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Volumn , Issue , 2013, Pages 25-65

Molecular mechanisms of colorectal carcinogenesis

Author keywords

Chromosomal instability; Colorectal cancer; Microsatellite instability; Mouse models; Serrated pathway

Indexed keywords


EID: 84929583628     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-8412-7_2     Document Type: Chapter
Times cited : (16)

References (270)
  • 1
    • 0034192381 scopus 로고    scopus 로고
    • Microsatellite instability at selected tetranucleotide repeats is associated with p53 mutations in non-small cell lung cancer
    • Ahrendt SA, Decker PA, Doffek K et al (2000) Microsatellite instability at selected tetranucleotide repeats is associated with p53 mutations in non-small cell lung cancer. Cancer Res 60(9):2488-2491
    • (2000) Cancer Res , vol.60 , Issue.9 , pp. 2488-2491
    • Ahrendt, S.A.1    Decker, P.A.2    Doffek, K.3
  • 2
    • 35148842479 scopus 로고    scopus 로고
    • FBXW7/hCDC4 is a general tumor suppressor in human cancer
    • Akhoondi S, Sun D, von der Lehr N et al (2007) FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 67(19):9006-9012
    • (2007) Cancer Res , vol.67 , Issue.19 , pp. 9006-9012
    • Akhoondi, S.1    Sun, D.2    Von Der Lehr, N.3
  • 4
    • 34249323787 scopus 로고    scopus 로고
    • Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells
    • Aoki K, Aoki M, Sugai M et al (2007) Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells. Oncogene 26(24):3511-3520
    • (2007) Oncogene , vol.26 , Issue.24 , pp. 3511-3520
    • Aoki, K.1    Aoki, M.2    Sugai, M.3
  • 5
    • 77951974883 scopus 로고    scopus 로고
    • CIMP status of interval colon cancers: Another piece to the puzzle
    • Arain MA, Sawhney M, Sheikh S et al (2010) CIMP status of interval colon cancers: another piece to the puzzle. Am J Gastroenterol 105(5):1189-1195
    • (2010) Am J Gastroenterol , vol.105 , Issue.5 , pp. 1189-1195
    • Arain, M.A.1    Sawhney, M.2    Sheikh, S.3
  • 6
    • 33748180713 scopus 로고    scopus 로고
    • Celecoxib for the prevention of colorectal adenomatous polyps
    • Arber N, Eagle CJ, Spicak J et al (2006) Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med 355(9):885-895
    • (2006) N Engl J Med , vol.355 , Issue.9 , pp. 885-895
    • Arber, N.1    Eagle, C.J.2    Spicak, J.3
  • 7
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    • Barbie DA, Tamayo P, Boehm JS et al (2009) Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462(7269):108-112
    • (2009) Nature , vol.462 , Issue.7269 , pp. 108-112
    • Barbie, D.A.1    Tamayo, P.2    Boehm, J.S.3
  • 8
    • 0035826823 scopus 로고    scopus 로고
    • Carcinogen-specifi c induction of genetic instability
    • Bardelli A, Cahill DP, Lederer G et al (2001) Carcinogen-specifi c induction of genetic instability. Proc Natl Acad Sci U S A 98(10):5770-5775
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.10 , pp. 5770-5775
    • Bardelli, A.1    Cahill, D.P.2    Lederer, G.3
  • 9
    • 8544232096 scopus 로고    scopus 로고
    • Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer
    • Bardi G, Parada LA, Bomme L et al (1997) Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer. Br J Cancer 76(6):765-769
    • (1997) Br J Cancer , vol.76 , Issue.6 , pp. 765-769
    • Bardi, G.1    Parada, L.A.2    Bomme, L.3
  • 10
    • 33845288081 scopus 로고    scopus 로고
    • A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas
    • Baron JA, Sandler RS, Bresalier RS et al (2006) A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas. Gastroenterology 131(6):1674-1682
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1674-1682
    • Baron, J.A.1    Sandler, R.S.2    Bresalier, R.S.3
  • 11
    • 0042991379 scopus 로고    scopus 로고
    • Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors
    • Bassing CH, Suh H, Ferguson DO et al (2003) Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114(3):359-370
    • (2003) Cell , vol.114 , Issue.3 , pp. 359-370
    • Bassing, C.H.1    Suh, H.2    Ferguson, D.O.3
  • 13
    • 28544446428 scopus 로고    scopus 로고
    • Microsatellite instability and colorectal cancer prognosis
    • Benatti P, Gafà R, Barana D et al (2005) Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res 11(23):8332-8340
    • (2005) Clin Cancer Res , vol.11 , Issue.23 , pp. 8332-8340
    • Benatti, P.1    Gafà, R.2    Barana, D.3
  • 14
    • 33748196958 scopus 로고    scopus 로고
    • Celecoxib for the prevention of sporadic colorectal adenomas
    • Bertagnolli MM, Eagle CJ, Zauber AG et al (2006) Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med 355(9):873-884
    • (2006) N Engl J Med , vol.355 , Issue.9 , pp. 873-884
    • Bertagnolli, M.M.1    Eagle, C.J.2    Zauber, A.G.3
  • 15
    • 64649096900 scopus 로고    scopus 로고
    • Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fl uorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803
    • Bertagnolli MM, Niedzwiecki D, Compton CC et al (2009) Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fl uorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803. J Clin Oncol 27(11):1814-1821
    • (2009) J Clin Oncol , vol.27 , Issue.11 , pp. 1814-1821
    • Bertagnolli, M.M.1    Niedzwiecki, D.2    Compton, C.C.3
  • 17
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • Bird AP (1986) CpG-rich islands and the function of DNA methylation. Nature 321(6067):209-213
    • (1986) Nature , vol.321 , Issue.6067 , pp. 209-213
    • Bird, A.P.1
  • 18
    • 0035011418 scopus 로고    scopus 로고
    • Stepwise deletions of PolyA sequences in mismatch repair-defi cient colorectal cancers
    • Blake C, Tsao J-L, Wu A, Shibata D (2001) Stepwise deletions of PolyA sequences in mismatch repair-defi cient colorectal cancers. Am J Pathol 158(5):1867-1870
    • (2001) Am J Pathol , vol.158 , Issue.5 , pp. 1867-1870
    • Blake, C.1    Tsao, J.-L.2    Wu, A.3    Shibata, D.4
  • 19
    • 77449130761 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer
    • Boland CR, Goel A (2010) Microsatellite instability in colorectal cancer. Gastroenterology 138(6):2073-2087.e3
    • (2010) Gastroenterology , vol.138 , Issue.6 , pp. 2073-2073e3
    • Boland, C.R.1    Goel, A.2
  • 20
    • 0032534069 scopus 로고    scopus 로고
    • A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
    • Boland CR, Thibodeau SN, Hamilton SR et al (1998) A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58(22):5248-5257
    • (1998) Cancer Res , vol.58 , Issue.22 , pp. 5248-5257
    • Boland, C.R.1    Thibodeau, S.N.2    Hamilton, S.R.3
  • 21
    • 0028286150 scopus 로고
    • Clonal karyotypic abnormalities in colorectal adenomas: Clues to the early genetic events in the adenoma-carcinoma sequence
    • Bomme L, Bardi G, Pandis N, Fenger C, Kronborg O, Heim S (1994) Clonal karyotypic abnormalities in colorectal adenomas: clues to the early genetic events in the adenoma-carcinoma sequence. Genes Chromosomes Cancer 10(3):190-196
    • (1994) Genes Chromosomes Cancer , vol.10 , Issue.3 , pp. 190-196
    • Bomme, L.1    Bardi, G.2    Pandis, N.3    Fenger, C.4    Kronborg, O.5    Heim, S.6
  • 22
    • 18444414011 scopus 로고    scopus 로고
    • Expression and gene amplifi cation of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome
    • Bondi J, Husdal A, Bukholm G, Nesland JM, Bakka A, Bukholm IRK (2005) Expression and gene amplifi cation of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome. J Clin Pathol 58(5):509-514
    • (2005) J Clin Pathol , vol.58 , Issue.5 , pp. 509-514
    • Bondi, J.1    Husdal, A.2    Bukholm, G.3    Nesland, J.M.4    Bakka, A.5    Bukholm, I.R.K.6
  • 23
    • 57249104892 scopus 로고    scopus 로고
    • Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis
    • Boparai KS, Dekker E, Van Eeden S et al (2008) Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis. Gastroenterology 135(6):2014-2018
    • (2008) Gastroenterology , vol.135 , Issue.6 , pp. 2014-2018
    • Boparai, K.S.1    Dekker, E.2    Van Eeden, S.3
  • 24
    • 77954702555 scopus 로고    scopus 로고
    • Increased colorectal cancer risk during follow-up in patients with hyperplastic polyposis syndrome: A multicentre cohort study
    • Boparai KS, Mathus-Vliegen EMH, Koornstra JJ et al (2010) Increased colorectal cancer risk during follow-up in patients with hyperplastic polyposis syndrome: a multicentre cohort study. Gut 59(8):1094-1100
    • (2010) Gut , vol.59 , Issue.8 , pp. 1094-1100
    • Boparai, K.S.1    Mathus-Vliegen, E.M.H.2    Koornstra, J.J.3
  • 25
  • 26
    • 75149156598 scopus 로고    scopus 로고
    • Protection from right- and left-sided colorectal neoplasms after colonoscopy: Population-based study
    • Brenner H, Hoffmeister M, Arndt V, Stegmaier C, Altenhofen L, Haug U (2010) Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study. J Natl Cancer Inst 102(2):89-95
    • (2010) J Natl Cancer Inst , vol.102 , Issue.2 , pp. 89-95
    • Brenner, H.1    Hoffmeister, M.2    Arndt, V.3    Stegmaier, C.4    Altenhofen, L.5    Haug, U.6
  • 27
    • 0029937720 scopus 로고    scopus 로고
    • Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis
    • Brentnall TA, Crispin DA, Bronner MP et al (1996) Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 56(6):1237-1240
    • (1996) Cancer Res , vol.56 , Issue.6 , pp. 1237-1240
    • Brentnall, T.A.1    Crispin, D.A.2    Bronner, M.P.3
  • 28
    • 19744380776 scopus 로고    scopus 로고
    • Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
    • Bresalier RS, Sandler RS, Quan H et al (2005) Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 352(11):1092-1102
    • (2005) N Engl J Med , vol.352 , Issue.11 , pp. 1092-1102
    • Bresalier, R.S.1    Sandler, R.S.2    Quan, H.3
  • 29
    • 4143084914 scopus 로고    scopus 로고
    • Colonoscopic miss rates for rightsided colon cancer: A population-based analysis
    • Bressler B, Paszat LF, Vinden C, Li C, He J, Rabeneck L (2004) Colonoscopic miss rates for rightsided colon cancer: a population-based analysis. Gastroenterology 127(2):452-456
    • (2004) Gastroenterology , vol.127 , Issue.2 , pp. 452-456
    • Bressler, B.1    Paszat, L.F.2    Vinden, C.3    Li, C.4    He, J.5    Rabeneck, L.6
  • 30
    • 77953323618 scopus 로고    scopus 로고
    • Phenotypic diversity in patients with multiple serrated polyps: A genetics clinic study
    • Buchanan DD, Sweet K, Drini M et al (2010) Phenotypic diversity in patients with multiple serrated polyps: a genetics clinic study. Int J Colorectal Dis 25(6):703-712
    • (2010) Int J Colorectal Dis , vol.25 , Issue.6 , pp. 703-712
    • Buchanan, D.D.1    Sweet, K.2    Drini, M.3
  • 31
    • 23244452684 scopus 로고    scopus 로고
    • Suppressing cancer: The importance of being senescent
    • Campisi J (2005) Suppressing cancer: the importance of being senescent. Science 309(5736):886-887
    • (2005) Science , vol.309 , Issue.5736 , pp. 886-887
    • Campisi, J.1
  • 32
    • 70349317146 scopus 로고    scopus 로고
    • Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer
    • Camps J, Nguyen QT, Padilla-Nash HM et al (2009) Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer. Genes Chromosomes Cancer 48(11):1002-1017
    • (2009) Genes Chromosomes Cancer , vol.48 , Issue.11 , pp. 1002-1017
    • Camps, J.1    Nguyen, Q.T.2    Padilla-Nash, H.M.3
  • 33
    • 33645074134 scopus 로고    scopus 로고
    • Chromosomal instability in MYH- and APCmutant adenomatous polyps
    • Cardoso J, Molenaar L, De Menezes RX et al (2006) Chromosomal instability in MYH- and APCmutant adenomatous polyps. Cancer Res 66(5):2514-2519
    • (2006) Cancer Res , vol.66 , Issue.5 , pp. 2514-2519
    • Cardoso, J.1    Molenaar, L.2    De Menezes, R.X.3
  • 34
    • 78649307591 scopus 로고    scopus 로고
    • V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a
    • Carragher LAS, Snell KR, Giblett SM et al (2010) V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. EMBO Mol Med 2(11):458-471
    • (2010) EMBO Mol Med , vol.2 , Issue.11 , pp. 458-471
    • Carragher, L.A.S.1    Snell, K.R.2    Giblett, S.M.3
  • 35
    • 84857451506 scopus 로고    scopus 로고
    • DCC constrains tumour progression via its dependence receptor activity
    • Castets M, Broutier L, Molin Y et al (2011) DCC constrains tumour progression via its dependence receptor activity. Nature 482(7386):534-537 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22158121
    • (2011) Nature , vol.482 , Issue.7386 , pp. 534-537
    • Castets, M.1    Broutier, L.2    Molin, Y.3
  • 36
    • 35948946506 scopus 로고    scopus 로고
    • Overexpression of Eg5 causes genomic instability and tumor formation in mice
    • Castillo A, Morse HC III, Godfrey VL, Naeem R, Justice MJ (2007) Overexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Res 67(21):10138-10147
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10138-10147
    • Castillo, A.1    Morse Iii, H.C.2    Godfrey, V.L.3    Naeem, R.4    Justice, M.J.5
  • 37
    • 0042991383 scopus 로고    scopus 로고
    • H2AX haploinsuffi ciency modifi es genomic stability and tumor susceptibility
    • Celeste A, Difi lippantonio S, Difi lippantonio MJ et al (2003) H2AX haploinsuffi ciency modifi es genomic stability and tumor susceptibility. Cell 114(3):371-383
    • (2003) Cell , vol.114 , Issue.3 , pp. 371-383
    • Celeste, A.1    Difi Lippantonio, S.2    Difi Lippantonio, M.J.3
  • 38
    • 0029013631 scopus 로고
    • Telomerase activity associated with acquisition of malignancy in human colorectal cancer
    • Chadeneau C, Hay K, Hirte HW, Gallinger S, Bacchetti S (1995) Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res 55(12):2533-2536
    • (1995) Cancer Res , vol.55 , Issue.12 , pp. 2533-2536
    • Chadeneau, C.1    Hay, K.2    Hirte, H.W.3    Gallinger, S.4    Bacchetti, S.5
  • 39
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub N, Baker SJ (2009) PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4:127-150
    • (2009) Annu Rev Pathol , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 40
    • 77951630296 scopus 로고    scopus 로고
    • Primary prevention of colorectal cancer
    • Chan AT, Giovannucci EL (2010) Primary prevention of colorectal cancer. Gastroenterology 138(6):2029-2043.e10
    • (2010) Gastroenterology , vol.138 , Issue.6 , pp. 2029-2029e10
    • Chan, A.T.1    Giovannucci, E.L.2
  • 41
    • 0036169109 scopus 로고    scopus 로고
    • Concordant CpG island methylation in hyperplastic polyposis
    • Chan AO-O, Issa J-PJ, Morris JS, Hamilton SR, Rashid A (2002) Concordant CpG island methylation in hyperplastic polyposis. Am J Pathol 160(2):529-536
    • (2002) Am J Pathol , vol.160 , Issue.2 , pp. 529-536
    • Ao-O, C.1    J-Pj, I.2    Morris, J.S.3    Hamilton, S.R.4    Rashid, A.5
  • 42
    • 0036082617 scopus 로고    scopus 로고
    • Oxidative stress inactivates the human DNA mismatch repair system
    • Chang CL, Marra G, Chauhan DP et al (2002) Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol 283(1):C148-C154
    • (2002) Am J Physiol Cell Physiol , vol.283 , Issue.1 , pp. C148-C154
    • Chang, C.L.1    Marra, G.2    Chauhan, D.P.3
  • 43
    • 23244460597 scopus 로고    scopus 로고
    • Crucial role of p53-dependent cellular senescence in suppression of Pten-defi cient tumorigenesis
    • Chen Z, Trotman LC, Shaffer D et al (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-defi cient tumorigenesis. Nature 436(7051):725-730
    • (2005) Nature , vol.436 , Issue.7051 , pp. 725-730
    • Chen, Z.1    Trotman, L.C.2    Shaffer, D.3
  • 44
    • 15744391017 scopus 로고    scopus 로고
    • Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation
    • Chirieac LR, Shen L, Catalano PJ, Issa J-P, Hamilton SR (2005) Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation. Am J Surg Pathol 29(4):429-436
    • (2005) Am J Surg Pathol , vol.29 , Issue.4 , pp. 429-436
    • Chirieac, L.R.1    Shen, L.2    Catalano, P.J.3    Issa, J.-P.4    Hamilton, S.R.5
  • 45
    • 33745752975 scopus 로고    scopus 로고
    • Hyperplastic polyposis syndrome: Phenotypic presentations and the role of MBD4 and MYH
    • Chow E, Lipton L, Lynch E et al (2006) Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH. Gastroenterology 131(1):30-39
    • (2006) Gastroenterology , vol.131 , Issue.1 , pp. 30-39
    • Chow, E.1    Lipton, L.2    Lynch, E.3
  • 46
    • 2342634448 scopus 로고    scopus 로고
    • Genetic and pathologic signifi cance of 1p, 17p, and 18q aneusomy and the ERBB2 gene in colorectal cancer and related normal colonic mucosa
    • Cianciulli A, Cosimelli M, Marzano R et al (2004) Genetic and pathologic signifi cance of 1p, 17p, and 18q aneusomy and the ERBB2 gene in colorectal cancer and related normal colonic mucosa. Cancer Genet Cytogenet 151(1):52-59
    • (2004) Cancer Genet Cytogenet , vol.151 , Issue.1 , pp. 52-59
    • Cianciulli, A.1    Cosimelli, M.2    Marzano, R.3
  • 47
    • 60749128400 scopus 로고    scopus 로고
    • Aspirin for the chemoprevention of colorectal adenomas: Meta-analysis of the randomized trials
    • Cole BF, Logan RF, Halabi S et al (2009) Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. J Natl Cancer Inst 101(4):256-266
    • (2009) J Natl Cancer Inst , vol.101 , Issue.4 , pp. 256-266
    • Cole, B.F.1    Logan, R.F.2    Halabi, S.3
  • 48
    • 0026726952 scopus 로고
    • Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas
    • Cottrell S, Bicknell D, Kaklamanis L, Bodmer WF (1992) Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas. Lancet 340(8820):626-630
    • (1992) Lancet , vol.340 , Issue.8820 , pp. 626-630
    • Cottrell, S.1    Bicknell, D.2    Kaklamanis, L.3    Bodmer, W.F.4
  • 49
    • 33646553656 scopus 로고    scopus 로고
    • TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription
    • Cuilliere-Dartigues P, El-Bchiri J, Krimi A et al (2006) TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription. Oncogene 25(32):4441-4448
    • (2006) Oncogene , vol.25 , Issue.32 , pp. 4441-4448
    • Cuilliere-Dartigues, P.1    El-Bchiri, J.2    Krimi, A.3
  • 50
    • 29544442045 scopus 로고    scopus 로고
    • Expression of concern: Bombardier et al., "comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis", N Engl J Med 2000;343:1520-8
    • Curfman GD, Morrissey S, Drazen JM (2005) Expression of concern: Bombardier et al., "Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis", N Engl J Med 2000;343:1520-8. N Engl J Med 353(26):2813-2814
    • (2005) N Engl J Med , vol.353 , Issue.26 , pp. 2813-2814
    • Curfman, G.D.1    Morrissey, S.2    Drazen, J.M.3
  • 51
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C et al (2002) Mutations of the BRAF gene in human cancer. Nature 417(6892):949-954
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 52
    • 67650385667 scopus 로고    scopus 로고
    • MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: Indications for distinct pathways and sequence of events
    • de Vogel S, Weijenberg MP, Herman JG et al (2009) MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events. Ann Oncol 20(7):1216-1222
    • (2009) Ann Oncol , vol.20 , Issue.7 , pp. 1216-1222
    • De Vogel, S.1    Weijenberg, M.P.2    Herman, J.G.3
  • 53
    • 10744230297 scopus 로고    scopus 로고
    • Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer
    • de Vos tot Nederveen Cappel WH, Meulenbeld HJ, Kleibeuker JH et al (2004) Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer. Int J Cancer 109(3):468-471
    • (2004) Int J Cancer , vol.109 , Issue.3 , pp. 468-471
    • De Vos Tot Nederveen Cappel, W.H.1    Meulenbeld, H.J.2    Kleibeuker, J.H.3
  • 54
    • 78650249084 scopus 로고    scopus 로고
    • Prognostic impact of microsatellite instability in colorectal cancer patients treated with adjuvant FOLFOX
    • Des Guetz G, Lecaille C, Mariani P et al (2010) Prognostic impact of microsatellite instability in colorectal cancer patients treated with adjuvant FOLFOX. Anticancer Res 30(10):4297-4301
    • (2010) Anticancer Res , vol.30 , Issue.10 , pp. 4297-4301
    • Des Guetz, G.1    Lecaille, C.2    Mariani, P.3
  • 55
    • 0029991547 scopus 로고    scopus 로고
    • Deletions at chromosome 1p by fl uorescence in situ hybridization are an early event in human colorectal tumorigenesis
    • Di Vinci A, Infusini E, Peveri C, Risio M, Rossini FP, Giaretti W (1996) Deletions at chromosome 1p by fl uorescence in situ hybridization are an early event in human colorectal tumorigenesis. Gastroenterology 111(1):102-107
    • (1996) Gastroenterology , vol.111 , Issue.1 , pp. 102-107
    • Di Vinci, A.1    Infusini, E.2    Peveri, C.3    Risio, M.4    Rossini, F.P.5    Giaretti, W.6
  • 56
    • 0037364659 scopus 로고    scopus 로고
    • Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients
    • Diep CB, Thorstensen L, Meling GI, Skovlund E, Rognum TO, Lothe RA (2003) Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients. J Clin Oncol 21(5):820-829
    • (2003) J Clin Oncol , vol.21 , Issue.5 , pp. 820-829
    • Diep, C.B.1    Thorstensen, L.2    Meling, G.I.3    Skovlund, E.4    Rognum, T.O.5    Lothe, R.A.6
  • 57
    • 84856912673 scopus 로고    scopus 로고
    • Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer
    • http://www.ncbi.nlm.nih.gov/pubmed/22240781
    • Dotan E, Meropol NJ, Zhu F et al (2012) Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer. Br J Cancer 106(4):748-755 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22240781
    • (2012) Br J Cancer , vol.106 , Issue.4 , pp. 748-755
    • Dotan, E.1    Meropol, N.J.2    Zhu, F.3
  • 58
    • 1842611683 scopus 로고    scopus 로고
    • Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells
    • Duesberg P, Fabarius A, Hehlmann R (2004) Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells. IUBMB Life 56(2):65-81
    • (2004) IUBMB Life , vol.56 , Issue.2 , pp. 65-81
    • Duesberg, P.1    Fabarius, A.2    Hehlmann, R.3
  • 59
    • 39649118620 scopus 로고    scopus 로고
    • Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: Classifi cation, molecular genetics, natural history, and clinical management
    • East JE, Saunders BP, Jass JR (2008) Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classifi cation, molecular genetics, natural history, and clinical management. Gastroenterol Clin North Am 37(1):25-46
    • (2008) Gastroenterol Clin North Am , vol.37 , Issue.1 , pp. 25-46
    • East, J.E.1    Saunders, B.P.2    Jass, J.R.3
  • 61
    • 54349087788 scopus 로고    scopus 로고
    • Myc's broad reach
    • Eilers M, Eisenman RN (2008) Myc's broad reach. Genes Dev 22(20):2755-2766
    • (2008) Genes Dev , vol.22 , Issue.20 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 62
    • 0034690610 scopus 로고    scopus 로고
    • Association of tumour site and sex with survival benefi t from adjuvant chemotherapy in colorectal cancer
    • Elsaleh H, Joseph D, Grieu F, Zeps N, Spry N, Iacopetta B (2000) Association of tumour site and sex with survival benefi t from adjuvant chemotherapy in colorectal cancer. Lancet 355(9217):1745-1750
    • (2000) Lancet , vol.355 , Issue.9217 , pp. 1745-1750
    • Elsaleh, H.1    Joseph, D.2    Grieu, F.3    Zeps, N.4    Spry, N.5    Iacopetta, B.6
  • 63
    • 0030706072 scopus 로고    scopus 로고
    • Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer
    • Engelhardt M, Drullinsky P, Guillem J, Moore MAS (1997) Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer. Clin Cancer Res 3(11):1931-1941
    • (1997) Clin Cancer Res , vol.3 , Issue.11 , pp. 1931-1941
    • Engelhardt, M.1    Drullinsky, P.2    Guillem, J.3    Moore, M.A.S.4
  • 64
    • 53549108607 scopus 로고    scopus 로고
    • Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype
    • English DR, Young JP, Simpson JA et al (2008) Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. Cancer Epidemiol Biomarkers Prev 17(7):1774-1780
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , Issue.7 , pp. 1774-1780
    • English, D.R.1    Young, J.P.2    Simpson, J.A.3
  • 65
    • 0034662626 scopus 로고    scopus 로고
    • Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
    • Esteller M, Sparks A, Toyota M et al (2000) Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 60(16):4366-4371
    • (2000) Cancer Res , vol.60 , Issue.16 , pp. 4366-4371
    • Esteller, M.1    Sparks, A.2    Toyota, M.3
  • 66
    • 0141731323 scopus 로고    scopus 로고
    • Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer
    • Fallik D, Borrini F, Boige V et al (2003) Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. Cancer Res 63(18):5738-5744
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 5738-5744
    • Fallik, D.1    Borrini, F.2    Boige, V.3
  • 68
    • 0030995125 scopus 로고    scopus 로고
    • Phenotype of mice lacking functional deleted in colorectal cancer (Dec) gene
    • Fazeli A, Dickinson SL, Hermiston ML et al (1997) Phenotype of mice lacking functional deleted in colorectal cancer (Dec) gene. Nature 386(6627):796-804
    • (1997) Nature , vol.386 , Issue.6627 , pp. 796-804
    • Fazeli, A.1    Dickinson, S.L.2    Hermiston, M.L.3
  • 69
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon ER (2011) Molecular genetics of colorectal cancer. Annu Rev Pathol 6:479-507
    • (2011) Annu Rev Pathol , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 70
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61(5):759-767
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 71
    • 0025056930 scopus 로고
    • Identifi cation of a chromosome 18q gene that is altered in colorectal cancers
    • Fearon ER, Cho KR, Nigro JM et al (1990) Identifi cation of a chromosome 18q gene that is altered in colorectal cancers. Science 247(4938):49-56
    • (1990) Science , vol.247 , Issue.4938 , pp. 49-56
    • Fearon, E.R.1    Cho, K.R.2    Nigro, J.M.3
  • 72
    • 0023848637 scopus 로고
    • Reduced genomic 5-methylcytosine content in human colonic neoplasia
    • Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M (1988) Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 48(5):1159-1161
    • (1988) Cancer Res , vol.48 , Issue.5 , pp. 1159-1161
    • Feinberg, A.P.1    Gehrke, C.W.2    Kuo, K.C.3    Ehrlich, M.4
  • 73
    • 7044223112 scopus 로고    scopus 로고
    • Phenotypic characteristics and risk of cancer development in hyperplastic polyposis: Case series and literature review
    • Ferrández A, Samowitz W, DiSario JA, Burt RW (2004) Phenotypic characteristics and risk of cancer development in hyperplastic polyposis: case series and literature review. Am J Gastroenterol 99(10):2012-2018
    • (2004) Am J Gastroenterol , vol.99 , Issue.10 , pp. 2012-2018
    • Ferrández, A.1    Samowitz, W.2    Disario, J.A.3    Burt, R.W.4
  • 74
    • 70350234735 scopus 로고    scopus 로고
    • Revving the throttle on an oncogene: CDK8 takes the driver seat
    • Firestein R, Hahn WC (2009) Revving the throttle on an oncogene: CDK8 takes the driver seat. Cancer Res 69(20):7899-7901
    • (2009) Cancer Res , vol.69 , Issue.20 , pp. 7899-7901
    • Firestein, R.1    Hahn, W.C.2
  • 75
    • 52949111487 scopus 로고    scopus 로고
    • CDK8 is a colorectal cancer oncogene that regulates [bgr]-catenin activity
    • Firestein R, Bass AJ, Kim SY et al (2008) CDK8 is a colorectal cancer oncogene that regulates [bgr]-catenin activity. Nature 455(7212):547-551
    • (2008) Nature , vol.455 , Issue.7212 , pp. 547-551
    • Firestein, R.1    Bass, A.J.2    Kim, S.Y.3
  • 76
    • 77951910398 scopus 로고    scopus 로고
    • CDK8 expression in 470 colorectal cancers in relation to β-catenin activation, other molecular alterations and patient survival
    • Firestein R, Shima K, Nosho K et al (2010) CDK8 expression in 470 colorectal cancers in relation to β-catenin activation, other molecular alterations and patient survival. Int J Cancer 126(12):2863-2873
    • (2010) Int J Cancer , vol.126 , Issue.12 , pp. 2863-2873
    • Firestein, R.1    Shima, K.2    Nosho, K.3
  • 77
    • 0035070046 scopus 로고    scopus 로고
    • Mutations in the APC tumour suppressor gene cause chromosomal instability
    • Fodde R, Kuipers J, Rosenberg C et al (2001) Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 3(4):433-438
    • (2001) Nat Cell Biol , vol.3 , Issue.4 , pp. 433-438
    • Fodde, R.1    Kuipers, J.2    Rosenberg, C.3
  • 78
    • 79251566171 scopus 로고    scopus 로고
    • Sessile serrated adenoma with early neoplastic progression: A clinicopathologic and molecular study
    • Fujita K, Yamamoto H, Matsumoto T et al (2011) Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study. Am J Surg Pathol 35(2):295-304
    • (2011) Am J Surg Pathol , vol.35 , Issue.2 , pp. 295-304
    • Fujita, K.1    Yamamoto, H.2    Matsumoto, T.3
  • 79
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem NJ, Godinho SA, Pellman D (2009) A mechanism linking extra centrosomes to chromosomal instability. Nature 460(7252):278-282
    • (2009) Nature , vol.460 , Issue.7252 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 81
    • 0035886839 scopus 로고    scopus 로고
    • Oxidative stress increases frameshift mutations in human colorectal cancer cells
    • Gasche C, Chang CL, Rhees J, Goel A, Boland CR (2001) Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Res 61(20):7444-7448
    • (2001) Cancer Res , vol.61 , Issue.20 , pp. 7444-7448
    • Gasche, C.1    Chang, C.L.2    Rhees, J.3    Goel, A.4    Boland, C.R.5
  • 82
    • 3042778750 scopus 로고    scopus 로고
    • Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma
    • Gertler R, Rosenberg R, Stricker D et al (2004) Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma. J Clin Oncol 22(10):1807-1814
    • (2004) J Clin Oncol , vol.22 , Issue.10 , pp. 1807-1814
    • Gertler, R.1    Rosenberg, R.2    Stricker, D.3
  • 83
    • 46449127476 scopus 로고    scopus 로고
    • Serrated adenoma is a risk factor for subsequent adenomatous polyps
    • Glazer E, Golla V, Forman R, Zhu H, Levi G, Bodenheimer HC Jr (2008) Serrated adenoma is a risk factor for subsequent adenomatous polyps. Dig Dis Sci 53(8):2204-2207
    • (2008) Dig Dis Sci , vol.53 , Issue.8 , pp. 2204-2207
    • Glazer, E.1    Golla, V.2    Forman, R.3    Zhu, H.4    Levi, G.5    Bodenheimer, H.C.6
  • 84
    • 0021950948 scopus 로고
    • Hypomethylation of DNA from benign and malignant human colon neoplasms
    • Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228(4696):187-190
    • (1985) Science , vol.228 , Issue.4696 , pp. 187-190
    • Goelz, S.E.1    Vogelstein, B.2    Hamilton, S.R.3    Feinberg, A.P.4
  • 85
    • 0033555627 scopus 로고    scopus 로고
    • Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers
    • Grady WM, Myeroff LL, Swinler SE et al (1999) Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res 59(2):320-324
    • (1999) Cancer Res , vol.59 , Issue.2 , pp. 320-324
    • Grady, W.M.1    Myeroff, L.L.2    Swinler, S.E.3
  • 87
    • 78649389948 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in pathogenesis and prevention of colorectal cancer
    • Hahn E, Kraus S, Arber N (2010) Role of cyclooxygenase-2 in pathogenesis and prevention of colorectal cancer. Dig Dis 28(4-5):585-589
    • (2010) Dig Dis , vol.28 , Issue.4-5 , pp. 585-589
    • Hahn, E.1    Kraus, S.2    Arber, N.3
  • 88
    • 42649125571 scopus 로고    scopus 로고
    • Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
    • Haigis KM, Kendall KR, Wang Y et al (2008) Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 40(5):600-608
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 600-608
    • Haigis, K.M.1    Kendall, K.R.2    Wang, Y.3
  • 89
    • 17944362664 scopus 로고    scopus 로고
    • Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
    • Hampel H, Frankel WL, Martin E et al (2005) Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med 352(18):1851-1860
    • (2005) N Engl J Med , vol.352 , Issue.18 , pp. 1851-1860
    • Hampel, H.1    Frankel, W.L.2    Martin, E.3
  • 90
    • 0035812238 scopus 로고    scopus 로고
    • Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas
    • Hawkins NJ, Ward RL (2001) Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst 93(17):1307-1313
    • (2001) J Natl Cancer Inst , vol.93 , Issue.17 , pp. 1307-1313
    • Hawkins, N.J.1    Ward, R.L.2
  • 91
    • 0036242782 scopus 로고    scopus 로고
    • CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
    • Hawkins N, Norrie M, Cheong K et al (2002) CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 122(5):1376-1387
    • (2002) Gastroenterology , vol.122 , Issue.5 , pp. 1376-1387
    • Hawkins, N.1    Norrie, M.2    Cheong, K.3
  • 92
    • 0032483439 scopus 로고    scopus 로고
    • Identifi cation of c-MYC as a target of the APC pathway
    • He T-C, Sparks AB, Rago C et al (1998) Identifi cation of c-MYC as a target of the APC pathway. Science 281(5382):1509-1512
    • (1998) Science , vol.281 , Issue.5382 , pp. 1509-1512
    • He, T.-C.1    Sparks, A.B.2    Rago, C.3
  • 93
    • 84864052231 scopus 로고    scopus 로고
    • Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition
    • Herz C, Schlürmann F, Batarello D et al (2011) Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition. Mol Carcinog 51(9):696-710 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21739483
    • (2011) Mol Carcinog , vol.51 , Issue.9 , pp. 696-710
    • Herz, C.1    Schlürmann, F.2    Batarello, D.3
  • 94
    • 56749176442 scopus 로고    scopus 로고
    • LKB1; Linking cell structure and tumor suppression
    • Hezel AF, Bardeesy N (2008) LKB1; linking cell structure and tumor suppression. Oncogene 27(55):6908-6919
    • (2008) Oncogene , vol.27 , Issue.55 , pp. 6908-6919
    • Hezel, A.F.1    Bardeesy, N.2
  • 95
    • 22144467708 scopus 로고    scopus 로고
    • Demographic and pathological characteristics of serrated polyps of colorectum
    • Higuchi T, Sugihara K, Jass JR (2005) Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 47(1):32-40
    • (2005) Histopathology , vol.47 , Issue.1 , pp. 32-40
    • Higuchi, T.1    Sugihara, K.2    Jass, J.R.3
  • 96
    • 78049482726 scopus 로고    scopus 로고
    • The presence of large serrated polyps increases risk for colorectal cancer
    • 1510.e1-3
    • Hiraoka S, Kato J, Fujiki S, et al (2010) The presence of large serrated polyps increases risk for colorectal cancer. Gastroenterology 139(5):1503-1510, 1510.e1-3
    • (2010) Gastroenterology , vol.139 , Issue.5 , pp. 1503-1510
    • Hiraoka, S.1    Kato, J.2    Fujiki, S.3
  • 97
    • 0037108710 scopus 로고    scopus 로고
    • Dissecting karyotypic patterns in colorectal tumors: Two distinct but overlapping pathways in the adenomacarcinoma transition
    • Höglund M, Gisselsson D, Hansen GB, Säll T, Mitelman F, Nilbert M (2002) Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenomacarcinoma transition. Cancer Res 62(20):5939-5946
    • (2002) Cancer Res , vol.62 , Issue.20 , pp. 5939-5946
    • Höglund, M.1    Gisselsson, D.2    Hansen, G.B.3    Säll, T.4    Mitelman, F.5    Nilbert, M.6
  • 99
    • 76549117990 scopus 로고    scopus 로고
    • Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
    • Hung KE, Maricevich MA, Richard LG et al (2010) Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc Natl Acad Sci U S A 107(4):1565-1570
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.4 , pp. 1565-1570
    • Hung, K.E.1    Maricevich, M.A.2    Richard, L.G.3
  • 101
    • 84856745726 scopus 로고    scopus 로고
    • A phase i study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors
    • Infante JR, Kurzrock R, Spratlin J et al (2012) A phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors. Cancer Chemother Pharmacol 69(1):165-172
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.1 , pp. 165-172
    • Infante, J.R.1    Kurzrock, R.2    Spratlin, J.3
  • 102
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363(6429):558-561
    • (1993) Nature , vol.363 , Issue.6429 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 103
    • 77949900799 scopus 로고    scopus 로고
    • Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical signifi cance
    • Iwatsuki M, Mimori K, Ishii H et al (2010) Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical signifi cance. Int J Cancer 126(8):1828-1837
    • (2010) Int J Cancer , vol.126 , Issue.8 , pp. 1828-1837
    • Iwatsuki, M.1    Mimori, K.2    Ishii, H.3
  • 104
    • 77950821678 scopus 로고    scopus 로고
    • PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy
    • Jani JP, Arcari J, Bernardo V et al (2010) PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy. Mol Cancer Ther 9(4):883-894
    • (2010) Mol Cancer Ther , vol.9 , Issue.4 , pp. 883-894
    • Jani, J.P.1    Arcari, J.2    Bernardo, V.3
  • 105
    • 14944370079 scopus 로고    scopus 로고
    • Endoscopic appearance of serrated adenomas in the colon
    • Jaramillo E, Tamura S, Mitomi H (2005) Endoscopic appearance of serrated adenomas in the colon. Endoscopy 37(3):254-260
    • (2005) Endoscopy , vol.37 , Issue.3 , pp. 254-260
    • Jaramillo, E.1    Tamura, S.2    Mitomi, H.3
  • 106
    • 33845608798 scopus 로고    scopus 로고
    • Classifi cation of colorectal cancer based on correlation of clinical, morphological and molecular features
    • Jass JR (2007) Classifi cation of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 50(1):113-130
    • (2007) Histopathology , vol.50 , Issue.1 , pp. 113-130
    • Jass, J.R.1
  • 107
    • 0006171447 scopus 로고    scopus 로고
    • Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum
    • Jass JR, Iino H, Ruszkiewicz A et al (2000) Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut 47(1):43-49
    • (2000) Gut , vol.47 , Issue.1 , pp. 43-49
    • Jass, J.R.1    Iino, H.2    Ruszkiewicz, A.3
  • 108
    • 33746092527 scopus 로고    scopus 로고
    • Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: Concept of a "fusion" pathway to colorectal cancer
    • Jass JR, Baker K, Zlobec I et al (2006) Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a "fusion" pathway to colorectal cancer. Histopathology 49(2):121-131
    • (2006) Histopathology , vol.49 , Issue.2 , pp. 121-131
    • Jass, J.R.1    Baker, K.2    Zlobec, I.3
  • 109
    • 0029950681 scopus 로고    scopus 로고
    • Familial giant hyperplastic polyposis predisposing to colorectal cancer: A new hereditary bowel cancer syndrome
    • Jeevaratnam P, Cottier DS, Browett PJ, Van De Water NS, Pokos V, Jass JR (1996) Familial giant hyperplastic polyposis predisposing to colorectal cancer: a new hereditary bowel cancer syndrome. J Pathol 179(1):20-25
    • (1996) J Pathol , vol.179 , Issue.1 , pp. 20-25
    • Jeevaratnam, P.1    Cottier, D.S.2    Browett, P.J.3    Van De Water, N.S.4    Pokos, V.5    Jass, J.R.6
  • 111
    • 0030867514 scopus 로고    scopus 로고
    • DNA demethylation and pericentromeric rearrangements of chromosome 1
    • Ji W, Hernandez R, Zhang XY et al (1997) DNA demethylation and pericentromeric rearrangements of chromosome 1. Mutat Res 379(1):33-41
    • (1997) Mutat Res , vol.379 , Issue.1 , pp. 33-41
    • Ji, W.1    Hernandez, R.2    Zhang, X.Y.3
  • 113
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW (1999) Cancer epigenetics comes of age. Nat Genet 21(2):163-167
    • (1999) Nat Genet , vol.21 , Issue.2 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 114
    • 33646798052 scopus 로고    scopus 로고
    • Mismatch repair status in the prediction of benefi t from adjuvant fl uorouracil chemotherapy in colorectal cancer
    • Jover R, Zapater P, Castells A et al (2006) Mismatch repair status in the prediction of benefi t from adjuvant fl uorouracil chemotherapy in colorectal cancer. Gut 55(6):848-855
    • (2006) Gut , vol.55 , Issue.6 , pp. 848-855
    • Jover, R.1    Zapater, P.2    Castells, A.3
  • 115
    • 33646391241 scopus 로고    scopus 로고
    • Infl uence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers
    • Jung B, Smith EJ, Doctolero RT et al (2006) Infl uence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers. Int J Cancer 118(10): 2509-2513
    • (2006) Int J Cancer , vol.118 , Issue.10 , pp. 2509-2513
    • Jung, B.1    Smith, E.J.2    Doctolero, R.T.3
  • 116
    • 33847015309 scopus 로고    scopus 로고
    • Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin
    • Jung BH, Beck SE, Cabral J et al (2007) Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin. Gastroenterology 132(2):633-644
    • (2007) Gastroenterology , vol.132 , Issue.2 , pp. 633-644
    • Jung, B.H.1    Beck, S.E.2    Cabral, J.3
  • 117
    • 0037443773 scopus 로고    scopus 로고
    • Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age
    • Kakar S, Burgart LJ, Thibodeau SN et al (2003) Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age. Cancer 97(6):1421-1427
    • (2003) Cancer , vol.97 , Issue.6 , pp. 1421-1427
    • Kakar, S.1    Burgart, L.J.2    Thibodeau, S.N.3
  • 118
    • 3242686837 scopus 로고    scopus 로고
    • BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum
    • Kambara T, Simms LA, Whitehall VLJ et al (2004) BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53(8):1137-1144
    • (2004) Gut , vol.53 , Issue.8 , pp. 1137-1144
    • Kambara, T.1    Simms, L.A.2    Whitehall, V.L.J.3
  • 119
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane MF, Loda M, Gaida GM et al (1997) Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57(5):808-811
    • (1997) Cancer Res , vol.57 , Issue.5 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3
  • 121
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefi t from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ et al (2008) K-ras mutations and benefi t from cetuximab in advanced colorectal cancer. N Engl J Med 359(17):1757-1765
    • (2008) N Engl J Med , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 122
    • 0033532869 scopus 로고    scopus 로고
    • Mitotic kinase expression and colorectal cancer progression
    • Katayama H, Ota T, Jisaki F et al (1999a) Mitotic kinase expression and colorectal cancer progression. J Natl Cancer Inst 91(13):1160-1162
    • (1999) J Natl Cancer Inst , vol.91 , Issue.13 , pp. 1160-1162
    • Katayama, H.1    Ota, T.2    Jisaki, F.3
  • 123
    • 0033034623 scopus 로고    scopus 로고
    • Clinical usefulness of telomerase activity and telomere length in the preoperative diagnosis of gastric and colorectal cancer
    • Katayama S, Shiota G, Oshimura M, Kawasaki H (1999b) Clinical usefulness of telomerase activity and telomere length in the preoperative diagnosis of gastric and colorectal cancer. J Cancer Res Clin Oncol 125(7):405-410
    • (1999) J Cancer Res Clin Oncol , vol.125 , Issue.7 , pp. 405-410
    • Katayama, S.1    Shiota, G.2    Oshimura, M.3    Kawasaki, H.4
  • 124
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna KK, Jackson SP (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27(3):247-254
    • (2001) Nat Genet , vol.27 , Issue.3 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 125
    • 33947546541 scopus 로고    scopus 로고
    • Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study
    • Kim GP, Colangelo LH, Wieand HS et al (2007) Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study. J Clin Oncol 25(7):767-772
    • (2007) J Clin Oncol , vol.25 , Issue.7 , pp. 767-772
    • Kim, G.P.1    Colangelo, L.H.2    Wieand, H.S.3
  • 126
    • 77349107376 scopus 로고    scopus 로고
    • DNA methylation markers in colorectal cancer
    • Kim MS, Lee J, Sidransky D (2010a) DNA methylation markers in colorectal cancer. Cancer Metastasis Rev 29(1):181-206
    • (2010) Cancer Metastasis Rev , vol.29 , Issue.1 , pp. 181-206
    • Kim, M.S.1    Lee, J.2    Sidransky, D.3
  • 127
    • 77951840779 scopus 로고    scopus 로고
    • KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype
    • Kim K-M, Lee EJ, Kim Y-H, Chang DK, Odze RD (2010b) KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype. Am J Surg Pathol 34(5):667-675
    • (2010) Am J Surg Pathol , vol.34 , Issue.5 , pp. 667-675
    • Kim, K.-M.1    Lee, E.J.2    Kim, Y.-H.3    Chang, D.K.4    Odze, R.D.5
  • 128
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87(2):159-170
    • (1996) Cell , vol.87 , Issue.2 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 130
    • 70949092350 scopus 로고    scopus 로고
    • Pragmatic classifi cation of superfi cial neoplastic colorectal lesions
    • Lambert R, Kudo SE, Vieth M et al (2009) Pragmatic classifi cation of superfi cial neoplastic colorectal lesions. Gastrointest Endosc 70(6):1182-1199
    • (2009) Gastrointest Endosc , vol.70 , Issue.6 , pp. 1182-1199
    • Lambert, R.1    Kudo, S.E.2    Vieth, M.3
  • 131
    • 2342613578 scopus 로고    scopus 로고
    • Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer
    • Lammi L, Arte S, Somer M et al (2004) Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet 74(5):1043-1050
    • (2004) Am J Hum Genet , vol.74 , Issue.5 , pp. 1043-1050
    • Lammi, L.1    Arte, S.2    Somer, M.3
  • 132
    • 33744818489 scopus 로고    scopus 로고
    • Immunohistochemical test for MLH1 and MSH2 expression predicts clinical outcome in stage II and III colorectal cancer patients
    • Lanza G, Gafà R, Santini A, Maestri I, Guerzoni L, Cavazzini L (2006) Immunohistochemical test for MLH1 and MSH2 expression predicts clinical outcome in stage II and III colorectal cancer patients. J Clin Oncol 24(15):2359-2367
    • (2006) J Clin Oncol , vol.24 , Issue.15 , pp. 2359-2367
    • Lanza, G.1    Gafà, R.2    Santini, A.3    Maestri, I.4    Guerzoni, L.5    Cavazzini, L.6
  • 133
    • 55849099654 scopus 로고    scopus 로고
    • Integrated analysis of homozygous deletions, focal amplifi cations, and sequence alterations in breast and colorectal cancers
    • Leary RJ, Lin JC, Cummins J et al (2008) Integrated analysis of homozygous deletions, focal amplifi cations, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci 105(42):16224-16229
    • (2008) Proc Natl Acad Sci , vol.105 , Issue.42 , pp. 16224-16229
    • Leary, R.J.1    Lin, J.C.2    Cummins, J.3
  • 134
    • 0037442224 scopus 로고    scopus 로고
    • Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis
    • Lee S-H, Chang DK, Goel A et al (2003) Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. J Immunol 170(4):2214-2220
    • (2003) J Immunol , vol.170 , Issue.4 , pp. 2214-2220
    • Lee, S.-H.1    Chang, D.K.2    Goel, A.3
  • 135
    • 77951647898 scopus 로고    scopus 로고
    • Role of the serrated pathway in colorectal cancer pathogenesis
    • Leggett B, Whitehall V (2010) Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology 138(6):2088-2100
    • (2010) Gastroenterology , vol.138 , Issue.6 , pp. 2088-2100
    • Leggett, B.1    Whitehall, V.2
  • 136
    • 0030906724 scopus 로고    scopus 로고
    • Characteristics of metachronous colorectal carcinoma occurring despite colonoscopic surveillance
    • Leggett BA, Cornwell M, Thomas LR et al (1997) Characteristics of metachronous colorectal carcinoma occurring despite colonoscopic surveillance. Dis Colon Rectum 40(5):603-608
    • (1997) Dis Colon Rectum , vol.40 , Issue.5 , pp. 603-608
    • Leggett, B.A.1    Cornwell, M.2    Thomas, L.R.3
  • 138
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • Lengauer C, Kinzler KW, Vogelstein B (1997) Genetic instability in colorectal cancers. Nature 386(6625):623-627
    • (1997) Nature , vol.386 , Issue.6625 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 139
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B (1998) Genetic instabilities in human cancers. Nature 396(6712):643-649
    • (1998) Nature , vol.396 , Issue.6712 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 141
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88(3):323-331
    • (1997) Cell , vol.88 , Issue.3 , pp. 323-331
    • Levine, A.J.1
  • 142
    • 62049084040 scopus 로고    scopus 로고
    • Association of large serrated polyps with synchronous advanced colorectal neoplasia
    • Li D, Jin C, McCulloch C et al (2009) Association of large serrated polyps with synchronous advanced colorectal neoplasia. Am J Gastroenterol 104(3):695-702
    • (2009) Am J Gastroenterol , vol.104 , Issue.3 , pp. 695-702
    • Li, D.1    Jin, C.2    McCulloch, C.3
  • 143
    • 79954490871 scopus 로고    scopus 로고
    • KRAS, BRAF and PIK3CA mutations in human colorectal cancer: Relationship with metastatic colorectal cancer
    • Li H-T, Lu Y-Y, An Y-X, Wang X, Zhao Q-C (2011) KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer. Oncol Rep 25(6):1691- 1697, Available from: http://www.ncbi.nlm.nih.gov/pubmed/21424126
    • (2011) Oncol Rep , vol.25 , Issue.6 , pp. 1691-1697
    • Li, H.-T.1    Lu, Y.-Y.2    An, Y.-X.3    Wang, X.4    Zhao, Q.-C.5
  • 146
    • 0028786695 scopus 로고
    • Deletion of 1p loci and microsatellite instability in colorectal polyps
    • Lothe RA, Andersen SN, Hofstad B et al (1995) Deletion of 1p loci and microsatellite instability in colorectal polyps. Genes Chromosomes Cancer 14(3):182-188
    • (1995) Genes Chromosomes Cancer , vol.14 , Issue.3 , pp. 182-188
    • Lothe, R.A.1    Andersen, S.N.2    Hofstad, B.3
  • 147
    • 0037422027 scopus 로고    scopus 로고
    • Hereditary colorectal cancer
    • Lynch HT, de la Chapelle A (2003) Hereditary colorectal cancer. N Engl J Med 348(10):919-932
    • (2003) N Engl J Med , vol.348 , Issue.10 , pp. 919-932
    • Lynch, H.T.1    De La Chapelle, A.2
  • 148
    • 0035090965 scopus 로고    scopus 로고
    • Colorectal carcinoma associated with serrated adenoma-prevalence, histological features, and prognosis
    • Mäkinen MJ, George SM, Jernvall P, Mäkelä J, Vihko P, Karttunen TJ (2001) Colorectal carcinoma associated with serrated adenoma-prevalence, histological features, and prognosis. J Pathol 193(3):286-294
    • (2001) J Pathol , vol.193 , Issue.3 , pp. 286-294
    • Mäkinen, M.J.1    George, S.M.2    Jernvall, P.3    Mäkelä, J.4    Vihko, P.5    Karttunen, T.J.6
  • 149
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: The fi rst 30 years
    • Malumbres M, Barbacid M (2003) RAS oncogenes: the fi rst 30 years. Nat Rev Cancer 3(6):459-465
    • (2003) Nat Rev Cancer , vol.3 , Issue.6 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 150
    • 13044281685 scopus 로고    scopus 로고
    • Target genes of β-catenin-T cell-factor/lymphoidenhancer-factor signaling in human colorectal carcinomas
    • Mann B, Gelos M, Siedow A et al (1999) Target genes of β-catenin-T cell-factor/lymphoidenhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A 96(4):1603-1608
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.4 , pp. 1603-1608
    • Mann, B.1    Gelos, M.2    Siedow, A.3
  • 151
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz S, Wang J, Myeroff L et al (1995) Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268(5215):1336-1338
    • (1995) Science , vol.268 , Issue.5215 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3
  • 152
    • 4344716258 scopus 로고    scopus 로고
    • Role of the dependence receptor DCC in colorectal cancer pathogenesis
    • Mehlen P, Fearon ER (2004) Role of the dependence receptor DCC in colorectal cancer pathogenesis. J Clin Oncol 22(16):3420-3428
    • (2004) J Clin Oncol , vol.22 , Issue.16 , pp. 3420-3428
    • Mehlen, P.1    Fearon, E.R.2
  • 153
    • 0032558787 scopus 로고    scopus 로고
    • The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
    • Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395(6704):801-804
    • (1998) Nature , vol.395 , Issue.6704 , pp. 801-804
    • Mehlen, P.1    Rabizadeh, S.2    Snipas, S.J.3    Assa-Munt, N.4    Salvesen, G.S.5    Bredesen, D.E.6
  • 154
    • 3342929410 scopus 로고    scopus 로고
    • Genetic conditions associated with intestinal juvenile polyps
    • Merg A, Howe JR (2004) Genetic conditions associated with intestinal juvenile polyps. Am J Med Genet C Semin Med Genet 129C(1):44-55
    • (2004) Am J Med Genet C Semin Med Genet , vol.129 C , Issue.1 , pp. 44-55
    • Merg, A.1    Howe, J.R.2
  • 155
    • 70449109147 scopus 로고    scopus 로고
    • Requirement for NF-B signalling in a mouse model of lung adenocarcinoma
    • Meylan E, Dooley AL, Feldser DM et al (2009) Requirement for NF-B signalling in a mouse model of lung adenocarcinoma. Nature 462(7269):104-107
    • (2009) Nature , vol.462 , Issue.7269 , pp. 104-107
    • Meylan, E.1    Dooley, A.L.2    Feldser, D.M.3
  • 156
    • 33749063204 scopus 로고    scopus 로고
    • Senescence and serration: A new twist to an old tale
    • Minoo P, Jass JR (2006) Senescence and serration: a new twist to an old tale. J Pathol 210(2):137-140
    • (2006) J Pathol , vol.210 , Issue.2 , pp. 137-140
    • Minoo, P.1    Jass, J.R.2
  • 157
    • 33749182353 scopus 로고    scopus 로고
    • Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis
    • Minoo P, Baker K, Goswami R et al (2006) Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis. Gut 55(10):1467-1474
    • (2006) Gut , vol.55 , Issue.10 , pp. 1467-1474
    • Minoo, P.1    Baker, K.2    Goswami, R.3
  • 158
    • 0033565255 scopus 로고    scopus 로고
    • Beta-catenin mutations are specifi c for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
    • Mirabelli-Primdahl L, Gryfe R, Kim H et al (1999) Beta-catenin mutations are specifi c for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway. Cancer Res 59(14):3346-3351
    • (1999) Cancer Res , vol.59 , Issue.14 , pp. 3346-3351
    • Mirabelli-Primdahl, L.1    Gryfe, R.2    Kim, H.3
  • 159
    • 0028291928 scopus 로고
    • Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors
    • Miyaki M, Konishi M, Kikuchi-Yanoshita R et al (1994) Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 54(11):3011-3020
    • (1994) Cancer Res , vol.54 , Issue.11 , pp. 3011-3020
    • Miyaki, M.1    Konishi, M.2    Kikuchi-Yanoshita, R.3
  • 160
    • 0033568145 scopus 로고    scopus 로고
    • Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer
    • Miyaki M, Iijima T, Kimura J et al (1999) Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. Cancer Res 59(18):4506-4509
    • (1999) Cancer Res , vol.59 , Issue.18 , pp. 4506-4509
    • Miyaki, M.1    Iijima, T.2    Kimura, J.3
  • 161
    • 0026894053 scopus 로고
    • Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
    • Miyoshi Y, Nagase H, Ando H et al (1992) Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1(4):229-233
    • (1992) Hum Mol Genet , vol.1 , Issue.4 , pp. 229-233
    • Miyoshi, Y.1    Nagase, H.2    Ando, H.3
  • 163
    • 15244362062 scopus 로고    scopus 로고
    • P53 abnormalities and outcomes in colorectal cancer: A systematic review
    • Munro AJ, Lain S, Lane DP (2005) P53 abnormalities and outcomes in colorectal cancer: a systematic review. Br J Cancer 92(3):434-444
    • (2005) Br J Cancer , vol.92 , Issue.3 , pp. 434-444
    • Munro, A.J.1    Lain, S.2    Lane, D.P.3
  • 164
    • 0034308106 scopus 로고    scopus 로고
    • Correlation of telomere lengths in normal and cancers tissue in the large bowel
    • Nakamura K-I, Furugori E, Esaki Y et al (2000) Correlation of telomere lengths in normal and cancers tissue in the large bowel. Cancer Lett 158(2):179-184
    • (2000) Cancer Lett , vol.158 , Issue.2 , pp. 179-184
    • Nakamura, K.-I.1    Furugori, E.2    Esaki, Y.3
  • 166
    • 0037059043 scopus 로고    scopus 로고
    • The role of chromosomal instability in tumor initiation
    • Nowak MA, Komarova NL, Sengupta A et al (2002) The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci U S A 99(25):16226-16231
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.25 , pp. 16226-16231
    • Nowak, M.A.1    Komarova, N.L.2    Sengupta, A.3
  • 167
    • 35948935265 scopus 로고    scopus 로고
    • Hyperplastic and serrated polyps of the colorectum
    • O'Brien MJ (2007) Hyperplastic and serrated polyps of the colorectum. Gastroenterol Clin North Am 36(4):947-968
    • (2007) Gastroenterol Clin North Am , vol.36 , Issue.4 , pp. 947-968
    • O'Brien, M.J.1
  • 168
    • 1842529801 scopus 로고    scopus 로고
    • Hyperplastic (serrated) polyps of the colorectum: Relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype
    • viii O'Brien MJ, Yang S, Clebanoff JL et al (2004) Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am J Surg Pathol 28(4):423-434
    • (2004) Am J Surg Pathol , vol.28 , Issue.4 , pp. 423-434
    • Viii O'Brien, M.J.1    Yang, S.2    Clebanoff, J.L.3
  • 169
    • 33751320353 scopus 로고    scopus 로고
    • Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points
    • O'Brien MJ, Yang S, Mack C et al (2006) Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol 30(12):1491-1501
    • (2006) Am J Surg Pathol , vol.30 , Issue.12 , pp. 1491-1501
    • O'Brien, M.J.1    Yang, S.2    Mack, C.3
  • 170
    • 33749069927 scopus 로고    scopus 로고
    • CpG island methylator phenotypelow (CIMP-low) in colorectal cancer: Possible associations with male sex and KRAS mutations
    • Ogino S, Kawasaki T, Kirkner GJ, Loda M, Fuchs CS (2006a) CpG island methylator phenotypelow (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. J Mol Diagn 8(5):582-588
    • (2006) J Mol Diagn , vol.8 , Issue.5 , pp. 582-588
    • Ogino, S.1    Kawasaki, T.2    Kirkner, G.J.3    Loda, M.4    Fuchs, C.S.5
  • 171
    • 33748040054 scopus 로고    scopus 로고
    • Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma
    • Ogino S, Odze RD, Kawasaki T et al (2006b) Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. Am J Surg Pathol 30(9):1175-1183
    • (2006) Am J Surg Pathol , vol.30 , Issue.9 , pp. 1175-1183
    • Ogino, S.1    Odze, R.D.2    Kawasaki, T.3
  • 172
    • 34249825736 scopus 로고    scopus 로고
    • Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype- low (CIMP-low) in colorectal cancer
    • Ogino S, Kawasaki T, Kirkner GJ, Suemoto Y, Meyerhardt JA, Fuchs CS (2007) Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype- low (CIMP-low) in colorectal cancer. Gut 56(11):1564-1571
    • (2007) Gut , vol.56 , Issue.11 , pp. 1564-1571
    • Ogino, S.1    Kawasaki, T.2    Kirkner, G.J.3    Suemoto, Y.4    Meyerhardt, J.A.5    Fuchs, C.S.6
  • 173
    • 58249089525 scopus 로고    scopus 로고
    • CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    • Ogino S, Nosho K, Kirkner GJ et al (2009a) CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 58(1):90-96
    • (2009) Gut , vol.58 , Issue.1 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 174
    • 76749132120 scopus 로고    scopus 로고
    • Prognostic signifi cance and molecular associations of 18q loss of heterozygosity: A cohort study of microsatellite stable colorectal cancers
    • Ogino S, Nosho K, Irahara N et al (2009b) Prognostic signifi cance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers. J Clin Oncol 27(27):4591-4598
    • (2009) J Clin Oncol , vol.27 , Issue.27 , pp. 4591-4598
    • Ogino, S.1    Nosho, K.2    Irahara, N.3
  • 175
    • 70350225838 scopus 로고    scopus 로고
    • Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype
    • Ogino S, Nosho K, Irahara N et al (2009c) Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. Clin Cancer Res 15(20):6412-6420
    • (2009) Clin Cancer Res , vol.15 , Issue.20 , pp. 6412-6420
    • Ogino, S.1    Nosho, K.2    Irahara, N.3
  • 176
    • 84856512550 scopus 로고    scopus 로고
    • Predictive and prognostic roles of BRAF mutation in stage III colon cancer: Results from intergroup trial CALGB 89803
    • Ogino S, Shima K, Meyerhardt J et al (2011) Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803. Clin Cancer Res 18(3):890- 900, Available from: http://www.ncbi.nlm.nih.gov/pubmed/22147942
    • (2011) Clin Cancer Res , vol.18 , Issue.3 , pp. 890-900
    • Ogino, S.1    Shima, K.2    Meyerhardt, J.3
  • 177
    • 0035866401 scopus 로고    scopus 로고
    • Chemoprevention of intestinal polyposis in the ApcΔ716 mouse by rofecoxib, a specifi c cyclooxygenase-2 inhibitor
    • Oshima M, Murai N, Kargman S et al (2001) Chemoprevention of intestinal polyposis in the ApcΔ716 mouse by rofecoxib, a specifi c cyclooxygenase-2 inhibitor. Cancer Res 61(4):1733-1740
    • (2001) Cancer Res , vol.61 , Issue.4 , pp. 1733-1740
    • Oshima, M.1    Murai, N.2    Kargman, S.3
  • 178
    • 36348961270 scopus 로고    scopus 로고
    • The cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer
    • Park DY, Sakamoto H, Kirley SD et al (2007) The cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer. Am J Pathol 171(5):1509-1519
    • (2007) Am J Pathol , vol.171 , Issue.5 , pp. 1509-1519
    • Park, D.Y.1    Sakamoto, H.2    Kirley, S.D.3
  • 179
    • 65249182632 scopus 로고    scopus 로고
    • The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis
    • Peddibhotla S, Lam MH, Gonzalez-Rimbau M, Rosen JM (2009) The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis. Proc Natl Acad Sci U S A 106(13):5159-5164
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.13 , pp. 5159-5164
    • Peddibhotla, S.1    Lam, M.H.2    Gonzalez-Rimbau, M.3    Rosen, J.M.4
  • 180
    • 78649437454 scopus 로고    scopus 로고
    • Relationship between sporadic hyperplastic polyps and colorectal neoplasia in Hispanic veterans
    • Pérez R, Lasa A, Toro DH, Cruz-Correa M, Martinez-Souss J (2010) Relationship between sporadic hyperplastic polyps and colorectal neoplasia in Hispanic veterans. P R Health Sci J 29(4):372-376
    • (2010) P R Health Sci J , vol.29 , Issue.4 , pp. 372-376
    • Pérez, R.1    Lasa, A.2    Toro, D.H.3    Cruz-Correa, M.4    Martinez-Souss, J.5
  • 181
    • 1842867040 scopus 로고    scopus 로고
    • Tumour-infi ltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic
    • Phillips SM, Banerjea A, Feakins R, Li SR, Bustin SA, Dorudi S (2004) Tumour-infi ltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic. Br J Surg 91(4):469-475
    • (2004) Br J Surg , vol.91 , Issue.4 , pp. 469-475
    • Phillips, S.M.1    Banerjea, A.2    Feakins, R.3    Li, S.R.4    Bustin, S.A.5    Dorudi, S.6
  • 182
    • 77951627056 scopus 로고    scopus 로고
    • The chromosomal instability pathway in colon cancer
    • Pino MS, Chung DC (2010) The chromosomal instability pathway in colon cancer. Gastroenterology 138(6):2059-2072
    • (2010) Gastroenterology , vol.138 , Issue.6 , pp. 2059-2072
    • Pino, M.S.1    Chung, D.C.2
  • 183
    • 0042887525 scopus 로고    scopus 로고
    • Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer
    • Plentz RR, Wiemann SU, Flemming P et al (2003) Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer. Gut 52(9):1304-1307
    • (2003) Gut , vol.52 , Issue.9 , pp. 1304-1307
    • Plentz, R.R.1    Wiemann, S.U.2    Flemming, P.3
  • 184
    • 14544300998 scopus 로고    scopus 로고
    • Systematic review of microsatellite instability and colorectal cancer prognosis
    • Popat S, Hubner R, Houlston RS (2005) Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 23(3):609-618
    • (2005) J Clin Oncol , vol.23 , Issue.3 , pp. 609-618
    • Popat, S.1    Hubner, R.2    Houlston, R.S.3
  • 185
    • 0026630266 scopus 로고
    • APC mutations occur early during colorectal tumorigenesis
    • Powell SM, Zilz N, Beazer-Barclay Y et al (1992) APC mutations occur early during colorectal tumorigenesis. Nature 359(6392):235-237
    • (1992) Nature , vol.359 , Issue.6392 , pp. 235-237
    • Powell, S.M.1    Zilz, N.2    Beazer-Barclay, Y.3
  • 186
    • 28844506365 scopus 로고    scopus 로고
    • Mutant KRAS in aberrant crypt foci (ACF): Initiation of colorectal cancer?
    • Pretlow TP, Pretlow TG (2005) Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer? Biochim Biophys Acta 1756(2):83-96
    • (2005) Biochim Biophys Acta , vol.1756 , Issue.2 , pp. 83-96
    • Pretlow, T.P.1    Pretlow, T.G.2
  • 187
    • 0035964458 scopus 로고    scopus 로고
    • Ras and Rho regulation of the cell cycle and oncogenesis
    • Pruitt K, Der CJ (2001) Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett 171(1):1-10
    • (2001) Cancer Lett , vol.171 , Issue.1 , pp. 1-10
    • Pruitt, K.1    Der, C.J.2
  • 189
    • 1542377277 scopus 로고    scopus 로고
    • Inactivation of hCDC4 can cause chromosomal instability
    • Rajagopalan H, Jallepalli PV, Rago C et al (2004) Inactivation of hCDC4 can cause chromosomal instability. Nature 428(6978):77-81
    • (2004) Nature , vol.428 , Issue.6978 , pp. 77-81
    • Rajagopalan, H.1    Jallepalli, P.V.2    Rago, C.3
  • 191
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatellite-instability status as a predictor of benefi t from fl uorouracil-based adjuvant chemotherapy for colon cancer
    • Ribic CM, Sargent DJ, Moore MJ et al (2003) Tumor microsatellite-instability status as a predictor of benefi t from fl uorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 349(3):247-257
    • (2003) N Engl J Med , vol.349 , Issue.3 , pp. 247-257
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3
  • 192
    • 80053169195 scopus 로고    scopus 로고
    • The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer
    • Roper J, Richardson MP, Wang WV et al (2011) The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. PLoS One 6(9):e25132
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e25132
    • Roper, J.1    Richardson, M.P.2    Wang, W.V.3
  • 193
    • 55849123268 scopus 로고    scopus 로고
    • Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance
    • Roschke AV, Glebov OK, Lababidi S, Gehlhaus KS, Weinstein JN, Kirsch IR (2008) Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance. Neoplasia 10(11):1222-1230
    • (2008) Neoplasia , vol.10 , Issue.11 , pp. 1222-1230
    • Roschke, A.V.1    Glebov, O.K.2    Lababidi, S.3    Gehlhaus, K.S.4    Weinstein, J.N.5    Kirsch, I.R.6
  • 194
    • 33645094924 scopus 로고    scopus 로고
    • Hyperplastic polyposis coli syndrome and colorectal carcinoma
    • Rubio CA, Stemme S, Jaramillo E, Lindblom A (2006) Hyperplastic polyposis coli syndrome and colorectal carcinoma. Endoscopy 38(3):266-270
    • (2006) Endoscopy , vol.38 , Issue.3 , pp. 266-270
    • Rubio, C.A.1    Stemme, S.2    Jaramillo, E.3    Lindblom, A.4
  • 196
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • Rudolph KL, Millard M, Bosenberg MW, DePinho RA (2001) Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 28(2):155-159
    • (2001) Nat Genet , vol.28 , Issue.2 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    Depinho, R.A.4
  • 197
    • 32544444419 scopus 로고    scopus 로고
    • The TP53 colorectal cancer international collaborative study on the prognostic and predictive signifi cance of p53 mutation: Infl uence of tumor site, type of mutation, and adjuvant treatment
    • Russo A, Bazan V, Iacopetta B, Kerr D, Soussi T, Gebbia N (2005) The TP53 colorectal cancer international collaborative study on the prognostic and predictive signifi cance of p53 mutation: infl uence of tumor site, type of mutation, and adjuvant treatment. J Clin Oncol 23(30):7518-7528
    • (2005) J Clin Oncol , vol.23 , Issue.30 , pp. 7518-7528
    • Russo, A.1    Bazan, V.2    Iacopetta, B.3    Kerr, D.4    Soussi, T.5    Gebbia, N.6
  • 198
    • 24144449572 scopus 로고    scopus 로고
    • Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
    • Samowitz WS, Albertsen H, Herrick J et al (2005a) Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 129(3):837-845
    • (2005) Gastroenterology , vol.129 , Issue.3 , pp. 837-845
    • Samowitz, W.S.1    Albertsen, H.2    Herrick, J.3
  • 199
    • 22244472992 scopus 로고    scopus 로고
    • Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    • Samowitz WS, Sweeney C, Herrick J et al (2005b) Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res 65(14):6063-6069
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6063-6069
    • Samowitz, W.S.1    Sweeney, C.2    Herrick, J.3
  • 200
    • 33845672260 scopus 로고    scopus 로고
    • Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer
    • Samowitz WS, Albertsen H, Sweeney C et al (2006) Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer. J Natl Cancer Inst 98(23):1731-1738
    • (2006) J Natl Cancer Inst , vol.98 , Issue.23 , pp. 1731-1738
    • Samowitz, W.S.1    Albertsen, H.2    Sweeney, C.3
  • 201
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y, Wang Z, Bardelli A et al (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304(5670):554
    • (2004) Science , vol.304 , Issue.5670 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 202
    • 20444374445 scopus 로고    scopus 로고
    • Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    • Samuels Y, Diaz LA, Schmidt-Kittler O et al (2005) Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 7(6):561-573
    • (2005) Cancer Cell , vol.7 , Issue.6 , pp. 561-573
    • Samuels, Y.1    Diaz, L.A.2    Schmidt-Kittler, O.3
  • 203
    • 68749109876 scopus 로고    scopus 로고
    • Serrated polyps of the large intestine: A molecular study comparing sessile serrated adenomas and hyperplastic polyps
    • Sandmeier D, Benhattar J, Martin P, Bouzourene H (2009) Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps. Histopathology 55(2):206-213
    • (2009) Histopathology , vol.55 , Issue.2 , pp. 206-213
    • Sandmeier, D.1    Benhattar, J.2    Martin, P.3    Bouzourene, H.4
  • 204
    • 33845613668 scopus 로고    scopus 로고
    • Microsatellite instability in interval colon cancers
    • Sawhney MS, Farrar WD, Gudiseva S et al (2006) Microsatellite instability in interval colon cancers. Gastroenterology 131(6):1700-1705
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1700-1705
    • Sawhney, M.S.1    Farrar, W.D.2    Gudiseva, S.3
  • 205
    • 84655164874 scopus 로고    scopus 로고
    • A phase I, dose-escalation study of the novel Pololike kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours
    • Schöffski P, Awada A, Dumez H et al (2012) A phase I, dose-escalation study of the novel Pololike kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours. Eur J Cancer 48(2):179-186
    • (2012) Eur J Cancer , vol.48 , Issue.2 , pp. 179-186
    • Schöffski, P.1    Awada, A.2    Dumez, H.3
  • 206
    • 78049475043 scopus 로고    scopus 로고
    • Proximal and large hyperplastic and nondysplastic serrated polyps detected by colonoscopy are associated with neoplasia
    • Schreiner MA, Weiss DG, Lieberman DA (2010) Proximal and large hyperplastic and nondysplastic serrated polyps detected by colonoscopy are associated with neoplasia. Gastroenterology 139(5):1497-1502
    • (2010) Gastroenterology , vol.139 , Issue.5 , pp. 1497-1502
    • Schreiner, M.A.1    Weiss, D.G.2    Lieberman, D.A.3
  • 207
    • 47649123223 scopus 로고    scopus 로고
    • Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome
    • Shia J (2008) Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. J Mol Diagn 10(4):293-300
    • (2008) J Mol Diagn , vol.10 , Issue.4 , pp. 293-300
    • Shia, J.1
  • 208
    • 0035110871 scopus 로고    scopus 로고
    • Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis
    • Shih I-M, Zhou W, Goodman SN, Lengauer C, Kinzler KW, Vogelstein B (2001) Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res 61(3):818-822
    • (2001) Cancer Res , vol.61 , Issue.3 , pp. 818-822
    • Shih, I.-M.1    Zhou, W.2    Goodman, S.N.3    Lengauer, C.4    Kinzler, K.W.5    Vogelstein, B.6
  • 209
    • 80052954051 scopus 로고    scopus 로고
    • TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers
    • Shima K, Morikawa T, Yamauchi M et al (2011) TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. PLoS One 6(9):e25062
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e25062
    • Shima, K.1    Morikawa, T.2    Yamauchi, M.3
  • 210
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • Shirasawa S, Furuse M, Yokoyama N, Sasazuki T (1993) Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260(5104):85-88
    • (1993) Science , vol.260 , Issue.5104 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3    Sasazuki, T.4
  • 211
    • 42649123671 scopus 로고    scopus 로고
    • Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps
    • Shrubsole MJ, Wu H, Ness RM, Shyr Y, Smalley WE, Zheng W (2008) Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps. Am J Epidemiol 167(9):1050-1058
    • (2008) Am J Epidemiol , vol.167 , Issue.9 , pp. 1050-1058
    • Shrubsole, M.J.1    Wu, H.2    Ness, R.M.3    Shyr, Y.4    Smalley, W.E.5    Zheng, W.6
  • 212
    • 33748092909 scopus 로고    scopus 로고
    • Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients
    • Sinicrope FA, Rego RL, Halling KC et al (2006) Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients. Gastroenterology 131(3):729-737
    • (2006) Gastroenterology , vol.131 , Issue.3 , pp. 729-737
    • Sinicrope, F.A.1    Rego, R.L.2    Halling, K.C.3
  • 213
    • 24144491263 scopus 로고    scopus 로고
    • Serrated polyps of the large intestine: A morphologic and molecular review of an evolving concept
    • Snover DC, Jass JR, Fenoglio-Preiser C, Batts KP (2005) Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept. Am J Clin Pathol 124(3):380-391
    • (2005) Am J Clin Pathol , vol.124 , Issue.3 , pp. 380-391
    • Snover, D.C.1    Jass, J.R.2    Fenoglio-Preiser, C.3    Batts, K.P.4
  • 214
    • 68149165771 scopus 로고    scopus 로고
    • Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
    • Souglakos J, Philips J, Wang R et al (2009) Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer 101(3):465-472
    • (2009) Br J Cancer , vol.101 , Issue.3 , pp. 465-472
    • Souglakos, J.1    Philips, J.2    Wang, R.3
  • 215
    • 0032521433 scopus 로고    scopus 로고
    • Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer
    • Sparks AB, Morin PJ, Vogelstein B, Kinzler KW (1998) Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer. Cancer Res 58(6):1130-1134
    • (1998) Cancer Res , vol.58 , Issue.6 , pp. 1130-1134
    • Sparks, A.B.1    Morin, P.J.2    Vogelstein, B.3    Kinzler, K.W.4
  • 216
    • 33750682008 scopus 로고    scopus 로고
    • High prevalence of sessile serrated adenomas with BRAF mutations: A prospective study of patients undergoing colonoscopy
    • Spring KJ, Zhao ZZ, Karamatic R et al (2006) High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology 131(5):1400-1407
    • (2006) Gastroenterology , vol.131 , Issue.5 , pp. 1400-1407
    • Spring, K.J.1    Zhao, Z.Z.2    Karamatic, R.3
  • 217
    • 0033592960 scopus 로고    scopus 로고
    • The onset and extent of genomic instability in sporadic colorectal tumor progression
    • Stoler DL, Chen N, Basik M et al (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc Natl Acad Sci U S A 96(26):15121-15126
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.26 , pp. 15121-15126
    • Stoler, D.L.1    Chen, N.2    Basik, M.3
  • 218
    • 24644515996 scopus 로고    scopus 로고
    • Prognostic and predictive relevance of microsatellite instability in colorectal cancer
    • Storojeva I, Boulay J-L, Heinimann K et al (2005) Prognostic and predictive relevance of microsatellite instability in colorectal cancer. Oncol Rep 14(1):241-249
    • (2005) Oncol Rep , vol.14 , Issue.1 , pp. 241-249
    • Storojeva, I.1    Boulay, J.-L.2    Heinimann, K.3
  • 220
    • 0028067504 scopus 로고
    • Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers
    • Suzuki H, Harpaz N, Tarmin L et al (1994) Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers. Cancer Res 54(18):4841-4844
    • (1994) Cancer Res , vol.54 , Issue.18 , pp. 4841-4844
    • Suzuki, H.1    Harpaz, N.2    Tarmin, L.3
  • 221
    • 77950900898 scopus 로고    scopus 로고
    • IGFBP7 is a p53-responsive gene specifi cally silenced in colorectal cancer with CpG island methylator phenotype
    • Suzuki H, Igarashi S, Nojima M et al (2010) IGFBP7 is a p53-responsive gene specifi cally silenced in colorectal cancer with CpG island methylator phenotype. Carcinogenesis 31(3):342-349
    • (2010) Carcinogenesis , vol.31 , Issue.3 , pp. 342-349
    • Suzuki, H.1    Igarashi, S.2    Nojima, M.3
  • 222
    • 0029808666 scopus 로고    scopus 로고
    • Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
    • Takagi Y, Kohmura H, Futamura M et al (1996) Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology 111(5):1369-1372
    • (1996) Gastroenterology , vol.111 , Issue.5 , pp. 1369-1372
    • Takagi, Y.1    Kohmura, H.2    Futamura, M.3
  • 223
    • 0031756444 scopus 로고    scopus 로고
    • Somatic alterations of the SMAD-2 gene in human colorectal cancers
    • Takagi Y, Koumura H, Futamura M et al (1998) Somatic alterations of the SMAD-2 gene in human colorectal cancers. Br J Cancer 78(9):1152-1155
    • (1998) Br J Cancer , vol.78 , Issue.9 , pp. 1152-1155
    • Takagi, Y.1    Koumura, H.2    Futamura, M.3
  • 224
    • 0033569955 scopus 로고    scopus 로고
    • Telomere shortening and the clinicopathologic characteristics of human colorectal carcinomas
    • Takagi S, Kinouchi Y, Hiwatashi N et al (1999) Telomere shortening and the clinicopathologic characteristics of human colorectal carcinomas. Cancer 86(8):1431-1436
    • (1999) Cancer , vol.86 , Issue.8 , pp. 1431-1436
    • Takagi, S.1    Kinouchi, Y.2    Hiwatashi, N.3
  • 225
    • 0037648703 scopus 로고    scopus 로고
    • Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers
    • Takahashi T, Sano B, Nagata T et al (2003) Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers. Cancer Sci 94(2):148-152
    • (2003) Cancer Sci , vol.94 , Issue.2 , pp. 148-152
    • Takahashi, T.1    Sano, B.2    Nagata, T.3
  • 226
    • 17144464406 scopus 로고    scopus 로고
    • Aberrant crypt foci of the colon as precursors of adenoma and cancer
    • Takayama T, Katsuki S, Takahashi Y et al (1998) Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 339(18):1277-1284
    • (1998) N Engl J Med , vol.339 , Issue.18 , pp. 1277-1284
    • Takayama, T.1    Katsuki, S.2    Takahashi, Y.3
  • 227
    • 53049097854 scopus 로고    scopus 로고
    • The Fbxw7/hCdc4 tumor suppressor in human cancer
    • Tan Y, Sangfelt O, Spruck C (2008) The Fbxw7/hCdc4 tumor suppressor in human cancer. Cancer Lett 271(1):1-12
    • (2008) Cancer Lett , vol.271 , Issue.1 , pp. 1-12
    • Tan, Y.1    Sangfelt, O.2    Spruck, C.3
  • 228
    • 0027171533 scopus 로고
    • Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region
    • Tanaka K, Yanoshita R, Konishi M et al (1993) Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region. Oncogene 8(8):2253-2258
    • (1993) Oncogene , vol.8 , Issue.8 , pp. 2253-2258
    • Tanaka, K.1    Yanoshita, R.2    Konishi, M.3
  • 229
    • 0036163763 scopus 로고    scopus 로고
    • Apoptosis index and apoptosis- related antigen expression in serrated adenoma of the colorectum: The saw-toothed structure may be related to inhibition of apoptosis
    • Tateyama H, Li W, Takahashi E, Miura Y, Sugiura H, Eimoto T (2002) Apoptosis index and apoptosis- related antigen expression in serrated adenoma of the colorectum: the saw-toothed structure may be related to inhibition of apoptosis. Am J Surg Pathol 26(2):249-256
    • (2002) Am J Surg Pathol , vol.26 , Issue.2 , pp. 249-256
    • Tateyama, H.1    Li, W.2    Takahashi, E.3    Miura, Y.4    Sugiura, H.5    Eimoto, T.6
  • 230
    • 0033942071 scopus 로고    scopus 로고
    • High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer
    • Tatsumoto N, Hiyama E, Murakami Y et al (2000) High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer. Clin Cancer Res 6(7):2696-2701
    • (2000) Clin Cancer Res , vol.6 , Issue.7 , pp. 2696-2701
    • Tatsumoto, N.1    Hiyama, E.2    Murakami, Y.3
  • 231
    • 0030687987 scopus 로고    scopus 로고
    • Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
    • Taylor SS, McKeon F (1997) Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89(5):727-735
    • (1997) Cell , vol.89 , Issue.5 , pp. 727-735
    • Taylor, S.S.1    McKeon, F.2
  • 233
    • 0035956878 scopus 로고    scopus 로고
    • Mechanisms underlying losses of heterozygosity in human colorectal cancers
    • Thiagalingam S, Laken S, Willson JKV et al (2001) Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc Natl Acad Sci U S A 98(5):2698-2702
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.5 , pp. 2698-2702
    • Thiagalingam, S.1    Laken, S.2    Willson, J.K.V.3
  • 234
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau SN, Bren G, Schaid D (1993) Microsatellite instability in cancer of the proximal colon. Science 260(5109):816-819
    • (1993) Science , vol.260 , Issue.5109 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 235
    • 67649652208 scopus 로고    scopus 로고
    • BRAF mutation in metastatic colorectal cancer
    • Tol J, Nagtegaal ID, Punt CJA (2009) BRAF mutation in metastatic colorectal cancer. N Engl J Med 361(1):98-99
    • (2009) N Engl J Med , vol.361 , Issue.1 , pp. 98-99
    • Tol, J.1    Nagtegaal, I.D.2    Punt, C.J.A.3
  • 236
    • 0030065384 scopus 로고    scopus 로고
    • Serrated adenomatous polyposis in humans
    • Torlakovic E, Snover DC (1996) Serrated adenomatous polyposis in humans. Gastroenterology 110(3):748-755
    • (1996) Gastroenterology , vol.110 , Issue.3 , pp. 748-755
    • Torlakovic, E.1    Snover, D.C.2
  • 240
    • 79958817037 scopus 로고    scopus 로고
    • Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer
    • Tran B, Kopetz S, Tie J et al (2011) Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer 117(20):4623- 4632, Available from: http://www.ncbi.nlm.nih.gov/pubmed/21456008
    • (2011) Cancer , vol.117 , Issue.20 , pp. 4623-4632
    • Tran, B.1    Kopetz, S.2    Tie, J.3
  • 241
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fl uorouracil, and leucovorin as fi rst-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Köhne C-H, Láng I et al (2011) Cetuximab plus irinotecan, fl uorouracil, and leucovorin as fi rst-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 29(15):2011-2019
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 2011-2019
    • Van Cutsem, E.1    Köhne, C.-H.2    Láng, I.3
  • 242
    • 24144432339 scopus 로고    scopus 로고
    • Clinical description of the Lynch syndrome [hereditary nonpolyposis colorectal cancer (HNPCC)]
    • Vasen HFA (2005) Clinical description of the Lynch syndrome [hereditary nonpolyposis colorectal cancer (HNPCC)]. Fam Cancer 4(3):219-225
    • (2005) Fam Cancer , vol.4 , Issue.3 , pp. 219-225
    • Vasen, H.F.A.1
  • 243
    • 0025848680 scopus 로고
    • The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)
    • Vasen HFA, Mecklin J-P, Meera Khan P, Lynch HT (1991) The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 34(5):424-425
    • (1991) Dis Colon Rectum , vol.34 , Issue.5 , pp. 424-425
    • Vasen, H.F.A.1    Mecklin, J.-P.2    Meera Khan, P.3    Lynch, H.T.4
  • 244
    • 0033063711 scopus 로고    scopus 로고
    • New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC
    • Vasen HFA, Watson P, Mecklin J-P, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology 116(6):1453-1456
    • (1999) Gastroenterology , vol.116 , Issue.6 , pp. 1453-1456
    • Vasen, H.F.A.1    Watson, P.2    Mecklin, J.-P.3    Lynch, H.T.4
  • 245
    • 13144307115 scopus 로고    scopus 로고
    • Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
    • Veigl ML, Kasturi L, Olechnowicz J et al (1998) Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A 95(15):8698-8702
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.15 , pp. 8698-8702
    • Veigl, M.L.1    Kasturi, L.2    Olechnowicz, J.3
  • 246
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, Fearon ER, Hamilton SR et al (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319(9):525-532
    • (1988) N Engl J Med , vol.319 , Issue.9 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 247
    • 0024514647 scopus 로고
    • Allelotype of colorectal carcinomas
    • Vogelstein B, Fearon E, Kern S et al (1989) Allelotype of colorectal carcinomas. Science 244(4901):207-211
    • (1989) Science , vol.244 , Issue.4901 , pp. 207-211
    • Vogelstein, B.1    Fearon, E.2    Kern, S.3
  • 248
    • 0034676455 scopus 로고    scopus 로고
    • Surfi ng the p53 network
    • Vogelstein B, Lane D, Levine AJ (2000) Surfi ng the p53 network. Nature 408(6810):307-310
    • (2000) Nature , vol.408 , Issue.6810 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 249
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
    • Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3):363-374
    • (2008) Cell , vol.132 , Issue.3 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3    Mahalingam, M.4    Green, M.R.5
  • 250
    • 68949107404 scopus 로고    scopus 로고
    • The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum
    • Wallace K, Grau MV, Ahnen D et al (2009) The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum. Cancer Epidemiol Biomarkers Prev 18(8):2310-2317
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , Issue.8 , pp. 2310-2317
    • Wallace, K.1    Grau, M.V.2    Ahnen, D.3
  • 251
    • 0141593677 scopus 로고    scopus 로고
    • BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair
    • Wang L, Cunningham JM, Winters JL et al (2003) BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res 63(17):5209-5212
    • (2003) Cancer Res , vol.63 , Issue.17 , pp. 5209-5212
    • Wang, L.1    Cunningham, J.M.2    Winters, J.L.3
  • 252
    • 2342557921 scopus 로고    scopus 로고
    • Three classes of genes mutated in colorectal cancers with chromosomal instability
    • Wang Z, Cummins JM, Shen D et al (2004) Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res 64(9):2998-3001
    • (2004) Cancer Res , vol.64 , Issue.9 , pp. 2998-3001
    • Wang, Z.1    Cummins, J.M.2    Shen, D.3
  • 253
    • 0034997971 scopus 로고    scopus 로고
    • Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
    • Ward R, Meagher A, Tomlinson I et al (2001) Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut 48(6):821-829
    • (2001) Gut , vol.48 , Issue.6 , pp. 821-829
    • Ward, R.1    Meagher, A.2    Tomlinson, I.3
  • 254
    • 0142087630 scopus 로고    scopus 로고
    • Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability
    • Ward RL, Cheong K, Ku S-L, Meagher A, O'Connor T, Hawkins NJ (2003) Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J Clin Oncol 21(20):3729-3736
    • (2003) J Clin Oncol , vol.21 , Issue.20 , pp. 3729-3736
    • Ward, R.L.1    Cheong, K.2    Ku, S.-L.3    Meagher, A.4    O'Connor, T.5    Hawkins, N.J.6
  • 255
    • 74549208765 scopus 로고
    • Heredity with reference to carcinoma-as shown by the study of the cases examined in the pathological laboratory of the University of Michigan, 1895-1913
    • Warthin A (1913) Heredity with reference to carcinoma-as shown by the study of the cases examined in the pathological laboratory of the University of Michigan, 1895-1913. Arch Intern Med 12(5):546-555
    • (1913) Arch Intern Med , vol.12 , Issue.5 , pp. 546-555
    • Warthin, A.1
  • 256
    • 33745541234 scopus 로고    scopus 로고
    • CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    • Weisenberger DJ, Siegmund KD, Campan M et al (2006) CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 38(7):787-793
    • (2006) Nat Genet , vol.38 , Issue.7 , pp. 787-793
    • Weisenberger, D.J.1    Siegmund, K.D.2    Campan, M.3
  • 257
    • 0035117307 scopus 로고    scopus 로고
    • Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability
    • Whitehall VL, Walsh MD, Young J, Leggett BA, Jass JR (2001) Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Res 61(3):827-830
    • (2001) Cancer Res , vol.61 , Issue.3 , pp. 827-830
    • Whitehall, V.L.1    Walsh, M.D.2    Young, J.3    Leggett, B.A.4    Jass, J.R.5
  • 258
    • 0027731797 scopus 로고
    • Prevention of colorectal cancer by colonoscopic polypectomy
    • Winawer SJ, Zauber AG, Ho MN et al (1993) Prevention of colorectal cancer by colonoscopic polypectomy. N Engl J Med 329(27):1977-1981
    • (1993) N Engl J Med , vol.329 , Issue.27 , pp. 1977-1981
    • Winawer, S.J.1    Zauber, A.G.2    Ho, M.N.3
  • 259
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S et al (2007) The genomic landscapes of human breast and colorectal cancers. Science 318(5853):1108-1113
    • (2007) Science , vol.318 , Issue.5853 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3
  • 260
    • 41649102270 scopus 로고    scopus 로고
    • Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential
    • Wu JM, Montgomery EA, Iacobuzio-Donahue CA (2008) Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential. Am J Clin Pathol 129(3):416-423
    • (2008) Am J Clin Pathol , vol.129 , Issue.3 , pp. 416-423
    • Wu, J.M.1    Montgomery, E.A.2    Iacobuzio-Donahue, C.A.3
  • 261
    • 1642299076 scopus 로고    scopus 로고
    • Methylation patterns defi ne two types of hyperplastic polyp associated with colorectal cancer
    • Wynter CVA, Walsh MD, Higuchi T, Leggett BA, Young J, Jass JR (2004) Methylation patterns defi ne two types of hyperplastic polyp associated with colorectal cancer. Gut 53(4):573-580
    • (2004) Gut , vol.53 , Issue.4 , pp. 573-580
    • Wynter, C.V.A.1    Walsh, M.D.2    Higuchi, T.3    Leggett, B.A.4    Young, J.5    Jass, J.R.6
  • 262
    • 73349134675 scopus 로고    scopus 로고
    • Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation
    • Yachida S, Mudali S, Martin SA, Montgomery EA, Iacobuzio-Donahue CA (2009) Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation. Am J Surg Pathol 33(12):1823-1832
    • (2009) Am J Surg Pathol , vol.33 , Issue.12 , pp. 1823-1832
    • Yachida, S.1    Mudali, S.2    Martin, S.A.3    Montgomery, E.A.4    Iacobuzio-Donahue, C.A.5
  • 263
    • 7044253667 scopus 로고    scopus 로고
    • BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: Relationship to histology and CpG island methylation status
    • Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ (2004) BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol 28(11):1452-1459
    • (2004) Am J Surg Pathol , vol.28 , Issue.11 , pp. 1452-1459
    • Yang, S.1    Farraye, F.A.2    Mack, C.3    Posnik, O.4    O'Brien, M.J.5
  • 264
    • 33750519632 scopus 로고    scopus 로고
    • The case for a genetic predisposition to serrated neoplasia in the colorectum: Hypothesis and review of the literature
    • Young J, Jass JR (2006) The case for a genetic predisposition to serrated neoplasia in the colorectum: hypothesis and review of the literature. Cancer Epidemiol Biomarkers Prev 15(10): 1778-1784
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , Issue.10 , pp. 1778-1784
    • Young, J.1    Jass, J.R.2
  • 265
    • 34948834584 scopus 로고    scopus 로고
    • Serrated pathway colorectal cancer in the population: Genetic consideration
    • Young J, Jenkins M, Parry S et al (2007) Serrated pathway colorectal cancer in the population: genetic consideration. Gut 56(10):1453-1459
    • (2007) Gut , vol.56 , Issue.10 , pp. 1453-1459
    • Young, J.1    Jenkins, M.2    Parry, S.3
  • 266
    • 0037112438 scopus 로고    scopus 로고
    • Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia
    • Yuen ST, Davies H, Chan TL et al (2002) Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 62(22):6451-6455
    • (2002) Cancer Res , vol.62 , Issue.22 , pp. 6451-6455
    • Yuen, S.T.1    Davies, H.2    Chan, T.L.3
  • 267
    • 70349331678 scopus 로고    scopus 로고
    • Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
    • Yun J, Rago C, Cheong I et al (2009) Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 325(5947):1555-1559
    • (2009) Science , vol.325 , Issue.5947 , pp. 1555-1559
    • Yun, J.1    Rago, C.2    Cheong, I.3
  • 268
    • 48249121979 scopus 로고    scopus 로고
    • Complementary functions of ATM and H2AX in development and suppression of genomic instability
    • Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW (2008) Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A 105(27):9302-9306
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.27 , pp. 9302-9306
    • Zha, S.1    Sekiguchi, J.2    Brush, J.W.3    Bassing, C.H.4    Alt, F.W.5
  • 269
    • 47649101956 scopus 로고    scopus 로고
    • Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome
    • Zhang L (2008) Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part II. The utility of microsatellite instability testing. J Mol Diagn 10(4):301-307
    • (2008) Part II. The Utility of Microsatellite Instability Testing. J Mol Diagn , vol.10 , Issue.4 , pp. 301-307
    • Zhang, L.1
  • 270
    • 0037132902 scopus 로고    scopus 로고
    • Counting alleles to predict recurrence of early-stage colorectal cancers
    • Zhou W, Goodman SN, Galizia G et al (2002) Counting alleles to predict recurrence of early-stage colorectal cancers. Lancet 359(9302):219-225
    • (2002) Lancet , vol.359 , Issue.9302 , pp. 219-225
    • Zhou, W.1    Goodman, S.N.2    Galizia, G.3


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