Allosteric modulation balances thermodynamic stability and restores function of Δf508 CFTR

Journal of Molecular Biology

Volumn 419, Issue 1-2, 2012, Pages 41-60

  Aleksandrov, Andrei A ^a   Kota, Pradeep ^a,b   Cui, Liying ^a   Jensen, Tim ^a   Alekseev, Alexey E ^c   Reyes, Santiago ^c   He, Lihua ^a   Gentzsch, Martina ^a,b   Aleksandrov, Luba A ^a   Dokholyan, Nikolay V ^a,b   Riordan, John R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c MAYO CLINIC   (United States)

Author keywords

ABC transporters; CFTR; DMD simulations; ion channel; protein thermal stability

Indexed keywords

ALPHA PHOSPHATE; PHOSPHATE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; THERMOSTABILITY;

MAMMALIA;

EID: 84860271643     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.03.001     Document Type: Article

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