Reactive oxygen species and antioxidants in pancreatic β-Cell function - Yin and yang

Systems Biology of Free Radicals and Antioxidants

Volumn , Issue , 2012, Pages 3319-3337

  Pi, Jingbo ^a   Zhang, Qiang ^a   Andersen, Melvin E ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Antioxidant; Insulin secretion; Nrf2; Oxidative stress; Pancreatic cells; ROS

Indexed keywords

EID: 84929138429     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-30018-9_159     Document Type: Chapter

References (151)

1. Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Tanaka M, Shiojima I, Hiroi Y, Yazaki Y (1997) Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest 100:1813-1821
2. Archer SL, Wu XC, Thebaud B, Moudgil R, Hashimoto K, Michelakis ED (2004) O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondriaderived hydrogen peroxide. Biol Chem 385:205-216
3. Armann B, Hanson MS, Hatch E, Steffen A, Fernandez LA (2007) Quantification of basal and stimulated ROS levels as predictors of islet potency and function. Am J Transplant 7:38-47
4. Arrigo AP (1999) Gene expression and the thiol redox state. Free Radic Biol Med 27:936-944
5. Ashcroft FM, Rorsman P (2012) Diabetes mellitus and the beta cell: The last ten years. Cell 148:1160-1171
6. Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ (2011) How does type 1 diabetes develop?: The notion of homicide or beta-cell suicide revisited. Diabetes 60:1370-1379
7. Barnes SK, Ozanne SE (2011) Pathways linking the early environment to long-term health and lifespan. Prog Biophys Mol Biol 106:323-336
8. Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH (2003) Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem 278:9796-9801
9. Bishayee A, Politis T, Darvesh AS (2010) Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer Treat Rev 36:43-53
10. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297:842-857
11. Bonekamp NA, Volkl A, Fahimi HD, Schrader M (2009) Reactive oxygen species and peroxisomes: struggling for balance. Biofactors 35:346-355
12. Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N (2004) Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 37:755-767
13. Brown AL, Lane J, Coverly J, Stocks J, Jackson S, Stephen A, Bluck L, Coward A, Hendrickx H (2009) Effects of dietary supplementation with the green tea polyphenol epigallocatechin- 3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr 101:886-894
14. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015
15. Buetler TM, Krauskopf A, Ruegg UT (2004) Role of superoxide as a signaling molecule. News Physiol Sci 19:120-123
16. CDC (2011) 2011 National Diabetes Fact Sheet. http://www.cdc.gov/DIABETES//pubs/estimates11.htm
17. Cettour-Rose P, Samec S, Russell AP, Summermatter S, Mainieri D, Carrillo-Theander C, Montani JP, Seydoux J, Rohner-Jeanrenaud F, Dulloo AG (2005) Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: A link between catch-up growth and later metabolic syndrome. Diabetes 54:751-756
18. Chen J, Wildman RP, Hamm LL, Muntner P, Reynolds K, Whelton PK, He J (2004) Association between inflammation and insulin resistance in U.S. nondiabetic adults: results from the Third National Health and Nutrition Examination Survey. Diabetes Care 27:2960-2965
19. Chen X, Scholl TO, Leskiw MJ, Donaldson MR, Stein TP (2003) Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy. J Clin Endocrinol Metab 88:5963-5968
20. Cohen G, Riahi Y, Shamni O, Guichardant M, Chatgilialoglu C, Ferreri C, Kaiser N, Sasson S (2011) Role of lipid peroxidation and PPAR-delta in amplifying glucose-stimulated insulin secretion. Diabetes 60:2830-2842
21. Collins S, Pi J, Yehuda-Shnaidman E (2012) Uncoupling and reactive oxygen species (ROS) - a double-edged sword for beta-cell function? "Moderation in all things". Best Pract Res Clin Endocrinol Metab 26:753-758
22. Costa A, Iguala I, Bedini J, Quinto L, Conget I (2002) Uric acid concentration in subjects at risk of type 2 diabetes mellitus: relationship to components of the metabolic syndrome. Metabolism 51:372-375
23. Cullinan SB, Diehl JA (2004) PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem 279:20108-20117
24. Darvesh AS, Aggarwal BB, Bishayee A (2012) Curcumin and liver cancer: A review. Curr Pharm Biotechnol 13:218-228
25. De Blasio MJ, Gatford KL, McMillen IC, Robinson JS, Owens JA (2007a) Placental restriction of fetal growth increases insulin action, growth, and adiposity in the young lamb. Endocrinology 148:1350-1358
26. De Blasio MJ, Gatford KL, Robinson JS, Owens JA (2007b) Placental restriction of fetal growth reduces size at birth and alters postnatal growth, feeding activity, and adiposity in the young lamb. Am J Physiol Regul Integr Comp Physiol 292:R875-R886
27. Dennery PA (2007) Effects of oxidative stress on embryonic development. Birth Defects Res C Embryo Today 81:155-162
28. Denu JM, Tanner KG (1998) Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37:5633-5642
29. Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82:47-95
30. Ebelt H, Peschke D, Bromme HJ, Morke W, Blume R, Peschke E (2000) Influence of melatonin on free radical-induced changes in rat pancreatic beta-cells in vitro. J Pineal Res 28:65-72
31. Eto K, Tsubamoto Y, Terauchi Y, Sugiyama T, Kishimoto T, Takahashi N, Yamauchi N, Kubota N, Murayama S, Aizawa T, Akanuma Y, Aizawa S, Kasai H, Yazaki Y, Kadowaki T (1999) Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283:981-985
32. Evans JL, Goldfine ID, Maddux BA, Grodsky GM (2003) Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52:1-8
33. Ezzedine K, Latreille J, Kesse-Guyot E, Galan P, Hercberg S, Guinot C, Malvy D (2010) Incidence of skin cancers during 5-year follow-up after stopping antioxidant vitamins and mineral supplementation. Eur J Cancer 46:3316-3322
34. Finkel T (1998) Oxygen radicals and signaling. Curr Opin Cell Biol 10:248-253
35. Finkel T (2003) Oxidant signals and oxidative stress. Curr Opin Cell Biol 15:247-254
36. Forman HJ, Torres M (2002) Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am J Respir Crit Care Med 166:S4-S8
37. Fridlyand LE, Philipson LH (2004) Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes 53:1942-1948
38. Fu J, Woods CG, Yehuda-Shnaidman E, Zhang Q, Wong V, Collins S, Sun G, Andersen ME, Pi J (2011) Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress. Environ Health Perspect 118:864-870
39. Fu J, Zhang Q, Woods CG, Zheng H, Yang B, Qu W, Andersen ME, Pi J (2013) Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in beta-cells: role of reactive oxygen species and induction of endogenous antioxidants. Pharm Res. doi:10.1007/S11095- 013-1013-8
40. Fujimoto S, Mukai E, Inagaki N (2011) Role of endogenous ROS production in impaired metabolism-secretion coupling of diabetic pancreatic beta cells. Prog Biophys Mol Biol 107:304-310
41. Gatford KL, Mohammad SN, Harland ML, De Blasio MJ, Fowden AL, Robinson JS, Owens JA (2008) Impaired beta-cell function and inadequate compensatory increases in beta-cell mass after intrauterine growth restriction in sheep. Endocrinology 149:5118-5127
42. Gatford KL, Simmons RA, De Blasio MJ, Robinson JS, Owens JA (2010) Review: placental programming of postnatal diabetes and impaired insulin action after IUGR. Placenta 31: S60-S65
43. Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Sesso HD, Buring JE (2009) Vitamins E and C in the prevention of prostate and total cancer in men: The physicians' health study II randomized controlled trial. JAMA 301:52-62
44. Goldstein BJ, Mahadev K, Wu X (2005a) Redox paradox: insulin action is facilitated by insulinstimulated reactive oxygen species with multiple potential signaling targets. Diabetes 54:311-321
45. Goldstein BJ, Mahadev K, Wu X, Zhu L, Motoshima H (2005b) Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal 7:1021-1031
46. Gurgul E, Lortz S, Tiedge M, Jorns A, Lenzen S (2004) Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines. Diabetes 53:2271-2280
47. Hales CN, Barker DJ (1992) Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis. Diabetologia 35:595-601
48. Hansen JM, Go YM, Jones DP (2006) Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling. Annu Rev Pharmacol Toxicol 46:215-234
49. Hayes JD, McMahonM(2006) The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer. Mol Cell 21:732-734
50. Henquin JC (2000) Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49:1751-1760
51. Henquin JC (2004) Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues. Diabetes 53(3):S48-S58
52. Higgins LG, Cavin C, Itoh K, Yamamoto M, Hayes JD (2008) Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffeespecific diterpenes cafestol and kahweol confer protection against acrolein. Toxicol Appl Pharmacol 226:328-337
53. Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J (2012) Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein beta during adipogenesis. Free Radic Biol Med 52:462-472
54. Houstis N, Rosen ED, Lander ES (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440:944-948
55. Hsu CH, Cheng AL (2007) Clinical studies with curcumin. Adv Exp Med Biol 595:471-480
56. Huypens P, Pillai R, Sheinin T, Schaefer S, Huang M, Odegaard ML, Ronnebaum SM, Wettig SD, Joseph JW (2011) The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells. Diabetologia 54:135-145
57. Itoh K, Mimura J, Yamamoto M (2010) Discovery of the negative regulator of Nrf2, Keap1: A historical overview. Antioxid Redox Signal 13:1665-1678
58. Itoh K, Tong KI, Yamamoto M (2004) Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 36:1208-1213
59. Janjic D, Maechler P, Sekine N, Bartley C, Annen AS, Wolheim CB (1999) Free radical modulation of insulin release in INS-1 cells exposed to alloxan. Biochem Pharmacol 57:639-648
60. Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB (2008) Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab 295: E1287-E1297
61. Jezek P, Dlaskova A, Plecita-Hlavata L (2012) Redox homeostasis in pancreatic beta cells. Oxid Med Cell Longev 2012:932838
62. Jones PM, Persaud SJ (1998) Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells. Endocr Rev 19:429-461
63. Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3-19
64. Kajimoto Y, Kaneto H (2004) Role of oxidative stress in pancreatic beta-cell dysfunction. Ann N Y Acad Sci 1011:168-176
65. Kamsler A, Segal M (2004) Hydrogen peroxide as a diffusible signal molecule in synaptic plasticity. Mol Neurobiol 29:167-178
66. Kaneto H, Kawamori D, Matsuoka TA, Kajimoto Y, Yamasaki Y (2005) Oxidative stress and pancreatic beta-cell dysfunction. Am J Ther 12:529-533
67. Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Matsuoka TA, Matsuhisa M, Yamasaki Y (2006) Role of oxidative stress, endoplasmic reticulum stress, and c-Jun Nterminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol 38:782-793
68. Kasuga M (2006) Insulin resistance and pancreatic beta cell failure. J Clin Invest 116:1756-1760
69. Kobayashi M, Yamamoto M (2006) Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 46:113-140
70. Kondo H, Mori S, Takino H, Kijima H, Yamasaki H, Ozaki M, Tetsuya I, Urata Y, Abe T, Sera Y, Yamakawa K, Kawasaki E, Yamaguchi Y, Kondo T, Eguchi K (2000) Attenuation of expression of gamma-glutamylcysteine synthetase by ribozyme transfection enhance insulin secretion by pancreatic beta cell line, MIN6. Biochem Biophys Res Commun 278:236-240
71. Kourie JI (1998) Interaction of reactive oxygen species with ion transport mechanisms. Am J Physiol 275:C1-C24
72. Kowluru A (2003) Regulatory roles for small G proteins in the pancreatic beta-cell: lessons from models of impaired insulin secretion. Am J Physiol Endocrinol Metab 285:E669-E684
73. Kraft R, Grimm C, Grosse K, Hoffmann A, Sauerbruch S, Kettenmann H, Schultz G, Harteneck C (2004) Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol Cell Physiol 286:C129-C137
74. Krauss S, Zhang CY, Lowell BB (2005) The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol 6:248-261
75. Krippeit-Drews P, Haberland C, Fingerle J, Drews G, Lang F (1995) Effects of H2O2 on membrane potential and [Ca2+]i of cultured rat arterial smooth muscle cells. Biochem Biophys Res Commun 209:139-145
76. Lee H, Lee YJ, Choi H, Ko EH, Kim JW (2009) Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem 284:10601-10609
77. Lee IM, Cook NR, Gaziano JM, Gordon D, Ridker PM, Manson JE, Hennekens CH, Buring JE (2005) Vitamin E in the primary prevention of cardiovascular disease and cancer: The women's health study: A randomized controlled trial. JAMA 294:56-65
78. Lehtihet M, Honkanen RE, Sjoholm A (2005) Glutamate inhibits protein phosphatases and promotes insulin exocytosis in pancreatic beta-cells. Biochem Biophys Res Commun 328:601-607
79. Lei XG, Vatamaniuk MZ (2011) Two tales of antioxidant enzymes on beta cells and diabetes. Antioxid Redox Signal 14:489-503
80. Leloup C, Tourrel-Cuzin C, Magnan C, Karaca M, Castel J, Carneiro L, Colombani AL, Ktorza A, Casteilla L, Penicaud L (2009) Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion. Diabetes 58:673-681
81. Lenzen S (2008) Oxidative stress: The vulnerable beta-cell. Biochem Soc Trans 36:343-347
82. Li X, Chen H, Epstein PN (2006) Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: reactive oxygen species may have a protective role in pancreatic {beta}-cells. Diabetes 55:1592-1604
83. Liu H, Colavitti R, Rovira II, Finkel T (2005) Redox-dependent transcriptional regulation. Circ Res 97:967-974
84. Liu Q, Zhang H, Smeester L, Zou F, Kesic M, Jaspers I, Pi J, Fry RC (2010) The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics 3:37
85. Lortz S, Gurgul-Convey E, Naujok O, Lenzen S (2013) Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets. Diabetologia 56:774-782
86. Maechler P, Jornot L, Wollheim CB (1999) Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem 274:27905-27913
87. Maechler P, Wollheim CB (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402:685-689
88. Maher J, Yamamoto M (2010) The rise of antioxidant signaling - the evolution and hormetic actions of Nrf2. Toxicol Appl Pharmacol 244:4-15
89. Mann CD, Neal CP, Garcea G, Manson MM, Dennison AR, Berry DP (2009) Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis. Eur J Cancer Prev 18:13-25
90. Martens GA, Cai Y, Hinke S, Stange G, Van de Casteele M, Pipeleers D (2005) Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J Biol Chem 280:20389-20396
91. McClung JP, Roneker CA, Mu W, Lisk DJ, Langlais P, Liu F, Lei XG (2004) Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc Natl Acad Sci USA 101:8852-8857
92. Montgomery SM, Ekbom A (2002) Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort. BMJ 324:26-27
93. Morgan D, Rebelato E, Abdulkader F, Graciano MF, Oliveira-Emilio HR, Hirata AE, Rocha MS, Bordin S, Curi R, Carpinelli AR (2009) Association of NAD(P)H oxidase with glucoseinduced insulin secretion by pancreatic beta-cells. Endocrinology 150:2197-2201
94. Mostyn A, Symonds ME (2009) Early programming of adipose tissue function: A large-animal perspective. Proc Nutr Soc 68:393-400
95. Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Meneur C, Permutt MA, Imai S (2005) Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab 2:105-117
96. Nakao C, Ookawara T, Sato Y, Kizaki T, Imazeki N, Matsubara O, Haga S, Suzuki K, Taniguchi N, Ohno H (2000) Extracellular superoxide dismutase in tissues from obese (ob/ob) mice. Free Radic Res 33:229-241
97. Nemoto S, Takeda K, Yu ZX, Ferrans VJ, Finkel T (2000) Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol 20:7311-7318
98. Newgard CB, McGarry JD (1995) Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu Rev Biochem 64:689-719
99. Newsholme P, Haber EP, Hirabara SM, Rebelato EL, Procopio J, Morgan D, Oliveira-Emilio HC, Carpinelli AR, Curi R (2007) Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol 583:9-24
100. Newsholme P, Krause M (2012) Nutritional regulation of insulin secretion: implications for diabetes. Clin Biochem Rev 33:35-47
101. Newsholme P, Morgan D, Rebelato E, Oliveira-Emilio HC, Procopio J, Curi R, Carpinelli A (2009) Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia 52:2489-2498
102. Newsholme P, Rebelato E, Abdulkader F, Krause M, Carpinelli A, Curi R (2012) Reactive oxygen and nitrogen species generation, antioxidant defenses, and beta-cell function: A critical role for amino acids. J Endocrinol 214:11-20
103. Nguyen T, Sherratt PJ, Pickett CB (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 43:233-260
104. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787-790
105. Norlin S, Ahlgren U, Edlund H (2005) Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion. Diabetes 54:125-132
106. Ostenson CG, Sandberg-Nordqvist AC, Chen J, Hallbrink M, Rotin D, Langel U, Efendic S (2002) Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucoseinduced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochem Biophys Res Commun 291:945-950
107. Owens JA, Gatford KL, De Blasio MJ, Edwards LJ, McMillen IC, Fowden AL (2007) Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth. J Physiol 584:935-949
108. Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, Sunaga Y, Yano H, Matsuura Y, Iwanaga T, Takai Y, Seino S (2000) CAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol 2:805-811
109. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE (2005) Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell 19:197-207
110. Patel KR, Scott E, Brown VA, Gescher AJ, Steward WP, Brown K (2011) Clinical trials of resveratrol. Ann N Y Acad Sci 1215:161-169
111. Phillips DI, Fall CH, Cooper C, Norman RJ, Robinson JS, Owens PC (1999) Size at birth and plasma leptin concentrations in adult life. Int J Obes Relat Metab Disord 23:1025-1029
112. Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S (2009) Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology 150:3040-3048
113. Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S (2007) Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes 56:1783-1791
114. Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME (2010) ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol 244:77-83
115. Prentki M, Nolan CJ (2006) Islet beta cell failure in type 2 diabetes. J Clin Invest 116:1802-1812
116. Rains JL, Jain SK (2011) Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 50:567-575
117. Rebelato E, Abdulkader F, Curi R, Carpinelli AR (2011) Control of the intracellular redox state by glucose participates in the insulin secretion mechanism. PLoS One 6:e24507
118. Rhee SG (2006) Cell signaling. H2O2, a necessary evil for cell signaling. Science 312:1882-1883
119. Rhee SG, Kang SW, Jeong W, Chang TS, Yang KS, Woo HA (2005) Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. Curr Opin Cell Biol 17:183-189
120. Ristow M, Zarse K, Oberbach A, Kloting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Bluher M (2009) Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci USA 106:8665-8670
121. Robertson RP (2006) Oxidative stress and impaired insulin secretion in type 2 diabetes. Curr Opin Pharmacol 6:615-619
122. Robertson RP (2009) Beta-cell deterioration during diabetes: what's in the gun? Trends Endocrinol Metab 20:388-393
123. Robertson RP (2010) Antioxidant drugs for treating beta-cell oxidative stress in type 2 diabetes: glucose-centric versus insulin-centric therapy. Discov Med 9:132-137
124. Sarre A, Gabrielli J, Vial G, Leverve XM, Assimacopoulos-Jeannet F (2011) Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulinsecreting cells. Free Radic Biol Med 52:142-150
125. Schmidt KN, Amstad P, Cerutti P, Baeuerle PA (1996) Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-kappaB. Adv Exp Med Biol 387:63-68
126. Schrader M, Fahimi HD (2006) Peroxisomes and oxidative stress. Biochim Biophys Acta 1763:1755-1766
127. Scott JA, King GL (2004) Oxidative stress and antioxidant treatment in diabetes. Ann N Y Acad Sci 1031:204-213
128. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM (2008) Vitamins E and C in the prevention of cardiovascular disease in men: The physicians' health study II randomized controlled trial. JAMA 300:2123-2133
129. Shao S, Fang Z, Yu X, Zhang M (2009) Transcription factors involved in glucose-stimulated insulin secretion of pancreatic beta cells. Biochem Biophys Res Commun 384:401-404
130. Sjoholm A, Lehtihet M, Efanov AM, Zaitsev SV, Berggren PO, Honkanen RE (2002) Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic beta-cells. Endocrinology 143:4592-4598
131. Soria B, Quesada I, Ropero AB, Pertusa JA, Martin F, Nadal A (2004) Novel players in pancreatic islet signaling: from membrane receptors to nuclear channels. Diabetes 53(1):S86-S91
132. Tabatabaei-Malazy O, Larijani B, Abdollahi M (2012) A systematic review of in vitro studies conducted on effect of herbal products on secretion of insulin from Langerhans islets. J Pharm Pharm Sci 15:447-466
133. Tabet F, Savoia C, Schiffrin EL, Touyz RM (2004) Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. J Cardiovasc Pharmacol 44:200-208
134. Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S (2006) Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest 116:984-995
135. Thomasset SC, Berry DP, Garcea G, Marczylo T, Steward WP, Gescher AJ (2007) Dietary polyphenolic phytochemicals-promising cancer chemopreventive agents in humans? A review of their clinical properties. Int J Cancer 120:451-458
136. Tiedge M, Lortz S, Drinkgern J, Lenzen S (1997) Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46: 1733-1742
137. Todt I, Ngezahayo A, Ernst A, Kolb HA (2001) Hydrogen peroxide inhibits gap junctional coupling and modulates intracellular free calcium in cochlear Hensen cells. J Membr Biol 181:107-114
138. Tooley JE, Waldron-Lynch F, Herold KC (2012) New and future immunomodulatory therapy in type 1 diabetes. Trends Mol Med 18:173-181
139. Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M (2011) Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes 60:119-126
140. Uchida K, Tominaga M (2011) TRPM2 modulates insulin secretion in pancreatic beta-cells. Islets 3:209-211
141. Victor VM, Rocha M, Herance R, Hernandez-Mijares A (2011) Oxidative stress and mitochondrial dysfunction in type 2 diabetes. Curr Pharm Des 17:3947-3958
142. Wei FY, Nagashima K, Ohshima T, Saheki Y, Lu YF, Matsushita M, Yamada Y, Mikoshiba K, Seino Y, Matsui H, Tomizawa K (2005) Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med 11:1104-1108
143. Wells JC (2011) The thrifty phenotype: an adaptation in growth or metabolism? Am J Hum Biol 23:65-75
144. Wiernsperger NF (2003) Oxidative stress as a therapeutic target in diabetes: revisiting the controversy. Diabetes Metab 29:579-585
145. Wollheim CB, Maechler P (2002) Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites. Diabetes 51(1):S37-S42
146. Xue P, Hou Y, Chen Y, Yang B, Fu J, Zheng H, Yarborough K, Woods CG, Liu D, Yamamoto M, Zhang Q, Andersen ME, Pi J (2013) Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes 62:845-854
147. Xue P, Hou Y, Zhang Q, Woods CG, Yarborough K, Liu H, Sun G, Andersen ME, Pi J (2011) Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response. Biochem Biophys Res Commun 407:360-365
148. Yamagata K, Senokuchi T, Lu M, Takemoto M, Fazlul Karim M, Go C, Sato Y, Hatta M, Yoshizawa T, Araki E, Miyazaki J, Song WJ (2011) Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 beta-cell line. Biochem Biophys Res Commun 407:620-625
149. Yang B, Fu J, Zheng H, Xue P, Yarborough K, Woods CG, Hou Y, Zhang Q, Andersen ME, Pi J (2012) Deficiency in the nuclear factor E2-related factor 2 renders pancreatic beta-cells vulnerable to arsenic-induced cell damage. Toxicol Appl Pharmacol 264:315-323
150. Zhao R, Hou Y, Zhang Q, Woods CG, Xue P, Fu J, Yarborough K, Guan D, Andersen ME, Pi J (2012) Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes. Environ Health Perspect 120:583-589
151. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782-787