CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

Nature Genetics

Volumn 38, Issue 7, 2006, Pages 787-793

  Weisenberger, Daniel J ^a   Siegmund, Kimberly D ^b   Campan, Mihaela ^a   Young, Joanne ^c   Long, Tiffany I ^a   Faasse, Mark A ^a   Kang, Gyeong Hoon ^d   Widschwendter, Martin ^e   Weener, Deborah ^a   Buchanan, Daniel ^c   Koh, Hoey ^f   Simms, Lisa ^f   Barker, Melissa ^c   Leggett, Barbara ^f   Levine, Joan ^b   Kim, Myungjin ^a   French, Amy J ^g   Thibodeau, Stephen N ^g   Jass, Jeremy ^h   Haile, Robert ^b   Laird, Peter W ^a   more..

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d Seoul National University Hospital   (South Korea)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^g MAYO CLINIC   (United States)

^h MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; DNA; DNA METHYLTRANSFERASE; K RAS PROTEIN; PROTEIN CDKN2A; PROTEIN MLH1; TUMOR MARKER; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CLUSTER ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; CPG ISLAND METHYLATOR PHENOTYPE; DNA METHYLATION; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA REPAIR; DNA, NEOPLASM; EPIGENESIS, GENETIC; GENE SILENCING; GENOMIC INSTABILITY; HUMANS; MICROSATELLITE REPEATS; MODELS, GENETIC; MUTATION; PHENOTYPE; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS B-RAF;

EID: 33745541234     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1834     Document Type: Article

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