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Volumn 21, Issue 20, 2003, Pages 3729-3736

Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1; PROTEIN P16; DNA; MICROSATELLITE DNA;

EID: 0142087630     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2003.03.123     Document Type: Article
Times cited : (172)

References (53)
  • 3
    • 0028057504 scopus 로고
    • Residual tumor (R) classification and prognosis
    • Hermanek P, Wittekind C: Residual tumor (R) classification and prognosis. Semin Surg Oncol 10:12-20, 1994
    • (1994) Semin Surg Oncol , vol.10 , pp. 12-20
    • Hermanek, P.1    Wittekind, C.2
  • 4
    • 0027239890 scopus 로고
    • Clinicopathologically diagnosed residual tumor after resection for colorectal cancer: A 20-year prospective study
    • Newland RC, Dent OF, Chapuis PH, et al: Clinicopathologically diagnosed residual tumor after resection for colorectal cancer: A 20-year prospective study. Cancer 72:1536-1542, 1993
    • (1993) Cancer , vol.72 , pp. 1536-1542
    • Newland, R.C.1    Dent, O.F.2    Chapuis, P.H.3
  • 5
    • 0035105560 scopus 로고    scopus 로고
    • The results of colorectal cancer treatment by p53 status: Treatment-specific overview
    • Petersen S, Thames HD, Nieder C, et al: The results of colorectal cancer treatment by p53 status: Treatment-specific overview. Dis Colon Rectum 44:322-333, 2001
    • (2001) Dis Colon Rectum , vol.44 , pp. 322-333
    • Petersen, S.1    Thames, H.D.2    Nieder, C.3
  • 6
    • 0035444798 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The "RASCAL II" study
    • Andreyev HJ, Norman AR, Cunningham D, et al: Kirsten ras mutations in patients with colorectal cancer: The "RASCAL II" study. Br J Cancer 85:692-696, 2001
    • (2001) Br J Cancer , vol.85 , pp. 692-696
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3
  • 7
    • 0028321495 scopus 로고
    • Allelic loss of chromosome 18q and prognosis in colorectal cancer
    • Jen J, Kim H, Piantadosi S, et al: Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 331:213-221, 1994
    • (1994) N Engl J Med , vol.331 , pp. 213-221
    • Jen, J.1    Kim, H.2    Piantadosi, S.3
  • 8
    • 0028596162 scopus 로고
    • The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival
    • Dix BR, Robbins P, Soong R, et al: The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival. Int J Cancer 59:747-751, 1994
    • (1994) Int J Cancer , vol.59 , pp. 747-751
    • Dix, B.R.1    Robbins, P.2    Soong, R.3
  • 9
    • 0029012338 scopus 로고
    • c-erbB-2 oncoprotein in relation to DNA ploidy and prognosis in colorectal adenocarcinoma
    • Sun XF, Carstensen JM, Stal O, et al: c-erbB-2 oncoprotein in relation to DNA ploidy and prognosis in colorectal adenocarcinoma. APMIS 103:309-315, 1995
    • (1995) APMIS , vol.103 , pp. 309-315
    • Sun, X.F.1    Carstensen, J.M.2    Stal, O.3
  • 10
    • 15644372023 scopus 로고    scopus 로고
    • Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: A frequent. p53-independent mutation associated with improved outcome in a randomized multi-institutional trial
    • Augenlicht LH, Wadler S, Corner G, et al: Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: A frequent. p53-independent mutation associated with improved outcome in a randomized multi-institutional trial. Cancer Res 57:1769-1775, 1997
    • (1997) Cancer Res , vol.57 , pp. 1769-1775
    • Augenlicht, L.H.1    Wadler, S.2    Corner, G.3
  • 11
    • 0036550089 scopus 로고    scopus 로고
    • Molecular markers in prognosis of colorectal cancer and prediction of response to treatment
    • Pasche B, Mulcahy M, Benson AB III: Molecular markers in prognosis of colorectal cancer and prediction of response to treatment. Best Pract Res Clin Gastroenterol 16:331-345, 2002
    • (2002) Best Pract Res Clin Gastroenterol , vol.16 , pp. 331-345
    • Pasche, B.1    Mulcahy, M.2    Benson III, A.B.3
  • 12
    • 18844464796 scopus 로고    scopus 로고
    • Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members
    • Watson P, Lin KM, Rodriguez-Bigas MA, et al: Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members. Cancer 83:259-266, 1998
    • (1998) Cancer , vol.83 , pp. 259-266
    • Watson, P.1    Lin, K.M.2    Rodriguez-Bigas, M.A.3
  • 13
    • 0034642605 scopus 로고    scopus 로고
    • Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer
    • Gryfe R, Kim H, Hsieh ET, et al: Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 342:69-77, 2000
    • (2000) N Engl J Med , vol.342 , pp. 69-77
    • Gryfe, R.1    Kim, H.2    Hsieh, E.T.3
  • 14
    • 0033831989 scopus 로고    scopus 로고
    • Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer
    • Wright CM, Dent OF, Barker M, et al: Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer. Br J Surg 87:1197-1202, 2000
    • (2000) Br J Surg , vol.87 , pp. 1197-1202
    • Wright, C.M.1    Dent, O.F.2    Barker, M.3
  • 15
    • 0034895979 scopus 로고    scopus 로고
    • P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma
    • Elsaleh H, Powell B, McCaul K, et al: P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma. Clin Cancer Res 7:1343-1349, 2001
    • (2001) Clin Cancer Res , vol.7 , pp. 1343-1349
    • Elsaleh, H.1    Powell, B.2    McCaul, K.3
  • 16
    • 13144307115 scopus 로고    scopus 로고
    • Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
    • Veigl ML, Kasturi L, Olechnowicz J, et al: Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A 95:8698-8702, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8698-8702
    • Veigl, M.L.1    Kasturi, L.2    Olechnowicz, J.3
  • 17
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman JG, Umar A, Polyak K, et al: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 95:6870-6875, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3
  • 18
    • 0036022107 scopus 로고    scopus 로고
    • Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers
    • Furukawa T, Konishi F, Masubuchi S, et al: Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers. Genes Chromosomes Cancer 35:1-10, 2002
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 1-10
    • Furukawa, T.1    Konishi, F.2    Masubuchi, S.3
  • 19
    • 0034946935 scopus 로고    scopus 로고
    • Methylation pattern of different regions of the MLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer
    • Menigatti M, Di Gregorio C, Borghi F, et al: Methylation pattern of different regions of the MLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer. Genes Chromosomes Cancer 31:357-361, 2001
    • (2001) Genes Chromosomes Cancer , vol.31 , pp. 357-361
    • Menigatti, M.1    Di Gregorio, C.2    Borghi, F.3
  • 20
    • 0030812206 scopus 로고    scopus 로고
    • Association between CpG island methylation and microsatellite instability in colorectal cancer
    • Ahuja N, Mohan AL, Li Q, et al: Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res 57:3370-3374, 1997
    • (1997) Cancer Res , vol.57 , pp. 3370-3374
    • Ahuja, N.1    Mohan, A.L.2    Li, Q.3
  • 21
    • 0033587747 scopus 로고    scopus 로고
    • CpG island methylator phenotype in colorectal cancer
    • Toyota M, Ahuja N, Ohe-Toyota M, et al: CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A 96:8681-8686, 1999
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8681-8686
    • Toyota, M.1    Ahuja, N.2    Ohe-Toyota, M.3
  • 22
    • 0034681117 scopus 로고    scopus 로고
    • Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
    • Toyota M, Ohe-Toyota M, Ahuja N, et al: Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci U S A 97:710-715, 2000
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 710-715
    • Toyota, M.1    Ohe-Toyota, M.2    Ahuja, N.3
  • 23
    • 0036242782 scopus 로고    scopus 로고
    • CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
    • Hawkins N, Norrie M, Cheong K, et al: CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 122:1376-1387, 2002
    • (2002) Gastroenterology , vol.122 , pp. 1376-1387
    • Hawkins, N.1    Norrie, M.2    Cheong, K.3
  • 24
    • 0025060806 scopus 로고
    • Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma
    • Moertel CG, Fleming TR, Macdonald JS, et al: Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 322:352-358, 1990
    • (1990) N Engl J Med , vol.322 , pp. 352-358
    • Moertel, C.G.1    Fleming, T.R.2    Macdonald, J.S.3
  • 25
    • 0031022988 scopus 로고    scopus 로고
    • Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer
    • O'Connell MJ, Mailliard JA, Kahn MJ, et al: Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer. J Clin Oncol 15:246-250, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 246-250
    • O'Connell, M.J.1    Mailliard, J.A.2    Kahn, M.J.3
  • 26
    • 0027436244 scopus 로고
    • The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project protocol C-03
    • Wolmark N, Rockette H, Fisher B, et al: The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 11:1879-1887, 1993
    • (1993) J Clin Oncol , vol.11 , pp. 1879-1887
    • Wolmark, N.1    Rockette, H.2    Fisher, B.3
  • 27
    • 0036033495 scopus 로고    scopus 로고
    • Radiotherapy in rectal cancer
    • Glimelius B: Radiotherapy in rectal cancer. Br Med Bull 64:141-157, 2002
    • (2002) Br Med Bull , vol.64 , pp. 141-157
    • Glimelius, B.1
  • 28
    • 0034997971 scopus 로고    scopus 로고
    • Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
    • Ward R, Meagher A, Tomlinson I, et al: Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut 48:821-829, 2001
    • (2001) Gut , vol.48 , pp. 821-829
    • Ward, R.1    Meagher, A.2    Tomlinson, I.3
  • 29
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
    • Herman JG, Graff JR, Myohanen S, et al: Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 93:9821-9826, 1996
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3
  • 30
    • 0037428805 scopus 로고    scopus 로고
    • CpG island methylation is a common finding in colorectal cancer cell lines
    • Suter C, Norrie M, Ku S, et al: CpG island methylation is a common finding in colorectal cancer cell lines. Br J Cancer 88:413-419, 2003
    • (2003) Br J Cancer , vol.88 , pp. 413-419
    • Suter, C.1    Norrie, M.2    Ku, S.3
  • 31
    • 0033135049 scopus 로고    scopus 로고
    • Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
    • Deng G, Chen A, Hong J, et al: Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res 59:2029-2033, 1999
    • (1999) Cancer Res , vol.59 , pp. 2029-2033
    • Deng, G.1    Chen, A.2    Hong, J.3
  • 32
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller M, Garcia-Foncillas J, Andion E, et al: Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343:1350-1354, 2000
    • (2000) N Engl J Med , vol.343 , pp. 1350-1354
    • Esteller, M.1    Garcia-Foncillas, J.2    Andion, E.3
  • 33
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane MF, Loda M, Gaida GM, et al: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57:808-811, 1997
    • (1997) Cancer Res , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3
  • 34
    • 0034607234 scopus 로고    scopus 로고
    • Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
    • Esteller M, Silva JM, Dominguez G, et al: Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 92:564-569, 2000
    • (2000) J Natl Cancer Inst , vol.92 , pp. 564-569
    • Esteller, M.1    Silva, J.M.2    Dominguez, G.3
  • 35
    • 0034607246 scopus 로고    scopus 로고
    • E-cadherin gene promoter hypermethylation in primary human gastric carcinomas
    • Tamura G, Yin J, Wang S, et al: E-cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst 92:569-573, 2000
    • (2000) J Natl Cancer Inst , vol.92 , pp. 569-573
    • Tamura, G.1    Yin, J.2    Wang, S.3
  • 36
    • 0035863495 scopus 로고    scopus 로고
    • K-ras and p16 aberrations confer poor prognosis in human colorectal cancer
    • Esteller M, Gonzalez S, Risques RA, et al: K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. J Clin Oncol 19:299-304, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 299-304
    • Esteller, M.1    Gonzalez, S.2    Risques, R.A.3
  • 37
    • 19244370208 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
    • Esteller M, Toyota M, Sanchez-Cespedes M, et al: Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 60:2368-2371, 2000
    • (2000) Cancer Res , vol.60 , pp. 2368-2371
    • Esteller, M.1    Toyota, M.2    Sanchez-Cespedes, M.3
  • 38
    • 0033737604 scopus 로고    scopus 로고
    • Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors
    • Zheng S, Chen P, McMillan A, et al: Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors. Carcinogenesis 21:2057-2064, 2000
    • (2000) Carcinogenesis , vol.21 , pp. 2057-2064
    • Zheng, S.1    Chen, P.2    McMillan, A.3
  • 39
    • 0033985151 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status
    • Esteller M, Tortola S, Toyota M, et al: Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res 60:129-133, 2000
    • (2000) Cancer Res , vol.60 , pp. 129-133
    • Esteller, M.1    Tortola, S.2    Toyota, M.3
  • 40
    • 0034607258 scopus 로고    scopus 로고
    • BRCA1 and E-cadherin promoter hypermethylation and gene inactivation in cancer-association or mechanism?
    • Fearon ER: BRCA1 and E-cadherin promoter hypermethylation and gene inactivation in cancer-association or mechanism? J Natl Cancer Inst 92:515-517, 2000
    • (2000) J Natl Cancer Inst , vol.92 , pp. 515-517
    • Fearon, E.R.1
  • 42
    • 0033568534 scopus 로고    scopus 로고
    • Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5′ CpG island in human tumors
    • Toyota M, Ho C, Ohe-Toyota M, et al: Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5′ CpG island in human tumors. Cancer Res 59:4535-4541, 1999
    • (1999) Cancer Res , vol.59 , pp. 4535-4541
    • Toyota, M.1    Ho, C.2    Ohe-Toyota, M.3
  • 43
    • 0343621494 scopus 로고    scopus 로고
    • Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
    • Costello JF, Fruhwald MC, Smiraglia DJ, et al: Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet 24:132-138, 2000
    • (2000) Nat Genet , vol.24 , pp. 132-138
    • Costello, J.F.1    Fruhwald, M.C.2    Smiraglia, D.J.3
  • 44
    • 0033523204 scopus 로고    scopus 로고
    • Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers
    • Halling KC, French AJ, McDonnell SK, et al: Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst 91:1295-1303, 1999
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1295-1303
    • Halling, K.C.1    French, A.J.2    McDonnell, S.K.3
  • 45
    • 0034690610 scopus 로고    scopus 로고
    • Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer
    • Elsaleh H, Joseph D, Grieu F, et al: Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer. Lancet 355:1745-1750, 2000
    • (2000) Lancet , vol.355 , pp. 1745-1750
    • Elsaleh, H.1    Joseph, D.2    Grieu, F.3
  • 46
    • 0032815220 scopus 로고    scopus 로고
    • Replication error in colorectal carcinoma: Association with loss of heterozygosity at mismatch repair loci and clinicopathological variables
    • Johannsdottir JT, Bergthorsson JT, Gretarsdottir S, et al: Replication error in colorectal carcinoma: Association with loss of heterozygosity at mismatch repair loci and clinicopathological variables. Anticancer Res 19:1821-1826, 1999
    • (1999) Anticancer Res , vol.19 , pp. 1821-1826
    • Johannsdottir, J.T.1    Bergthorsson, J.T.2    Gretarsdottir, S.3
  • 47
    • 0032867362 scopus 로고    scopus 로고
    • Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
    • Salahshor S, Kressner U, Fischer H, et al: Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor. Br J Cancer 81:190-193, 1999
    • (1999) Br J Cancer , vol.81 , pp. 190-193
    • Salahshor, S.1    Kressner, U.2    Fischer, H.3
  • 48
    • 0033036918 scopus 로고    scopus 로고
    • Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers
    • Messerini L, Ciantelli M, Baglioni S, et al: Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers. Hum Pathol 30:629-634, 1999
    • (1999) Hum Pathol , vol.30 , pp. 629-634
    • Messerini, L.1    Ciantelli, M.2    Baglioni, S.3
  • 49
    • 0035812238 scopus 로고    scopus 로고
    • Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas
    • Hawkins NJ, Ward RL: Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst 93:1307-1313, 2001
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1307-1313
    • Hawkins, N.J.1    Ward, R.L.2
  • 50
    • 0033011006 scopus 로고    scopus 로고
    • Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog
    • Tomlinson I, Bodmer W: Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog. Nat Med 5:11-12, 1999
    • (1999) Nat Med , vol.5 , pp. 11-12
    • Tomlinson, I.1    Bodmer, W.2
  • 51
    • 12244294056 scopus 로고    scopus 로고
    • CD103+ intraepithelial lymphocytes: A unique population in microsatellite unstable sporadic colorectal cancer
    • Quinn E, Hawkins N, Yip L, et al: CD103+ intraepithelial lymphocytes: A unique population in microsatellite unstable sporadic colorectal cancer. Eur J Cancer 39:469-475, 2003
    • (2003) Eur J Cancer , vol.39 , pp. 469-475
    • Quinn, E.1    Hawkins, N.2    Yip, L.3
  • 52
    • 0036827692 scopus 로고    scopus 로고
    • Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer
    • Whitehall VL, Wynter CV, Walsh MD, et al: Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer. Cancer Res 62:6011-6014, 2002
    • (2002) Cancer Res , vol.62 , pp. 6011-6014
    • Whitehall, V.L.1    Wynter, C.V.2    Walsh, M.D.3
  • 53
    • 0035875903 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma
    • Smyrk TC, Watson P, Kaul K, et al: Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma. Cancer 91:2417-2422, 2001
    • (2001) Cancer , vol.91 , pp. 2417-2422
    • Smyrk, T.C.1    Watson, P.2    Kaul, K.3


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