Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics

Cellular and Molecular Life Sciences

Volumn 72, Issue 7, 2015, Pages 1377-1403

  Mornon, Jean Paul ^a   Hoffmann, Brice ^a   Jonic, Slavica ^a   Lehn, Pierre ^b   Callebaut, Isabelle ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

Author keywords

ABC exporters; CFTR; Chloride channel; Molecular dynamics; Molecular modeling

Indexed keywords

AMINO ACID; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MUTANT PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOPLASM; CYTOSOL; EXTRACELLULAR MATRIX; GENE DELETION; GENE MUTATION; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BINDING SITES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOPLASM; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION, MISSENSE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84928493859     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-014-1749-2     Document Type: Article

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