Thermal instability of Δf508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: Protection by single suppressor mutations and inhibiting channel activity

Biochemistry

Volumn 51, Issue 25, 2012, Pages 5113-5124

  Liu, Xuehong ^a   O'Donnell, Nicolette ^a   Landstrom, Allison ^a   Skach, William R ^a   Dawson, David C ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE EFFECT; CHANNEL ACTIVITY; CHANNEL FUNCTIONS; CHLORIDE CHANNELS; CONFORMATIONAL DEFECTS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; INVERSE RELATIONSHIP; MAMMALIAN CELLS; MUTANT PROTEINS; PROTEIN MATURATION; ROOM TEMPERATURE; TEMPERATURE-SENSITIVE; THERAPEUTIC MODALITY; THERMAL INACTIVATION; THERMAL INSTABILITIES; THERMAL SENSITIVITY; XENOPUS OOCYTE;

CHLORINE COMPOUNDS; DEFECTS; PROTEINS;

THERMODYNAMIC STABILITY;

MUTANT PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; FEMALE; MEMBRANE CONDUCTANCE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STABILITY; ROOM TEMPERATURE; THERMOSTABILITY; XENOPUS LAEVIS;

ANIMALS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GENES, SUPPRESSOR; HOT TEMPERATURE; HUMANS; OOCYTES; PHENYLALANINE; POINT MUTATION; PROTEIN STABILITY; XENOPUS LAEVIS;

MAMMALIA;

EID: 84862874979     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300018e     Document Type: Article

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