Defective telomere lagging strand synthesis in cells lacking WRN helicase activity

Science

Volumn 306, Issue 5703, 2004, Pages 1951-1953

  Crabbe, Laure ^a   Verdun, Ramiro E ^a   Haggblom, Candy I ^a   Karlseder, Jan ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENES; PATIENT TREATMENT;

GROWTH RATE; SYNDROME; TELOMERE;

CELLS;

HELICASE;

ENZYME ACTIVITY;

ARTICLE; CELL DIVISION; CONTROLLED STUDY; DELETION MUTANT; DNA REPLICATION ORIGIN; DNA STRAND; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOSIS INDEX; PRIORITY JOURNAL; SISTER CHROMATID; TELOMERE; VERNER MORRISON SYNDROME;

ALLELES; ANAPHASE; CELL CYCLE PROTEINS; CELL LINE; CELLS, CULTURED; CHROMATIDS; CHROMOSOMES, HUMAN; DNA DAMAGE; DNA HELICASES; DNA-BINDING PROTEINS; GENOMIC INSTABILITY; HELA CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MODELS, GENETIC; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RECQ HELICASES; S PHASE; TELOMERASE; TELOMERE; TUMOR SUPPRESSOR PROTEINS; WERNER SYNDROME;

EID: 10344256183     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1103619     Document Type: Article

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29. We thank J. Campisi for WRN cDNAs; K. Damm for BIBR1532; H. Maruyama for antibody preparation; T. de Lange for discussion; members of the Karlseder lab and colleagues at The Salk, particularly V. Lundblad, for comments on the manuscript; B. Pau for co-directorship of a thesis committee (L.C.); R. Wang for CO-FISH suggestion and advice; and S. Chang for sharing unpublished data and material. Supported by the Mathers Foundation and NIH grant no. GM069525 (J.K.) and by a President's Fellowship and the Volontariat International program by the French Ministry of Foreign Affairs (L.C.).