-
1
-
-
36849012027
-
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
-
Nejentsev S., et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007, 450:887-892.
-
(2007)
Nature
, vol.450
, pp. 887-892
-
-
Nejentsev, S.1
-
2
-
-
42449144715
-
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families
-
Erlich H., et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008, 57:1084-1092.
-
(2008)
Diabetes
, vol.57
, pp. 1084-1092
-
-
Erlich, H.1
-
3
-
-
58149096363
-
Concordance for islet autoimmunity among monozygotic twins
-
Redondo M.J., et al. Concordance for islet autoimmunity among monozygotic twins. N. Engl. J. Med. 2008, 359:2849-2850.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 2849-2850
-
-
Redondo, M.J.1
-
4
-
-
43849096855
-
Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study
-
Harjutsalo V., et al. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008, 371:1777-1782.
-
(2008)
Lancet
, vol.371
, pp. 1777-1782
-
-
Harjutsalo, V.1
-
5
-
-
34548783929
-
The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design
-
TEDDY Study Group
-
TEDDY Study Group The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr. Diabetes 2007, 8:286-298.
-
(2007)
Pediatr. Diabetes
, vol.8
, pp. 286-298
-
-
-
6
-
-
0041666293
-
Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial
-
Steffes M.W., et al. Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 2003, 26:832-836.
-
(2003)
Diabetes Care
, vol.26
, pp. 832-836
-
-
Steffes, M.W.1
-
7
-
-
0021359025
-
Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset
-
Stiller C., et al. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 1984, 223:1362-1367.
-
(1984)
Science
, vol.223
, pp. 1362-1367
-
-
Stiller, C.1
-
8
-
-
0025049497
-
Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin
-
Bougnères P.F., et al. Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin. Diabetes 1990, 39:1264-1272.
-
(1990)
Diabetes
, vol.39
, pp. 1264-1272
-
-
Bougnères, P.F.1
-
9
-
-
0025039679
-
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
-
Baekkeskov S., et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990, 347:151-156.
-
(1990)
Nature
, vol.347
, pp. 151-156
-
-
Baekkeskov, S.1
-
10
-
-
16144361909
-
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
-
Tian J., et al. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat. Med. 1996, 2:1348-1353.
-
(1996)
Nat. Med.
, vol.2
, pp. 1348-1353
-
-
Tian, J.1
-
11
-
-
0031831753
-
Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice
-
Tisch R., et al. Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. Diabetes 1998, 47:894-899.
-
(1998)
Diabetes
, vol.47
, pp. 894-899
-
-
Tisch, R.1
-
12
-
-
0029146498
-
Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65)
-
Pleau J.M., et al. Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65). Clin. Immunol. Immunopathol. 1995, 76:90-95.
-
(1995)
Clin. Immunol. Immunopathol.
, vol.76
, pp. 90-95
-
-
Pleau, J.M.1
-
13
-
-
21344461521
-
Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes
-
Agardh C.D., et al. Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J. Diabetes Complications 2005, 19:238-246.
-
(2005)
J. Diabetes Complications
, vol.19
, pp. 238-246
-
-
Agardh, C.D.1
-
14
-
-
79960743608
-
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial
-
Wherrett D.K., et al. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet 2011, 378:319-327.
-
(2011)
Lancet
, vol.378
, pp. 319-327
-
-
Wherrett, D.K.1
-
15
-
-
55249110198
-
GAD treatment and insulin secretion in recent-onset type 1 diabetes
-
Ludvigsson J., et al. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008, 359:1909-1920.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1909-1920
-
-
Ludvigsson, J.1
-
16
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
Nakayama M., et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005, 435:220-223.
-
(2005)
Nature
, vol.435
, pp. 220-223
-
-
Nakayama, M.1
-
17
-
-
0025837184
-
Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
-
Zhang Z.J., et al. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:10252-10256.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 10252-10256
-
-
Zhang, Z.J.1
-
18
-
-
0028099535
-
Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes
-
Bergerot I., et al. Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes. J. Autoimmun. 1994, 7:655-663.
-
(1994)
J. Autoimmun.
, vol.7
, pp. 655-663
-
-
Bergerot, I.1
-
19
-
-
0030456670
-
Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes
-
Harrison L.C., et al. Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes. J. Exp. Med. 1996, 184:2167-2174.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 2167-2174
-
-
Harrison, L.C.1
-
20
-
-
18144391496
-
Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1
-
Skyler J.S., et al. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1. Diabetes Care 2005, 28:1068-1076.
-
(2005)
Diabetes Care
, vol.28
, pp. 1068-1076
-
-
Skyler, J.S.1
-
21
-
-
0037198427
-
Effects of insulin in relatives of patients with type 1 diabetes mellitus
-
The Diabetes Prevention Trial - Type 1 Diabetes Study Group
-
The Diabetes Prevention Trial - Type 1 Diabetes Study Group Effects of insulin in relatives of patients with type 1 diabetes mellitus. N. Engl. J. Med. 2002, 346:1685-1691.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 1685-1691
-
-
-
22
-
-
55749104546
-
Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial
-
Näntö-Salonen K., et al. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial. Lancet 2008, 372:1746-1755.
-
(2008)
Lancet
, vol.372
, pp. 1746-1755
-
-
Näntö-Salonen, K.1
-
23
-
-
0033846982
-
No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group
-
Pozzilli P., et al. No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group. Diabetologia 2000, 43:1000-1004.
-
(2000)
Diabetologia
, vol.43
, pp. 1000-1004
-
-
Pozzilli, P.1
-
24
-
-
17444437590
-
Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial. Diabète Insuline Orale group
-
Chaillous L., et al. Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial. Diabète Insuline Orale group. Lancet 2000, 356:545-549.
-
(2000)
Lancet
, vol.356
, pp. 545-549
-
-
Chaillous, L.1
-
25
-
-
79953220761
-
Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
-
Fourlanos S., et al. Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes. Diabetes 2011, 60:1237-1245.
-
(2011)
Diabetes
, vol.60
, pp. 1237-1245
-
-
Fourlanos, S.1
-
26
-
-
84858055230
-
Webcast: Interim Results of a Phase I clinical Trial of a DNA Plasmid Vaccine (BHI-3021) for T1D
-
DiabetesPro [online],
-
Gottlieb, P. (2010) Webcast: Interim Results of a Phase I clinical Trial of a DNA Plasmid Vaccine (BHI-3021) for T1D. DiabetesPro [online], http://professional.diabetes.org/Presentations_Details.aspx%3Fsession=3575.
-
(2010)
-
-
Gottlieb, P.1
-
27
-
-
44849138907
-
Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization
-
Achenbach P., et al. Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization. Curr. Diab. Rep. 2008, 8:87-93.
-
(2008)
Curr. Diab. Rep.
, vol.8
, pp. 87-93
-
-
Achenbach, P.1
-
28
-
-
77957855176
-
+ T cells are involved in development and control of human autoimmune type 1 diabetes
-
+ T cells are involved in development and control of human autoimmune type 1 diabetes. J. Clin. Invest. 2010, 120:3641-3650.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3641-3650
-
-
Jiang, H.1
-
29
-
-
0035944844
-
Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial
-
Raz I., et al. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 2001, 358:1749-1753.
-
(2001)
Lancet
, vol.358
, pp. 1749-1753
-
-
Raz, I.1
-
30
-
-
33845687082
-
DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes
-
Elias D., et al. DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes. Ann. N. Y. Acad. Sci. 2006, 1079:340-344.
-
(2006)
Ann. N. Y. Acad. Sci.
, vol.1079
, pp. 340-344
-
-
Elias, D.1
-
31
-
-
34249812097
-
® is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial
-
® is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial. Diabetes Metab. Res. Rev. 2007, 23:292-298.
-
(2007)
Diabetes Metab. Res. Rev.
, vol.23
, pp. 292-298
-
-
Raz, I.1
-
32
-
-
34249820806
-
Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study
-
Lazar L., et al. Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study. Diabetes Metab. Res. Rev. 2007, 23:286-291.
-
(2007)
Diabetes Metab. Res. Rev.
, vol.23
, pp. 286-291
-
-
Lazar, L.1
-
33
-
-
34249786263
-
Effect of heat shock protein peptide DiaPep277 on β-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials
-
Schloot N.C., et al. Effect of heat shock protein peptide DiaPep277 on β-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials. Diabetes Metab. Res. Rev. 2007, 23:276-285.
-
(2007)
Diabetes Metab. Res. Rev.
, vol.23
, pp. 276-285
-
-
Schloot, N.C.1
-
34
-
-
0642307067
-
Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study
-
Stene L.C., et al. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. Am. J. Clin. Nutr. 2003, 78:1128-1134.
-
(2003)
Am. J. Clin. Nutr.
, vol.78
, pp. 1128-1134
-
-
Stene, L.C.1
-
35
-
-
34748917229
-
Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes
-
Norris J.M., et al. Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes. JAMA 2007, 298:1420-1428.
-
(2007)
JAMA
, vol.298
, pp. 1420-1428
-
-
Norris, J.M.1
-
36
-
-
29144446163
-
Low levels of 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes
-
Pozzilli P., et al. Low levels of 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes. Horm. Metab. Res. 2005, 37:680-683.
-
(2005)
Horm. Metab. Res.
, vol.37
, pp. 680-683
-
-
Pozzilli, P.1
-
37
-
-
33750915052
-
Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)
-
Littorin B., et al. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS). Diabetologia 2006, 49:2847-2852.
-
(2006)
Diabetologia
, vol.49
, pp. 2847-2852
-
-
Littorin, B.1
-
38
-
-
36849031364
-
Comparative therapeutic effects of orally administered 1, 25-dihydroxyvitamin D3 and 1alpha-hydroxyvitamin D3 on type-1 diabetes in non-obese diabetic mice fed a normal-calcaemic diet
-
Driver J., et al. Comparative therapeutic effects of orally administered 1, 25-dihydroxyvitamin D3 and 1alpha-hydroxyvitamin D3 on type-1 diabetes in non-obese diabetic mice fed a normal-calcaemic diet. Clin. Exp. Immunol. 2008, 151:76-85.
-
(2008)
Clin. Exp. Immunol.
, vol.151
, pp. 76-85
-
-
Driver, J.1
-
39
-
-
79958822945
-
Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
-
Cooper J.D., et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 2011, 60:1624-1631.
-
(2011)
Diabetes
, vol.60
, pp. 1624-1631
-
-
Cooper, J.D.1
-
40
-
-
84858051996
-
Webcast: Nutritional Intervention to Prevent (NIP) type 1 diabetes, a pilot trial
-
DiabetesPro [online],
-
Chase, H.P. (2010) Webcast: Nutritional Intervention to Prevent (NIP) type 1 diabetes, a pilot trial. DiabetesPro [online], http://professional.diabetes.org/Presentations_Details.aspx%3Fsession=3583.
-
(2010)
-
-
Chase, H.P.1
-
41
-
-
79951655976
-
No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes
-
Bizzarri C., et al. No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes. Diabetes 2010, 33:1962-1963.
-
(2010)
Diabetes
, vol.33
, pp. 1962-1963
-
-
Bizzarri, C.1
-
42
-
-
77951965439
-
Infant feeding and the risk of type 1 diabetes
-
Knip M., et al. Infant feeding and the risk of type 1 diabetes. Am. J. Clin. Nutr. 2010, 91:1506-1513.
-
(2010)
Am. J. Clin. Nutr.
, vol.91
, pp. 1506-1513
-
-
Knip, M.1
-
43
-
-
82355163472
-
Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
-
Knip M., et al. Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR). Am. J. Clin. Nutr. 2011, 94(Suppl.):1814S-1820S.
-
(2011)
Am. J. Clin. Nutr.
, vol.94
, Issue.SUPPL.
-
-
Knip, M.1
-
44
-
-
78149475225
-
Dietary intervention in infancy and later signs of beta-cell autoimmunity
-
Knip M., et al. Dietary intervention in infancy and later signs of beta-cell autoimmunity. N. Engl. J. Med. 2010, 363:1900-1908.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1900-1908
-
-
Knip, M.1
-
45
-
-
54549122338
-
Innate immunity and intestinal microbiota in the development of type 1 diabetes
-
Wen L., et al. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 2008, 455:1109-1113.
-
(2008)
Nature
, vol.455
, pp. 1109-1113
-
-
Wen, L.1
-
46
-
-
0035807589
-
Development of type 1 diabetes despite severe hereditary B-cell deficiency
-
Martin S., et al. Development of type 1 diabetes despite severe hereditary B-cell deficiency. N. Engl. J. Med. 2001, 345:1036-1040.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1036-1040
-
-
Martin, S.1
-
47
-
-
36849027817
-
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
-
Hu C.Y., et al. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J. Clin. Invest. 2007, 117:3857-3867.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3857-3867
-
-
Hu, C.Y.1
-
48
-
-
4644225746
-
Investigation of the role of B-cells in type 1 diabetes in the NOD mouse
-
Wong F.S., et al. Investigation of the role of B-cells in type 1 diabetes in the NOD mouse. Diabetes 2004, 53:2581-2587.
-
(2004)
Diabetes
, vol.53
, pp. 2581-2587
-
-
Wong, F.S.1
-
49
-
-
70449480577
-
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
-
Pescovitz M.D., et al. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N. Engl. J. Med. 2009, 361:2143-2152.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2143-2152
-
-
Pescovitz, M.D.1
-
50
-
-
84858033768
-
Webcast: Treatment of Type 1 diabetes with Rituxumab - 2 year follow up
-
DiabetesPro [online],
-
Pescovitz, M.D. (2010) Webcast: Treatment of Type 1 diabetes with Rituxumab - 2 year follow up. DiabetesPro [online], http://professional.diabetes.org/presentations_details.aspx%3Fsession=3463.
-
(2010)
-
-
Pescovitz, M.D.1
-
51
-
-
80051940031
-
Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes
-
Herold K.C., et al. Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes. J. Immunol. 2011, 187:1998-2005.
-
(2011)
J. Immunol.
, vol.187
, pp. 1998-2005
-
-
Herold, K.C.1
-
52
-
-
78650899002
-
+ effector memory T cells based on CD2 expression
-
+ effector memory T cells based on CD2 expression. Am. J. Transplant. 2011, 11:22-33.
-
(2011)
Am. J. Transplant.
, vol.11
, pp. 22-33
-
-
Lo, D.J.1
-
53
-
-
0028900297
-
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
-
Lenschow D.J., et al. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 1995, 181:1145-1155.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 1145-1155
-
-
Lenschow, D.J.1
-
54
-
-
0033682056
-
+ immunoregulatory T cells that control autoimmune diabetes
-
+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000, 12:431-440.
-
(2000)
Immunity
, vol.12
, pp. 431-440
-
-
Salomon, B.1
-
55
-
-
78650286569
-
In situ protection against islet allograft rejection by CTLA4Ig transduction
-
Londrigan S.L., et al. In situ protection against islet allograft rejection by CTLA4Ig transduction. Transplantation 2010, 90:951-957.
-
(2010)
Transplantation
, vol.90
, pp. 951-957
-
-
Londrigan, S.L.1
-
56
-
-
79960912796
-
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
-
Orban T., et al. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet 2011, 378:412-419.
-
(2011)
Lancet
, vol.378
, pp. 412-419
-
-
Orban, T.1
-
57
-
-
0028178492
-
A non-activating " humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo
-
Alegre M.L., et al. A non-activating " humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation 1994, 57:1537-1543.
-
(1994)
Transplantation
, vol.57
, pp. 1537-1543
-
-
Alegre, M.L.1
-
58
-
-
77649169766
-
Immune therapy for type 1 diabetes mellitus - what is unique about anti-CD3 antibodies?
-
Chatenoud L. Immune therapy for type 1 diabetes mellitus - what is unique about anti-CD3 antibodies?. Nat. Rev. Endocrinol. 2010, 6:149-157.
-
(2010)
Nat. Rev. Endocrinol.
, vol.6
, pp. 149-157
-
-
Chatenoud, L.1
-
59
-
-
0034712195
-
In vitro characterization of five humanized OKT3 effector function variant antibodies
-
Xu D., et al. In vitro characterization of five humanized OKT3 effector function variant antibodies. Cell. Immunol. 2000, 200:16-26.
-
(2000)
Cell. Immunol.
, vol.200
, pp. 16-26
-
-
Xu, D.1
-
60
-
-
0031569177
-
CD3 antibody-induced dominant self tolerance in overty diabetic NOD mice
-
Chatenoud L., et al. CD3 antibody-induced dominant self tolerance in overty diabetic NOD mice. J. Immunol. 1997, 158:2947-2954.
-
(1997)
J. Immunol.
, vol.158
, pp. 2947-2954
-
-
Chatenoud, L.1
-
61
-
-
0141796312
-
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
-
Belghith M., et al. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat. Med. 2003, 9:1202-1208.
-
(2003)
Nat. Med.
, vol.9
, pp. 1202-1208
-
-
Belghith, M.1
-
62
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud L., et al. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:123-127.
-
(1994)
Proc. Natl. Acad. Sci. U.S.A.
, vol.91
, pp. 123-127
-
-
Chatenoud, L.1
-
63
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold K.C., et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 2002, 346:1692-1698.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
-
64
-
-
67649933375
-
Treatment of patients with new onset type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years
-
Herold K.C., et al. Treatment of patients with new onset type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years. Clin. Immunol. 2009, 132:166-173.
-
(2009)
Clin. Immunol.
, vol.132
, pp. 166-173
-
-
Herold, K.C.1
-
65
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
Keymeulen B., et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N. Engl. J. Med. 2005, 352:2598-2608.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 2598-2608
-
-
Keymeulen, B.1
-
66
-
-
77949266510
-
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
-
Keymeulen B., et al. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 2010, 53:614-623.
-
(2010)
Diabetologia
, vol.53
, pp. 614-623
-
-
Keymeulen, B.1
-
67
-
-
80051471700
-
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial
-
Sherry N., et al. Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial. Lancet 2011, 378:487-497.
-
(2011)
Lancet
, vol.378
, pp. 487-497
-
-
Sherry, N.1
-
68
-
-
84858055231
-
Webcast: AbATE (Anti-CD3 mAb)
-
DiabetesPro [online],
-
Gitelman, S.E. (2011) Webcast: AbATE (Anti-CD3 mAb). DiabetesPro [online], http://professional.diabetes.org/Presentations_Details.aspx%3Fsession=3791.
-
(2011)
-
-
Gitelman, S.E.1
-
69
-
-
0032105481
-
® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
-
® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin. Biochem. 1998, 31:335-340.
-
(1998)
Clin. Biochem.
, vol.31
, pp. 335-340
-
-
Sehgal, S.N.1
-
70
-
-
77956257716
-
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
-
Grinberg-Bleyer Y., et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J. Exp. Med. 2010, 207:1871-1878.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1871-1878
-
-
Grinberg-Bleyer, Y.1
-
71
-
-
80755169996
-
Rapamycin plus IL-2 combination therapy in subjects with T1D results in a sustained increase in IL-2 responsiveness and a transient decrease in C-peptide levels
-
Long S.A., et al. Rapamycin plus IL-2 combination therapy in subjects with T1D results in a sustained increase in IL-2 responsiveness and a transient decrease in C-peptide levels. Diabetes 2011, 60(Suppl. 1):A91.
-
(2011)
Diabetes
, vol.60
, Issue.SUPPL. 1
-
-
Long, S.A.1
-
72
-
-
80051744661
-
Type 1 diabetes immunotherapy: is the glass half empty or half full?
-
Herold K.C., Bluestone J.A. Type 1 diabetes immunotherapy: is the glass half empty or half full?. Sci. Transl. Med. 2011, 3:95fs1.
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Herold, K.C.1
Bluestone, J.A.2
-
73
-
-
0036314243
-
Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
-
Rabinovitch A., et al. Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes 2002, 51:638-645.
-
(2002)
Diabetes
, vol.51
, pp. 638-645
-
-
Rabinovitch, A.1
-
74
-
-
0028215907
-
Peptide therapy for diabetes in NOD mice
-
Elias D., Cohen I.R. Peptide therapy for diabetes in NOD mice. Lancet 1994, 343:704-706.
-
(1994)
Lancet
, vol.343
, pp. 704-706
-
-
Elias, D.1
Cohen, I.R.2
-
75
-
-
0028787305
-
Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277
-
Elias D., Cohen I.R. Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277. Diabetes 1995, 44:1132-1138.
-
(1995)
Diabetes
, vol.44
, pp. 1132-1138
-
-
Elias, D.1
Cohen, I.R.2
-
76
-
-
0030999981
-
Immunological aspects of nutritional diabetes prevention in NOD mice: a pilot study for the cow's milk-based IDDM prevention trial
-
Karges W., et al. Immunological aspects of nutritional diabetes prevention in NOD mice: a pilot study for the cow's milk-based IDDM prevention trial. Diabetes 1997, 46:557-564.
-
(1997)
Diabetes
, vol.46
, pp. 557-564
-
-
Karges, W.1
-
77
-
-
23844525846
-
A comprehensive review of interventions in the NOD mouse and implications for translation
-
Shoda L.K.M., et al. A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 2005, 23:115-126.
-
(2005)
Immunity
, vol.23
, pp. 115-126
-
-
Shoda, L.K.M.1
-
78
-
-
78149375691
-
T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes
-
Babad J., et al. T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes. Immunology 2010, 131:459-465.
-
(2010)
Immunology
, vol.131
, pp. 459-465
-
-
Babad, J.1
-
79
-
-
77951776390
-
Genetics, pathogenesis and clinical interventions in type 1 diabetes
-
Bluestone J.A., et al. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010, 464:1293-1300.
-
(2010)
Nature
, vol.464
, pp. 1293-1300
-
-
Bluestone, J.A.1
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