-
2
-
-
0035282921
-
Mitochondrial proton leak and the uncoupling protein 1 homologues
-
Stuart, J. A., Cadenas, S., Jekabsons, M. B., Roussel, D. & Brand, M. D. Mitochondrial proton leak and the uncoupling protein 1 homologues. Biochim. Biophys. Acta 1504, 144-158 (2001).
-
(2001)
Biochim. Biophys. Acta
, vol.1504
, pp. 144-158
-
-
Stuart, J.A.1
Cadenas, S.2
Jekabsons, M.B.3
Roussel, D.4
Brand, M.D.5
-
3
-
-
0030809576
-
Reactive oxygen species, mitochondria, apoptosis and aging
-
Papa, S. & Skulachev, V. P. Reactive oxygen species, mitochondria, apoptosis and aging. Mol. Cell. Biochem. 174, 305-319 (1997).
-
(1997)
Mol. Cell. Biochem.
, vol.174
, pp. 305-319
-
-
Papa, S.1
Skulachev, V.P.2
-
4
-
-
0035174486
-
Mitochondrial uncoupling proteins in mammals and plants
-
Borecky, J., Maia, I. G. & Arruda, P. Mitochondrial uncoupling proteins in mammals and plants. Biosci. Rep. 21, 201-212 (2001).
-
(2001)
Biosci. Rep.
, vol.21
, pp. 201-212
-
-
Borecky, J.1
Maia, I.G.2
Arruda, P.3
-
6
-
-
0031019249
-
Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
-
Fleury, C. et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genet. 15, 269-272 (1997).
-
(1997)
Nature Genet.
, vol.15
, pp. 269-272
-
-
Fleury, C.1
-
7
-
-
15144356206
-
Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
-
Gimeno, R. E. et al. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46, 900-906 (1997).
-
(1997)
Diabetes
, vol.46
, pp. 900-906
-
-
Gimeno, R.E.1
-
8
-
-
0030988140
-
Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
-
Boss, O. et al. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408, 39-42 (1997).
-
(1997)
FEBS Lett.
, vol.408
, pp. 39-42
-
-
Boss, O.1
-
9
-
-
0031560941
-
UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
-
Vidal-Puig, A., Solanes, G., Grujic, D., Flier, J. S. & Lowell, B. B. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem. Biophys. Res. Commun. 235, 79-82 (1997).
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.235
, pp. 79-82
-
-
Vidal-Puig, A.1
Solanes, G.2
Grujic, D.3
Flier, J.S.4
Lowell, B.B.5
-
10
-
-
0030869755
-
Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
-
Gong, D. W., He, Y., Karas, M. & Reitman, M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin. J. Biol. Chem. 272, 24129-24132 (1997). References 6-10 are the original papers that describe the discovery of UCP2 and UCP3.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24129-24132
-
-
Gong, D.W.1
He, Y.2
Karas, M.3
Reitman, M.4
-
11
-
-
0024539333
-
The uncoupling protein dimer can form a disulfide cross-link between the mobile C-terminal SH groups
-
Klingenberg, M. & Appel, M. The uncoupling protein dimer can form a disulfide cross-link between the mobile C-terminal SH groups. Eur. J. Biochem. 180, 123-131 (1989).
-
(1989)
Eur. J. Biochem.
, vol.180
, pp. 123-131
-
-
Klingenberg, M.1
Appel, M.2
-
12
-
-
0021322138
-
Thermogenic mechanisms in brown fat
-
Nicholls, D. G. & Locke, R. M. Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 1-64 (1984). A classic review of UCP1 and BAT biochemistry and physiology.
-
(1984)
Physiol. Rev.
, vol.64
, pp. 1-64
-
-
Nicholls, D.G.1
Locke, R.M.2
-
13
-
-
0347989317
-
Brown adipose tissue: Function and physiological significance
-
Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004). A comprehensive, up-to-date review of BAT physiology, which includes a detailed discussion of the role of UCP1 in thermogenesis.
-
(2004)
Physiol. Rev.
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
14
-
-
0024465138
-
Stimulation of glucose transport by insulin and norepinephrine in isolated rat brown adipocytes
-
Marette, A. & Bukowiecki, L. J. Stimulation of glucose transport by insulin and norepinephrine in isolated rat brown adipocytes. Am. J. Physiol. 257, C714-C721 (1989).
-
(1989)
Am. J. Physiol.
, vol.257
-
-
Marette, A.1
Bukowiecki, L.J.2
-
15
-
-
0026678142
-
Insulin and noradrenaline independently stimulate the translocation of glucose transporters from intracellular stores to the plasma membrane in mouse brown adipocytes
-
Omatsu-Kanbe, M. & Kitasato, H. Insulin and noradrenaline independently stimulate the translocation of glucose transporters from intracellular stores to the plasma membrane in mouse brown adipocytes. FEBS Lett. 314, 246-250 (1992).
-
(1992)
FEBS Lett.
, vol.314
, pp. 246-250
-
-
Omatsu-Kanbe, M.1
Kitasato, H.2
-
16
-
-
0017744488
-
Purification and properties of mitochondrial adenosine triphosphatase of hamster brown adipose tissue
-
Houstek, J. & Drahota, Z. Purification and properties of mitochondrial adenosine triphosphatase of hamster brown adipose tissue. Biochim. Bophys. Acta 484, 127-139 (1977).
-
(1977)
Biochim. Bophys Acta
, vol.484
, pp. 127-139
-
-
Houstek, J.1
Drahota, Z.2
-
17
-
-
0017371154
-
The mitochondrial ATPase of brown adipose tissue. Purification and comparison with the mitochondrial ATPase from beef heart
-
Cannon, B. & Vogel, G. The mitochondrial ATPase of brown adipose tissue. Purification and comparison with the mitochondrial ATPase from beef heart. FEBS Lett. 76, 284-289 (1977).
-
(1977)
FEBS Lett.
, vol.76
, pp. 284-289
-
-
Cannon, B.1
Vogel, G.2
-
18
-
-
0032901360
-
Structure and function of the uncoupling protein from brown adipose tissue
-
Klingenberg, M. & Huang, S. G. Structure and function of the uncoupling protein from brown adipose tissue. Biochim. Biophys. Acta 1415, 271-296 (1999).
-
(1999)
Biochim. Biophys. Acta
, vol.1415
, pp. 271-296
-
-
Klingenberg, M.1
Huang, S.G.2
-
19
-
-
0027980820
-
+ transport activity of the reconstituted uncoupling protein
-
+ transport activity of the reconstituted uncoupling protein. J. Biol. Chem. 269, 2508-2515 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2508-2515
-
-
Winkler, E.1
Klingenberg, M.2
-
20
-
-
0032582799
-
The mechanism of proton transport mediated by mitochondrial uncoupling proteins
-
Garlid, K. D., Jaburek, M. & Jezek, P. The mechanism of proton transport mediated by mitochondrial uncoupling proteins. FEBS Lett. 438, 10-14 (1998).
-
(1998)
FEBS Lett.
, vol.438
, pp. 10-14
-
-
Garlid, K.D.1
Jaburek, M.2
Jezek, P.3
-
21
-
-
0025930608
-
Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation
-
Skulachev, V. P. Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation. FEBS Lett. 294, 158-162 (1991).
-
(1991)
FEBS Lett.
, vol.294
, pp. 158-162
-
-
Skulachev, V.P.1
-
22
-
-
0028110005
-
Transport of anions and protons by the mitochondrial uncoupling protein and its regulation by nucleotides and fatty acids. A new look at old hypotheses
-
Jezek, P., Orosz, D. E., Modriansky, M. & Garlid, K. D. Transport of anions and protons by the mitochondrial uncoupling protein and its regulation by nucleotides and fatty acids. A new look at old hypotheses. J. Biol. Chem. 269, 26184-26190 (1994). References 21 and 22 outline the development of the fatty-acid-cycling model of UCP function.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 26184-26190
-
-
Jezek, P.1
Orosz, D.E.2
Modriansky, M.3
Garlid, K.D.4
-
23
-
-
0030039607
-
On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein
-
Garlid, K. D., Orosz, D. E., Modriansky, M., Vassanelli, S., & Jezek, P. On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J. Biol. Chem. 271, 2615-2620 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2615-2620
-
-
Garlid, K.D.1
Orosz, D.E.2
Modriansky, M.3
Vassanelli, S.4
Jezek, P.5
-
25
-
-
0343900275
-
The uncoupling protein UCP 1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter
-
Gonzalez-Barroso, M. M., Fleury, C., Bouillaud, F., Nicholls, D. G. & Rial, E. The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter. J. Biol. Chem. 273, 15528-15532 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15528-15532
-
-
Gonzalez-Barroso, M.M.1
Fleury, C.2
Bouillaud, F.3
Nicholls, D.G.4
Rial, E.5
-
26
-
-
0342733589
-
How do uncoupling proteins uncouple?
-
Garlid, K. D., Jaburek, M., Jezek, P. & Varecha, M. How do uncoupling proteins uncouple? Biochim. Biophys. Acta 1459, 383-389 (2000).
-
(2000)
Biochim. Biophys. Acta
, vol.1459
, pp. 383-389
-
-
Garlid, K.D.1
Jaburek, M.2
Jezek, P.3
Varecha, M.4
-
27
-
-
0035212941
-
Mechanism of uncoupling protein action
-
Garlid, K. D., Jaburek, M. & Jezek, P. Mechanism of uncoupling protein action. Biochem. Soc. Trans 29, 803-806 (2001).
-
(2001)
Biochem. Soc. Trans
, vol.29
, pp. 803-806
-
-
Garlid, K.D.1
Jaburek, M.2
Jezek, P.3
-
28
-
-
1042286448
-
Alkylsulfonates activate the uncoupling protein UCP1: Implications for the transport mechanism
-
Rial, E., Aguirregoitia, E., Jimenez-Jimenez, J. & Ledesma, A. Alkylsulfonates activate the uncoupling protein UCP1: implications for the transport mechanism. Biochim. Biophys. Acta 1608, 122-130 (2004).
-
(2004)
Biochim. Biophys. Acta
, vol.1608
, pp. 122-130
-
-
Rial, E.1
Aguirregoitia, E.2
Jimenez-Jimenez, J.3
Ledesma, A.4
-
29
-
-
0034735799
-
Coenzyme Q is an obligatory cofactor for uncoupling protein function
-
Echtay, K. S., Winkler, E. & Klingenberg, M. Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 408, 609-613 (2000).
-
(2000)
Nature
, vol.408
, pp. 609-613
-
-
Echtay, K.S.1
Winkler, E.2
Klingenberg, M.3
-
30
-
-
0018358214
-
Brown adipose tissue mitochondria
-
Nicholls, D. G. Brown adipose tissue mitochondria. Biochim. Biophys. Acta 549, 1-29 (1979).
-
(1979)
Biochim. Biophys. Acta
, vol.549
, pp. 1-29
-
-
Nicholls, D.G.1
-
31
-
-
0025154843
-
- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria
-
- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria. J. Biol. Chem. 265, 19303-19311 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 19303-19311
-
-
Jezek, P.1
Garlid, K.D.2
-
32
-
-
0017817970
-
Brown-adipose-tissue mitochondria: Photoaffinity labelling of the regulatory site of energy dissipation
-
Heaton, G. M., Wagenvoord, R. J., Kemp, A. Jr & Nicholls, D. G. Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. Eur. J. Biochem. 82, 515-521 (1978). A classic paper describing identification of UCP1.
-
(1978)
Eur. J. Biochem.
, vol.82
, pp. 515-521
-
-
Heaton, G.M.1
Wagenvoord, R.J.2
Kemp Jr., A.3
Nicholls, D.G.4
-
33
-
-
85047686497
-
A history of UCP1
-
Nicholls, D. G. A history of UCP1. Biochem. Soc. Trans 29, 751-755 (2001). A mini-review giving an historic perspective on the discovery of UCP1.
-
(2001)
Biochem. Soc. Trans
, vol.29
, pp. 751-755
-
-
Nicholls, D.G.1
-
34
-
-
0017264191
-
Hamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site
-
Nicholls, D. G. Hamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site. Eur. J. Biochem. 62, 223-228 (1976).
-
(1976)
Eur. J. Biochem.
, vol.62
, pp. 223-228
-
-
Nicholls, D.G.1
-
35
-
-
0034673976
-
Uncoupling proteins 1 and 3 are regulated differently
-
Hagen, T., Zhang, C. Y., Vianna, C. R. & Lowell, B. B. Uncoupling proteins 1 and 3 are regulated differently. Biochemistry 39, 5845-5851 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 5845-5851
-
-
Hagen, T.1
Zhang, C.Y.2
Vianna, C.R.3
Lowell, B.B.4
-
36
-
-
0032980686
-
Fasting and leptin modulate adipose and muscle uncoupling protein: Divergent effects between messenger ribonucleic acid and protein expression
-
Sivitz, W. I., Fink, B. D. & Donohoue, P. A. Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression. Endocrinology 140, 1511-1519 (1999).
-
(1999)
Endocrinology
, vol.140
, pp. 1511-1519
-
-
Sivitz, W.I.1
Fink, B.D.2
Donohoue, P.A.3
-
37
-
-
0035937856
-
Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation
-
Pecqueur, C. et al. Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J. Biol. Chem. 276, 8705-8712 (2001). References 36 and 37 clearly show that the amount of UCP2 mRNA, in different tissues and in different physiological states, does not predict the amount or presence of UCP2 protein.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8705-8712
-
-
Pecqueur, C.1
-
38
-
-
0031829766
-
The uncoupling proteins, a review
-
Boss, O., Muzzin, P. & Giacobino, J. P. The uncoupling proteins, a review. Eur. J. Endocrinol. 139, 1-9 (1998).
-
(1998)
Eur. J. Endocrinol.
, vol.139
, pp. 1-9
-
-
Boss, O.1
Muzzin, P.2
Giacobino, J.P.3
-
39
-
-
0034650763
-
The uncoupling protein homologues: UCP1, UCP2, UCP 3, StUCP and AtUCR
-
Ricquier, D. & Bouillaud, F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCR Biochem. J. 345, 161-179 (2000).
-
(2000)
Biochem. J.
, vol.345
, pp. 161-179
-
-
Ricquier, D.1
Bouillaud, F.2
-
40
-
-
0037253404
-
The 'novel' 'uncoupling' proteins UCP2 and UCP3; what do they realty do? Pros and cons for suggested functions
-
Nedergaard, J. & Cannon, B. The 'novel' 'uncoupling' proteins UCP2 and UCP3; what do they realty do? Pros and cons for suggested functions. Exp. Physiol. 88, 65-84 (2003).
-
(2003)
Exp. Physiol.
, vol.88
, pp. 65-84
-
-
Nedergaard, J.1
Cannon, B.2
-
41
-
-
0038168520
-
Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10
-
Jaburek, M. & Garlid, K. D. Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10. J. Biol. Chem. 278, 25825-25831 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25825-25831
-
-
Jaburek, M.1
Garlid, K.D.2
-
43
-
-
0006877856
-
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
-
Clapham, J. C. et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406, 415-418 (2000).
-
(2000)
Nature
, vol.406
, pp. 415-418
-
-
Clapham, J.C.1
-
44
-
-
0035875366
-
A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast
-
Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B. & Brand, M. D. A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast. Biochem. J. 356, 779-789 (2001).
-
(2001)
Biochem. J.
, vol.356
, pp. 779-789
-
-
Stuart, J.A.1
Harper, J.A.2
Brindle, K.M.3
Jekabsons, M.B.4
Brand, M.D.5
-
45
-
-
0035947694
-
Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria
-
Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B. & Brand, M. D. Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. J. Biol. Chem. 276, 18633-18639 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18633-18639
-
-
Stuart, J.A.1
Harper, J.A.2
Brindle, K.M.3
Jekabsons, M.B.4
Brand, M.D.5
-
46
-
-
0036182511
-
Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria
-
Harper, J. A. et al. Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem. J. 361, 49-56 (2002).
-
(2002)
Biochem. J.
, vol.361
, pp. 49-56
-
-
Harper, J.A.1
-
47
-
-
0037169484
-
The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3
-
Cadenas, S. et al. The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J. Biol. Chem. 277, 2773-2778 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2773-2778
-
-
Cadenas, S.1
-
48
-
-
18244379331
-
Superoxide activates mitochondrial uncoupling proteins
-
Echtay, K. S. et al. Superoxide activates mitochondrial uncoupling proteins. Nature 415, 96-99 (2002). Seminal work on the regulation of uncoupling proteins by superoxide.
-
(2002)
Nature
, vol.415
, pp. 96-99
-
-
Echtay, K.S.1
-
49
-
-
0037039366
-
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
-
Krauss, S., Zhang, C. Y. & Lowell, B. B. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc. Natl Acad. Sci. USA 99, 118-122 (2002). Shows that endogenous UCP2 mediates proton leak in intact cells.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 118-122
-
-
Krauss, S.1
Zhang, C.Y.2
Lowell, B.B.3
-
50
-
-
0346340042
-
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
-
Krauss, S. et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction. J. Clin. Invest. 112, 1831-1842 (2003). Highlights the significance of superoxide-medlated activation of UCP2 in β-cell pathophysiology and type-2 diabetes. Shows that increased UCP2 activity causes hyperglycaemia-induced loss of glucose sensing in β-cells.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1831-1842
-
-
Krauss, S.1
-
51
-
-
0034717074
-
Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
-
Gong, D. W. et al. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J. Biol. Chem. 275, 16251-16257 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16251-16257
-
-
Gong, D.W.1
-
52
-
-
0034717015
-
Energy metabolism in uncoupling protein 3 gene knockout mice
-
Vidal-Puig, A. J. et al. Energy metabolism in uncoupling protein 3 gene knockout mice. J. Biol. Cnem. 275, 16258-16266 (2000). Shows that endogenous UCP3 has a role in limiting superoxide production.
-
(2000)
J. Biol. Cnem.
, vol.275
, pp. 16258-16266
-
-
Vidal-Puig, A.J.1
-
53
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
-
Zhang, C. Y. et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes. Cell 105, 745-755 (2001). Shows the critical role of UCP2 in vivo in the pathophysiology of β-cell dysfunction and type-2 diabetes.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
-
54
-
-
0035827595
-
In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism
-
Cline, G. W. et al. In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. J. Biol. Chem. 276, 20240-20244 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20240-20244
-
-
Cline, G.W.1
-
55
-
-
0346814090
-
Superoxide activates uncoupling proteins by generating carbon-centered radicals and Initiating lipid peroxidation: Studies using a mitochondria- targeted spin trap derived from α-phenyl-N-tert-butylnitrone
-
Murphy, M. P. et al. Superoxide activates uncoupling proteins by generating carbon-centered radicals and Initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from α-phenyl-N-tert- butylnitrone. J. Biol. Chem. 278, 48534-48545 (2003). Outlines a basic model of the pathway by which superoxide might activate UCP1 and its homologues..
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48534-48545
-
-
Murphy, M.P.1
-
56
-
-
0037033039
-
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
-
Echtay, K. S., Murphy, M. P., Smith, R. A., Talbot, D. A. & Brand, M. D. Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J. Biol. Chem. 277, 47129-47135 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 47129-47135
-
-
Echtay, K.S.1
Murphy, M.P.2
Smith, R.A.3
Talbot, D.A.4
Brand, M.D.5
-
57
-
-
0038266426
-
Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein
-
Considine, M. J. et al. Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein. J. Biol. Chem. 278, 22298-22302 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22298-22302
-
-
Considine, M.J.1
-
58
-
-
0041465009
-
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
-
Echtay, K. S. et al. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 22, 4103-4110 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 4103-4110
-
-
Echtay, K.S.1
-
59
-
-
0038419546
-
Activating ω-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3
-
Zackova, M., Skobisova, E., Urbankova, E. & Jezek, P. Activating ω-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3. J. Biol. Chem. 278, 20761-20769 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20761-20769
-
-
Zackova, M.1
Skobisova, E.2
Urbankova, E.3
Jezek, P.4
-
60
-
-
0037773721
-
Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
-
Jaburek, M. et al. Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. J. Biol. Chem. 274, 26003-26007 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26003-26007
-
-
Jaburek, M.1
-
61
-
-
1842409029
-
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
-
Enerback, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94 (1997). Shows that UCP1 is responsible for cold-exposure-induced, non-shivering thermogenesis.
-
(1997)
Nature
, vol.387
, pp. 90-94
-
-
Enerback, S.1
-
62
-
-
0033667705
-
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
-
Arsenijevic, D. et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nature Genet. 26, 435-439 (2000). First report of a UCP2-knockout-mouse model; shows that endogenous UCP2 protein has a role in limiting ROS production.
-
(2000)
Nature Genet.
, vol.26
, pp. 435-439
-
-
Arsenijevic, D.1
-
64
-
-
3543099847
-
Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage
-
Hoerter, J. et al. Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage. Circulation 110, 528-533 (2004).
-
(2004)
Circulation
, vol.110
, pp. 528-533
-
-
Hoerter, J.1
-
65
-
-
0344982956
-
Pharmacology: Uncoupling the agony from ecstasy
-
Mills, E. M., Banks, M. L., Sprague, J. E. & Finkel, T. Pharmacology: uncoupling the agony from ecstasy. Nature 426, 403-404 (2003).
-
(2003)
Nature
, vol.426
, pp. 403-404
-
-
Mills, E.M.1
Banks, M.L.2
Sprague, J.E.3
Finkel, T.4
-
66
-
-
0642272500
-
Uncoupling protein 3 as a mitochondrial fatty acid anion exporter
-
Schrauwen, P. et al. Uncoupling protein 3 as a mitochondrial fatty acid anion exporter. FASEB J. 17, 2272-2274 (2003).
-
(2003)
FASEB J.
, vol.17
, pp. 2272-2274
-
-
Schrauwen, P.1
-
67
-
-
0035133171
-
Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
-
Himms-Hagen, J. & Harper, M. E. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp. Biol. Med. (Maywood) 226, 78-84 (2001).
-
(2001)
Exp. Biol. Med. (Maywood)
, vol.226
, pp. 78-84
-
-
Himms-Hagen, J.1
Harper, M.E.2
-
68
-
-
0023790275
-
A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria
-
Alexson, S. E. & Nedergaard, J. A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria. J. Biol. Chem. 263, 13564-13571 (1988).
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 13564-13571
-
-
Alexson, S.E.1
Nedergaard, J.2
-
69
-
-
0033969421
-
Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism
-
Boss, O., Hagen, T. & Lowell, B. B. Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes 49, 143-156 (2000).
-
(2000)
Diabetes
, vol.49
, pp. 143-156
-
-
Boss, O.1
Hagen, T.2
Lowell, B.B.3
-
70
-
-
0033525848
-
Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes
-
Gong, D. W., He, Y. & Reitman, M. L. Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes. Biochem. Biophys. Res. Commun. 256, 27-32 (1999).
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.256
, pp. 27-32
-
-
Gong, D.W.1
He, Y.2
Reitman, M.L.3
-
71
-
-
0032189845
-
Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
-
Argyropoulos, G. et al. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. J. Clin. Invest. 102, 1345-1351 (1998).
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1345-1351
-
-
Argyropoulos, G.1
-
72
-
-
0032884928
-
Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis
-
Chung, W. K. et al. Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis. Diabetes 48, 1890-1895 (1999).
-
(1999)
Diabetes
, vol.48
, pp. 1890-1895
-
-
Chung, W.K.1
-
73
-
-
0033002467
-
The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis
-
Chung, W. K. et al. The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis. Int. J. Obes. Relat. Metab. Disord. 23 (Suppl. 6), S49-S50 (1999).
-
(1999)
Int. J. Obes. Relat. Metab. Disord.
, vol.23
, Issue.SUPPL. 6
-
-
Chung, W.K.1
-
74
-
-
0030729851
-
High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
-
Korshunov, S. S., Skulachev, V. P. & Starkov, A. A. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416, 15-18 (1997).
-
(1997)
FEBS Lett.
, vol.416
, pp. 15-18
-
-
Korshunov, S.S.1
Skulachev, V.P.2
Starkov, A.A.3
-
75
-
-
0038061012
-
A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
-
Negre-Salvayre, A. et al. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J. 11, 809-815 (1997). First formulation of the hypothesis that UCP homologues regulate superoxide production.
-
(1997)
FASEB J.
, vol.11
, pp. 809-815
-
-
Negre-Salvayre, A.1
-
76
-
-
0036965865
-
Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells
-
Duval, C. et al. Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells. Biochem. Cell Biol. 80, 757-764 (2002).
-
(2002)
Biochem. Cell Biol.
, vol.80
, pp. 757-764
-
-
Duval, C.1
-
77
-
-
4043147798
-
Mitochondrial superoxide: Production, biological effects, and activation of uncoupling proteins
-
Brand, M. D. et al. Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic. Biol. Med. 37, 755-767 (2004).
-
(2004)
Free Radic. Biol. Med.
, vol.37
, pp. 755-767
-
-
Brand, M.D.1
-
78
-
-
0346094388
-
Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3
-
Talbot, D. A., Lambert, A. J. & Brand, M. D. Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3. FEBS Lett. 556, 111-115 (2004).
-
(2004)
FEBS Lett.
, vol.556
, pp. 111-115
-
-
Talbot, D.A.1
Lambert, A.J.2
Brand, M.D.3
-
79
-
-
2242425423
-
Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
-
Brand, M. D. et al. Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. Biochem. J. 368, 597-603 (2002).
-
(2002)
Biochem. J.
, vol.368
, pp. 597-603
-
-
Brand, M.D.1
-
80
-
-
0042526012
-
Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes
-
Teshima, Y., Akao, M., Jones, S. P. & Marban, E. Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ. Res. 93, 192-200 (2003).
-
(2003)
Circ. Res.
, vol.93
, pp. 192-200
-
-
Teshima, Y.1
Akao, M.2
Jones, S.P.3
Marban, E.4
-
81
-
-
0041464712
-
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
-
Mattiasson, G. et al. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nature Med. 9, 1062-1068 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 1062-1068
-
-
Mattiasson, G.1
-
82
-
-
0242468451
-
Uncoupling protein 2 prevents neuronal death including that occurring during seizures: A mechanism for preconditioning
-
Diano, S. et al. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology 144, 5014-5021 (2003).
-
(2003)
Endocrinology
, vol.144
, pp. 5014-5021
-
-
Diano, S.1
-
83
-
-
2642573308
-
Resistance to cerebral ischemic injury in UCP2 knockout mice: Evidence for a role of UCP 2 as a regulator of mitochondrial glutathione levels
-
de Bilbao, F. et al. Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. J. Neurochem. 89, 1283-1292 (2004).
-
(2004)
J. Neurochem.
, vol.89
, pp. 1283-1292
-
-
De Bilbao, F.1
-
84
-
-
0032787462
-
+ channels and insulin secretion: Their role in health and disease
-
+ channels and insulin secretion: their role in health and disease. Diabetologia 42, 903-919 (1999).
-
(1999)
Diabetologia
, vol.42
, pp. 903-919
-
-
Ashcroft, F.M.1
Gribble, F.M.2
-
85
-
-
0031892853
-
Pancreatic β-cell glucokinase: Dosing the gap between theoretical concepts and experimental realities
-
Matschinsky, F. M., Glaser, B. & Magnuson, M. A. Pancreatic β-cell glucokinase: dosing the gap between theoretical concepts and experimental realities. Diabetes 47, 307-315 (1998).
-
(1998)
Diabetes
, vol.47
, pp. 307-315
-
-
Matschinsky, F.M.1
Glaser, B.2
Magnuson, M.A.3
-
87
-
-
0033582196
-
2+ dependent exocytosis in pancreatic β cells
-
2+ dependent exocytosis in pancreatic β cells. Proc. Natl Acad. Sci. USA 96, 760-765 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 760-765
-
-
Takahashi, N.1
-
88
-
-
0034990987
-
Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
-
Chan, C. B. et al. Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 50, 1302-1310 (2001).
-
(2001)
Diabetes
, vol.50
, pp. 1302-1310
-
-
Chan, C.B.1
-
89
-
-
0032991716
-
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
-
Chan, C. B. et al. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48, 1482-1486 (1999). Shows that the forced overexpression of UCP2 in pancreatic β-cells causes loss of glucose sensing.
-
(1999)
Diabetes
, vol.48
, pp. 1482-1486
-
-
Chan, C.B.1
-
90
-
-
0036829870
-
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
-
Joseph, J. W. et al. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 51, 3211-3219 (2002). Shows that the absence of UCP2 protects against high-fat-diet-induced β-cell dysfunction.
-
(2002)
Diabetes
, vol.51
, pp. 3211-3219
-
-
Joseph, J.W.1
-
91
-
-
0043268763
-
Pancreatic β-cell lipotoxicity induced by Overexpression of hormone-sensitive lipase
-
Winzell, M. S. et al. Pancreatic β-cell lipotoxicity induced by Overexpression of hormone-sensitive lipase. Diabetes 52, 2057-2065 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 2057-2065
-
-
Winzell, M.S.1
-
92
-
-
0037192853
-
Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia
-
Laybutt, D. R. et al. Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia. J. Biol. Chem. 277, 10912-10921 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 10912-10921
-
-
Laybutt, D.R.1
-
93
-
-
0034577567
-
Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats
-
Kassis, N. et al. Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats. Int. J. Exp. Diabetes Res. 1, 185-193 (2000).
-
(2000)
Int. J. Exp. Diabetes Res.
, vol.1
, pp. 185-193
-
-
Kassis, N.1
-
94
-
-
0037984371
-
Visualizing superoxide production in normal and diabetic rat islets of langerhans
-
Bindokas, V. P. et al. Visualizing superoxide production in normal and diabetic rat islets of langerhans. J. Biol. Chem. 278, 9796-9801 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9796-9801
-
-
Bindokas, V.P.1
-
95
-
-
0035078830
-
Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion?
-
Lameloise, N., Muzzin, P., Prentki, M. & Assimacopoulos-Jeannet, F. Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 50, 803-809 (2001).
-
(2001)
Diabetes
, vol.50
, pp. 803-809
-
-
Lameloise, N.1
Muzzin, P.2
Prentki, M.3
Assimacopoulos-Jeannet, F.4
-
96
-
-
1642546212
-
Over-expression of sterol regulatory element binding protein-1c in rat pancreatic islets induces iipogenesis and decreases glucose-stimulated insulin release: Modulation by 5-aminoimidazole-4-carboxamide ribonucleoside
-
Diraison, F. et al. Over-expression of sterol regulatory element binding protein-1c in rat pancreatic islets induces iipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside. Biochem. J. 378, 769-778 (2003).
-
(2003)
Biochem. J.
, vol.378
, pp. 769-778
-
-
Diraison, F.1
-
97
-
-
3843145012
-
Role of UCP-2 up-regulation and TG accumulation in impaired glucose-stimulated insulin secretion in a β-cell lipotoxicity model overexpressing SREBP-1c
-
Yamashita, T. et al. Role of UCP-2 up-regulation and TG accumulation in impaired glucose-stimulated insulin secretion in a β-cell lipotoxicity model overexpressing SREBP-1c. Endocrinology 145, 3566-3577 (2004).
-
(2004)
Endocrinology
, vol.145
, pp. 3566-3577
-
-
Yamashita, T.1
-
98
-
-
0038165514
-
Mitochondrial functional state in clonal pancreatic β-cells exposed to free fatty acids
-
Koshkin, V., Wang, X., Scherer, P. E., Chan, C. B. & Wheeler, M. B. Mitochondrial functional state in clonal pancreatic β-cells exposed to free fatty acids. J. Biol. Chem. 278, 19709-19715 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19709-19715
-
-
Koshkin, V.1
Wang, X.2
Scherer, P.E.3
Chan, C.B.4
Wheeler, M.B.5
-
99
-
-
10944265062
-
Free fatty acid induced β-cell defects are dependent on uncoupling protein 2 expression
-
Joseph, J. W. et al. Free fatty acid induced β-cell defects are dependent on uncoupling protein 2 expression. J. Biol. Chem. 279, 51049-51056 (2004). Shows that the absence of UCP2 protects against fatty-acid-induced β-cell dysfunction.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51049-51056
-
-
Joseph, J.W.1
-
100
-
-
0034464215
-
Inhibition of glucose-induced insulin secretion by 4-hydroxy-2-nonenal and other lipid peroxidation products
-
Miwa, I., Ichimura, N., Sugiura, M., Hamada, Y. & Taniguchi, S. Inhibition of glucose-induced insulin secretion by 4-hydroxy-2-nonenal and other lipid peroxidation products. Endocrinology 141, 2767-2772 (2000).
-
(2000)
Endocrinology
, vol.141
, pp. 2767-2772
-
-
Miwa, I.1
Ichimura, N.2
Sugiura, M.3
Hamada, Y.4
Taniguchi, S.5
-
101
-
-
0036153256
-
Minireview: Secondary β-cell failure in type 2 diabetes - A convergence of glucotoxicity and lipotoxidty
-
Poitout, V. & Robertson, H. P. Minireview: Secondary β-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxidty. Endocrinology 143, 339-342 (2002).
-
(2002)
Endocrinology
, vol.143
, pp. 339-342
-
-
Poitout, V.1
Robertson, H.P.2
-
102
-
-
0242497235
-
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
-
Pebay-Peyroula, E. et al. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature 426, 39-44 (2003).
-
(2003)
Nature
, vol.426
, pp. 39-44
-
-
Pebay-Peyroula, E.1
-
103
-
-
0027222094
-
The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins
-
Miroux, B., Frossard, V., Raimbault, S., Ricquier, D. & Bouillaud, P. The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins. EMBO J. 12, 3739-3745 (1993).
-
(1993)
EMBO J.
, vol.12
, pp. 3739-3745
-
-
Miroux, B.1
Frossard, V.2
Raimbault, S.3
Ricquier, D.4
Bouillaud, P.5
-
104
-
-
0036139671
-
The mitochondrial uncoupling protein UCP1: A gated pore
-
Arechaga, I., Ledesma, A. & Rial, E. The mitochondrial uncoupling protein UCP1: a gated pore. IUBMB Life 52, 165-173 (2001).
-
(2001)
IUBMB Life
, vol.52
, pp. 165-173
-
-
Arechaga, I.1
Ledesma, A.2
Rial, E.3
-
105
-
-
0032995203
-
Structure-function relationship in UCP1
-
Mingenberg, M., Echtay, K. S., Bienengraeber, M., Winkler, E. & Huang, S. G. Structure-function relationship in UCP1. Int. J. Obes. Relat. Metab. Disord. 23(Suppl. 6), S24-S29 (1999). Comprehensive review of UCP1-mediated proton transport, summarizing the work that led to the formulation of the proton-buffering model.
-
(1999)
Int. J. Obes. Relat. Metab. Disord.
, vol.23
, Issue.SUPPL. 6
-
-
Mingenberg, M.1
Echtay, K.S.2
Bienengraeber, M.3
Winkler, E.4
Huang, S.G.5
-
106
-
-
0030881775
-
Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition
-
Modriansky, M., Murdza-Inglis, D. L., Patel, H. V., Freeman, K. B. & Garlid, K. D. Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition. J. Biol. Chem. 272, 24759-24762 (1997). Important paper showing the critical role of arginine residues in mediating inhibition of UCP1 by purine nucleotides.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24759-24762
-
-
Modriansky, M.1
Murdza-Inglis, D.L.2
Patel, H.V.3
Freeman, K.B.4
Garlid, K.D.5
-
107
-
-
0034972150
-
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
-
Esterbauer, H. et al. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nature Genet. 28, 178-183 (2001).
-
(2001)
Nature Genet.
, vol.28
, pp. 178-183
-
-
Esterbauer, H.1
-
108
-
-
0036830548
-
A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans
-
Krempler, F. et al. A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 51, 3331-3335 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 3331-3335
-
-
Krempler, F.1
-
109
-
-
12444292715
-
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects
-
Sesti, G. et al. A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 52, 1280-1283 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 1280-1283
-
-
Sesti, G.1
-
110
-
-
10744222893
-
Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in β-cells and modulates clinical profiles of Japanese type 2 diabetic patients
-
Sasahara, M. et al. Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in β-cells and modulates clinical profiles of Japanese type 2 diabetic patients. Diabetes 53, 482-485 (2004).
-
(2004)
Diabetes
, vol.53
, pp. 482-485
-
-
Sasahara, M.1
-
111
-
-
0035856980
-
Biochemistry and molecular cell biology of diabetic complications
-
Brownlee, M. Biochemistry and molecular cell biology of diabetic complications. Nature 414, 813-820 (2001).
-
(2001)
Nature
, vol.414
, pp. 813-820
-
-
Brownlee, M.1
-
112
-
-
0035856942
-
Mitochondrial function in normal and diabetic β-cells
-
Maechler, P. & Wollheim, C. B. Mitochondrial function in normal and diabetic β-cells. Nature 414, 807-812 (2001).
-
(2001)
Nature
, vol.414
, pp. 807-812
-
-
Maechler, P.1
Wollheim, C.B.2
-
113
-
-
0033856196
-
Oxygen consumption oscillates in single donal pancreatic β-cells (HIT)
-
Porterfield, D. M. et al. Oxygen consumption oscillates in single donal pancreatic β-cells (HIT). Diabetes 49, 1511-1516 (2000).
-
(2000)
Diabetes
, vol.49
, pp. 1511-1516
-
-
Porterfield, D.M.1
-
114
-
-
44949272730
-
A time-efficient, linear-space local similarity algorithm
-
Huang, X. & Miller, W. E. A time-efficient, linear-space local similarity algorithm. Adv. Appl. Math. 12, 337-357 (1991).
-
(1991)
Adv. Appl. Math.
, vol.12
, pp. 337-357
-
-
Huang, X.1
Miller, W.E.2
|