Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: Role of reactive oxygen species and induction of endogenous antioxidants

Pharmaceutical Research

Volumn 30, Issue 9, 2013, Pages 2248-2259

  Fu, Jingqi ^a   Zhang, Qiang ^a   Woods, Courtney G ^a   Zheng, Hongzhi ^a   Yang, Bei ^a,b   Qu, Weidong ^c   Andersen, Melvin E ^a   Pi, Jingbo ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

antioxidant; computational model; insulin secretion; Nrf2; ROS; sulforaphane

Indexed keywords

REACTIVE OXYGEN METABOLITE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; INSULIN RELEASE; MATHEMATICAL MODEL; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; CELL LINE; CELLS, CULTURED; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISOTHIOCYANATES; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84883289123     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1013-8     Document Type: Article

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