ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

Toxicology and Applied Pharmacology

Volumn 244, Issue 1, 2010, Pages 77-83

  Pi, Jingbo ^a   Zhang, Qiang ^a   Fu, Jingqi ^a,b   Woods, Courtney G ^a,c   Hou, Yongyong ^a,b   Corkey, Barbara E ^d   Collins, Sheila ^a,e   Andersen, Melvin E ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

^c EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antioxidant; Insulin secretion; Nrf2; Oxidative stress; Pancreatic beta cells; ROS; Ucp2

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIMYCIN A1; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; HYDROGEN PEROXIDE; PEROXIREDOXIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOCTIC ACID; TRANSCRIPTION FACTOR NRF2; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2;

ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; DIET; GLUCOSE METABOLISM; HUMAN; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; VITAMIN SUPPLEMENTATION;

ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; ION CHANNELS; MITOCHONDRIAL PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 77649275621     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.05.025     Document Type: Review

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