TRPM2 modulates insulin secretion in pancreatic β-cells

Islets

Volumn 3, Issue 4, 2011, Pages 209-211

  Uchida, Kunitoshi ^a   Tominaga, Makoto ^a,b  

^a OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^b University of Advanced Studies   (Japan)

Author keywords

Glucose tolerance; Incretin hormone; Insulin secretion; Intracellular Ca 2+; Pancreatic cell; TRPM2

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM ION; CLUSTERIN; GLUCOSE; INCRETIN; INSULIN; VOLTAGE GATED CALCIUM CHANNEL;

CALCIUM CELL LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HORMONAL REGULATION; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; KNOCKOUT MOUSE; NONHUMAN; NOTE; PANCREAS ISLET BETA CELL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ANIMALS; DISEASE MODELS, ANIMAL; GLUCOSE INTOLERANCE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; TRPM CATION CHANNELS;

EID: 79960086411     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.3.4.16130     Document Type: Note

References (23)

1. Islam MS. Calcium signaling in the islets. Adv Exp Med Biol 2011; 654:235-59.
2. i oscillations in transgenically derived beta-cells. J Biol Chem 1998; 273:10402-10.
3. Akiba Y, Kato S, Katsube K, Nakamura M, Takeuchi K, Ishii H, et al. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochem Biophys Res Commun 2004; 321:219-25. (Pubitemid 39055627)
4. Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I. Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes 2009; 58:174-84.
5. Casas S, Novials A, Reimann F, Gomis R, Gribble FM. Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia 2008; 51:2252-62.
6. 2+ channel ECaC1 in rat pancreatic islets. J Histochem Cytochem 2002; 50:789-98.
7. Hiriart M, Aguilar-Bryan L. Channel regulation of glucose sensing in the pancreatic beta-cell. Am J Physiol Endocrinol Metab 2008; 295:1298-306.
8. Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol 2008; 10:1421-30.
9. Aoyagi K, Ohara-Imaizumi M, Nishiwaki C, Nakamichi Y, Nagamatsu S. Insulin/phosphoinositide-3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic beta-cells. Biochem J 2010; 432:375-86.
10. Cheng H, Beck A, Launay P, Gross SA, Stokes AJ, Kinet JP, et al. TRPM4 controls insulin secretion in pancreatic beta-cells. Cell Calcium 2007; 41:51-61. (Pubitemid 44872619)
11. Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, et al. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes 2011; 60:119-26.
12. -/- mice. Proc Natl Acad Sci USA 2010; 107:5208-13.
13. Brixel LR, Monteilh-Zoller MK, Ingenbrandt CS, Fleig A, Penner R, Enklaar T, et al. TRPM5 regulates glucose-stimulated insulin secretion. Pflugers Arch 2010; 460:69-76.
14. Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, et al. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol 2007; 8:312-20. (Pubitemid 46745381)
15. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, et al. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 2001; 411:595-9. (Pubitemid 32531407)
16. 2+ channel protein (TRPC7) highly expressed in brain. Genomics 1998; 54:124-31.
17. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, et al. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 2002; 9:163-73. (Pubitemid 34127780)
18. Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, et al. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med 2008; 14:738-47. (Pubitemid 351953041)
19. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, et al. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 2006; 25:1804-15.
20. Qian F, Huang P, Ma L, Kuznetsov A, Tamarina N, Philipson LH. TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Diabetes 2002; 51:183-9.
21. Takasawa S, Nata K, Yonekura H, Okamoto H. Cyclic ADP-ribose in insulin secretion from pancreatic beta cells. Science 1993; 259:370-3. (Pubitemid 23055680)
22. 2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels. J Cell Mol Med 2009; 13:3260-7.
23. 2+-release channel in beta cells. Sci Signal 2009; 2:23.