Free radical modulation of insulin release in INS-1 cells exposed to alloxan

Biochemical Pharmacology

Volumn 57, Issue 6, 1999, Pages 639-648

  Janjic, Danilo ^a   Maechler, Pierre ^a   Bartley, Clarissa ^a   Annen, Anne Sofie ^a   Wollheim, Claes B ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Alloxan; Calcium; Diabetes; Free radicals; INS 1D cells; Insulin secretion

Indexed keywords

ADRENALIN; ALLOXAN; ANTIOXIDANT; BUTYLATED HYDROXYANISOLE; FREE RADICAL; GLUCOSE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; COLORIMETRY; CONTROLLED STUDY; IN VITRO STUDY; INSULIN RELEASE; INSULINOMA; MEMBRANE POTENTIAL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ALLOXAN; ANTIOXIDANTS; BUTYLATED HYDROXYANISOLE; CALCIUM; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICALS; GLUCOSE; HUMANS; INSULIN; INSULINOMA; MEMBRANE POTENTIALS; TUMOR CELLS, CULTURED;

EID: 0033560073     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00346-3     Document Type: Article

References (46)

1. Lenzen S., Panten U. Alloxan History and mechanism of action . Diabetologia. 31:1988;337-342.
2. Rerup C.C. Drugs producing diabetes through damage of insulin-secreting cells. Pharmacol Rev. 22:1970;485-518.
3. Uchigata Y., Yamamoto H., Kawamura A., Okamoto H. Protection by superoxide dismutase, catalase, and poly (ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against inhibition of proinsulin synthesis. J Biol Chem. 257:1982;6084-6088.
4. Grankvist K., Marklund S., Täljedal I.B. Superoxide dismutase is a prophylactic against alloxan diabetes. Nature. 294:1981;158-160.
5. Malaisse W.J., Malaise-Lagae F., Sener A., Pipeleers D.G. Determinants of the selective toxicity of alloxan to the pancreatic B cell. Proc Natl Acad Sci USA. 79:1982;927-930.
6. Asayama K., English D., Slonim A.E., Burr I.M. Chemiluminescence as an index of drug-induced free radical production in pancreatic islets. Diabetes. 33:1984;160-163.
7. Okamoto H. The molecular basis of experimental diabetes. Okamoto H., Molecular Biology of the Islets of Langerhans. 1990;209-231 Cambridge University Press, Cambridge.
8. Wilson G.L., Patton N.J., McCord J.M., Mullins D.W., Mossman B.T. Mechanisms of streptozotocin- and alloxan-induced damage in rat B cells. Diabetologia. 27:1984;587-591.
9. Takasu N., Asawa T., Komiya I., Nagasawa Y., Yamada T. Alloxan-induced DNA strand breaks in pancreatic islets. J Biol Chem. 266:1991;2112-2114.
10. Lenzen S., Brand F.H., Panten U. Structural requirements of alloxan and ninhydrin for glucokinase inhibition and of glucose protection against inhibition. Br J Pharmacol. 95:1988;851-859.
11. Lenzen S., Freytag S., Panten U., Flatt P.R., Bailey C.J. Alloxan and ninhydrin inhibition of hexokinase from pancreatic islets and tumoural insulin-secreting cells. Pharmacol Toxicol. 66:1990;57-162.
12. Asfari M., Janjic D., Meda P., Li G., Halban P.A., Wollheim C.B. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology. 130:1992;167-178.
13. Sekine N., Cirulli V., Regazzi R., Brown L.J., Gine E., Tamarit-Rodriguez J., Girotti M., Marie S., MacDonald M.J., Wollheim C.B., Rutter G.A. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells. J Biol Chem. 269:1994;4895-4902.
14. Janjic D., Wollheim C.B. Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia. 35:1992;482-485.
15. 2+ and G-proteins. Diab Rev. 4:1996;276-297.
16. Elfgang C., Eckert R., Lichtenberg-Frate H., Butterweck A., Traub O., Klein R.A., Hulser D.F., Willecke K. Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J Cell Biol. 129:1995;805-817.
17. Sekine N., Ullrich S., Regazzi R., Pralong W.F., Wollheim C.B. Postreceptor signaling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1. Endocrinology. 137:1996;1841-1850.
18. Halliwell B., Gulteridge J.M.C. Free Radicals in Biology and Medicine. 1989;Clarendon Press, Oxford.
19. Dunn J.S., Sheehan H.L., Mc Letchie N.G.B. Necrosis of islets of Langerhans produced experimentally. Lancet. I:1943;484-487.
20. Winterbroun C.C., Cowden W.B., Sutton H.C. Auto-oxidation of dialuric acid, divicine and isouramil. Biochem Pharmacol. 38:1989;611-618.
21. Winterbroun C.C., Munday R. Glutathione-mediated redox cycling of alloxan. Biochem Pharmacol. 38:1989;271-277.
22. Holmgren A., Lyckeborg C. Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase. Proc Natl Acad Sci USA. 77:1980;5149-5152.
23. Grankvist K., Holmgren A., Luthman M., Täljedal I.B. Thioredoxin and thioredoxin reductase in pancreatic islets may participate in diabetogenic free-radical production. Biochem Biophys Res Commun. 107:1982;1412-1418.
24. Grankvist K., Marklund S. Effect of extracellularly generated free radicals on the plasma membrane permeability of isolated pancreatic B-cells. Int J Biochem. 18:1986;109-113.
25. + and adenine nucleotides, membrane potential and volume change in vitro . Diabetologia. 27:1984;379-386.
26. Zhang H., Brunk U.T. Alloxan cytotoxicity is highly potentiated by plasma membrane- and lysosomal-associated iron a study on a model system of cultured j-774 cells . Diabetologia. 36:1993;707-715.
27. Boquist L. Alloxan diabetogenicity determinants of potentiation, protection and B-cell selectivity . Diabète Metab. 15:1989;23-29.
28. Traber J., Suter M., Walter P., Richter C. In vivo modulation of total and mitochondrial glutathione in rat liver. Biochem Pharmacol. 43:1992;961-964.
29. 2+ transport. Mol Cell Biochem. 118:1992;141-151.
30. Grankvist K., Marklund S.L., Täljedal I.-B. CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J. 199:1981;393-398.
31. Pipeleers D., Van De Winkel M. Pancreatic B cells possess defense mechanisms against cell-specific toxicity. Proc Natl Acad Sci USA. 83:1986;5267-5271.
32. Eizirik D.L., Sandler S. Functional restoration of cultured mouse pancreatic islets after in vitro exposure to alloxan. Pharmacol Toxicol. 63:1988;396-399.
33. Eizirik D., Pipeleers D.G., Ling Z., Welsh N., Helleström C., Andersson A. Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proc Natl Acad Sci USA. 91:1994;9253-9256.
34. Gorray K.C., Sorresso D., Moak S.A., Maimon J., Greenwald R.A., Schneider B.S. Comparison of superoxide dismutase activities in isolated rat and guinea pig islets of Langerhans. Horm Metab Res. 25:1993;649-650.
35. Sener A., Malaisse W.J. Resistance to alloxan of tumoral insulin-producing cells. FEBS Lett. 193:1985;150-152.
36. Flatt P.R., Shibier O., Ioannides C., Swanston-Flatt S.K. Studies on the chemical and immunological destruction of insulin-secreting islet cell tumours. Exp Clin Endocrinol. 93:1989;193-202.
37. Driggers W.J., LeDoux S.P., Wilson G.L. Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. J Biol Chem. 268:1993;22042-22045.
38. Henquin J.C., Malvaux P., Lambert A.E. Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues. Diabetologia. 16:1979;253-260.
39. Weaver D.C., McDaniel M.L., Naber S.P., Barry C.D., Lacy P.E. Alloxan stimulation and inhibition of insulin release from isolated rat islets of Langerhans. Diabetes. 27:1978;1205-1214.
40. Pagliara A.S., Stillings S.N., Zawalich W.S., Williams A.D., Matschinsky F.M. Glucose and 3-0-methylglucose protection against alloxan poisoning of pancreatic alpha and beta cells. Diabetes. 26:1977;973-979.
41. Dean P.M., Matthews E.K. The bioelectrical properties of pancreatic islet cells effect of diabetogenic agents . Diabetologia. 8:1972;173-178.
42. 2+ in pancreatic β-cells exposed to streptozotocin or alloxan. Toxicology. 63:1990;263-271.
43. 2 in the rat insulin-secreting cell line CRI-G1. J Physiol. 501:1997;59-66.
44. + channels in free radical-mediated inhibition of insulin secretion in rat pancreatic β-cells. Diabetes. 44:1995;878-883.
45. Kennedy E.D., Maechler P., Wollheim C.B. Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells. Diabetes. 47:1998;374-380.
46. Maechler P., Kennedy E.D., Pozzan T., Wollheim C.B. Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells. EMBO J. 16:1997;3833-3841.