Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: Involvement of cellular adaptive response to oxidative stress

Environmental Health Perspectives

Volumn 118, Issue 6, 2010, Pages 864-870

  Fu, Jingqi ^a,b   Woods, Courtney G ^a   Yehuda Shnaidman, Einav ^a   Zhang, Qiang ^a   Wong, Victoria ^a   Collins, Sheila ^a   Sun, Guifan ^b   Andersen, Melvin E ^a   Pi, Jingbo ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Arsenic; Diabetes; Insulin secretion; Nrf2; Oxidative stress; Pancreatic beta cells; ROS

Indexed keywords

ANTIOXIDANT; ARSENIC; GLUTATHIONE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER; TRANSCRIPTION FACTOR NRF2; GLUCOSE; INSULIN; TRANSCRIPTION FACTOR NF E2;

ARTICLE; BASAL CELL; CELL DAMAGE; CONTROLLED STUDY; EXPOSURE; GENE TARGETING; GLUCOSE METABOLISM; GLUCOSE STIMULATED INSULIN SECRETION; GLUCOSE TRANSPORT; INSULIN RELEASE; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; SECRETION (PROCESS); TIME; TOXICITY;

ARSENIC; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; NF-E2 TRANSCRIPTION FACTOR; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 77953255611     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0901608     Document Type: Article

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