CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

Nature

Volumn 433, Issue 7028, 2005, Pages 876-880

  Vergani, Paola ^a   Lockless, Steve W ^a   Nairn, Angus C ^a,b   Gadsby, David C ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOLOGICAL MEMBRANES; DIMERIZATION; DIMERS; DISSOCIATION; HYDROLYSIS;

CHANNEL GATES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR); ION CHANNELS; TRANSMEMBRANE DOMAINS;

PROTEINS;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ARGININE; ASPARAGINE; CHLORIDE CHANNEL; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMIC ACID; GLUTAMINE; LYSINE; THREONINE; TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR PROTEIN, HUMAN;

BIOLOGY;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYSTIC FIBROSIS; DIMERIZATION; DISSOCIATION CONSTANT; HUMAN; HYDROGEN BOND; HYDROLYSIS; MICHAELIS MENTEN KINETICS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; THERMODYNAMICS; XENOPUS LAEVIS; CHEMISTRY; DRUG EFFECT; ELECTROPHYSIOLOGY; ENZYME ACTIVE SITE; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; CATALYTIC DOMAIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIMERIZATION; ELECTROPHYSIOLOGY; HUMANS; HYDROLYSIS; ION CHANNEL GATING; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS;

EID: 14544300522     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03313     Document Type: Article

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