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Volumn 18, Issue 3, 2012, Pages 890-900

Predictive and prognostic roles of BRAF mutation in stage III colon cancer: Results from intergroup trial CALGB 89803

(16)  Ogino, Shuji a,b   Shima, Kaori a   Meyerhardt, Jeffrey A a   McCleary, Nadine J a   Ng, Kimmie a   Hollis, Donna d   Saltz, Leonard B e   Mayer, Robert J a   Schaefer, Paul f   Whittom, Renaud g   Hantel, Alexander h   Benson III, Al B i   Spiegelman, Donna b,c   Goldberg, Richard M j   Bertagnolli, Monica M b   Fuchs, Charles S a,b  


Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; IRINOTECAN;

EID: 84856512550     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-2246     Document Type: Article
Times cited : (244)

References (50)
  • 1
    • 22244472992 scopus 로고    scopus 로고
    • Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    • Samowitz WS, Sweeney C, Herrick J, Albertsen H, Levin TR, Murtaugh MA, et al. Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res 2005;65:6063-9.
    • (2005) Cancer Res , vol.65 , pp. 6063-6069
    • Samowitz, W.S.1    Sweeney, C.2    Herrick, J.3    Albertsen, H.4    Levin, T.R.5    Murtaugh, M.A.6
  • 2
    • 54249165951 scopus 로고    scopus 로고
    • Hypermethylator phenotype in sporadic colon cancer: Study on a population-based series of 582 cases
    • Barault L, Charon-Barra C, Jooste V, de la Vega MF, Martin L, Roignot P, et al. Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases. Cancer Res 2008;68:8541-6.
    • (2008) Cancer Res , vol.68 , pp. 8541-8546
    • Barault, L.1    Charon-Barra, C.2    Jooste, V.3    De La Vega, M.F.4    Martin, L.5    Roignot, P.6
  • 3
    • 56649084987 scopus 로고    scopus 로고
    • Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample
    • Nosho K, Irahara N, Shima K, Kure S, Kirkner GJ, Schernhammer ES, et al. Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PLoS One 2008;3:e3698.
    • (2008) PLoS One , vol.3
    • Nosho, K.1    Irahara, N.2    Shima, K.3    Kure, S.4    Kirkner, G.J.5    Schernhammer, E.S.6
  • 6
    • 77949759545 scopus 로고    scopus 로고
    • The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status
    • Dahlin AM, Palmqvist R, Henriksson ML, Jacobsson M, Eklof V, Rutegard J, et al. The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status. Clin Cancer Res 2010;16:1845-55.
    • (2010) Clin Cancer Res , vol.16 , pp. 1845-1855
    • Dahlin, A.M.1    Palmqvist, R.2    Henriksson, M.L.3    Jacobsson, M.4    Eklof, V.5    Rutegard, J.6
  • 7
    • 77950356773 scopus 로고    scopus 로고
    • Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study
    • Naguib A, Mitrou PN, Gay LJ, Cooke JC, Luben RN, Ball RY, et al. Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study. BMC Cancer 2010;10:99.
    • (2010) BMC Cancer , vol.10 , pp. 99
    • Naguib, A.1    Mitrou, P.N.2    Gay, L.J.3    Cooke, J.C.4    Luben, R.N.5    Ball, R.Y.6
  • 10
    • 84860589077 scopus 로고    scopus 로고
    • Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal vs. distal colorectum
    • In press
    • Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R, et al. Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal vs. distal colorectum. Gut. In press 2012.
    • (2012) Gut
    • Yamauchi, M.1    Morikawa, T.2    Kuchiba, A.3    Imamura, Y.4    Qian, Z.R.5    Nishihara, R.6
  • 12
    • 44849132638 scopus 로고    scopus 로고
    • Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer
    • Nagasaka T, Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, et al. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology 2008;134:1950-60, 60 e1.
    • (2008) Gastroenterology , vol.134
    • Nagasaka, T.1    Koi, M.2    Kloor, M.3    Gebert, J.4    Vilkin, A.5    Nishida, N.6
  • 13
    • 52049085300 scopus 로고    scopus 로고
    • Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
    • Suehiro Y, Wong CW, Chirieac LR, Kondo Y, Shen L, Webb CR, et al. Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. Clin Cancer Res 2008;14:2560-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 2560-2569
    • Suehiro, Y.1    Wong, C.W.2    Chirieac, L.R.3    Kondo, Y.4    Shen, L.5    Webb, C.R.6
  • 14
    • 50349091081 scopus 로고    scopus 로고
    • Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer
    • French AJ, Sargent DJ, Burgart LJ, Foster NR, Kabat BF, Goldberg R, et al. Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer. Clin Cancer Res 2008;14: 3408-15.
    • (2008) Clin Cancer Res , vol.14 , pp. 3408-3415
    • French, A.J.1    Sargent, D.J.2    Burgart, L.J.3    Foster, N.R.4    Kabat, B.F.5    Goldberg, R.6
  • 15
    • 77953688634 scopus 로고    scopus 로고
    • Clinicopathological and protein characterization of BRAF- And K-RAS-mutated colorectal cancer and implications for prognosis
    • Zlobec I, Bihl MP, Schwarb H, Terracciano L, Lugli A. Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis. Int J Cancer 2010;127:367-80.
    • (2010) Int J Cancer , vol.127 , pp. 367-380
    • Zlobec, I.1    Bihl, M.P.2    Schwarb, H.3    Terracciano, L.4    Lugli, A.5
  • 16
    • 58249089525 scopus 로고    scopus 로고
    • CpGisland methylator phenotype, microsatellite instability,BRAF mutation and clinical outcome in colon cancer
    • Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, Loda M, et al.CpGisland methylator phenotype, microsatellite instability,BRAF mutation and clinical outcome in colon cancer. Gut 2009;58:90-6.
    • (2009) Gut , vol.58 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3    Kawasaki, T.4    Meyerhardt, J.A.5    Loda, M.6
  • 17
    • 75749102647 scopus 로고    scopus 로고
    • Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
    • Roth AD, Tejpar S, Delorenzi M, Yan P, Fiocca R, Klingbiel D, et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol 2010;28:466-74.
    • (2010) J Clin Oncol , vol.28 , pp. 466-474
    • Roth, A.D.1    Tejpar, S.2    Delorenzi, M.3    Yan, P.4    Fiocca, R.5    Klingbiel, D.6
  • 18
    • 73449118889 scopus 로고    scopus 로고
    • Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers
    • Kim JH, Shin SH,Kwon HJ, Cho NY, Kang GH. Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers. Virchow Arch 2009;455:485-94.
    • (2009) Virchow Arch , vol.455 , pp. 485-494
    • Kim, J.H.1    Shin, S.H.2    Kwon, H.J.3    Cho, N.Y.4    Kang, G.H.5
  • 19
    • 68149165771 scopus 로고    scopus 로고
    • Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
    • Souglakos J, Philips J, Wang R, Marwah S, Silver M, Tzardi M, et al. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer 2009;101:465-72.
    • (2009) Br J Cancer , vol.101 , pp. 465-472
    • Souglakos, J.1    Philips, J.2    Wang, R.3    Marwah, S.4    Silver, M.5    Tzardi, M.6
  • 20
    • 78649473910 scopus 로고    scopus 로고
    • The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients
    • Farina-Sarasqueta A, van Lijnschoten G, Moerland E, Creemers GJ, Lemmens VE, Rutten HJ, et al. The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol 2010;21:2396-402.
    • (2010) Ann Oncol , vol.21 , pp. 2396-2402
    • Farina-Sarasqueta, A.1    Van Lijnschoten, G.2    Moerland, E.3    Creemers, G.J.4    Lemmens, V.E.5    Rutten, H.J.6
  • 21
    • 77953292460 scopus 로고    scopus 로고
    • BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients' outcome
    • Saridaki Z, Papadatos-Pastos D, Tzardi M, Mavroudis D, Bairaktari E, Arvanity H, et al. BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients' outcome. Br J Cancer 2010;102:1762-8.
    • (2010) Br J Cancer , vol.102 , pp. 1762-1768
    • Saridaki, Z.1    Papadatos-Pastos, D.2    Tzardi, M.3    Mavroudis, D.4    Bairaktari, E.5    Arvanity, H.6
  • 22
    • 67650552462 scopus 로고    scopus 로고
    • Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas
    • Kalady MF, Sanchez JA, Manilich E, Hammel J, Casey G, Church JM. Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas. Dis Colon Rectum 2009;52: 1039-45.
    • (2009) Dis Colon Rectum , vol.52 , pp. 1039-1045
    • Kalady, M.F.1    Sanchez, J.A.2    Manilich, E.3    Hammel, J.4    Casey, G.5    Church, J.M.6
  • 23
    • 64649096900 scopus 로고    scopus 로고
    • Microsatellite instability predicts improves response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and leukemia group B protocol 89803
    • BertagnolliMM,Niedzwiecki D, Compton CC, Hahn HP, Hall M, Damas B, et al. Microsatellite instability predicts improves response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: cancer and leukemia group B protocol 89803. J Clin Oncol 2009;27:1814-21.
    • (2009) J Clin Oncol , vol.27 , pp. 1814-1821
    • Bertagnolli, M.M.1    Niedzwiecki, D.2    Compton, C.C.3    Hahn, H.P.4    Hall, M.5    Damas, B.6
  • 24
    • 73349114941 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
    • Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, Meade AM, et al. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol 2009;27:5931-7.
    • (2009) J Clin Oncol , vol.27 , pp. 5931-5937
    • Richman, S.D.1    Seymour, M.T.2    Chambers, P.3    Elliott, F.4    Daly, C.L.5    Meade, A.M.6
  • 25
    • 79953856354 scopus 로고    scopus 로고
    • Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer
    • Hutchins G, Southward K, Handley K, Magill L, Beaumont C, Stahlschmidt J, et al. Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer. J Clin Oncol 2011;29:1261-70.
    • (2011) J Clin Oncol , vol.29 , pp. 1261-1270
    • Hutchins, G.1    Southward, K.2    Handley, K.3    Magill, L.4    Beaumont, C.5    Stahlschmidt, J.6
  • 26
    • 34548160680 scopus 로고    scopus 로고
    • Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: Results of CALGB 89803
    • DOI 10.1200/JCO.2007.11.2144
    • Saltz LB, Niedzwiecki D, Hollis D, Goldberg RM, Hantel A, Thomas JP, et al. Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803. J Clin Oncol 2007; 25:3456-61. (Pubitemid 47310883)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.23 , pp. 3456-3461
    • Saltz, L.B.1    Niedzwiecki, D.2    Hollis, D.3    Goldberg, R.M.4    Hantel, A.5    Thomas, J.P.6    Fields, A.L.A.7    Mayer, R.J.8
  • 28
    • 33749069927 scopus 로고    scopus 로고
    • CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: Possible associations with male sex and KRAS mutations
    • DOI 10.2353/jmoldx.2006.060082
    • Ogino S, Kawasaki T, Kirkner GJ, Loda M, Fuchs CS. CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. J Mol Diagn 2006;8:582-8. (Pubitemid 44774157)
    • (2006) Journal of Molecular Diagnostics , vol.8 , Issue.5 , pp. 582-588
    • Ogino, S.1    Kawasaki, T.2    Kirkner, G.J.3    Loda, M.4    Fuchs, C.S.5
  • 30
    • 73149107502 scopus 로고    scopus 로고
    • KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803
    • Ogino S, Meyerhardt JA, Irahara N, Niedzwiecki D, Hollis D, Saltz LB, et al. KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803. Clin Cancer Res 2009;15: 7322-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 7322-7329
    • Ogino, S.1    Meyerhardt, J.A.2    Irahara, N.3    Niedzwiecki, D.4    Hollis, D.5    Saltz, L.B.6
  • 32
    • 79151469394 scopus 로고    scopus 로고
    • Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer
    • Glimelius B, Garmo H, Berglund A, Fredriksson LA, Berglund M, Kohnke H, et al. Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Pharmacogenomics J 2011;11:61-71.
    • (2011) Pharmacogenomics J , vol.11 , pp. 61-71
    • Glimelius, B.1    Garmo, H.2    Berglund, A.3    Fredriksson, L.A.4    Berglund, M.5    Kohnke, H.6
  • 34
    • 47949089043 scopus 로고    scopus 로고
    • Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N′-bis(2-chloroethyl)-N-nitrosurea in camptothecin- resistant cells
    • Ma LC, Kuo CC, Liu JF, Chen LT, Chang JY. Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N′-bis(2-chloroethyl)-N-nitrosurea in camptothecin- resistant cells. Mol Pharmacol 2008;74:517-26.
    • (2008) Mol Pharmacol , vol.74 , pp. 517-526
    • Ma, L.C.1    Kuo, C.C.2    Liu, J.F.3    Chen, L.T.4    Chang, J.Y.5
  • 35
    • 77949274921 scopus 로고    scopus 로고
    • Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETACC 3-EORTC 40993-SAKK 60/00 trial)
    • abstract 4001
    • Tejpar S, Bosman F, Delorenzi M, Fiocca R, Yan P, Klingbiel D, et al. Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETACC 3-EORTC 40993-SAKK 60/00 trial). J Clin Oncol 2009;27: abstract 4001.
    • (2009) J Clin Oncol , vol.27
    • Tejpar, S.1    Bosman, F.2    Delorenzi, M.3    Fiocca, R.4    Yan, P.5    Klingbiel, D.6
  • 36
    • 82555191051 scopus 로고    scopus 로고
    • Cancer immunology-analysis of host and tumor factors for personalized medicine
    • Ogino S, Galon J, Fuchs CS, Dranoff G. Cancer immunology-analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol 2011;8:711-9.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 711-719
    • Ogino, S.1    Galon, J.2    Fuchs, C.S.3    Dranoff, G.4
  • 37
    • 79851511414 scopus 로고    scopus 로고
    • Molecular pathological epidemiology of colorectal neoplasia: An emerging transdisciplinary and interdisciplinary field
    • Ogino S, Chan AT, Fuchs CS, Giovannucci E. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut 2011;60:397-411.
    • (2011) Gut , vol.60 , pp. 397-411
    • Ogino, S.1    Chan, A.T.2    Fuchs, C.S.3    Giovannucci, E.4
  • 38
    • 77955122376 scopus 로고    scopus 로고
    • New strategies in colorectal cancer: Biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways
    • Dasari A, Messersmith WA. New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways. Clin Cancer Res 2010;16:3811-8.
    • (2010) Clin Cancer Res , vol.16 , pp. 3811-3818
    • Dasari, A.1    Messersmith, W.A.2
  • 39
    • 77951711694 scopus 로고    scopus 로고
    • Prognostic and predictive biomarkers in resected colon cancer: Current status and future perspectives for integrating genomics into biomarker discovery
    • Tejpar S, Bertagnolli M, Bosman F, Lenz HJ, Garraway L, Waldman F, et al. Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery. Oncologist 2010;15:390-404.
    • (2010) Oncologist , vol.15 , pp. 390-404
    • Tejpar, S.1    Bertagnolli, M.2    Bosman, F.3    Lenz, H.J.4    Garraway, L.5    Waldman, F.6
  • 40
    • 77952956887 scopus 로고    scopus 로고
    • Oncogenic mutations as predictive factors in colorectal cancer
    • Lievre A, Blons H, Laurent-Puig P. Oncogenic mutations as predictive factors in colorectal cancer. Oncogene 2010;29:3033-43.
    • (2010) Oncogene , vol.29 , pp. 3033-3043
    • Lievre, A.1    Blons, H.2    Laurent-Puig, P.3
  • 41
    • 79957523828 scopus 로고    scopus 로고
    • KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
    • De RoockW, Vriendt VD, Normanno N, Ciardiello F, Tejpar S. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol 2011;12: 594-603.
    • (2011) Lancet Oncol , vol.12 , pp. 594-603
    • De Roock, W.1    Vriendt, V.D.2    Normanno, N.3    Ciardiello, F.4    Tejpar, S.5
  • 42
    • 53049108631 scopus 로고    scopus 로고
    • Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11
    • Rodriguez R, Hansen LT, Phear G, Scorah J, Spang-Thomsen M, Cox A, et al. Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11. Clin Cancer Res 2008;14: 5476-83.
    • (2008) Clin Cancer Res , vol.14 , pp. 5476-5483
    • Rodriguez, R.1    Hansen, L.T.2    Phear, G.3    Scorah, J.4    Spang-Thomsen, M.5    Cox, A.6
  • 43
    • 55949099916 scopus 로고    scopus 로고
    • Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines
    • Vilar E, Scaltriti M, Balmana J, Saura C, Guzman M, Arribas J, et al. Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines. Br J Cancer 2008;99:1607-12.
    • (2008) Br J Cancer , vol.99 , pp. 1607-1612
    • Vilar, E.1    Scaltriti, M.2    Balmana, J.3    Saura, C.4    Guzman, M.5    Arribas, J.6
  • 44
    • 79958828886 scopus 로고    scopus 로고
    • DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy
    • Sinicrope FA, Foster NR, Thibodeau SN, Marsoni S, Monges G, Labianca R, et al. DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy. J Natl Cancer Inst 2011;103:863-75.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 863-875
    • Sinicrope, F.A.1    Foster, N.R.2    Thibodeau, S.N.3    Marsoni, S.4    Monges, G.5    Labianca, R.6
  • 45
    • 43049130760 scopus 로고    scopus 로고
    • LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    • DOI 10.1002/ijc.23470
    • Ogino S, Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, et al. LINE-1 hypomethylation is inversely associated with microsatellite instability and CpGmethylator phenotype in colorectal cancer. Int J Cancer 2008;122:2767-73. (Pubitemid 351631379)
    • (2008) International Journal of Cancer , vol.122 , Issue.12 , pp. 2767-2773
    • Ogino, S.1    Kawasaki, T.2    Nosho, K.3    Ohnishi, M.4    Suemoto, Y.5    Kirkner, G.J.6    Fuchs, C.S.7
  • 46
    • 78650186379 scopus 로고    scopus 로고
    • Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer
    • Tanaka N, Huttenhower C, Nosho K, Baba Y, Shima K, Quackenbush J, et al. Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. AmJ Pathol 2010;177:2731-40.
    • (2010) AmJ Pathol , vol.177 , pp. 2731-2740
    • Tanaka, N.1    Huttenhower, C.2    Nosho, K.3    Baba, Y.4    Shima, K.5    Quackenbush, J.6
  • 47
    • 80052929478 scopus 로고    scopus 로고
    • CpG island methylation in colorectal cancer: Past, present and future
    • Curtin K, Slattery ML, Samowitz WS. CpG island methylation in colorectal cancer: past, present and future. Pathol Res Int 2011;2011: 902674.
    • (2011) Pathol Res Int , vol.2011 , pp. 902674
    • Curtin, K.1    Slattery, M.L.2    Samowitz, W.S.3
  • 50
    • 66749121440 scopus 로고    scopus 로고
    • DNA demethylation protects from cleavable complex stabilization and DNA strand breakage induced by the topoisomerase type I inhibitor camptothecin
    • Orta ML, Mateos S, Cortes F. DNA demethylation protects from cleavable complex stabilization and DNA strand breakage induced by the topoisomerase type I inhibitor camptothecin. Mutagenesis 2009;24:237-44.
    • (2009) Mutagenesis , vol.24 , pp. 237-244
    • Orta, M.L.1    Mateos, S.2    Cortes, F.3


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