN; PROINSULIN; SULFONYLUREA DERIVATIVE; SULFONYLUREA RECEPTOR 1;

ALPHA HELIX; DIABETES MELLITUS; DISULFIDE BOND; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; HUMAN; INSULIN RELEASE; INSULIN SYNTHESIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN FOLDING; RECEPTOR BINDING; SECRETORY GRANULE; SHORT SURVEY;

ANIMALS; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; MODELS, BIOLOGICAL; MUTATION; PROINSULIN; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

VERTEBRATA;

EID: 67749096213     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R109.009936     Document Type: Short Survey

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