Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 25, 2014, Pages 9145-9150

  Choudhury, Hassanul G ^a,b,c   Tong, Zhen ^d   Mathavan, Indran ^a,b,c   Li, Yanyan ^e   Iwata, So ^a,b,c,f   Zirah, Séverine ^e   Rebuffat, Sylvie ^e   Van Veen, Hendrik W ^d   Beis, Konstantinos ^a,b,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Harwell Science and Innovation Campus   (United Kingdom)

^c RUTHERFORD APPLETON LABORATORY   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e CNRS   (France)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

Antimicrobial peptide ABC exporter; Membrane transporter crystal structure; Microcin immunity protein; Substrate binding; Transport mechanism

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE; CYSTEINE; DETERGENT; DIMER; HOMODIMER; MICROCIN J25; MONOMER; PROTEOLIPOSOME;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL IMMUNITY; BACTERIAL STRAIN; BINDING AFFINITY; CHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ESCHERICHIA COLI; GROWTH CURVE; LIGAND BINDING; MEMBRANE VESICLE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE BOUND OUTWARD OCCLUDED STATE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; SALMONELLA TYPHIMURIUM; STEREOSPECIFICITY; WILD TYPE;

ANTIMICROBIAL PEPTIDE ABC EXPORTER; MEMBRANE TRANSPORTER CRYSTAL STRUCTURE; MICROCIN IMMUNITY PROTEIN; SUBSTRATE BINDING; TRANSPORT MECHANISM;

AMINO ACID SUBSTITUTION; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIOCINS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84903478669     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320506111     Document Type: Article

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