Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis

Cancer Research

Volumn 61, Issue 3, 2001, Pages 818-822

  Shih, I M ^a   Zhou, W ^a   Goodman, S N ^a   Lengauer, C ^a   Kinzler, K W ^a   Vogelstein, B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADENOMA; ALLELE; ARTICLE; CHROMOSOME; CHROMOSOME 5Q; COLORECTAL TUMOR; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOMA; ALLELIC IMBALANCE; COLORECTAL NEOPLASMS; DNA PRIMERS; DNA, NEOPLASM; GENETIC MARKERS; HUMANS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROBABILITY;

EID: 0035110871     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Colorectal tumors
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3. Genetic instabilities in human cancers
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5. DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers
6. Genetic instability and Darwinian selection in tumours
7. APC mutations in colorectal tumors with mismatch repair deficiency
8. DNA flow cytometry of endoscopically examined colorectal adenomas and adenocarcinomas
9. K-ras2 mutation spectrum, DNA aneuploidy, and epithelial cell proliferation in colorectal adenomas
10. A model of DNA aneuploidization and evolution in colorectal cancer
11. K-ras2 activation and genome instability increase proliferation and size of FAP adenomas
12. Flow cytometric detection of aneuploidy in colorectal adenomas
13. Digital PCR
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15. APC mutations occur early during colorectal tumorigenesis
16. Molecular beacons: Probes that fluoresce upon hybridization
17. Multicolor molecular beacons for allele discrimination
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20. Genetic instability in colorectal cancers
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24. APC mutations are sufficient for the growth of early colorectal adenomas
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33. Allelic imbalance in lichen sclerosus, hyperplasia, and intraepithelial neoplasia of the vulva
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