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Volumn 23, Issue PA, 2015, Pages 29-36

Genome instability of ageing stem cells-Induction and defence mechanisms

Author keywords

Ageing; Cancer; Checkpoint; DNA repair; Genome maintenance; Stem cell

Indexed keywords

APOPTOSIS; ARTICLE; CELL AGING; CELL DAMAGE; CELL DIFFERENTIATION; CELL RENEWAL; CELL SURVIVAL; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA END JOINING REPAIR; DNA REPAIR; DNA REPLICATION; DNA STRAND; DNA STRAND BREAKAGE; GENOME; GENOMIC INSTABILITY; GERMLINE MUTATION; HUMAN; MITOCHONDRIAL RESPIRATION; NONHUMAN; SENESCENCE; STEM CELL; TELOMERE; TELOMERE SHORTENING; ANIMAL; GENETICS; MUTATION; PHYSIOLOGY;

EID: 84931573069     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2015.01.004     Document Type: Review
Times cited : (38)

References (98)
  • 1
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • (in vivo & in vitro evidence)
    • Allsopp R.C., Morin G.B., DePinho R., Harley C.B., Weissman I.L. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 2003, 102:517-520. (in vivo & in vitro evidence).
    • (2003) Blood , vol.102 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 2
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi S.E., Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L., DePinho R.A. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000, 406:641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 3
    • 67349161638 scopus 로고    scopus 로고
    • Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence
    • (in vivo evidence)
    • Attema J.L., Pronk C.J., Norddahl G.L., Nygren J.M., Bryder D. Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence. Oncogene 2009, 28:2238-2243. (in vivo evidence).
    • (2009) Oncogene , vol.28 , pp. 2238-2243
    • Attema, J.L.1    Pronk, C.J.2    Norddahl, G.L.3    Nygren, J.M.4    Bryder, D.5
  • 4
    • 84907013527 scopus 로고    scopus 로고
    • Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/cernunnos deficiency
    • (in vivo evidence)
    • Avagyan S., Churchill M., Yamamoto K., Crowe J.L., Li C., Lee B.J., Zheng T., Mukherjee S., Zha S. Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/cernunnos deficiency. Blood 2014, 124:1622-1625. (in vivo evidence).
    • (2014) Blood , vol.124 , pp. 1622-1625
    • Avagyan, S.1    Churchill, M.2    Yamamoto, K.3    Crowe, J.L.4    Li, C.5    Lee, B.J.6    Zheng, T.7    Mukherjee, S.8    Zha, S.9
  • 5
    • 84904043095 scopus 로고    scopus 로고
    • Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle
    • (in vivo & in vitro evidence)
    • Beerman I., Seita J., Inlay M.A., Weissman I.L., Rossi D.J. Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle. Cell Stem Cell 2014, 15:37-50. (in vivo & in vitro evidence).
    • (2014) Cell Stem Cell , vol.15 , pp. 37-50
    • Beerman, I.1    Seita, J.2    Inlay, M.A.3    Weissman, I.L.4    Rossi, D.J.5
  • 7
    • 84896717088 scopus 로고    scopus 로고
    • Is non-homologous end-joining really an inherently error-prone process?
    • Betermier M., Bertrand P., Lopez B.S. Is non-homologous end-joining really an inherently error-prone process?. PLoS Genet. 2014, 10:e1004086.
    • (2014) PLoS Genet. , vol.10 , pp. e1004086
    • Betermier, M.1    Bertrand, P.2    Lopez, B.S.3
  • 9
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
    • Brown J.P., Wei W., Sedivy J.M. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 1997, 277:831-834.
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 10
    • 77954950116 scopus 로고    scopus 로고
    • Progeria syndromes and ageing: what is the connection? Nature reviews
    • Burtner C.R., Kennedy B.K. Progeria syndromes and ageing: what is the connection? Nature reviews. Mol. Cell. Biol. 2010, 11:567-578.
    • (2010) Mol. Cell. Biol. , vol.11 , pp. 567-578
    • Burtner, C.R.1    Kennedy, B.K.2
  • 12
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003, 361:393-395.
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 15
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • (in vivo evidence)
    • Chen C., Liu Y., Liu R., Ikenoue T., Guan K.L., Liu Y., Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 2008, 205:2397-2408. (in vivo evidence).
    • (2008) J. Exp. Med. , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6    Zheng, P.7
  • 16
    • 84878240136 scopus 로고    scopus 로고
    • Molecular regulation of stem cell quiescence
    • Cheung T.H., Rando T.A. Molecular regulation of stem cell quiescence. Nat. Rev. Mol. Cell Biol. 2013, 14:329-340.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 329-340
    • Cheung, T.H.1    Rando, T.A.2
  • 17
    • 0033553516 scopus 로고    scopus 로고
    • P53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin L., Artandi S.E., Shen Q., Tam A., Lee S.L., Gottlieb G.J., Greider C.W., DePinho R.A. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999, 97:527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.L.5    Gottlieb, G.J.6    Greider, C.W.7    DePinho, R.A.8
  • 20
    • 84861768586 scopus 로고    scopus 로고
    • Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening
    • Chow T.T., Zhao Y., Mak S.S., Shay J.W., Wright W.E. Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening. Genes Dev. 2012, 26:1167-1178.
    • (2012) Genes Dev. , vol.26 , pp. 1167-1178
    • Chow, T.T.1    Zhao, Y.2    Mak, S.S.3    Shay, J.W.4    Wright, W.E.5
  • 21
    • 69249209608 scopus 로고    scopus 로고
    • RecQ helicases: multifunctional genome caretakers
    • Chu W.K., Hickson I.D. RecQ helicases: multifunctional genome caretakers. Nat. Rev. Cancer 2009, 9:644-654.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 644-654
    • Chu, W.K.1    Hickson, I.D.2
  • 22
    • 34249056493 scopus 로고    scopus 로고
    • High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny
    • (in vivo & in vitro evidence)
    • Conboy M.J., Karasov A.O., Rando T.A. High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. PLoS Biol. 2007, 5:e102. (in vivo & in vitro evidence).
    • (2007) PLoS Biol. , vol.5 , pp. e102
    • Conboy, M.J.1    Karasov, A.O.2    Rando, T.A.3
  • 24
    • 10344256183 scopus 로고    scopus 로고
    • Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
    • Crabbe L., Verdun R.E., Haggblom C.I., Karlseder J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 2004, 306:1951-1953.
    • (2004) Science , vol.306 , pp. 1951-1953
    • Crabbe, L.1    Verdun, R.E.2    Haggblom, C.I.3    Karlseder, J.4
  • 26
    • 71149093724 scopus 로고    scopus 로고
    • How telomeres solve the end-protection problem
    • de Lange T. How telomeres solve the end-protection problem. Science 2009, 326:948-952.
    • (2009) Science , vol.326 , pp. 948-952
    • de Lange, T.1
  • 27
    • 84876133540 scopus 로고    scopus 로고
    • Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?
    • DeGregori J. Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?. Oncogene 2013, 32:1869-1875.
    • (2013) Oncogene , vol.32 , pp. 1869-1875
    • DeGregori, J.1
  • 28
    • 84865737521 scopus 로고    scopus 로고
    • Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle
    • (in vivo & in vitro evidence)
    • Didier N., Hourde C., Amthor H., Marazzi G., Sassoon D. Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle. EMBO Mol. Med. 2012, 4:910-923. (in vivo & in vitro evidence).
    • (2012) EMBO Mol. Med. , vol.4 , pp. 910-923
    • Didier, N.1    Hourde, C.2    Amthor, H.3    Marazzi, G.4    Sassoon, D.5
  • 32
    • 35548929551 scopus 로고    scopus 로고
    • Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations
    • Feng Z., Hu W., Teresky A.K., Hernando E., Cordon-Cardo C., Levine A.J. Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:16633-16638.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 16633-16638
    • Feng, Z.1    Hu, W.2    Teresky, A.K.3    Hernando, E.4    Cordon-Cardo, C.5    Levine, A.J.6
  • 36
    • 84866952680 scopus 로고    scopus 로고
    • Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
    • (in vivo evidence)
    • Garaycoechea J.I., Crossan G.P., Langevin F., Daly M., Arends M.J., Patel K.J. Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature 2012, 489:571-575. (in vivo evidence).
    • (2012) Nature , vol.489 , pp. 571-575
    • Garaycoechea, J.I.1    Crossan, G.P.2    Langevin, F.3    Daly, M.4    Arends, M.J.5    Patel, K.J.6
  • 38
    • 0042490798 scopus 로고    scopus 로고
    • Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line
    • Goriely A., McVean G.A., Rojmyr M., Ingemarsson B., Wilkie A.O. Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line. Science 2003, 301:643-646.
    • (2003) Science , vol.301 , pp. 643-646
    • Goriely, A.1    McVean, G.A.2    Rojmyr, M.3    Ingemarsson, B.4    Wilkie, A.O.5
  • 39
    • 62649115931 scopus 로고    scopus 로고
    • Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
    • (in vivo evidence)
    • Greenow K.R., Clarke A.R., Jones R.H. Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. Oncogene 2009, 28:1443-1453. (in vivo evidence).
    • (2009) Oncogene , vol.28 , pp. 1443-1453
    • Greenow, K.R.1    Clarke, A.R.2    Jones, R.H.3
  • 40
    • 0026055983 scopus 로고
    • Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1
    • Hara E., Tsurui H., Shinozaki A., Nakada S., Oda K. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun. 1991, 179:528-534.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 528-534
    • Hara, E.1    Tsurui, H.2    Shinozaki, A.3    Nakada, S.4    Oda, K.5
  • 46
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • Hoeijmakers J.H. DNA damage, aging, and cancer. N. Engl. J. Med. 2009, 361:1475-1485.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1475-1485
    • Hoeijmakers, J.H.1
  • 51
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson S.P., Bartek J. The DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 54
    • 34548601610 scopus 로고    scopus 로고
    • Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU
    • (in vivo & in vitro evidence)
    • Kiel M.J., He S., Ashkenazi R., Gentry S.N., Teta M., Kushner J.A., Jackson T.L., Morrison S.J. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature 2007, 449:238-242. (in vivo & in vitro evidence).
    • (2007) Nature , vol.449 , pp. 238-242
    • Kiel, M.J.1    He, S.2    Ashkenazi, R.3    Gentry, S.N.4    Teta, M.5    Kushner, J.A.6    Jackson, T.L.7    Morrison, S.J.8
  • 56
    • 84861768346 scopus 로고    scopus 로고
    • Telomere end processing: unexpected complexity at the end game
    • Lundblad V. Telomere end processing: unexpected complexity at the end game. Genes Dev. 2012, 26:1123-1127.
    • (2012) Genes Dev. , vol.26 , pp. 1123-1127
    • Lundblad, V.1
  • 57
    • 0032526476 scopus 로고    scopus 로고
    • Age changes in stem cells of murine small intestinal crypts
    • (in vivo evidence)
    • Martin K., Kirkwood T.B., Potten C.S. Age changes in stem cells of murine small intestinal crypts. Exp. Cell. Res. 1998, 241:316-323. (in vivo evidence).
    • (1998) Exp. Cell. Res. , vol.241 , pp. 316-323
    • Martin, K.1    Kirkwood, T.B.2    Potten, C.S.3
  • 58
    • 33947223187 scopus 로고    scopus 로고
    • DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse
    • Maser R.S., Wong K.K., Sahin E., Xia H., Naylor M., Hedberg H.M., Artandi S.E., DePinho R.A. DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol. Cell. Biol. 2007, 27:2253-2265.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 2253-2265
    • Maser, R.S.1    Wong, K.K.2    Sahin, E.3    Xia, H.4    Naylor, M.5    Hedberg, H.M.6    Artandi, S.E.7    DePinho, R.A.8
  • 62
    • 65049086788 scopus 로고    scopus 로고
    • Hematopoietic stem cell aging is associated with functional decline and delayed cell cycle progression
    • (in vivo evidence)
    • Noda S., Ichikawa H., Miyoshi H. Hematopoietic stem cell aging is associated with functional decline and delayed cell cycle progression. Biochem. Biophys. Res. Commun. 2009, 383:210-215. (in vivo evidence).
    • (2009) Biochem. Biophys. Res. Commun. , vol.383 , pp. 210-215
    • Noda, S.1    Ichikawa, H.2    Miyoshi, H.3
  • 64
    • 0036591968 scopus 로고    scopus 로고
    • Intestinal stem cells protect their genome by selective segregation of template DNA strands
    • (in vivo evidence)
    • Potten C.S., Owen G., Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J. Cell Sci. 2002, 115:2381-2388. (in vivo evidence).
    • (2002) J. Cell Sci. , vol.115 , pp. 2381-2388
    • Potten, C.S.1    Owen, G.2    Booth, D.3
  • 65
    • 77955419733 scopus 로고    scopus 로고
    • The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres
    • Rai R., Zheng H., He H., Luo Y., Multani A., Carpenter P.B., Chang S. The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J. 2010, 29:2598-2610.
    • (2010) EMBO J. , vol.29 , pp. 2598-2610
    • Rai, R.1    Zheng, H.2    He, H.3    Luo, Y.4    Multani, A.5    Carpenter, P.B.6    Chang, S.7
  • 66
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • (in vivo & in vitro evidence)
    • Rossi D.J., Bryder D., Seita J., Nussenzweig A., Hoeijmakers J., Weissman I.L. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007, 447:725-729. (in vivo & in vitro evidence).
    • (2007) Nature , vol.447 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 67
    • 35848943667 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging
    • (in vivo evidence)
    • Rossi D.J., Seita J., Czechowicz A., Bhattacharya D., Bryder D., Weissman I.L. Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. Cell Cycle 2007, 6:2371-2376. (in vivo evidence).
    • (2007) Cell Cycle , vol.6 , pp. 2371-2376
    • Rossi, D.J.1    Seita, J.2    Czechowicz, A.3    Bhattacharya, D.4    Bryder, D.5    Weissman, I.L.6
  • 68
    • 79952338609 scopus 로고    scopus 로고
    • Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging
    • (in vivo & in vitro evidence)
    • Rübe C.E., Fricke A., Widmann T.A., Furst T., Madry H., Pfreundschuh M., Rübe C. Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. PLoS ONE 2011, 6:e17487. (in vivo & in vitro evidence).
    • (2011) PLoS ONE , vol.6 , pp. e17487
    • Rübe, C.E.1    Fricke, A.2    Widmann, T.A.3    Furst, T.4    Madry, H.5    Pfreundschuh, M.6    Rübe, C.7
  • 71
    • 70349559919 scopus 로고    scopus 로고
    • Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
    • (in vivo evidence)
    • Ruzankina Y., Schoppy D.W., Asare A., Clark C.E., Vonderheide R.H., Brown E.J. Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat. Genet. 2009, 41:1144-1149. (in vivo evidence).
    • (2009) Nat. Genet. , vol.41 , pp. 1144-1149
    • Ruzankina, Y.1    Schoppy, D.W.2    Asare, A.3    Clark, C.E.4    Vonderheide, R.H.5    Brown, E.J.6
  • 75
    • 79952751557 scopus 로고    scopus 로고
    • Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes
    • (in vivo & in vitro evidence)
    • Schepers A.G., Vries R., van den Born M., van de Wetering M., Clevers H. Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J. 2011, 30:1104-1109. (in vivo & in vitro evidence).
    • (2011) EMBO J. , vol.30 , pp. 1104-1109
    • Schepers, A.G.1    Vries, R.2    van den Born, M.3    van de Wetering, M.4    Clevers, H.5
  • 76
    • 33745762804 scopus 로고    scopus 로고
    • Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells
    • (in vivo & in vitro evidence)
    • Shinin V., Gayraud-Morel B., Gomes D., Tajbakhsh S. Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat. Cell Biol. 2006, 8:677-687. (in vivo & in vitro evidence).
    • (2006) Nat. Cell Biol. , vol.8 , pp. 677-687
    • Shinin, V.1    Gayraud-Morel, B.2    Gomes, D.3    Tajbakhsh, S.4
  • 84
    • 84918789922 scopus 로고    scopus 로고
    • More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny
    • (in vitro evidence)
    • Vahidi Ferdousi L., Rocheteau P., Chayot R., Montagne B., Chaker Z., Flamant P., Tajbakhsh S., Ricchetti M. More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny. Stem Cell Res. 2014, 13:492-507. (in vitro evidence).
    • (2014) Stem Cell Res. , vol.13 , pp. 492-507
    • Vahidi Ferdousi, L.1    Rocheteau, P.2    Chayot, R.3    Montagne, B.4    Chaker, Z.5    Flamant, P.6    Tajbakhsh, S.7    Ricchetti, M.8
  • 86
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader J.E. Cells of origin in cancer. Nature 2011, 469:314-322.
    • (2011) Nature , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 87
    • 0344132640 scopus 로고    scopus 로고
    • Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement
    • (in vivo evidence)
    • Wang C., Sinha Hikim A.P., Lue Y.H., Leung A., Baravarian S., Swerdloff R.S. Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement. J. Androl. 1999, 20:509-518. (in vivo evidence).
    • (1999) J. Androl. , vol.20 , pp. 509-518
    • Wang, C.1    Sinha Hikim, A.P.2    Lue, Y.H.3    Leung, A.4    Baravarian, S.5    Swerdloff, R.S.6
  • 89
    • 84911397097 scopus 로고    scopus 로고
    • Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres
    • (in vivo & in vitro evidence)
    • Wang J., Lu X., Sakk V., Klein C.A., Rudolph K.L. Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres. Blood 2014, 124:3237-3240. (in vivo & in vitro evidence).
    • (2014) Blood , vol.124 , pp. 3237-3240
    • Wang, J.1    Lu, X.2    Sakk, V.3    Klein, C.A.4    Rudolph, K.L.5
  • 93
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright W.E., Piatyszek M.A., Rainey W.E., Byrd W., Shay J.W. Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 1996, 18:173-179.
    • (1996) Dev. Genet. , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 95
    • 54449092731 scopus 로고    scopus 로고
    • Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
    • (in vivo & in vitro evidence)
    • Yalcin S., Zhang X., Luciano J.P., Mungamuri S.K., Marinkovic D., Vercherat C., Sarkar A., Grisotto M., Taneja R., Ghaffari S. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J. Biol. Chem. 2008, 283:25692-25705. (in vivo & in vitro evidence).
    • (2008) J. Biol. Chem. , vol.283 , pp. 25692-25705
    • Yalcin, S.1    Zhang, X.2    Luciano, J.P.3    Mungamuri, S.K.4    Marinkovic, D.5    Vercherat, C.6    Sarkar, A.7    Grisotto, M.8    Taneja, R.9    Ghaffari, S.10
  • 96
    • 84872037830 scopus 로고    scopus 로고
    • Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation
    • (in vivo evidence)
    • Yu W.M., Liu X., Shen J., Jovanovic O., Pohl E.E., Gerson S.L., Finkel T., Broxmeyer H.E., Qu C.K. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell 2013, 12:62-74. (in vivo evidence).
    • (2013) Cell Stem Cell , vol.12 , pp. 62-74
    • Yu, W.M.1    Liu, X.2    Shen, J.3    Jovanovic, O.4    Pohl, E.E.5    Gerson, S.L.6    Finkel, T.7    Broxmeyer, H.E.8    Qu, C.K.9
  • 97
    • 84891301320 scopus 로고    scopus 로고
    • Causes and consequences of replication stress
    • Zeman M.K., Cimprich K.A. Causes and consequences of replication stress. Nat. Cell Biol. 2014, 16:2-9.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 2-9
    • Zeman, M.K.1    Cimprich, K.A.2


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