Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 11, 2014, Pages 4049-4054

  Kodan, Atsushi ^a   Yamaguchi, Tomohiro ^b   Nakatsu, Toru ^b,c   Sakiyama, Keita ^b   Hipolito, Christopher J ^d   Fujioka, Akane ^b   Hirokane, Ryo ^b   Ikeguchi, Keiji ^b   Watanabe, Bunta ^b   Hiratake, Jun ^b   Kimura, Yasuhisa ^b   Suga, Hiroaki ^d   Ueda, Kazumitsu ^a,b   Kato, Hiroaki ^b,c  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c RIKEN HARIMA INSTITUTE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

ABC transporter; Macrocyclic peptide; Membrane protein; Multidrug resistance; X ray crystallography

Indexed keywords

ADENOSINE TRIPHOSPHATE; CMABCB1 PROTEIN; MULTIDRUG RESISTANCE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOSOL; EXTRACELLULAR SPACE; HYDROLYSIS; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

ABC TRANSPORTER; MACROCYCLIC PEPTIDE; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE; X-RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; CRYSTALLOGRAPHY; DRUG DISCOVERY; ION CHANNEL GATING; MODELS, MOLECULAR; NEOPLASMS; P-GLYCOPROTEIN; PICHIA; PROTEIN CONFORMATION; RHODOPHYTA; SACCHAROMYCES CEREVISIAE; X-RAY DIFFRACTION;

EID: 84896512558     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321562111     Document Type: Article

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