Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 4, 2011, Pages 559-571

  Qian, Feng ^a   El Hiani, Yassine ^a   Linsdell, Paul ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Chloride channel; Cystic fibrosis transmembrane conductance regulator; Ion channel pore; Patch clamp; Permeation; Site directed mutagenesis; Substituted cysteine accessibility

Indexed keywords

[2 (TRIMETHYLAMMONIUM)ETHYL]; [2 SULFONATOETHYL]; CYSTEINE; MESYLIC ACID; TRANSMEMBRANE CONDUCTANCE REGULATOR; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELLULAR DISTRIBUTION; CHANNEL GATING; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOPLASM; EXTRACELLULAR SPACE; MEMBRANE CHANNEL; MEMBRANE MODEL; MEMBRANE STRUCTURE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN FUNCTION;

AMINO ACID SEQUENCE; ANIMALS; CRICETINAE; CYSTEINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MESYLATES; PATCH-CLAMP TECHNIQUES;

EID: 80054724207     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-0998-2     Document Type: Article

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