-
2
-
-
38149119821
-
LKB1 protein expression in neuroendocrine tumors of the lung
-
Amin RM, Hiroshima K, Iyoda A, Hoshi K, Honma K, Kuroki M et al. (2008). LKB1 protein expression in neuroendocrine tumors of the lung. Pathol Int 58: 84-88.
-
(2008)
Pathol Int
, vol.58
, pp. 84-88
-
-
Amin, R.M.1
Hiroshima, K.2
Iyoda, A.3
Hoshi, K.4
Honma, K.5
Kuroki, M.6
-
3
-
-
28844507521
-
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome
-
Aretz S, Stienen D, Uhlhaas S, Loff S, Back W, Pagenstecher C et al. (2005). High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. Hum Mutat 26: 513-519.
-
(2005)
Hum Mutat
, vol.26
, pp. 513-519
-
-
Aretz, S.1
Stienen, D.2
Uhlhaas, S.3
Loff, S.4
Back, W.5
Pagenstecher, C.6
-
4
-
-
35548963883
-
LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning
-
Asada N, Sanada K, Fukada Y. (2007). LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning. J Neurosci 27: 11769-11775.
-
(2007)
J Neurosci
, vol.27
, pp. 11769-11775
-
-
Asada, N.1
Sanada, K.2
Fukada, Y.3
-
5
-
-
0033054479
-
LKB1 somatic mutations in sporadic tumors
-
Avizienyte E, Loukola A, Roth S, Hemminki A, Tarkkanen M, Salovaara R et al. (1999). LKB1 somatic mutations in sporadic tumors. Am J Pathol 154: 677-681.
-
(1999)
Am J Pathol
, vol.154
, pp. 677-681
-
-
Avizienyte, E.1
Loukola, A.2
Roth, S.3
Hemminki, A.4
Tarkkanen, M.5
Salovaara, R.6
-
6
-
-
0032523997
-
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors
-
Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE et al. (1998). Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. Cancer Res 58: 2087-2090.
-
(1998)
Cancer Res
, vol.58
, pp. 2087-2090
-
-
Avizienyte, E.1
Roth, S.2
Loukola, A.3
Hemminki, A.4
Lothe, R.A.5
Stenwig, A.E.6
-
7
-
-
0038614742
-
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
-
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA et al. (2003). Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J 22: 3062-3072.
-
(2003)
EMBO J
, vol.22
, pp. 3062-3072
-
-
Baas, A.F.1
Boudeau, J.2
Sapkota, G.P.3
Smit, L.4
Medema, R.5
Morrice, N.A.6
-
8
-
-
1542777034
-
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
-
Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ et al. (2004a). Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116: 457-466.
-
(2004)
Cell
, vol.116
, pp. 457-466
-
-
Baas, A.F.1
Kuipers, J.2
van der Wel, N.N.3
Batlle, E.4
Koerten, H.K.5
Peters, P.J.6
-
9
-
-
2942729619
-
LKB1 tumor suppressor protein: PARtaker in cell polarity
-
Baas AF, Smit L, Clevers H. (2004b). LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol 14: 312-319.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 312-319
-
-
Baas, A.F.1
Smit, L.2
Clevers, H.3
-
10
-
-
0037068461
-
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
-
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE et al. (2002). Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419: 162-167.
-
(2002)
Nature
, vol.419
, pp. 162-167
-
-
Bardeesy, N.1
Sinha, M.2
Hezel, A.F.3
Signoretti, S.4
Hathaway, N.A.5
Sharpless, N.E.6
-
11
-
-
34247511497
-
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
-
Barnes AP, Lilley BN, Pan YA, Plummer LJ, Powell AW, Raines AN et al. (2007). LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 129: 549-563.
-
(2007)
Cell
, vol.129
, pp. 549-563
-
-
Barnes, A.P.1
Lilley, B.N.2
Pan, Y.A.3
Plummer, L.J.4
Powell, A.W.5
Raines, A.N.6
-
12
-
-
19944413010
-
Genome-wide survey of protein kinases required for cell cycle progression
-
Bettencourt-Dias M, Giet R, Sinka R, Mazumdar A, Lock WG, Balloux F et al. (2004). Genome-wide survey of protein kinases required for cell cycle progression. Nature 432: 980-987.
-
(2004)
Nature
, vol.432
, pp. 980-987
-
-
Bettencourt-Dias, M.1
Giet, R.2
Sinka, R.3
Mazumdar, A.4
Lock, W.G.5
Balloux, F.6
-
13
-
-
0842288323
-
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S et al. (2004). TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303: 848-851.
-
(2004)
Science
, vol.303
, pp. 848-851
-
-
Bhowmick, N.A.1
Chytil, A.2
Plieth, D.3
Gorska, A.E.4
Dumont, N.5
Shappell, S.6
-
14
-
-
0032054770
-
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer
-
Bignell GR, Barfoot R, Seal S, Collins N, Warren W, Stratton MR. (1998). Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res 58: 1384-1386.
-
(1998)
Cancer Res
, vol.58
, pp. 1384-1386
-
-
Bignell, G.R.1
Barfoot, R.2
Seal, S.3
Collins, N.4
Warren, W.5
Stratton, M.R.6
-
15
-
-
0037593654
-
Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: Phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha
-
Blumer JB, Bernard ML, Peterson YK, Nezu J, Chung P, Dunican DJ et al. (2003). Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha. J Biol Chem 278: 23217-23220.
-
(2003)
J Biol Chem
, vol.278
, pp. 23217-23220
-
-
Blumer, J.B.1
Bernard, M.L.2
Peterson, Y.K.3
Nezu, J.4
Chung, P.5
Dunican, D.J.6
-
16
-
-
34250844968
-
The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division
-
Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, Goldberg ML et al. (2007). The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Development 134: 2183-2193.
-
(2007)
Development
, vol.134
, pp. 2183-2193
-
-
Bonaccorsi, S.1
Mottier, V.2
Giansanti, M.G.3
Bolkan, B.J.4
Williams, B.5
Goldberg, M.L.6
-
17
-
-
13444293128
-
Analysis of the LKB1-STRAD-MO25 complex
-
Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D et al. (2004). Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci 117: 6365-6375.
-
(2004)
J Cell Sci
, vol.117
, pp. 6365-6375
-
-
Boudeau, J.1
Scott, J.W.2
Resta, N.3
Deak, M.4
Kieloch, A.5
Komander, D.6
-
18
-
-
0347318052
-
The AMP-activated protein kinase cascade - a unifying system for energy control
-
Carling D. (2004). The AMP-activated protein kinase cascade - a unifying system for energy control. Trends Biochem Sci 29: 18-24.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 18-24
-
-
Carling, D.1
-
19
-
-
33947100984
-
Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer
-
Carretero J, Medina PP, Blanco R, Smit L, Tang M, Roncador G et al. (2007). Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. Oncogene 26: 1616-1625.
-
(2007)
Oncogene
, vol.26
, pp. 1616-1625
-
-
Carretero, J.1
Medina, P.P.2
Blanco, R.3
Smit, L.4
Tang, M.5
Roncador, G.6
-
20
-
-
1442358790
-
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton
-
Cohen D, Brennwald PJ, Rodriguez-Boulan E, Musch A. (2004). Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol 164: 717-727.
-
(2004)
J Cell Biol
, vol.164
, pp. 717-727
-
-
Cohen, D.1
Brennwald, P.J.2
Rodriguez-Boulan, E.3
Musch, A.4
-
21
-
-
34250346081
-
Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling
-
Cohen D, Tian Y, Musch A. (2007). Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling. Mol Biol Cell 18: 2203-2215.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 2203-2215
-
-
Cohen, D.1
Tian, Y.2
Musch, A.3
-
22
-
-
0034141636
-
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
-
Collins SP, Reoma JL, Gamm DM, Uhler MD. (2000). LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J 345(Part 3): 673-680.
-
(2000)
Biochem J
, vol.345
, Issue.PART 3
, pp. 673-680
-
-
Collins, S.P.1
Reoma, J.L.2
Gamm, D.M.3
Uhler, M.D.4
-
23
-
-
38849193504
-
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
-
Contreras CM, Gurumurthy S, Haynie JM, Shirley LJ, Akbay EA, Wingo SN et al. (2008). Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res 68: 759-766.
-
(2008)
Cancer Res
, vol.68
, pp. 759-766
-
-
Contreras, C.M.1
Gurumurthy, S.2
Haynie, J.M.3
Shirley, L.J.4
Akbay, E.A.5
Wingo, S.N.6
-
24
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. (2004). Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 18: 1533-1538.
-
(2004)
Genes Dev
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.L.5
-
25
-
-
12444302178
-
Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas
-
De Leng WW, Westerman AM, Weterman MA, De Rooij FW, Dekken Hv H, De Goeij AF et al. (2003). Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. Clin Cancer Res 9: 3065-3072.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3065-3072
-
-
De Leng, W.W.1
Westerman, A.M.2
Weterman, M.A.3
De Rooij, F.W.4
Dekken, H.H.5
De Goeij, A.F.6
-
26
-
-
0030969575
-
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
-
Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E. (1997). MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89: 297-308.
-
(1997)
Cell
, vol.89
, pp. 297-308
-
-
Drewes, G.1
Ebneth, A.2
Preuss, U.3
Mandelkow, E.M.4
Mandelkow, E.5
-
27
-
-
0036801052
-
Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz-Jeghers syndrome
-
Dunlop MG. (2002). Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz-Jeghers syndrome. Gut 51(Suppl 5): V21-V27.
-
(2002)
Gut
, vol.51
, Issue.SUPPL. 5
-
-
Dunlop, M.G.1
-
28
-
-
33746615950
-
PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells
-
Elbert M, Cohen D, Musch A. (2006). PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells. Mol Biol Cell 17: 3345-3355.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 3345-3355
-
-
Elbert, M.1
Cohen, D.2
Musch, A.3
-
29
-
-
0035142924
-
Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome
-
Entius MM, Keller JJ, Westerman AM, van Rees BP, van Velthuysen ML, de Goeij AF et al. (2001). Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. J Clin Pathol 54: 126-131.
-
(2001)
J Clin Pathol
, vol.54
, pp. 126-131
-
-
Entius, M.M.1
Keller, J.J.2
Westerman, A.M.3
van Rees, B.P.4
van Velthuysen, M.L.5
de Goeij, A.F.6
-
30
-
-
0034610730
-
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
-
Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, Aaltonen LA et al. (2000). Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene 19: 164-168.
-
(2000)
Oncogene
, vol.19
, pp. 164-168
-
-
Esteller, M.1
Avizienyte, E.2
Corn, P.G.3
Lothe, R.A.4
Baylin, S.B.5
Aaltonen, L.A.6
-
31
-
-
56749174260
-
Polarity proteins in migration and invasion
-
Etienne-Manneville S. (2008). Polarity proteins in migration and invasion. Oncogene 27: 6970-6980.
-
(2008)
Oncogene
, vol.27
, pp. 6970-6980
-
-
Etienne-Manneville, S.1
-
32
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. (2005). Metformin and reduced risk of cancer in diabetic patients. BMJ 330: 1304-1305.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
33
-
-
35748943872
-
Dialogue between LKB1 and AMPK: A hot topic at the cellular pole
-
pe51
-
Forcet C, Billaud M. (2007). Dialogue between LKB1 and AMPK: a hot topic at the cellular pole. Sci STKE 2007: pe51.
-
(2007)
Sci STKE
-
-
Forcet, C.1
Billaud, M.2
-
34
-
-
21144470441
-
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity
-
Forcet C, Etienne-Manneville S, Gaude H, Fournier L, Debilly S, Salmi M et al. (2005). Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Hum Mol Genet 14: 1283-1292.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 1283-1292
-
-
Forcet, C.1
Etienne-Manneville, S.2
Gaude, H.3
Fournier, L.4
Debilly, S.5
Salmi, M.6
-
35
-
-
0033775035
-
An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers
-
Forster LF, Defres S, Goudie DR, Baty DU, Carey FA. (2000). An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers. J Clin Pathol 53: 791-793.
-
(2000)
J Clin Pathol
, vol.53
, pp. 791-793
-
-
Forster, L.F.1
Defres, S.2
Goudie, D.R.3
Baty, D.U.4
Carey, F.A.5
-
36
-
-
0034464147
-
Very high risk of cancer in familial Peutz-Jeghers syndrome
-
Giardiello FM, Brensinger JD, Tersmette AC, Goodman SN, Petersen GM, Booker SV et al. (2000). Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119: 1447-1453.
-
(2000)
Gastroenterology
, vol.119
, pp. 1447-1453
-
-
Giardiello, F.M.1
Brensinger, J.D.2
Tersmette, A.C.3
Goodman, S.N.4
Petersen, G.M.5
Booker, S.V.6
-
38
-
-
0023192463
-
Increased risk of cancer in the Peutz-Jeghers syndrome
-
Giardiello FM, Welsh SB, Hamilton SR, Offerhaus GJ, Gittelsohn AM, Booker SV et al. (1987). Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 316: 1511-1514.
-
(1987)
N Engl J Med
, vol.316
, pp. 1511-1514
-
-
Giardiello, F.M.1
Welsh, S.B.2
Hamilton, S.R.3
Offerhaus, G.J.4
Gittelsohn, A.M.5
Booker, S.V.6
-
39
-
-
0032403068
-
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome
-
Gruber SB, Entius MM, Petersen GM, Laken SJ, Longo PA, Boyer R et al. (1998). Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome. Cancer Res 58: 5267-5270.
-
(1998)
Cancer Res
, vol.58
, pp. 5267-5270
-
-
Gruber, S.B.1
Entius, M.M.2
Petersen, G.M.3
Laken, S.J.4
Longo, P.A.5
Boyer, R.6
-
40
-
-
0033522144
-
Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma
-
Guldberg P, thor Straten P, Ahrenkiel V, Seremet T, Kirkin AF, Zeuthen J. (1999). Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. Oncogene 18: 1777-1780.
-
(1999)
Oncogene
, vol.18
, pp. 1777-1780
-
-
Guldberg, P.1
thor Straten, P.2
Ahrenkiel, V.3
Seremet, T.4
Kirkin, A.F.5
Zeuthen, J.6
-
41
-
-
39149083762
-
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
-
Gurumurthy S, Hezel AF, Sahin E, Berger JH, Bosenberg MW, Bardeesy N. (2008). LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res 68: 55-63.
-
(2008)
Cancer Res
, vol.68
, pp. 55-63
-
-
Gurumurthy, S.1
Hezel, A.F.2
Sahin, E.3
Berger, J.H.4
Bosenberg, M.W.5
Bardeesy, N.6
-
42
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS et al. (2008). AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30: 214-226.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
-
43
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
-
Hardie DG. (2007). AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 8: 774-785.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
44
-
-
56749171378
-
Linking epithelial polarity and carcinogenesis by multitasking Heliobacter pylori virulence factor CagA
-
Hatakeyama M. (2008). Linking epithelial polarity and carcinogenesis by multitasking Heliobacter pylori virulence factor CagA. Oncogene 27: 7047-7054.
-
(2008)
Oncogene
, vol.27
, pp. 7047-7054
-
-
Hatakeyama, M.1
-
45
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP et al. (2003). Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2: 28.
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
-
46
-
-
33744782567
-
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome
-
Hearle N, Schumacher V, Menko FH, Olschwang S, Boardman LA, Gille JJ et al. (2006). Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res 12: 3209-3215.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3209-3215
-
-
Hearle, N.1
Schumacher, V.2
Menko, F.H.3
Olschwang, S.4
Boardman, L.A.5
Gille, J.J.6
-
47
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A et al. (1998). A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391: 184-187.
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
-
48
-
-
0031012344
-
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
-
Hemminki A, Tomlinson I, Markie D, Jarvinen H, Sistonen P, Bjorkqvist AM et al. (1997). Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet 15: 87-90.
-
(1997)
Nat Genet
, vol.15
, pp. 87-90
-
-
Hemminki, A.1
Tomlinson, I.2
Markie, D.3
Jarvinen, H.4
Sistonen, P.5
Bjorkqvist, A.M.6
-
49
-
-
39749194712
-
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
-
Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G et al. (2008). Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol 28: 2414-2425.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 2414-2425
-
-
Hezel, A.F.1
Gurumurthy, S.2
Granot, Z.3
Swisa, A.4
Chu, G.C.5
Bailey, G.6
-
50
-
-
49649085586
-
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
-
Horman S, Morel N, Vertommen D, Hussain N, Neumann D, Beauloye C et al. (2008). AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase. J Biol Chem 283: 18505-18512.
-
(2008)
J Biol Chem
, vol.283
, pp. 18505-18512
-
-
Horman, S.1
Morel, N.2
Vertommen, D.3
Hussain, N.4
Neumann, D.5
Beauloye, C.6
-
51
-
-
44449103256
-
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
-
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL et al. (2008). Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 412: 211-221.
-
(2008)
Biochem J
, vol.412
, pp. 211-221
-
-
Huang, X.1
Wullschleger, S.2
Shpiro, N.3
McGuire, V.A.4
Sakamoto, K.5
Woods, Y.L.6
-
52
-
-
34548212805
-
The Par-1/MARK family of protein kinases: From polarity to metabolism
-
Hurov J, Piwnica-Worms H. (2007). The Par-1/MARK family of protein kinases: from polarity to metabolism. Cell Cycle 6: 1966-1969.
-
(2007)
Cell Cycle
, vol.6
, pp. 1966-1969
-
-
Hurov, J.1
Piwnica-Worms, H.2
-
53
-
-
34248357199
-
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
-
Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR et al. (2007). Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci USA 104: 5680-5685.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5680-5685
-
-
Hurov, J.B.1
Huang, M.2
White, L.S.3
Lennerz, J.4
Choi, C.S.5
Cho, Y.R.6
-
54
-
-
33845200848
-
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
-
Ikediobi ON, Davies H, Bignell G, Edkins S, Stevens C, O'Meara S et al. (2006). Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol Cancer Ther 5: 2606-2612.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2606-2612
-
-
Ikediobi, O.N.1
Davies, H.2
Bignell, G.3
Edkins, S.4
Stevens, C.5
O'Meara, S.6
-
55
-
-
29244431680
-
Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis
-
Jansen M, de Leng WW, Baas AF, Myoshi H, Mathus-Vliegen L, Taketo MM et al. (2006). Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis. Gut 55: 1-5.
-
(2006)
Gut
, vol.55
, pp. 1-5
-
-
Jansen, M.1
de Leng, W.W.2
Baas, A.F.3
Myoshi, H.4
Mathus-Vliegen, L.5
Taketo, M.M.6
-
56
-
-
0000152018
-
Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance
-
Jeghers H, Mc KV, Katz KH. (1949). Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. N Engl J Med 241: 1031-1036.
-
(1949)
N Engl J Med
, vol.241
, pp. 1031-1036
-
-
Jeghers, H.1
Mc, K.V.2
Katz, K.H.3
-
57
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P et al. (2007). LKB1 modulates lung cancer differentiation and metastasis. Nature 448: 807-810.
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
-
58
-
-
0037444404
-
Growth and molecular profile of lung cancer cells expressing ectopic LKB1: Down-regulation of the phosphatidylinositol 30-phosphate kinase/PTEN pathway
-
Jimenez AI, Fernandez P, Dominguez O, Dopazo A, Sanchez-Cespedes M. (2003). Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 30-phosphate kinase/PTEN pathway. Cancer Res 63: 1382-1388.
-
(2003)
Cancer Res
, vol.63
, pp. 1382-1388
-
-
Jimenez, A.I.1
Fernandez, P.2
Dominguez, O.3
Dopazo, A.4
Sanchez-Cespedes, M.5
-
59
-
-
0037173013
-
Role of Lkb1, the causative gene of Peutz-Jegher0s syndrome, in embryogenesis and polyposis
-
Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A et al. (2002). Role of Lkb1, the causative gene of Peutz-Jegher0s syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci USA 99: 8903-8908.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8903-8908
-
-
Jishage, K.1
Nezu, J.2
Kawase, Y.3
Iwata, T.4
Watanabe, M.5
Miyoshi, A.6
-
60
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y et al. (2005). AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18: 283-293.
-
(2005)
Mol Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
-
61
-
-
41349114071
-
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
-
Katajisto P, Vaahtomeri K, Ekman N, Ventela E, Ristimaki A, Bardeesy N et al. (2008). LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet 40: 455-459.
-
(2008)
Nat Genet
, vol.40
, pp. 455-459
-
-
Katajisto, P.1
Vaahtomeri, K.2
Ekman, N.3
Ventela, E.4
Ristimaki, A.5
Bardeesy, N.6
-
62
-
-
33845411885
-
The LKB1 tumor suppressor kinase in human disease
-
Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M et al. (2007). The LKB1 tumor suppressor kinase in human disease. Biochim Biophys Acta 1775: 63-75.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 63-75
-
-
Katajisto, P.1
Vallenius, T.2
Vaahtomeri, K.3
Ekman, N.4
Udd, L.5
Tiainen, M.6
-
63
-
-
0024284814
-
Identification of genes required for cytoplasmic localization in early C. elegans embryos
-
Kemphues KJ, Priess JR, Morton DG, Cheng NS. (1988). Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52: 311-320.
-
(1988)
Cell
, vol.52
, pp. 311-320
-
-
Kemphues, K.J.1
Priess, J.R.2
Morton, D.G.3
Cheng, N.S.4
-
64
-
-
33745578957
-
Smad4signalling in T cells is required for suppression of gastrointestinal cancer
-
Kim BG, Li C, Qiao W, Mamura M, Kasprzak B, Anver M et al. (2006). Smad4signalling in T cells is required for suppression of gastrointestinal cancer. Nature 441: 1015-1019.
-
(2006)
Nature
, vol.441
, pp. 1015-1019
-
-
Kim, B.G.1
Li, C.2
Qiao, W.3
Mamura, M.4
Kasprzak, B.5
Anver, M.6
-
65
-
-
33751013309
-
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3
-
Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N et al. (2006). Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol 26: 8217-8227.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8217-8227
-
-
Koh, H.J.1
Arnolds, D.E.2
Fujii, N.3
Tran, T.T.4
Rogers, M.J.5
Jessen, N.6
-
66
-
-
48249102662
-
Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients
-
Koivunen JP, Kim J, Lee J, Rogers AM, Park JO, Zhao X et al. (2008). Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. Br J Cancer 99: 245-252.
-
(2008)
Br J Cancer
, vol.99
, pp. 245-252
-
-
Koivunen, J.P.1
Kim, J.2
Lee, J.3
Rogers, A.M.4
Park, J.O.5
Zhao, X.6
-
67
-
-
34250827107
-
Energy-dependent regulation of cell structure by AMP-activated protein kinase
-
Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE et al. (2007). Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 447: 1017-1020.
-
(2007)
Nature
, vol.447
, pp. 1017-1020
-
-
Lee, J.H.1
Koh, H.2
Kim, M.3
Kim, Y.4
Lee, S.Y.5
Karess, R.E.6
-
68
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M et al. (2007). The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9: 218-224.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
-
69
-
-
2942527434
-
Relative frequency and morphology of cancers in STK11 mutation carriers
-
Lim W, Olschwang S, Keller JJ, Westerman AM, Menko FH, Boardman LA et al. (2004). Relative frequency and morphology of cancers in STK11 mutation carriers. Gastroenterology 126: 1788-1794.
-
(2004)
Gastroenterology
, vol.126
, pp. 1788-1794
-
-
Lim, W.1
Olschwang, S.2
Keller, J.J.3
Westerman, A.M.4
Menko, F.H.5
Boardman, L.A.6
-
70
-
-
18744399860
-
Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling
-
Lin-Marq N, Borel C, Antonarakis SE. (2005). Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. Mol Genet Genomics 273: 184-196.
-
(2005)
Mol Genet Genomics
, vol.273
, pp. 184-196
-
-
Lin-Marq, N.1
Borel, C.2
Antonarakis, S.E.3
-
71
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, Boudeau J et al. (2004). LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 23: 833-843.
-
(2004)
EMBO J
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
-
72
-
-
0037461735
-
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
-
Martin SG, St Johnston D. (2003). A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421: 379-384.
-
(2003)
Nature
, vol.421
, pp. 379-384
-
-
Martin, S.G.1
St Johnston, D.2
-
73
-
-
26444610333
-
LKB1 interacts with and phosphorylates PTEN: A functional link between two proteins involved in cancer predisposing syndromes
-
Mehenni H, Lin-Marq N, Buchet-Poyau K, Reymond A, Collart MA, Picard D et al. (2005). LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. Hum Mol Genet 14: 2209-2219.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2209-2219
-
-
Mehenni, H.1
Lin-Marq, N.2
Buchet-Poyau, K.3
Reymond, A.4
Collart, M.A.5
Picard, D.6
-
74
-
-
39049157916
-
Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells
-
Memmott RM, Gills JJ, Hollingshead M, Powers MC, Chen Z, Kemp B et al. (2008). Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Res 68: 580-588.
-
(2008)
Cancer Res
, vol.68
, pp. 580-588
-
-
Memmott, R.M.1
Gills, J.J.2
Hollingshead, M.3
Powers, M.C.4
Chen, Z.5
Kemp, B.6
-
75
-
-
34248185949
-
LKB1 and AMPK maintain epithelial cell polarity under energetic stress
-
Mirouse V, Swick LL, Kazgan N, St Johnston D, Brenman JE. (2007). LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol 177: 387-392.
-
(2007)
J Cell Biol
, vol.177
, pp. 387-392
-
-
Mirouse, V.1
Swick, L.L.2
Kazgan, N.3
St Johnston, D.4
Brenman, J.E.5
-
76
-
-
0033692749
-
Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome
-
Miyaki M, Iijima T, Hosono K, Ishii R, Yasuno M, Mori T et al. (2000). Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. Cancer Res 60: 6311-6313.
-
(2000)
Cancer Res
, vol.60
, pp. 6311-6313
-
-
Miyaki, M.1
Iijima, T.2
Hosono, K.3
Ishii, R.4
Yasuno, M.5
Mori, T.6
-
77
-
-
0037089467
-
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
-
Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM. (2002). Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 62: 2261-2266.
-
(2002)
Cancer Res
, vol.62
, pp. 2261-2266
-
-
Miyoshi, H.1
Nakau, M.2
Ishikawa, T.O.3
Seldin, M.F.4
Oshima, M.5
Taketo, M.M.6
-
78
-
-
0037102428
-
Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
-
Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM. (2002). Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res 62: 4549-4553.
-
(2002)
Cancer Res
, vol.62
, pp. 4549-4553
-
-
Nakau, M.1
Miyoshi, H.2
Seldin, M.F.3
Imamura, M.4
Oshima, M.5
Taketo, M.M.6
-
79
-
-
33645090940
-
Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
-
Narbonne P, Roy R. (2006). Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development 133: 611-619.
-
(2006)
Development
, vol.133
, pp. 611-619
-
-
Narbonne, P.1
Roy, R.2
-
80
-
-
0034988818
-
Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma
-
Olschwang S, Boisson C, Thomas G. (2001). Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma. J Med Genet 38: 356-360.
-
(2001)
J Med Genet
, vol.38
, pp. 356-360
-
-
Olschwang, S.1
Boisson, C.2
Thomas, G.3
-
82
-
-
35548952703
-
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization
-
Partanen JI, Nieminen AI, Makela TP, Klefstrom J. (2007). Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 104: 14694-14699.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14694-14699
-
-
Partanen, J.I.1
Nieminen, A.I.2
Makela, T.P.3
Klefstrom, J.4
-
83
-
-
42049113832
-
Lkb1 deficiency causes prostate neoplasia in the mouse
-
Pearson HB, McCarthy A, Collins CM, Ashworth A, Clarke AR. (2008). Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res 68: 2223-2232.
-
(2008)
Cancer Res
, vol.68
, pp. 2223-2232
-
-
Pearson, H.B.1
McCarthy, A.2
Collins, C.M.3
Ashworth, A.4
Clarke, A.R.5
-
85
-
-
0026007226
-
Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignum
-
Podczaski E, Kaminski PF, Pees RC, Singapuri K, Sorosky JI. (1991). Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignum. Gynecol Oncol 42: 74-78.
-
(1991)
Gynecol Oncol
, vol.42
, pp. 74-78
-
-
Podczaski, E.1
Kaminski, P.F.2
Pees, R.C.3
Singapuri, K.4
Sorosky, J.I.5
-
86
-
-
0037125996
-
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
-
Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V et al. (2002). Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci USA 99: 12327-12332.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12327-12332
-
-
Rossi, D.J.1
Ylikorkala, A.2
Korsisaari, N.3
Salovaara, R.4
Luukko, K.5
Launonen, V.6
-
87
-
-
0032908579
-
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas
-
Rowan A, Bataille V, MacKie R, Healy E, Bicknell D, Bodmer W et al. (1999). Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas. J Invest Dermatol 112: 509-511.
-
(1999)
J Invest Dermatol
, vol.112
, pp. 509-511
-
-
Rowan, A.1
Bataille, V.2
MacKie, R.3
Healy, E.4
Bicknell, D.5
Bodmer, W.6
-
88
-
-
0038107613
-
Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms
-
Sahin F, Maitra A, Argani P, Sato N, Maehara N, Montgomery E et al. (2003). Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol 16: 686-691.
-
(2003)
Mod Pathol
, vol.16
, pp. 686-691
-
-
Sahin, F.1
Maitra, A.2
Argani, P.3
Sato, N.4
Maehara, N.5
Montgomery, E.6
-
89
-
-
20044370885
-
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
-
Sakamoto K, McCarthy A, Smith D, Green KA, Grahame Hardie D, Ashworth A et al. (2005). Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J 24: 1810-1820.
-
(2005)
EMBO J
, vol.24
, pp. 1810-1820
-
-
Sakamoto, K.1
McCarthy, A.2
Smith, D.3
Green, K.A.4
Grahame Hardie, D.5
Ashworth, A.6
-
90
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM et al. (2002). Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 62: 3659-3662.
-
(2002)
Cancer Res
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
-
91
-
-
0036499467
-
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome
-
Sapkota GP, Boudeau J, Deak M, Kieloch A, Morrice N, Alessi DR. (2002a). Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J 362: 481-490.
-
(2002)
Biochem J
, vol.362
, pp. 481-490
-
-
Sapkota, G.P.1
Boudeau, J.2
Deak, M.3
Kieloch, A.4
Morrice, N.5
Alessi, D.R.6
-
92
-
-
0036901639
-
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
-
Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C et al. (2002b). Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J 368: 507-516.
-
(2002)
Biochem J
, vol.368
, pp. 507-516
-
-
Sapkota, G.P.1
Deak, M.2
Kieloch, A.3
Morrice, N.4
Goodarzi, A.A.5
Smythe, C.6
-
93
-
-
0035375261
-
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
-
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR et al. (2001b). Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. J Biol Chem 276: 19469-19482.
-
(2001)
J Biol Chem
, vol.276
, pp. 19469-19482
-
-
Sapkota, G.P.1
Kieloch, A.2
Lizcano, J.M.3
Lain, S.4
Arthur, J.S.5
Williams, M.R.6
-
94
-
-
0035184065
-
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
-
Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ et al. (2001). STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol 159: 2017-2022.
-
(2001)
Am J Pathol
, vol.159
, pp. 2017-2022
-
-
Sato, N.1
Rosty, C.2
Jansen, M.3
Fukushima, N.4
Ueki, T.5
Yeo, C.J.6
-
95
-
-
0035082644
-
Prevention of pancreatic cancer induction in hamsters by metformin
-
Schneider MB, Matsuzaki H, Haorah J, Ulrich A, Standop J, Ding XZ et al. (2001). Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology 120: 1263-1270.
-
(2001)
Gastroenterology
, vol.120
, pp. 1263-1270
-
-
Schneider, M.B.1
Matsuzaki, H.2
Haorah, J.3
Ulrich, A.4
Standop, J.5
Ding, X.Z.6
-
96
-
-
5344228270
-
The CREB coactivator TORC2 functions as a calciumand cAMP-sensitive coincidence detector
-
Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S et al. (2004). The CREB coactivator TORC2 functions as a calciumand cAMP-sensitive coincidence detector. Cell 119: 61-74 .
-
(2004)
Cell
, vol.119
, pp. 61-74
-
-
Screaton, R.A.1
Conkright, M.D.2
Katoh, Y.3
Best, J.L.4
Canettieri, G.5
Jeffries, S.6
-
97
-
-
33750619348
-
Glucose metabolism and cancer
-
Shaw RJ. (2006). Glucose metabolism and cancer. Curr Opin Cell Biol 18: 598-608.
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 598-608
-
-
Shaw, R.J.1
-
98
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA et al. (2004a). The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6: 91-99.
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
-
99
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA et al. (2004b). The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101: 3329-3335.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
-
100
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA et al. (2005). The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
-
101
-
-
34247478454
-
LKB1/STRAD promotes axon initiation during neuronal polarization
-
Shelly M, Cancedda L, Heilshorn S, Sumbre G, Poo MM. (2007). LKB1/STRAD promotes axon initiation during neuronal polarization. Cell 129: 565-577.
-
(2007)
Cell
, vol.129
, pp. 565-577
-
-
Shelly, M.1
Cancedda, L.2
Heilshorn, S.3
Sumbre, G.4
Poo, M.M.5
-
102
-
-
34848892187
-
Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner
-
Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M et al. (2007). Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation 116: 1585-1595.
-
(2007)
Circulation
, vol.116
, pp. 1585-1595
-
-
Song, P.1
Wu, Y.2
Xu, J.3
Xie, Z.4
Dong, Y.5
Zhang, M.6
-
103
-
-
45549094869
-
Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells
-
Song P, Xie Z, Wu Y, Xu J, Dong Y, Zou MH. (2008). Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. J Biol Chem 283: 12446-12455.
-
(2008)
J Biol Chem
, vol.283
, pp. 12446-12455
-
-
Song, P.1
Xie, Z.2
Wu, Y.3
Xu, J.4
Dong, Y.5
Zou, M.H.6
-
104
-
-
0042090214
-
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
-
Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D. (2003). Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene 22: 4752-4756.
-
(2003)
Oncogene
, vol.22
, pp. 4752-4756
-
-
Spicer, J.1
Rayter, S.2
Young, N.3
Elliott, R.4
Ashworth, A.5
Smith, D.6
-
105
-
-
0024350881
-
Cancer and the Peutz-Jeghers syndrome
-
Spigelman AD, Murday V, Phillips RK. (1989). Cancer and the Peutz-Jeghers syndrome. Gut 30: 1588-1590.
-
(1989)
Gut
, vol.30
, pp. 1588-1590
-
-
Spigelman, A.D.1
Murday, V.2
Phillips, R.K.3
-
106
-
-
0032984141
-
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers
-
Su GH, Hruban RH, Bansal RK, Bova GS, Tang DJ, Shekher MC et al. (1999). Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol 154: 1835-1840.
-
(1999)
Am J Pathol
, vol.154
, pp. 1835-1840
-
-
Su, G.H.1
Hruban, R.H.2
Bansal, R.K.3
Bova, G.S.4
Tang, D.J.5
Shekher, M.C.6
-
107
-
-
33645022897
-
Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice
-
Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM. (2006). Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Oncogene 25: 1816-1820.
-
(2006)
Oncogene
, vol.25
, pp. 1816-1820
-
-
Takeda, H.1
Miyoshi, H.2
Kojima, Y.3
Oshima, M.4
Taketo, M.M.5
-
108
-
-
0037096833
-
Growth arrest by the LKB1 tumor suppressor: Induction of p21(WAF1/CIP1)
-
Tiainen M, Vaahtomeri K, Ylikorkala A, Makela TP. (2002). Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). Hum Mol Genet 11: 1497-1504.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1497-1504
-
-
Tiainen, M.1
Vaahtomeri, K.2
Ylikorkala, A.3
Makela, T.P.4
-
109
-
-
0033529838
-
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
-
Tiainen M, Ylikorkala A, Makela TP. (1999). Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci USA 96: 9248-9251.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 9248-9251
-
-
Tiainen, M.1
Ylikorkala, A.2
Makela, T.P.3
-
111
-
-
5144232989
-
Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2
-
Udd L, Katajisto P, Rossi DJ, Lepisto A, Lahesmaa AM, Ylikorkala A et al. (2004). Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. Gastroenterology 127: 1030-1037.
-
(2004)
Gastroenterology
, vol.127
, pp. 1030-1037
-
-
Udd, L.1
Katajisto, P.2
Rossi, D.J.3
Lepisto, A.4
Lahesmaa, A.M.5
Ylikorkala, A.6
-
112
-
-
33745966059
-
LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome
-
Volikos E, Robinson J, Aittomaki K, Mecklin JP, Jarvinen H, Westerman AM et al. (2006). LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. J Med Genet 43: e18.
-
(2006)
J Med Genet
, vol.43
-
-
Volikos, E.1
Robinson, J.2
Aittomaki, K.3
Mecklin, J.P.4
Jarvinen, H.5
Westerman, A.M.6
-
113
-
-
0032893658
-
Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers0 syndrome provides evidence for a hamartoma-(adenoma)- carcinoma sequence
-
Wang ZJ, Ellis I, Zauber P, Iwama T, Marchese C, Talbot I et al. (1999). Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers0 syndrome provides evidence for a hamartoma-(adenoma)- carcinoma sequence. J Pathol 188: 9-13.
-
(1999)
J Pathol
, vol.188
, pp. 9-13
-
-
Wang, Z.J.1
Ellis, I.2
Zauber, P.3
Iwama, T.4
Marchese, C.5
Talbot, I.6
-
114
-
-
0031827021
-
Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes
-
Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I. (1998). Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. Am J Pathol 153: 363-366.
-
(1998)
Am J Pathol
, vol.153
, pp. 363-366
-
-
Wang, Z.J.1
Taylor, F.2
Churchman, M.3
Norbury, G.4
Tomlinson, I.5
-
115
-
-
0034090975
-
The C. elegans par-4gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry
-
Watts JL, Morton DG, Bestman J, Kemphues KJ. (2000). The C. elegans par-4gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 127: 1467-1475.
-
(2000)
Development
, vol.127
, pp. 1467-1475
-
-
Watts, J.L.1
Morton, D.G.2
Bestman, J.3
Kemphues, K.J.4
-
116
-
-
29244474612
-
Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
-
Wei C, Amos CI, Stephens LC, Campos I, Deng JM, Behringer RR et al. (2005). Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res 65: 11297-11303.
-
(2005)
Cancer Res
, vol.65
, pp. 11297-11303
-
-
Wei, C.1
Amos, C.I.2
Stephens, L.C.3
Campos, I.4
Deng, J.M.5
Behringer, R.R.6
-
117
-
-
39749102904
-
Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling
-
Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL et al. (2008). Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. Clin Cancer Res 14: 1167-1171.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1167-1171
-
-
Wei, C.1
Amos, C.I.2
Zhang, N.3
Wang, X.4
Rashid, A.5
Walker, C.L.6
-
118
-
-
0033541557
-
Peutz-Jeghers syndrome: 78-year follow-up of the original family
-
Westerman AM, Entius MM, de Baar E, Boor PP, Koole R, van Velthuysen ML et al. (1999). Peutz-Jeghers syndrome: 78-year follow-up of the original family. Lancet 353: 1211-1215.
-
(1999)
Lancet
, vol.353
, pp. 1211-1215
-
-
Westerman, A.M.1
Entius, M.M.2
de Baar, E.3
Boor, P.P.4
Koole, R.5
van Velthuysen, M.L.6
-
119
-
-
41149117383
-
LKB1 and AMPK in cell polarity and division
-
Williams T, Brenman JE. (2008). LKB1 and AMPK in cell polarity and division. Trends Cell Biol 18: 193-198.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 193-198
-
-
Williams, T.1
Brenman, J.E.2
-
120
-
-
33646573080
-
Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells
-
Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U et al. (2006). Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. J Biol Chem 281: 6366-6375.
-
(2006)
J Biol Chem
, vol.281
, pp. 6366-6375
-
-
Xie, Z.1
Dong, Y.2
Zhang, M.3
Cui, M.Z.4
Cohen, R.A.5
Riek, U.6
-
121
-
-
0038498340
-
Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome
-
Yee NS, Furth EE, Pack M. (2003). Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome. Cancer Biol Ther 2: 38-47.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 38-47
-
-
Yee, N.S.1
Furth, E.E.2
Pack, M.3
-
122
-
-
0035903028
-
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
-
Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M et al. (2001). Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293: 1323-1326.
-
(2001)
Science
, vol.293
, pp. 1323-1326
-
-
Ylikorkala, A.1
Rossi, D.J.2
Korsisaari, N.3
Luukko, K.4
Alitalo, K.5
Henkemeyer, M.6
-
123
-
-
0028888507
-
Feminizing Sertoli cell tumors in boys with Peutz-Jeghers syndrome
-
Young S, Gooneratne S, Straus II FH, Zeller WP, Bulun SE, Rosenthal IM. (1995). Feminizing Sertoli cell tumors in boys with Peutz-Jeghers syndrome. Am J Surg Pathol 19: 50-58.
-
(1995)
Am J Surg Pathol
, vol.19
, pp. 50-58
-
-
Young, S.1
Gooneratne, S.2
Straus II, F.H.3
Zeller, W.P.4
Bulun, S.E.5
Rosenthal, I.M.6
-
124
-
-
33751284806
-
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
-
Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. (2006). Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 66: 10269-10273.
-
(2006)
Cancer Res
, vol.66
, pp. 10269-10273
-
-
Zakikhani, M.1
Dowling, R.2
Fantus, I.G.3
Sonenberg, N.4
Pollak, M.5
-
125
-
-
33751204464
-
AMP-activated protein kinase regulates the assembly of epithelial tight junctions
-
Zhang L, Li J, Young LH, Caplan MJ. (2006). AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci USA 103: 17272-17277.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17272-17277
-
-
Zhang, L.1
Li, J.2
Young, L.H.3
Caplan, M.J.4
-
126
-
-
38849204971
-
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
-
Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI. (2008). The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res 68: 740-748.
-
(2008)
Cancer Res
, vol.68
, pp. 740-748
-
-
Zhang, S.1
Schafer-Hales, K.2
Khuri, F.R.3
Zhou, W.4
Vertino, P.M.5
Marcus, A.I.6
-
127
-
-
33846521353
-
Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase
-
Zheng B, Cantley LC. (2007). Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc Natl Acad Sci USA 104: 819-822.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 819-822
-
-
Zheng, B.1
Cantley, L.C.2
|