Hematopoietic stem cell ageing is uncoupled from p16 INK4A -mediated senescence

Oncogene

Volumn 28, Issue 22, 2009, Pages 2238-2243

  Attema, J L ^a   Pronk, C J H ^a   Norddahl, G L ^a   Nygren, J M ^a   Bryder, D ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Ageing; Hematopoiesis; Senescence; Stem cells

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL AGING; CELL DIVISION; CELL PROLIFERATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; FIBROBLAST; GENE LOCUS; GENE REPRESSION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE;

ANIMALS; CELL AGING; CELL LINE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA; EPIGENESIS, GENETIC; HEMATOPOIETIC STEM CELLS; HISTONES; METHYLATION; MICE; PROMOTER REGIONS, GENETIC; UP-REGULATION;

MURINAE; PROCESSA;

EID: 67349161638     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.94     Document Type: Article

References (26)

1. Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale ST, Weissman IL. (2007). Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci USA 104: 12371-12376.
2. Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C et al. (2007). The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 21: 525-530.
3. Bryder D, Rossi DJ, Weissman IL. (2006). Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol 169: 338-346.
4. Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. (1999). The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164-168.
5. Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM et al. (2006). Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443: 421-426.
6. Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. (2005). SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121: 1109-1121.
7. Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y. (2007). pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16IN-K4alpha tumor suppressor gene. Genes Dev 21: 49-54.
8. Mansson R, Hultquist A, Luc S, Yang L, Anderson K, Kharazi S et al. (2007). Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity 26: 407-419.
9. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC et al. (1995). 5 CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1: 686-692.
10. Nygren JM, Bryder D. (2008). A novel assay to trace proliferation history in vivo reveals that enhanced divisional kinetics accompany loss of hematopoietic stem cell self-renewal. PLoS ONE 3: e3710.
11. Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuizen M, Nakauchi H. (2006). Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 203: 2247-2253.
12. Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y et al. (2001). Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409: 1067-1070.
13. Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL et al. (2003). Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423: 302-305.
14. Patel AC, Anna CH, Foley JF, Stockton PS, Tyson FL, Barrett JC et al. (2000). Hypermethylation of the p16 (Ink4a) promoter in B6C3F1 mouse primary lung adenocarcinomas and mouse lung cell lines. Carcinogenesis 21: 1691-1700.
15. Pearce DJ, Anjos-Afonso F, Ridler CM, Eddaoudi A, Bonnet D. (2007). Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging. Stem Cells 25: 828-835.
16. Pronk CJ, Rossi DJ, Mansson R, Attema JL, Norddahl GL, Chan CK et al. (2007). Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell 1: 428-442.
17. Randall TD, Weissman IL. (1998). Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population? Stem Cells 16: 38-48.
18. Reik W. (2007). Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447: 425-432.
19. Ringrose L, Paro R. (2007). Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development 134: 223-232.
20. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ et al. (2005). Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 102: 9194-9199.
21. Rossi DJ, Jamieson CH, Weissman IL. (2008). Stems cells and the pathways to aging and cancer. Cell 132: 681-696.
22. Schneider R, Bannister AJ, Myers FA, Thorne AW, Crane-Robinson C, Kouzarides T. (2004). Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol 6: 73-77.
23. Sharpless NE, DePinho RA. (2007). How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8: 703-713.
24. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. (2008). Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev 22: 3115-3120.
25. Sudo K, Ema H, Morita Y, Nakauchi H. (2000). Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 192: 1273-1280.
26. Zindy F, Quelle DE, Roussel MF, Sherr CJ. (1997). Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15: 203-211.