-
1
-
-
21144457217
-
Functional analysis of PIK3CA gene mutations in human colorectal cancer
-
DOI 10.1158/0008-5472.CAN-04-4114
-
Ikenoue T, Kanai F, Hikiba Y, et al: Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 65: 4562-4567, 2005. (Pubitemid 40740791)
-
(2005)
Cancer Research
, vol.65
, Issue.11
, pp. 4562-4567
-
-
Ikenoue, T.1
Kanai, F.2
Hikiba, Y.3
Obata, T.4
Tanaka, Y.5
Imamura, J.6
Ohta, M.7
Jazag, A.8
Guleng, B.9
Tateishi, K.10
Asaoka, Y.11
Matsumura, M.12
Kawabe, T.13
Omata, M.14
-
2
-
-
34247245135
-
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells
-
DOI 10.1593/neo.06823
-
Cengel KA, Voong KR, Chandrasekaran S, et al: Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells. Neoplasia 9: 341-348, 2007. (Pubitemid 46608301)
-
(2007)
Neoplasia
, vol.9
, Issue.4
, pp. 341-348
-
-
Cengel, K.A.1
Voong, K.R.2
Chandrasekaran, S.3
Maggiorella, L.4
Brunner, T.B.5
Stanbridge, E.6
Kao, G.D.7
McKenna, W.G.8
Bernhard, E.J.9
-
3
-
-
34247281958
-
Signal transducer and activator of transcripton 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase inductioa
-
Tsareva SA, Moriggl R, Corvinus FM, et al: Signal transducer and activator of transcripton 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase inductioa Neoplasia 9: 279-291, 2007.
-
(2007)
Neoplasia
, vol.9
, pp. 279-291
-
-
Tsareva, S.A.1
Moriggl, R.2
Corvinus, F.M.3
-
4
-
-
36849074161
-
Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2 overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation
-
Chiang CT, Way TD, Tsai SJ and Lin JK: Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2 overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. FEBS Lett 581: 5735-5742, 2007.
-
(2007)
FEBS Lett
, vol.581
, pp. 5735-5742
-
-
Chiang, C.T.1
Way, T.D.2
Tsai, S.J.3
Lin, J.K.4
-
5
-
-
42149083899
-
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
-
DOI 10.1002/ijc.23388
-
Barault L, Veyries N, Jooste V, et al: Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int J Cancer 122: 2255-2259, 2008. (Pubitemid 351542328)
-
(2008)
International Journal of Cancer
, vol.122
, Issue.10
, pp. 2255-2259
-
-
Barault, L.1
Veyrie, N.2
Jooste, V.3
Lecorre, D.4
Chapusot, C.5
Ferraz, J.-M.6
Lievre, A.7
Cortet, M.8
Bouvier, A.-M.9
Rat, P.10
Roignot, P.11
Faivre, J.12
Laurent-Puig, P.13
Piard, F.14
-
7
-
-
33749316418
-
The epidermal growth factor receptor pathway: A model for targeted therapy
-
DOI 10.1158/1078-0432.CCR-05-1554
-
Scaltriti M and Baselga J: The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res 12: 5268-5272, 2006. (Pubitemid 44497237)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.18
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
8
-
-
70349939382
-
Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
-
Siena S, Sartore-Bianchi A, Di Nicolantonio F, Balfour J and Bardelli A: Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J Natl Cancer Inst 101: 1308-1324, 2009.
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 1308-1324
-
-
Siena, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Balfour, J.4
Bardelli, A.5
-
9
-
-
0029022018
-
Mutations of ras genes in human tumours
-
Kiaris H and Spandidos DA: Mutations of ras genes in human tumours. Int J Oncol 7: 413-421, 1995.
-
(1995)
Int J Oncol
, vol.7
, pp. 413-421
-
-
Kiaris, H.1
Spandidos, D.A.2
-
10
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
DOI 10.1158/0008-5472.CAN-06-4158
-
Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al: Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 67: 2643-2648, 2007. (Pubitemid 46548951)
-
(2007)
Cancer Research
, vol.67
, Issue.6
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di, N.F.3
Zanon, C.4
Moroni, M.5
Veronese, S.6
Siena, S.7
Bardelli, A.8
-
11
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre A, Bachet JB, Le Corre D, et al: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 66: 3992-3995, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
-
12
-
-
28244484956
-
Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer
-
Frattini M, Signoroni S, Pilotti S, et al: Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer. Cancer Res 65: 1122-1127, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 1122-1127
-
-
Frattini, M.1
Signoroni, S.2
Pilotti, S.3
-
13
-
-
44449090596
-
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving Panitumumab alone
-
Freeman DJ, Juan T, Reiner M, et al: Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving Panitumumab alone. Clin Colorectal Cancer 7: 184-190, 2008.
-
(2008)
Clin Colorectal Cancer
, vol.7
, pp. 184-190
-
-
Freeman, D.J.1
Juan, T.2
Reiner, M.3
-
14
-
-
3042628862
-
Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival
-
Jemal A, Clegg LX, Ward E, et al: Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer 101: 3-27, 2004.
-
(2004)
Cancer
, vol.101
, pp. 3-27
-
-
Jemal, A.1
Clegg, L.X.2
Ward, E.3
-
15
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targetd monoclonal antibodies
-
Sartore-Bianchi A, Martini M, Molinari F, et al: PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targetd monoclonal antibodies. Cancer Res 69: 1851-1857, 2009.
-
(2009)
Cancer Res
, vol.69
, pp. 1851-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
-
16
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E, et al: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl Med 360: 1408-1417, 2009.
-
(2009)
N Engl Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
17
-
-
77954215850
-
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
-
Tol J, Dijkstra JR, Klomp M, et al: Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. Eur J Cancer 46: 1997-2009, 2010.
-
(2010)
Eur J Cancer
, vol.46
, pp. 1997-2009
-
-
Tol, J.1
Dijkstra, J.R.2
Klomp, M.3
-
18
-
-
77957205044
-
Predictive and prognostic value of KRAS mutations in metastatic colorectal cancer patients treated with cetuximab: A meta-analysis of 22 studies
-
Qiu LX, Mao C, Zhang J, et al: Predictive and prognostic value of KRAS mutations in metastatic colorectal cancer patients treated with cetuximab: a meta-analysis of 22 studies. Eur J Cancer 46: 2781-2787, 2010.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2781-2787
-
-
Qiu, L.X.1
Mao, C.2
Zhang, J.3
-
19
-
-
65349189958
-
American Society of Clinical Oncology provisional clinical opinion: Testirg for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
Allegra CJ, Jessup JM, Somerfield MR, et al: American Society of Clinical Oncology provisional clinical opinion: testirg for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol 27: 2091-2096, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2091-2096
-
-
Allegra, C.J.1
Jessup, J.M.2
Somerfield, M.R.3
-
20
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of Cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, et al: Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of Cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 11: 753-762, 2010.
-
(2010)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
-
21
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al: High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554-561, 2004
-
(2004)
Science
, vol.304
, pp. 554-561
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
22
-
-
0031918619
-
Role of K-ras mutations in colorectal carcinoma
-
Chiang JM: Role of K-ras mutations in colorectal carcinoma. Cancer Lett 126: 179-185, 1998.
-
(1998)
Cancer Lett
, vol.126
, pp. 179-185
-
-
Chiang, J.M.1
-
23
-
-
34548280882
-
Mutations of the PIK3CA gene in hereditary colorectal cancers
-
DOI 10.1002/ijc.22829
-
Miyaki M, Iijima T, Yamaguchi T, et al: Mutations of the PIK3CA gene in hereditary colorectal cancers. Int J Cancer 121: 1627-1630, 2007. (Pubitemid 47328725)
-
(2007)
International Journal of Cancer
, vol.121
, Issue.7
, pp. 1627-1630
-
-
Miyaki, M.1
Iijima, T.2
Yamaguchi, T.3
Takahashi, K.4
Matsumoto, H.5
Yasutome, M.6
Funata, N.7
Mori, T.8
-
24
-
-
0031690152
-
Activation of the ras genes in malignant and premalignant colorectal tumors
-
Glarakis IS, Sawa S and Spandidos DA: Activation of the ras genes in malignant and premalignant colorectal tumors. Oncol Rep 5: 1451-1454, 1998. (Pubitemid 28474093)
-
(1998)
Oncology Reports
, vol.5
, Issue.6
, pp. 1451-1454
-
-
Glarakis, I.S.1
Savva, S.2
Spandidos, D.A.3
-
25
-
-
23844497341
-
Sensitive sequencing method for KRAS mutation detection by pyrosequencing
-
Ogino S, Kawasaki T, Brahmandam M, et al: Sensitive sequencing method for KRAS mutation detection by Pyrosequencirg. J Mol Diagn 7: 413-421, 2005. (Pubitemid 41149657)
-
(2005)
Journal of Molecular Diagnostics
, vol.7
, Issue.3
, pp. 413-421
-
-
Ogino, S.1
Kawasaki, T.2
Brahmandam, M.3
Yan, L.4
Cantor, M.5
Nangyal, C.6
Mino-Kenudson, M.7
Lauwers, G.Y.8
Loda, M.9
Fuchs, C.S.10
-
26
-
-
22144452507
-
The prevalence of PIK3CA mutations in gastric and colon cancer
-
DOI 10.1016/j.ejca.2005.04.022, PII S0959804905003448
-
Velho S, Oliveira C, Ferreira A, et al: The prevalence of PIK3CA mutations ingastric and colon cancer. Eur J Cancer 41: 1649-1654, 2005. (Pubitemid 40981849)
-
(2005)
European Journal of Cancer
, vol.41
, Issue.11
, pp. 1649-1654
-
-
Velho, S.1
Oliveira, C.2
Ferreira, A.3
Ferreira, A.C.4
Suriano, G.5
Schwartz Jr., S.6
Duval, A.7
Carneiro, F.8
Machado, J.C.9
Hamelin, R.10
Seruca, R.11
-
27
-
-
34548676803
-
PIK3CA mutation is predictive of poor survival in patients with colorectal cancer
-
DOI 10.1002/ijc.22890
-
Kato S, Iida S, Higuchi T, et al: PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int J Cancer 121: 1771-1778, 2007. (Pubitemid 47417296)
-
(2007)
International Journal of Cancer
, vol.121
, Issue.8
, pp. 1771-1778
-
-
Kato, S.1
Iida, S.2
Higuchi, T.3
Ishikawa, T.4
Takagi, Y.5
Yasuno, M.6
Enomoto, M.7
Uetake, H.8
Sugihara, K.9
-
28
-
-
38949133202
-
PIK3CA cancer mutations display gender and tissue specificity patterns
-
DOI 10.1002/humu.20648
-
Benvenuti S, Frattini M, Arena S, et al: PIK3CA cancer mutations display gender and tissue specificity patterns. Hum Mutat 29: 284-288, 2008. (Pubitemid 351240601)
-
(2008)
Human Mutation
, vol.29
, Issue.2
, pp. 284-288
-
-
Benvenuti, S.1
Frattini, M.2
Arena, S.3
Zanon, C.4
Cappelletti, V.5
Coradini, D.6
Daidone, M.G.7
Pilotti, S.8
Pierotti, M.A.9
Bardelli, A.10
-
29
-
-
67649652208
-
BRAF mutation in metastatic colorectal cancer
-
Tol J, Nagtegaal ID and Punt CJ: BRAF mutation in metastatic colorectal cancer. N Engl J Med 361: 98-99, 2009.
-
(2009)
N Engl J Med
, vol.361
, pp. 98-99
-
-
Tol, J.1
Nagtegaal, I.D.2
Punt, C.J.3
-
30
-
-
73349114941
-
KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
-
Richman SD, Seymour MT, Chambers P, et al: KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol 27: 5931-5937, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5931-5937
-
-
Richman, S.D.1
Seymour, M.T.2
Chambers, P.3
-
31
-
-
63049111794
-
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
-
Ogino S, Nosho K, Kirkner GJ, et al: PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol 27: 1477-1484, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1477-1484
-
-
Ogino, S.1
Nosho, K.2
Kirkner, G.J.3
|