Phenylalanine 368 of multidrug resistance-associated protein 4 (MRP4/ABCC4) plays a crucial role in substrate-specific transport activity

Biochemical Pharmacology

Volumn 84, Issue 3, 2012, Pages 366-373

  Wittgen, Hanneke G M ^a   Van Den Heuvel, Jeroen J M W ^a   Krieger, Elmar ^a   Schaftenaar, Gijs ^a   Russel, Frans G M ^a   Koenderink, Jan B ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ATP binding cassette; Baculovirus; Membrane transport; MRP4; Mutagenesis

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ARGININE; CYCLIC GMP; ESTRADIOL 17 GLUCURONIDE; FOLIC ACID; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 4; PHENYLALANINE; PHENYLALANINE 368; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACULOVIRUS; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; EXPRESSION VECTOR; GAIN OF FUNCTION MUTATION; KINETICS; LOSS OF FUNCTION MUTATION; MEMBRANE VESICLE; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; DOWN-REGULATION; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHENYLALANINE; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; SUBSTRATE SPECIFICITY;

EID: 84861971438     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.04.012     Document Type: Article

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