IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype

Carcinogenesis

Volumn 31, Issue 3, 2010, Pages 342-349

  Suzuki, Hiromu ^a   Igarashi, Shinichi ^a   Nojima, Masanori ^a   Maruyama, Reo ^a   Yamamoto, Eiichiro ^a   Kai, Masahiro ^a   Akashi, Hirofumi ^a   Watanabe, Yoshiyuki ^b   Yamamoto, Hiroyuki ^a   Sasaki, Yasushi ^a   Itoh, Fumio ^b   Imai, Kohzoh ^a   Sugai, Tamotsu ^c   Shen, Lanlan ^d   Issa, Jean Pierre J ^d   Shinomura, Yasuhisa ^a   Tokino, Takashi ^a   Toyota, Minoru ^a  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c IWATE MEDICAL UNIVERSITY   (Japan)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; HISTONE H3; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 7; PROTEIN P53; SOMATOMEDIN BINDING PROTEIN; UNCLASSIFIED DRUG; 5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; BRAF PROTEIN, HUMAN; DNA; DRUG DERIVATIVE; HISTONE; HYBRID PROTEIN; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN RELATED PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED PROTEIN 1; TUMOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN METHYLATION; ADENOCARCINOMA; ADENOMA; CELL AGING; CHEMISTRY; COLORECTAL TUMOR; CONSENSUS SEQUENCE; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADENOMA; AZACITIDINE; CELL AGING; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CONSENSUS SEQUENCE; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; GENE SILENCING; GENES, P53; HISTONES; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; NEOPLASM PROTEINS; PHENOTYPE; PROTO-ONCOGENE PROTEINS B-RAF; RECOMBINANT FUSION PROTEINS; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77950900898     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp179     Document Type: Article

References (51)

1. Kinzler, K.W. et al. (1996) Lessons from hereditary colorectal cancer. Cell, 87, 159-170.
2. Jones, P.A. et al. (2007) The epigenomics of cancer. Cell, 128, 683-692.
3. Kanai, Y. et al. (2007) Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis, 28, 2434-2442.
4. Ushijima, T. et al. (2005) Aberrant methylations in cancer cells: where do they come from? Cancer Sci., 96, 206-211.
5. Toyota, M. et al. (1999) CpG island methylator phenotype in colorectal cancer. Proc. Natl Acad. Sci. USA, 96, 8681-8686.
6. Shen, L. et al. (2007) Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc. Natl Acad. Sci. USA, 104, 18654-18659.
7. Toyota, M. et al. (2000) Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc. Natl Acad. Sci. USA, 97, 710-715.
8. Weisenberger, D.J. et al. (2006) CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat. Genet., 38, 787-793.
9. Serrano, M. et al. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88, 593-602.
10. Zhu, J. et al. (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev., 12, 2997-3007.
11. Kortlever, R.M. et al. (2006) Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat. Cell Biol., 8, 877-884.
12. Qian, Y. et al. (2008) DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J. Biol. Chem., 283, 2896-2905.
13. el-Deiry, W.S. (1998) Regulation of p53 downstream genes. Semin. Cancer Biol., 8, 345-357.
14. Maruyama, R. et al. (2006) Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. Cancer Res., 66, 4574-4583.
15. Burger, A.M. et al. (1998) Down-regulation of T1A12/mac25, a novel insulin-like growth factor binding protein related gene, is associated with disease progression in breast carcinomas. Oncogene, 16, 2459-2467.
16. Landberg, G. et al. (2001) Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors. Oncogene, 20, 3497-3505.
17. Lin, J. et al. (2007) Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression. J. Pathol., 212, 83-90
18. Yamashita, S. et al. (2006) Chemical genomic screening for methylationsilenced genes in gastric cancer cell lines using 5-aza-2′-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci., 97, 64-71.
19. Wajapeyee, N. et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell, 132, 363-374.
20. Toyota, M. et al. (2008) Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res., 68, 4123-4132.
21. Rhee, I. et al. (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature, 416, 552-556.
22. Bunz, F. et al. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science, 282, 1497-1501.
23. Herman, J.G. et al. (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl Acad. Sci. USA, 93, 9821-9826.
24. Sasaki, Y. et al. (2003) Identification of the interleukin 4 receptor alpha gene as a direct target for p73. Cancer Res., 63, 8145-8152.
25. Nojima, M. et al. (2007) Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene, 26, 4699-4713.
26. Akino, K. et al. (2005) The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. Gastroenterology, 129, 156-169.
27. Eisen, M.B. et al. (1998) Cluster analysis and display of genome-wide expression patterns. Proc. Natl Acad. Sci. USA, 95, 14863-14868.
28. Barski, A. et al. (2007) High-resolution profiling of histone methylations in the human genome. Cell, 129, 823-837.
29. Chen, J.Y. et al. (1993) Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences. Oncogene, 8, 2159-2166.
30. Yu, J. et al. (1999) Identification and classification of p53-regulated genes. Proc. Natl Acad. Sci. USA, 96, 14517-14522.
31. Adachi, K. et al. (2004) Identification of SCN3B as a novel p53-inducible proapoptotic gene. Oncogene, 23, 7791-7798.
32. Minoo, P. et al. (2007) Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer. Mod. Pathol., 20, 331-338.
33. Gazin, C. et al. (2007) An elaborate pathway required for Ras-mediated epigenetic silencing. Nature, 449, 1073-1077.
34. Bakin, A.V. et al. (1999) Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science, 283, 387-390.
35. Davies, H. et al. (2002) Mutations of the BRAF gene in human cancer. Nature, 417, 949-954.
36. Rajagopalan, H. et al. (2002) Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature, 418, 934.
37. Michaloglou, C. et al. (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature, 436, 720-724.
38. Minoo, P. et al. (2006) Senescence and serration: a new twist to an old tale. J. Pathol., 210, 137-140.
39. Riley, T. et al. (2008) Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol., 9, 402-412.
40. Buckbinder, L. et al. (1995) Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature, 377, 646-649.
41. Suzuki, H. et al. (2000) Inactivation of the 14-3-3 sigma gene is associated with 5′ CpG island hypermethylation in human cancers. Cancer Res., 60, 4353-4357.
42. Wales, M.M. et al. (1995) p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat. Med., 1, 570-577.
43. Lin, J. et al. (2008) Reactivation of IGFBP7 by DNA demethylation inhibits human colon cancer cell growth in vitro. Cancer Biol. Ther., 7, 1896-1900
44. Egger, G. et al. (2006) Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc. Natl Acad. Sci. USA, 103, 14080-14085.
45. Sprenger, C.C. et al. (2002) Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis. Oncogene, 21, 140-147.
46. Wilson, H.M. et al. (2002) Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism. Cell Growth Differ., 13, 205-213.
47. Chen, Y. et al. (2007) Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) has potential tumour-suppressive activity in human lung cancer. J. Pathol., 211, 431-438.
48. Mutaguchi, K. et al. (2003) Restoration of insulin-like growth factor binding protein-related protein 1 has a tumor-suppressive activity through induction of apoptosis in human prostate cancer. Cancer Res., 63, 7717-7723.
49. Sato, Y. et al. (2007) Strong suppression of tumor growth by insulin-like growth factor-binding protein-related protein 1/tumor-derived cell adhesion factor/mac25. Cancer Sci., 98, 1055-1063.
50. Akaogi, K. et al. (1994) Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells. Biochem. Biophys. Res. Commun., 198, 1046-1053.
51. Sato, J. et al. (1999) Identification of cell-binding site of angiomodulin (AGM/TAF/Mac25) that interacts with heparan sulfates on cell surface. J. Cell. Biochem., 75, 187-195.