MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: Indications for distinct pathways and sequence of events

Annals of Oncology

Volumn 20, Issue 7, 2009, Pages 1216-1222

  de Vogel, S ^a   Weijenberg, M P ^a   Herman, J G ^b   Wouters, K A D ^a   de Goeij, A F P M ^a   van den Brandt, P A ^a   de Bruine A P ^a   van Engeland, M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

APC; BRAF; CRC; KRAS mutations; MGMT methylation; MLH1 methylation

Indexed keywords

APC PROTEIN; B RAF KINASE; K RAS PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN MLH1;

ADULT; AGED; ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; EPIGENETICS; FEMALE; FRAMESHIFT MUTATION; GENE MUTATION; GENE SILENCING; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; GENE SILENCING; GENES, APC; GENES, RAS; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; NUCLEAR PROTEINS; POINT MUTATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 67650385667     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdn782     Document Type: Article

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