Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage

Toxicology and Applied Pharmacology

Volumn 264, Issue 3, 2012, Pages 315-323

  Yang, Bei ^a,b   Fu, Jingqi ^a   Zheng, Hongzhi ^a   Xue, Peng ^a   Yarborough, Kathy ^a   Woods, Courtney G ^a   Hou, Yongyong ^a   Zhang, Qiang ^a   Andersen, Melvin E ^a   Pi, Jingbo ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Arsenic; Cytotoxicity; Diabetes; Islets; Nrf2; Oxidative stress; Pancreatic cell

Indexed keywords

ACETYLCYSTEINE; ARSENIC; ARSENIC DERIVATIVE; ARSENIC TRIOXIDE; BETA ACTIN; GLUCOSE; LAMIN A; MESSENGER RNA; MONOMETHYLARSONOUS ACID; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CHRONIC STRESS; CONTROLLED STUDY; CYTOTOXICITY; ENVIRONMENTAL STRESS; EXPOSURE; GENE; INSULIN RELEASE; KNOCKOUT MOUSE; LENTIVIRINAE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NRF2 GENE; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; ARSENIC; CELL LINE; ENVIRONMENTAL POLLUTANTS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; INSULIN-SECRETING CELLS; MICE; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

MUS;

EID: 84867434261     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.09.012     Document Type: Article

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