Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients

Journal of Clinical Oncology

Volumn 21, Issue 5, 2003, Pages 820-829

  Diep, Chieu B ^a   Thorstensen, Lin ^a   Meling, Gunn Iren ^a   Skovlund, Eva ^a   Rognum, Torleiv O ^a   Lothe, Ragnhild A ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TUMOR MARKER; TUMOR PROTEIN; DNA; MICROSATELLITE DNA;

ALLELIC IMBALANCE; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CHROMOSOME 14Q; CHROMOSOME 17P; CHROMOSOME 18Q; CHROMOSOME 1P; CHROMOSOME 20Q; CHROMOSOME DELETION; CHROMOSOME LOSS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA DETERMINATION; FOLLOW UP; GENE LOCUS; GENE MUTATION; GENETIC MARKER; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROGNOSIS; TREATMENT OUTCOME; ADULT; AGED; ALLELE; CHROMOSOME 1; CHROMOSOME 14; CHROMOSOME 17; CHROMOSOME 18; CHROMOSOME 20; CLINICAL TRIAL; COLORECTAL TUMOR; COMPARATIVE STUDY; FEMALE; GENETICS; HETEROZYGOSITY LOSS; MALE; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; MUTATION; PATHOLOGY; PROSPECTIVE STUDY; RISK FACTOR; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 20; COLORECTAL NEOPLASMS; DNA, NEOPLASM; FEMALE; GENETIC MARKERS; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037364659     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2003.05.190     Document Type: Article

References (90)

1. Norwegian Cancer Registry: Cancer in Norway. 2001; http://www. kreftregisteret.no/
2. McMichael AJ, Giles GG: Colorectal cancer. Cancer Surv 19-20:77-98, 1994
3. Aaltonen LA, Pennanen S, Leach FS, et al: Clues to the pathogenesis of familial colorectal cancer. Science 260:812-816, 1993
4. Lothe RA, Peltomäki P, Meling GI, et al: Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history. Cancer Res 53:5849-5852, 1993
5. Thibodeau SN, Bren G, Schaid DJ: Microsatellite instability in cancer of the proximal colon. Science 260:816-819, 1993
6. Ionov Y, Peinado MA, Malkhosyan S, et al: Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonie carcinogenesis. Nature 363:558-561, 1993
7. Fishel R, Kolodner RD: Identification of mismatch repair genes and their role in the development of cancer. Curr Opin Genet Dev 5:382-395, 1995
8. Lengauer C, Kinzler KW, Vogelstein B: Genetic instability in colorectal cancers. Nature 386:623-627, 1997
9. Halling KC, French AJ, McDonnell SK, et al: Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst 91:1295-1303, 1999
10. Johannsdottir JT, Bergthorsson JT, Gretarsdottir S, et al: Replication error in colorectal carcinoma: Association with loss of heterozygosity at mismatch repair loci and clinicopathological variables. Anticancer Res 19:1821-1826, 1999
11. Gryfe R, Kim H, Hsieh ET, et al: Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 342:69-77, 2000
12. Massa MJ, Iniesta P, Gonzalez-Quevedo R, et al: Differential prognosis of replication error phenotype and loss of heterozygosity in sporadic colorectal cancer. Eur J Cancer 35:1676-1682, 1999
13. Elsaleh H, Powell B, Soontrapornchai P, et al: p53 gene mutation, microsatellite instability and adjuvant chemotherapy: Impact on survival of 388 patients with Dukes' C colon carcinoma. Oncology 58:52-59, 2000
14. Messerini L, Ciantelli M, Baglioni S, et al: Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers. Hum Pathol 30:629-634, 1999
15. Lukish JR, Muro K, DeNobile J, et al: Prognostic significance of DNA replication errors in young patients with colorectal cancer. Ann Surg 227:51-56, 1998
16. Watanabe T, Wu TT, Catalano PJ, et al: Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med 344:1196-1206, 2001
17. Hemminki A, Mecklin JP, Jarvinen H, et al: Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology 119:921-928, 2000
18. Wright CM, Dent OF, Barker M, et al: Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer. Br J Surg 87:1197-1202, 2000
19. Ward R, Meagher A, Tomlinson I, et al: Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut 48:821-829, 2001
20. Salahshor S, Kressner U, Fischer H, et al: Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor. Br J Cancer 81:190-193, 1999
21. Curran B, Lenehan K, Mulcahy H, et al: Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3, N0, M0) colorectal cancer. Gut 46:200-204, 2000
22. Vogelstein B, Fearon ER, Kern SE, et al: Allelotype of colorectal carcinomas. Science 244:207-211, 1989
23. Thorstensen L, Qvist H, Nesland JM, et al: Allelotype profiles of local recurrences and distant metastases from colorectal-cancer patients. Int J Cancer 69:452-456, 1996
24. Ookawa K, Sakamoto M, Hirohashi S, et al: Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. Int J Cancer 53:382-387, 1993
25. Lothe RA, Andersen SN, Hofstad B, et al: Deletion of 1p loci and microsatellite instability in colorectal polyps. Genes Chromosomes Cancer 14:182-188, 1995
26. Heim S, Mitelman F: Tumor of the digestive tract, in Cancer Cytogenetics: Chromosomal and Molecular Genetic Aberrations of Tumor Cells. New York, NY, John Wiley & Sons, 1995, pp 332-350
27. Thorstensen L, Qvist H, Heim S, et al: Evaluation of Ip losses in primary carcinomas, local recurrences and peripheral metastases from colorectal cancer patients. Neoplasia 2:514-522, 2000
28. Bomme L, Heim S, Bardi G, et al: Allelic imbalance and cytogenetic deletion of 1p in colorectal adenomas: A target region identified between DIS199 and DIS234. Genes Chromosomes Cancer 21:185-194, 1998
29. Young J, Searle J, Stitz R, et al: Loss of heterozygosity at the human RAP1A/Krev-1 locus is a rare event in colorectal tumors. Cancer Res 52:285-289, 1992
30. Praml C, Finke LH, Herfarth C, et al: Deletion mapping defines different regions in Ip34.2-pter that may harbor genetic information related to human colorectal cancer. Oncogene 11:1357-1362, 1995
31. Leister I, Weith A, Bruderlein S, et al: Human colorectal cancer: High frequency of deletions at chromosome 1p35. Cancer Res 50:7232-7235, 1990
32. Tanaka K, Yanoshita R, Konishi M, et al: Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region. Oncogene 8:2253-2258, 1993
33. Mitelman F: Catalog of chromosome aberrations in cancer. New York, NY, Wiley-Liss, 1998, CD-ROM
34. Thorstensen L, Qvist H, Nesland JM, et al: Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas. Scand J Gastroenterol 36:1327-1331, 2001
35. Muleris M, Salmon RJ, Zafrani B, et al: Consistent deficiencies of chromosome 18 and of the short arm of chromosome 17 in eleven cases of human large bowel cancer: A possible recessive determinism. Ann Genet 28:206-213, 1985
36. Meling GI, Lothe RA, Børresen AL, et al: The TP53 tumour suppressor gene in colorectal carcinomas: I. Genetic alterations on chromosome 17. Br J Cancer 67:88-92, 1993
37. Reichmann A, Martin P, Levin B: Chromosomal banding patterns in human large bowel cancer. Int J Cancer 28:431-440, 1981
38. Matlashewski G, Lamb P, Pim D, et al: Isolation and characterization of a human p53 cDNA clone: Expression of the human p53 gene. EMBO J 3:3257-3262, 1984
39. Fearon ER, Cho KR, Nigro JM, et al: Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247:49-56, 1990
40. Eppert K, Scherer SW, Ozcelik H, et al: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86:543-552, 1996
41. Thiagalingam S, Lengauer C, Leach FS, et al: Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 13:343-346, 1996
42. Gerdes H, Chen Q, Elahi AH, et al: Recurrent deletions involving chromosomes 1, 5, 17, and 18 in colorectal carcinoma: Possible role in biological and clinical behavior of tumors. Anticancer Res 15:13-24, 1995
43. Jen J, Kim H, Piantadosi S, et al: Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 331:213-221, 1994
44. Borresen-Dale AL, Lothe RA, Meling GI, et al: TP53 and long-term prognosis in colorectal cancer: Mutations in the L3 zinc-binding domain predict poor survival. Clin Cancer Res 4:203-210, 1998
45. O'Connell MJ, Schaid DJ, Ganju V, et al: Current status of adjuvant chemotherapy for colorectal cancer: Can molecular markers play a role in predicting prognosis? Cancer 70:1732-1739, 1992
46. Iino H, Fukayama M, Maeda Y, et al: Molecular genetics for clinical management of colorectal carcinoma. 17p, 18q, and 22q loss of heterozygosity and decreased DCC expression are correlated with the metastatic potential. Cancer 73:1324-1331, 1994
47. Ogunbiyi OA, Goodfellow PJ, Herfarth K, et al: Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. J Clin Oncol 16:427-433, 1998
48. Lanza G, Matteuzzi M, Gafa R, et al: Chromosome 18q allelic loss and prognosis in stage II and III colon cancer. Int J Cancer 79:390-395, 1998
49. Martinez-Lopez E, Abad A, Font A, et al: Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer. Gastroenterology 114:1180-1187, 1998
50. Jernvall P, Makinen MJ, Karttunen TJ, et al: Loss of heterozygosity at 18q21 is indicative of recurrence and therefore poor prognosis in a subset of colorectal cancers. Br J Cancer 79:903-908, 1999
51. Font A, Abad A, Monzo M, et al: Prognostic value of K-ras mutations and allelic imbalance on chromosome 18q in patients with resected colorectal cancer. Dis Colon Rectum 44:549-557, 2001
52. Laurent-Puig P, Olschwang S, Delattre O, et al: Survival and acquired genetic alterations in colorectal cancer. Gastroenterology 102:1136-1141, 1992
53. Kern SE, Fearon ER, Tersmette KW, et al: Clinical and pathological associations with allelic loss in colorectal carcinoma. JAMA 261:3099-3103, 1989
54. Carethers JM, Hawn MT, Greenson JK, et al: Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology 114:1188-1195, 1998
55. Dix BR, Robbins P, Soong R, et al: The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival. Int J Cancer 59:747-751, 1994
56. Khine K, Smith DR, Goh HS: High frequency of allelic deletion on chromosome 17p in advanced colorectal cancer. Cancer 73:28-35, 1994
57. McLeod HL, Murray GI: Tumour markers of prognosis in colorectal cancer. Br J Cancer 79:191-203, 1999
58. Petersen S, Thames HD, Nieder C, et al: The results of colorectal cancer treatment by p53 status: Treatment-specific overview. Dis Colon Rectum 44:322-333, 2001
59. Andreyev HJ, Norman AR, Cunningham D, et al: Kirsten ras mutations in patients with colorectal cancer: The multicenter "RASCAL" study. J Natl Cancer Inst 90:675-684, 1998
60. Andreyev HJ, Norman AR, Cunningham D, et al: Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study. Br J Cancer 85:692-696, 2001
61. Parada LA, Maranon A, Hallen M, et al: Cytogenetic analyses of secondary liver tumors reveal significant differences in genomic imbalances between primary and metastatic colon carcinomas. Clin Exp Metastasis 17:471-479, 1999
62. AI-Mulla F, Keith WN, Pickford IR, et al: Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases. Genes Chromosomes Cancer 24:306-314, 1999
63. Korn WM, Yasutake T, Kuo WL, et al: Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastatic to liver, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. Genes Chromosomes Cancer 25:82-90, 1999
64. Nanashima A, Yamaguchi H, Yasutake T, et al: Gain of chromosome 20 is a frequent aberration in liver metastasis of colorectal cancers. Dig Dis Sci 42:1388-1393, 1997
65. Hidaka S, Yasutake T, Takeshita H, et al: Differences in 20q 13.2 copy number between colorectal cancers with and without liver metastasis. Clin Cancer Res 6:2712-2717, 2000
66. Nakao K, Shibusawa M, Ishihara A, et al: Genetic changes in colorectal carcinoma tumors with liver metastases analyzed by comparative genomic hybridization and DNA ploidy. Cancer 91:721-726, 2001
67. Thorstensen L, Diep CB, Meling GI, et al: WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability. Gastroenterology 121:1275-1280, 2001
68. Meling GI, Lothe RA, Børresen AL, et al: Genetic alterations within the retinoblastoma locus in colorectal carcinomas: Relation to DNA ploidy pattern studied by flow cytometric analysis. Br J Cancer 64:475-480, 1991
69. Kunkel LM, Smith KD, Boyer SH, et al: Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants. Proc Natl Acad Sci U S A 74:1245-1249, 1977
70. Vogelstein B, Fearon ER, Hamilton SR, et al: Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532, 1988
71. De Angelis PM, Stokke T, Beigi M, et al: Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer. Int J Colorectal Dis 16:38-45, 2001
72. GDB: GDB Human Genome Database [database online]. 2001. Http://www.gdb.org/
73. Skotheim RI, Diep CB, Kraggerud SM, et al: Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA. Cancer Genet Cytogenet 127:64-70, 2001
74. Boland CR, Thibodeau SN, Hamilton SR, et al: A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58:5248-5257, 1998
75. Praml C, Savelyeva L, Perri P, et al: Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells. Cancer Res 58:5014-5018, 1998
76. Bando T, Kato Y, Ihara Y, et al: Loss of heterozygosity of 14q32 in colorectal carcinoma. Cancer Genet Cytogenet 111:161-165, 1999
77. Young J, Leggett B, Ward M, et al: Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas. Oncogene 8:671-675, 1993
78. Paredes-Zaglul A, Kang JJ, Essig YP, et al: Analysis of colorectal cancer by comparative genomic hybridization: Evidence for induction of the metastatic phenotype by loss of tumor suppressor genes. Clin Cancer Res 4:879-886, 1998
79. De Angelis PM, Clausen OP, Schjolberg A, et al: Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes. Br J Cancer 80:526-535, 1999
80. Aust DE, Willenbucher RF, Terdiman JP, et al: Chromosomal alterations in ulcerative colitis-related and sporadic colorectal cancers by comparative genomic hybridization. Hum Pathol 31:109-114, 2000
81. Ried T, Knutzen R, Steinbeck R, et al: Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer 15:234-245, 1996
82. Nakao K, Shibusawa M, Tsunoda A, et al: Genetic changes in primary colorectal cancer by comparative genomic hybridization. Surg Today 28:567-569, 1998
83. Meijer GA, Hermsen MA, Baak JP, et al: Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation. J Clin Pathol 51:901-909, 1998
84. Delattre O, Olschwang S, Law DJ, et al: Multiple genetic alterations in distal and proximal colorectal cancer. Lancet 2:353-356, 1989
85. Watatani M, Yoshida T, Kuroda K, et al: Allelic loss of chromosome 17p, mutation of the p53 gene, and microsatellite instability in right- and left-sided colorectal cancer. Cancer 77:1688-1693, 1996
86. Bardi G, Sukhikh T, Pandis N, et al: Karyotypic characterization of colorectal adenocarcinomas. Genes Chromosomes Cancer 12:97-109, 1995
87. Gryfe R, Swallow C, Bapat B, et al: Molecular biology of colorectal cancer. Curr Probl Cancer 21:233-300, 1997
88. Arends JW: Molecular interactions in the Vogelstein model of colorectal carcinoma. J Pathol 190:412-416, 2000
89. Cho KR, Fearon ER: DCC: Linking tumor suppressor genes and altered cell surface interactions in cancer? Curr Opin Genet Dev 5:72-78, 1995
90. Ogunbiyi OA, Goodfellow PJ, Gagliardi G, et al: Prognostic value of chromosome 1p allelic loss in colon cancer. Gastroenterology 113:761-766, 1997