Mutant KRAS in aberrant crypt foci (ACF): Initiation of colorectal cancer?

Biochimica et Biophysica Acta - Reviews on Cancer

Volumn 1756, Issue 2, 2005, Pages 83-96

  Pretlow, Theresa P ^a   Pretlow, Thomas G ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Aberrant crypt foci; Colorectal cancer; KRAS; Premalignant lesion; Putative precursors of colorectal cancer

Indexed keywords

CARCINOGEN; FRIZZLED PROTEIN; K RAS PROTEIN; WNT PROTEIN;

CANCER RISK; CARCINOGENESIS; CELL TRANSFORMATION; CHROMOSOMAL INSTABILITY; COLORECTAL CANCER; DYSPLASIA; EPIGENETICS; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENETIC DISORDER; HUMAN; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; METHYLATION; NONHUMAN; ONCOGENE K RAS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; DNA METHYLATION; GENES; GENES, RAS; HUMANS; MUTATION;

ANIMALIA;

EID: 28844506365     PISSN: 0304419X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbcan.2005.06.002     Document Type: Review

References (150)

1. H. Mori, Y. Yamada, T. Kuno, and Y. Hirose Aberrant crypt foci and beta-catenin accumulated crypts; significance and roles for colorectal carcinogenesis Mutat. Res. 566 2004 191 208
2. M. Takahashi, and K. Wakabayashi Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents Cancer Sci. 95 2004 475 480
3. L. Cheng, and M.D. Lai Aberrant crypt foci as microscopic precursors of colorectal cancer World J. Gastroenterol. 9 2003 2642 2649
4. R.P. Bird Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings Cancer Lett. 37 1987 147 151
5. M.A. O'Riordan, B.J. Barrow, J.A. Jurcisek, T.A. Stellato, and T.P. Pretlow Aberrant crypts in the colons of humans and carcinogen-treated rats are enzyme-altered Proc. Am. Assoc. Cancer Res. 31 1990 85
6. T.P. Pretlow, B.J. Barrow, W.S. Ashton, M.A. O'Riordan, T.G. Pretlow, J.A. Jurcisek, and T.A. Stellato Aberrant crypts: putative preneoplastic foci in human colonic mucosa Cancer Res. 51 1991 1564 1567
7. L. Roncucci, D. Stamp, A. Medline, J.B. Cullen, and W.R. Bruce Identification and quantification of aberrant crypt foci and microadenomas in the human colon Hum. Pathol. 22 1991 287 294
8. L. Roncucci, A. Medline, and W.R. Bruce Classification of aberrant crypt foci and microadenomas in human colon Cancer Epidemiol. Biomarkers Prev. 1 1991 57 60
9. Y. Feng, R.J. Wagner, A.J. Fretland, W.K. Becker, A.M. Cooley, T.P. Pretlow, K.J. Lee, and D.W. Hein Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2′-dimethyl- 4-aminobiphenyl Cancer Res. 56 1996 527 531
10. J.E. Paulsen, I.-L. Steffensen, E. Namork, D.W. Hein, and J. Alexander Effect of acetylator genotype on 3,2′-dimethyl-4-aminobiphenyl induced aberrant crypt foci in the colon of hamsters Carcinogenesis 17 1996 459 465
11. K. Sugiyama, Y. Oda, K. Otori, S. Kato, T. Hasebe, T. Fujii, H. Tajiri, and H. Esumi Induction of aberrant crypt foci and flat-type adenocarcinoma in the colons of dogs by N-ethyl-N′-nitro-nitrosoguanidine and their sequential changes Jpn. J. Cancer Res. 88 1997 934 940
12. T.P. Pretlow, M.A. O'Riordan, T.G. Pretlow, and T.A. Stellato Aberrant crypts in human colonic mucosa: putative preneoplastic lesions J. Cell. Biochem., Suppl. 16G 1992 55 62
13. R.P. Bird Role of aberrant crypt foci in understanding the pathogenesis of colon cancer Cancer Lett. 93 1995 55 71
14. T.P. Pretlow, B. Siddiki, L.H. Augenlicht, T.G. Pretlow, and Y.S. Kim Aberrant crypt foci (ACF)-Earliest recognized players or innocent bystanders in colon carcinogenesis W. Schmiegel J. Schölmerich Colorectal Cancer: Molecular Mechanisms, Premalignant State and Its Prevention Falk Symposium vol. 109 1999 Kluwer Academic Publishers Hingham, MA 67 82
15. R.P. Bird, and C.K. Good The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer Toxicol. Lett. 112-113 2000 395 402
16. S.A. Stopera, L.C. Murphy, and R.P. Bird Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer Carcinogenesis 13 1992 2081 2085
17. A.A. Vivona, B. Shpitz, A. Medline, W.R. Bruce, K. Hay, M.A. Ward, H.S. Stern, and S. Gallinger K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis Carcinogenesis 14 1993 1777 1781
18. T.P. Pretlow, T.A. Brasitus, N.C. Fulton, C. Cheyer, and E.L. Kaplan K-ras mutations in putative preneoplastic lesions in human colon J. Natl. Cancer Inst. 85 1993 2004 2007
19. N. Shivapurkar, Z. Tang, A. Ferreira, S. Nasim, C. Garett, and O. Alabaster Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumors induced by azoxymethane in Fischer-344 rats on high-risk diet Carcinogenesis 15 1994 775 778
20. N.H. Zaidi, T.P. Pretlow, M.A. O'Riordan, L.L. Dumenco, E. Allay, and S.L. Gerson Transgenic expression of human MGMT protects against azoxymethane induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon Carcinogenesis 16 1995 451 456
21. T. Takayama, M. Ohi, T. Hayashi, K. Miyanishi, A. Nobuoka, T. Nakajima, T. Satoh, R. Takimoto, J. Kato, S. Sakamaki, and Y. Niitsu Analysis of K-ras, APC, and b-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis Gastroenterology 121 2001 599 611
22. Y. Kishimoto, T. Morisawa, A. Hosoda, G. Shiota, H. Kawasaki, and J. Hasegawa Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane J. Exp. Clin. Cancer Res. 21 2002 203 211
23. E.A. McLellan, and R.P. Bird Aberrant crypts: potential preneoplastic lesions in the murine colon Cancer Res. 48 1988 6187 6192
24. T.P. Pretlow, R.P. Bird, Correspondence re: Y. Yamada, et al., Frequent b-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. Cancer Res. 60 (2000) 3323-3327.
25. Sequential analysis of morphological and biological properties of b-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis, Cancer Res. 61 (2001) 1874-1878;
26. Cancer Res. 61 (2001) 7699-7700.
27. Y. Yamada, N. Yoshimi, Y. Hirose, K. Kawabata, K. Matsunaga, M. Shimizu, A. Hara, and H. Mori Frequent B-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis Cancer Res. 60 2000 3323 3327
28. Y. Yamada, N. Yoshimi, Y. Hirose, K. Matsunaga, M. Katayama, K. Sakata, M. Shimizu, T. Kuno, and H. Mori Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis Cancer Res. 61 2001 1874 1878
29. J.E. Paulsen, E.M. Loberg, H.B. Olstorn, H. Knutsen, I.L. Steffensen, and J. Alexander Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat Cancer Res. 65 2005 121 129
30. G. Caderni, A.P. Femia, A. Giannini, A. Favuzza, C. Luceri, M. Salvadori, and P. Dolara Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis Cancer Res. 63 2003 2388 2392
31. M. Ochiai, M. Watanabe, M. Nakanishi, A. Taguchi, T. Sugimura, and H. Nakagama Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats Cancer Lett. 220 2005 67 74
32. R.P. Bird, D. Salo, C. Lasko, and C. Good A novel methodological approach to study the level of specific protein and gene expression in aberrant crypt foci putative preneoplastic colonic lesions by Western blotting and RT-PCR Cancer Lett. 116 1997 15 19
33. T.P. Pretlow, M.A. O'Riordan, K.M. Spancake, and T.G. Pretlow Two types of putative preneoplastic lesions identified by hexosaminidase activity in whole-mounts of colons from F344 rats treated with carcinogen Am. J. Pathol. 142 1993 1695 1700
34. G. Caderni, A. Giannini, L. Lancioni, C. Luceri, A. Biggeri, and P. Dolara Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis Br. J. Cancer 71 1995 763 769
35. P. Dolara, G. Caderni, L. Lancioni, A. Giannini, A. Anastasi, M. Fazi, and G. Castiglione Aberrant crypt foci in human colon carcinogenesis Cancer Detect. Prev. 21 1997 135 140
36. T. Yokota, K. Sugano, H. Kondo, D. Saito, K. Sugihara, N. Fukayama, H. Ohkura, A. Ochiai, and S. Yoshida Detection of aberrant crypt foci by magnifying colonoscopy Gastrointest. Endosc. 46 1997 61 65
37. T. Takayama, S. Katsuki, Y. Takahashi, M. Ohi, S. Nojiri, S. Sakamaki, J. Kato, K. Kogawa, H. Miyake, and Y. Niitsu Aberrant crypt foci of the colon as precursors of adenoma and cancer N. Engl. J. Med. 339 1998 1277 1284
38. D.G. Adler, C.J. Gostout, D. Sorbi, L.J. Burgart, L. Wang, and W.S. Harmsen Endoscopic identification and quantification of aberrant crypt foci in the human colon Gastrointest. Endosc. 56 2002 657 662
39. D. Moxon, M. Raza, R. Kenney, R. Ewing, A. Arozullah, J.B. Mason, and R.E. Carroll Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population Clin. Gastroenterol. Hepatol. 3 2005 271 278
40. R.E. Rudolph, J.A. Dominitz, J.W. Lampe, L. Levy, P. Qu, S.S. Li, P.D. Lampe, M.P. Bronner, and J.D. Potter Risk factors for colorectal cancer in relation to number and size of aberrant crypt foci in humans Cancer Epidemiol. Biomarkers Prev. 14 2005 605 608
41. E.A. McLellan, and R.P. Bird Specificity study to evaluate induction of aberrant crypts in murine colons Cancer Res. 48 1988 6183 6186
42. E.A. McLellan, A. Medline, and R.P. Bird Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions Cancer Res. 51 1991 5270 5274
43. B. Tudek, R.P. Bird, and W.R. Bruce Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods Cancer Res. 49 1989 1236 1240
44. E.A. McLellan, A. Medline, and R.P. Bird Dose response and proliferative characteristics of aberrant crypt foci: putative preneoplastic lesions in rat colon Carcinogenesis 12 1991 2093 2098
45. T.P. Pretlow, M.A. O'Riordan, M.F. Kolman, and J.A. Jurcisek Colonic aberrant crypts in azoxymethane-treated F344 rats have decreased hexosaminidase activity Am. J. Pathol. 136 1990 13 16
46. E.E. Deschner Experimentally induced cancer of the colon Cancer 34 1974 824 828
47. G.M. Williams, V. Chandrasekaran, S. Katayama, and J.H. Weisburger Carcinogenicity of 3-methyl-2-naphthlamine and 3,2′-dimethyl-4- aminobiphenyl to the bladder and gastrointestinal tract of the Syrian golden hamster with atypical proliferative enteritis J. Natl. Cancer Inst. 67 1981 481 488
48. Y. Fujimitsu, H. Nakanishi, K.-i. Inada, T. Yamachika, M. Ichinose, H. Fukami, and M. Tatematsu Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts Jpn. J. Cancer Res. 87 1996 1199 1203
49. S. Takahashi, K. Ogawa, H. Ohshima, H. Esumi, N. Ito, and T. Sugimura Induction of aberrant crypt foci in the large intestine of F344 rats by oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Jpn. J. Cancer Res. 82 1991 135 137
50. N. Tachino, R. Hayashi, C. Liew, G. Bailey, and R. Dashwood Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonic aberrant crypts in the rat Mol. Carcinog. 12 1995 187 192
51. Z. Tanakamaru, I. Mori, A. Nishikawa, F. Furukawa, M. Takahashi, and H. Mori Essential similarities between spontaneous and MeIQx-promoted aberrant crypt foci in the F344 rat colon Cancer Lett. 172 2001 143 149
52. T. Sugimura Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process Mutat. Res. 150 1985 33 41
53. F. Furukawa, A. Nishikawa, Y. Kitahori, Z. Tanakamaru, and M. Hirose Spontaneous development of aberrant crypt foci in F344 rats J. Exp. Clin. Cancer Res. 21 2002 197 201
54. T.P. Pretlow, W. Edelmann, R. Kucherlapati, T.G. Pretlow, and L.H. Augenlicht Spontaneous aberrant crypt foci (ACF) in Apc1638N mice with a mutant Apc allele Am. J. Pathol. 163 2003 1757 1763
55. K.P. Janssen, F. el-Marjou, D. Pinto, X. Sastre, D. Rouillard, C. Fouquet, T. Soussi, D. Louvard, and S. Robine Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice Gastroenterology 123 2002 492 504
56. T.P. Pretlow, C. Cheyer, and M.A. O'Riordan Aberrant crypt foci and colon tumors in F344 rats have similar increases in proliferative activity Int. J. Cancer 56 1994 599 602
57. M. Ochiai, M. Ushigome, K. Fujiwara, T. Ubagai, T. Kawamori, T. Sugimura, M. Nagao, and H. Nakagama Characterization of dysplastic aberrant crypt foci in the rat colon Induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Am. J. Pathol. 163 2003 1607 1614
58. B.A. Magnuson, N. Shirtliff, and R.P. Bird Resistance of aberrant crypt foci to apoptosis induced by azoxymethane in rats chronically fed cholic acid Carcinogenesis 15 1994 1459 1462
59. M.A. Pereira, L.H. Barnes, V.L. Rassman, G.V. Kelloff, and V.E. Steele Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents Carcinogenesis 15 1994 1049 1054
60. M.J. Wargovich, C.-D. Chen, A. Jimenez, V.E. Steele, M. Velasco, L.C. Stephens, R. Price, K. Gray, and G.J. Kelloff Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat Cancer Epidemiol. Biomarkers Prev. 5 1996 355 360
61. D.E. Corpet, and S. Tache Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency Nutr Cancer 43 2002 1 21
62. T.P. Pretlow, M.A. O'Riordan, G.A. Somich, S.B. Amini, and T.G. Pretlow Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate Carcinogenesis 13 1992 1509 1512
63. B.A. Magnuson, I. Carr, and R.P. Bird Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid Cancer Res. 53 1993 4499 4504
64. T.P. Pretlow, and T.G. Pretlow Neoplasia and preneoplasia of the intestines P. Bannasch W. Gössner Pathology of Neoplasia and Preneoplasia in Rodents, EULEP Color Atlas of Pathology 1997 F.K. Schattauer New York 75 94
65. Y. Gokmen-Polar, N.R. Murray, M.A. Velasco, Z. Gatalica, and A.P. Fields Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis Cancer Res. 61 2001 1375 1381
66. I. Thorup Histomorphological and immunohistochemical characterization of colonic aberrant crypt foci in rats: relationship to growth factor expression Carcinogenesis 18 1997 465 472
67. P.R. Nambiar, M. Nakanishi, R. Gupta, E. Cheung, A. Firouzi, X.J. Ma, C. Flynn, M. Dong, K. Guda, J. Levine, R. Raja, L. Achenie, and D.W. Rosenberg Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer Cancer Res. 64 2004 6394 6401
68. 3 inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin Cancer Epidemiol. Biomarkers Prev. 11 2002 1653 1662
69. M. Jenab, J. Chen, and L.U. Thompson Sialomucin production in aberrant crypt foci relates to degree of dysplasia and rate of cell proliferation Cancer Lett. 165 2001 19 25
70. A.P. Femia, P. Dolara, and G. Caderni Mucin-depleted foci (MDF) in the colon of rats treated with azoxymethane (AOM) are useful biomarkers for colon carcinogenesis Carcinogenesis 25 2004 277 281
71. M. Takahashi, M. Mutoh, T. Kawamori, T. Sugimura, and K. Wakabayashi Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis Carcinogenesis 21 2000 1319 1327
72. T. Furihata, H. Kawamata, K. Kubota, and T. Fujimori Evaluation of the malignant potential of aberrant crypt foci by immunohistochemical staining for b-catenin in inflammation-induced rat colon carcinogenesis Int. J. Mol. Med. 9 2002 353 358
73. R.H. Dashwood, M. Suzui, H. Nakagama, T. Sugimura, and M. Nagao High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat Cancer Res. 58 1998 1127 1129
74. C. De Filippo, G. Caderni, M. Bazzicalupo, C. Briani, A. Giannini, M. Fazi, and P. Dolara Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats Br. J. Cancer 77 1998 2148 2151
75. M. Toyota, T. Ushijima, H. Kakiuchi, M. Watanabe, K. Imai, A. Yachi, T. Sugimura, and M. Nagao cDNA cloning of the rat APC gene and assignment to chromosome 18 Mamm. Genome 6 1995 746 748
76. K. Matsumoto, T. Iwase, I. Hirono, Y. Nishida, Y. Iwahori, T. Hori, M. Asamoto, N. Takasuka, D.J. Kim, T. Ushijima, M. Nagao, and H. Tsuda Demonstration of ras and p53 gene mutations in carcinomas in the forestomach and intestine and soft tissue sarcomas induced by N-methyl-N-nitrosourea in the rat Jpn. J. Cancer Res. 88 1997 129 136
77. N. Shivapurkar, S.A. Belinsky, D.C. Wolf, Z. Tang, and O. Alabaster Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane Cancer Lett. 96 1995 63 70
78. N. Shivapurkar, K.J. Nikula, T. Tanaka, Z.C. Tang, and O. Alabaster Absence of p53 gene mutations in rat colon carcinomas induced through the synergistic interaction between methylazoxymethanol and X-irradiation Cancer Lett. 113 1997 9 16
79. S.H. Erdman, H.D. Wu, L.J. Hixson, D.J. Ahnen, and E.W. Gerner Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine-treated rats Mol. Carcinog. 19 1997 137 144
80. P.R. Nambiar, C. Giardina, K. Guda, W. Aizu, R. Raja, and D.W. Rosenberg Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model Cancer Res. 62 2002 3667 3674
81. S.A. Stopera, and R.P. Bird Immunohistochemical demonstration of mutant p53 tumour suppressor gene product in aberrant crypt foci Cytobios 73 1993 73 88
82. C. Luceri, C. De Filippo, G. Caderni, L. Gambacciani, M. Salvadori, A. Giannini, and P. Dolara Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis Carcinogenesis 21 2000 1753 1756
83. I.-M. Siu, T.G. Pretlow, S.B. Amini, and T.P. Pretlow Identification of dysplasia in human colonic aberrant crypt foci Am. J. Pathol. 150 1997 1805 1813
84. B. Shpitz, Y. Bomstein, Y. Mekori, R. Cohen, Z. Kaufman, D. Neufeld, M. Galkin, and J. Bernheim Aberrant crypt foci in human colons: distribution and histomorphologic characteristics Hum. Pathol. 29 1998 469 475
85. R. Nascimbeni, V. Villanacci, P.P. Mariani, E. Di Betta, M. Ghirardi, F. Donato, and B. Salerni Aberrant crypt foci in the human colon: frequency and histologic patterns in patients with colorectal cancer or diverticular disease Am. J. Surg. Pathol. 23 1999 1256 1263
86. N. Yamashita, T. Minamoto, A. Ochia, M. Onda, and H. Esumi Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of colon Gastroenterology 108 1995 434 440
87. L. Roncucci, S. Modica, M. Pedroni, M.G. Tamassia, M. Ghidoni, L. Losi, R. Fante, C. Di Gregorio, A. Manenti, L. Gafa, and M. Ponz de Leon Aberrant crypt foci in patients with colorectal cancer Br. J. Cancer 77 1998 2343 2348
88. L. Roncucci, M. Pedroni, R. Fante, C. Di Gregorio, and M. Ponz de Leon Cell kinetic evaluation of human colonic aberrant crypts Cancer Res. 53 1993 3726 3729
89. B. Shpitz, Y. Bomstein, Y. Mekori, R. Cohen, Z. Kaufman, M. Grankin, and J. Bernheim Proliferating cell nuclear antigen as a marker of cell kinetics in aberrant crypt foci, hyperplastic polyps, adenomas, and adenocarcinomas of the human colon Am. J. Surg. 174 1997 425 430
90. M.R. Nucci, C.R. Robinson, P. Longo, P. Campbell, and S.R. Hamilton Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa Hum. Pathol. 28 1997 1396 1407
91. L. Roncucci, M. Pedroni, F. Vaccina, P. Benatti, L. Marzona, and A. De Pol Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics Cell Prolif. 33 2000 1 18
92. K. Otori, K. Sugiyama, T. Hasebe, S. Fukushima, and H. Esumi Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation Cancer Res. 55 1995 4743 4746
93. D. Kristt, K. Bryan, and R. Gal Colonic aberrant crypts may originate from impaired fissioning: relevance to increased risk of neoplasia Hum. Pathol. 30 1999 1449 1458
94. S.L. Preston, W.M. Wong, A.O. Chan, R. Poulsom, R. Jeffery, R.A. Goodlad, N. Mandir, G. Elia, M. Novelli, W.F. Bodmer, I.P. Tomlinson, and N.A. Wright Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission Cancer Res. 63 2003 3819 3825
95. R.E. Carroll Colon preparation for magnification endoscopy: a rapid novel approach Endoscopy 36 2004 609 611
96. R.H. Riddell, H. Goldman, D.F. Ransohoff, H.D. Appelman, C.M. Fenoglio, R.C. Haggitt, C. Ahren, P. Correa, S.R. Hamilton, B.C. Morson, S.C. Sommers, and J.H. Yardley Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications Hum. Pathol. 14 1983 931 966
97. C. di Gregorio, L. Losi, R. Fante, S. Modica, M. Ghidoni, M. Pedroni, M.G. Tamassia, L. Gafa, M. Ponz de Leon, and L. Roncucci Histology of aberrant crypt foci in the human colon Histopathology 30 1997 328 334
98. H. Bouzourene, P. Chaubert, W. Seelentag, F.T. Bosman, and E. Saraga Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease Hum. Pathol. 30 1999 66 71
99. A.O. Chan, R.R. Broaddus, P.S. Houlihan, J.P. Issa, S.R. Hamilton, and A. Rashid CpG island methylation in aberrant crypt foci of the colorectum Am. J. Pathol. 160 2002 1823 1830
100. J. Jen, S.M. Powell, N. Papadopoulos, K.J. Smith, S.R. Hamilton, B. Vogelstein, and K.W. Kinzler Molecular determinants of dysplasia in colorectal lesions Cancer Res. 54 1994 5523 5526
101. T.P. Pretlow, E. Roukhadze, M.A. O'Riordan, J.C. Chan, S.B. Amini, and T.A. Stellato Carcinoembryonic antigen in human colonic aberrant crypt foci Gastroenterology 107 1994 1719 1725
102. A.K. Konstantakos, I.-M. Siu, T.G. Pretlow, T.A. Stellato, and T.P. Pretlow Human aberrant crypt foci with carcinoma in situ from a patient with sporadic colon cancer Gastroenterology 111 1996 772 777
103. L. Augenlicht Adhesion molecules, cellular differentiation, and colonic crypt architecture. Gastroenterology 107 1994 1894 1898
104. R.G. Hardy, C. Tselepis, J. Hoyland, Y. Wallis, T.P. Pretlow, I. Talbot, D.S. Sanders, G. Matthews, D. Morton, and J. Jankowski Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon Gut 50 2002 513 519
105. X.P. Hao, J.E. Willis, T.G. Pretlow, J.S. Rao, G.T. MacLennan, I.C. Talbot, and T.P. Pretlow Loss of fragile histidine triad (Fhit) expression in colorectal carcinomas and premalignant lesions Cancer Res. 60 2000 18 21
106. E. Hiyama, K. Hiyama, T. Yokoyama, and J.W. Shay Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues Neoplasia 3 2001 17 26
107. T.P. Pretlow, H.A. Pilch, and T.G. Pretlow Increased telomerase (hTERT) protein in human aberrant crypt foci (ACF) and colon tumors FASEB J. 17 2003 A1190 A1191
108. X.P. Hao, T.G. Pretlow, J.S. Rao, and T.P. Pretlow Inducible nitric oxide synthase (iNOS) is expressed similarly in multiple aberrant crypt foci, colorectal tumors from the same patients Cancer Res. 61 2001 419 422
109. X-related antigen expression in human malignant and nonmalignant colonic tissues Cancer Res. 46 1986 2627 2632
110. S.H. Itzkowitz, E.J. Bloom, W.A. Kokal, G. Modin, S.-I. Hakomori, and Y.S. Kim Sialosyl-Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients Cancer 66 1990 1960 1966
111. X antigens in human colorectal polyps J. Natl. Cancer Inst. 78 1987 479 488
112. K. Miyanishi, T. Takayama, M. Ohi, T. Hayashi, A. Nobuoka, T. Nakajima, R. Takimoto, K. Kogawa, J. Kato, S. Sakamaki, and Y. Niitsu Glutathione s-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis Gastroenterology 121 2001 865 874
113. A. Nobuoka, T. Takayama, K. Miyanishi, T. Sato, K. Takanashi, T. Hayashi, T. Kukitsu, Y. Sato, M. Takahashi, T. Okamoto, T. Matsunaga, J. Kato, M. Oda, T. Azuma, and Y. Niitsu Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid Gastroenterology 127 2004 428 443
114. C.Y. Dai, E.E. Furth, R. Mick, J. Koh, T. Takayama, Y. Niitsu, and G.H. Enders p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation Gastroenterology 119 2000 929 942
115. P.J. Fialkow Clonal origin of human tumors Biochim. Biophys. Acta 458 1976 283 321
116. E.R. Fearon, S.R. Hamilton, and B. Vogelstein Clonal analysis of human colorectal tumors Science 238 1987 193 197
117. I.-M. Siu, D.R. Robinson, S. Schwartz, H.-J. Kung, T.G. Pretlow, R.B. Petersen, and T.P. Pretlow The identification of monoclonality in human aberrant crypt foci Cancer Res. 59 1999 63 66
118. A.J. Smith, H.S. Stern, M. Penner, K. Hay, A. Mitri, B.V. Bapat, and S. Gallinger Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons Cancer Res. 54 1994 5527 5530
119. L. Losi, L. Roncucci, C. di Gregorio, M. Ponz de Leon, and J. Benhattar K-ras and p53 mutations in human colorectal aberrant crypt foci J. Pathol. 178 1996 259 263
120. N. Shivapurkar, L. Huang, B. Ruggeri, P.A. Swalsky, A. Bakker, S. Finkelstein, A. Frost, and S. Silverberg K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients Cancer Lett. 115 1997 39 46
121. J.D. Potter, J. Bigler, L. Fosdick, R.M. Bostick, E. Kampman, C. Chen, T.A. Louis, and P. Grambsch Colorectal adenomatous and hyperplastic polyps: Smoking and N- acetyltransferase 2 polymorphisms Cancer Epidemiol. Biomarkers Prev. 8 1999 69 75
122. E. Giovannucci Martinez, and M.E. Tobacco Colorectal cancer, and adenomas: a review of the evidence J. Natl. Cancer Inst. 88 1996 1717 1730
123. M.F. Denissenko, A. Pao, M. Tang, and G.P. Pfeifer Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53 Science 274 1996 430 432
124. S.M. Powell, N. Zilz, Y. Beazer-Barclay, T.M. Bryan, S.R. Hamilton, S.N. Thibodeau, B. Vogelstein, and K.W. Kinzler APC mutations occur early during colorectal tumorigenesis Nature (London) 359 1992 235 237
125. K.W. Kinzler, and B. Vogelstein Lessons from hereditary colorectal cancer Cell 87 1996 159 170
126. K. Otori, M. Konishi, K. Sugiyama, T. Hasebe, T. Shimoda, R. Kikuchi-Yanoshita, K. Mukai, S. Fukushima, M. Miyaki, and H. Esumi Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue Cancer 83 1998 896 900
127. E.R. Fearon, and B. Vogelstein A genetic model for colorectal tumorigenesis Cell 61 1990 759 767
128. R. Beach, A.O. Chan, T.T. Wu, J.A. White, J.S. Morris, S. Lunagomez, R.R. Broaddus, J.P. Issa, S.R. Hamilton, and A. Rashid BRAF mutations in aberrant crypt foci and hyperplastic polyposis Am. J. Pathol. 166 2005 1069 1075
129. X.P. Hao, T.G. Pretlow, J.S. Rao, and T.P. Pretlow b-catenin expression is altered in human colonic aberrant crypt foci Cancer Res. 61 2001 8085 8088
130. T.P. Pretlow, and T.G. Pretlow Human aberrant crypt foci: c-myc and b-catenin expressions are altered more often than Apc expression Proc. Am. Assoc. Cancer Res. 43 2002 519 520
131. J.M. Mariadason, C. Nicholas, K.E. L'Italien, M. Zhuang, H.J. Smartt, B.G. Heerdt, W. Yang, G.A. Corner, A.J. Wilson, L. Klampfer, D. Arango, and L.H. Augenlicht Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis Gastroenterology 128 2005 1081 1088
132. G. Deng, G.A. Song, E. Pong, M. Sleisenger, and Y.S. Kim Promoter methylation inhibits APC gene expression by causing changes in chromatin conformation and interfering with the binding of transcription factor CCAAT-binding factor Cancer Res. 64 2004 2692 2698
133. H. Suzuki, D.N. Watkins, K.-W. Jair, K.E. Schuebel, S.D. Markowitz, W.-D. Chen, T.P. Pretlow, B. Yang, Y. Akiyama, M.v. Engeland, M. Toyota, T. Tokino, Y. Hinoda, K. Imai, J.G. Herman, and S.B. Baylin Epigenetic inactivation of SFRP genes allows constitutive Wnt signaling in colorectal cancer Nat. Genet. 36 2004 417 422
134. B. Vogelstein, E.R. Fearon, S.E. Kern, S.R. Hamilton, A.C. Preisinger, Y. Nakamura, and R. White Allelotype of colorectal carcinomas Science 244 1989 207 211
135. C. Lengauer, K.W. Kinzler, and B. Vogelstein Genetic instability in colorectal cancers Nature 386 1997 623 627
136. L. Luo, B. Li, and T.P. Pretlow DNA alterations in human aberrant crypt foci and colon cancers by random primed polymerase chain reaction (PCR) Cancer Res. 63 2003 6166 6169
137. L. Luo, G.-Q. Shen, K.A. Stiffler, Q. Wang, and T.P. Pretlow Loss of heterozygosity (LOH) in human aberrant crypt foci (ACF), putative precursors of colon cancer Proc. Am. Assoc. Cancer Res. 46 2005 923
138. L.A. Aaltonen, P. Peltomäki, F.S. Leach, P. Sistonen, L. Pylkkänen, J.-P. Mecklin, H. Järvinen, S.M. Powell, J. Jen, S.R. Hamilton, G.M. Petersen, K.W. Kinzler, B. Vogelstein, and A. de la Chapelle Clues to the pathogenesis of familial colorectal cancer Science 260 1993 812 816
139. S.N. Thibodeau, G. Bren, and D. Schaid Microsatellite instability in cancer of the proximal colon Science 260 1993 816 819
140. L.H. Augenlicht, C. Richards, G. Corner, and T.P. Pretlow Evidence for genomic instability in human colonic aberrant crypt foci Oncogene 12 1996 1767 1772
141. C.D. Heinen, N. Shivapurkar, Z. Tang, J. Groden, and O. Alabaster Microsatellite instability in aberrant crypt foci from human colons Cancer Res. 56 1996 5339 5341
142. H. Li, L. Myeroff, D. Smiraglia, M.F. Romero, T.P. Pretlow, L. Kasturi, J. Lutterbaugh, R.M. Rerko, G. Casey, J.P. Issa, J. Willis, J.K. Willson, C. Plass, and S.D. Markowitz SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers Proc. Natl. Acad. Sci. U. S. A. 100 2003 8412 8417
143. L. Luo, W.-d. Chen, and T.P. Pretlow CpG island methylation in aberrant crypt foci and cancers from the same patients Int. J. Cancer 115 2005 747 751
144. B. Vogelstein, E.R. Fearon, S.R. Hamilton, S.E. Kern, A.C. Preisinger, M. Leppert, Y. Nakamura, R. White, A.M.M. Smits, and J.L. Bos Genetic alterations during colorectal-tumor development N. Engl. J. Med. 319 1988 525 532
145. G. Smith, F.A. Carey, J. Beattie, M.J. Wilkie, T.J. Lightfoot, J. Coxhead, R.C. Garner, R.J. Steele, and C.R. Wolf Mutations in APC, Kirsten-ras, and p53-alternative genetic pathways to colorectal cancer Proc. Natl. Acad. Sci. U. S. A. 99 2002 9433 9438
146. E.A. McLellan, R.A. Owen, K.A. Stepniewska, J.P. Sheffield, and N.R. Lemoine High frequency of K-ras mutations in sporadic colorectal adenomas Gut 34 1993 392 396
147. K. Otori, Y. Oda, K. Sugiyama, T. Hasebe, K. Mukai, T. Fujii, H. Tajiri, S. Yoshida, S. Fukushima, and H. Esumi High frequency of K-ras mutations in human colorectal hyperplastic polyps Gut 40 1997 660 663
148. N.J. Hawkins, and R.L. Ward Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas J. Natl. Cancer Inst. 93 2001 1307 1313
149. S.R. Hamilton Origin of colorectal cancers in hyperplastic polyps and serrated adenomas: another truism bites the dust J.Natl. Cancer Inst. 93 2001 1282 1283
150. T. Takayama, and Y. Niitsu In which step does the K-ras mutation occur in colorectal carcinogenesis? J. Gastroenterol. 39 2004 596 597