Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel

Journal of Biological Chemistry

Volumn 289, Issue 41, 2014, Pages 28149-28159

  El Hiani, Yassine ^a   Linsdell, Paul ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; CHLORINE COMPOUNDS; ELECTROPHYSIOLOGY; ENZYME ACTIVITY;

CHLORIDE CHANNELS; CONFORMATIONAL CHANGE; CYSTEINE RESIDUES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; NUCLEOTIDE-BINDING DOMAIN; PATCH CLAMP RECORDING; RELATIVE ROTATION; TRANS-MEMBRANE DOMAINS;

BIOLOGICAL MEMBRANES;

ADENOSINE TRIPHOSPHATE; CADMIUM; CYSTEINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR PROTEIN, HUMAN; CHLORIDE; DIVALENT CATION; RECOMBINANT PROTEIN;

ALPHA HELIX; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HYDROLYSIS; NONHUMAN; PATCH CLAMP TECHNIQUE; PROTEIN STRUCTURE; PROTEIN TRANSPORT; TRANSMEMBRANE DOMAIN; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENE EXPRESSION; GENETICS; ION TRANSPORT; MEMBRANE POTENTIAL; METABOLISM; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CADMIUM; CATIONS, DIVALENT; CHLORIDES; CHO CELLS; CRICETULUS; CYSTEINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GENE EXPRESSION; ION CHANNEL GATING; ION TRANSPORT; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907610568     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.593103     Document Type: Article

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