Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

Science

Volumn 323, Issue 5922, 2009, Pages 1718-1722

  Aller, Stephen G ^a   Yu, Jodie ^a   Ward, Andrew ^a   Weng, Yue ^a,c   Chittaboina, Srinivas ^a   Zhuo, Rupeng ^b   Harrell, Patina M ^b   Trinh, Yenphuong T ^b   Zhang, Qinghai ^a   Urbatsch, Ina L ^b   Chang, Geoffrey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b TEXAS TECH UNIVERSITY   (United States)

^c WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; CYCLIC VALINESELENAZOLE; GLYCOPROTEIN P; SELENAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL;

CANCER; CYTOPLASM; DRUG RESISTANCE; LIPID; MOLECULAR ANALYSIS; PEPTIDE; PROTEIN; TOXIN;

AROMATIZATION; ARTICLE; CONFORMATIONAL TRANSITION; CYTOPLASM; DRUG PROTEIN BINDING; HYDROPHOBICITY; LIPID BILAYER; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; STEREOCHEMISTRY;

EID: 63449139456     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1168750     Document Type: Article

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