Structures of ABCB10, a human ATP-binding cassette transporter in apo- And nucleotide-bound states

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 24, 2013, Pages 9710-9715

  Shintre, Chitra A ^a   Pike, Ashley C W ^a   Li, Qiuhong ^a,d   Kim, Jung In ^a,e   Barr, Alastair J ^a,f   Goubin, Solenne ^a   Shrestha, Leela ^a   Yang, Jing ^a   Berridge, Georgina ^a   Ross, Jonathan ^a   Stansfeld, Phillip J ^b   Sansom, Mark S P ^b   Edward, Aled M ^c   Bountra, Chas ^a   Marsden, Brian D ^a   Von Delft, Frank ^a   Bullock, Alex N ^a   Gileadi, Opher ^a   Burgess Brown, Nicola A ^a   Carpenter, Elisabeth P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF TORONTO   (Canada)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^e ETH ZURICH   (Switzerland)

^f UNIVERSITY OF WESTMINSTER   (United Kingdom)

Author keywords

Abc mitochondrial erythroid; Cardiolipin; Human membrane protein structure; Nucleotide complex; X ray crystallography

Indexed keywords

ABCB10 PROTEIN; ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; HOMODIMER; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE;

ABC MITOCHONDRIAL ERYTHROID; CARDIOLIPIN; HUMAN MEMBRANE PROTEIN STRUCTURE; NUCLEOTIDE COMPLEX; X-RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SF9 CELLS;

MAMMALIA;

EID: 84879002569     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217042110     Document Type: Article

References (38)

1. Locher KP (2009) Review. Structure and mechanism of ATP-binding cassette transporters. Philos Trans R Soc Lond B Biol Sci 364(1514):239-245.
2. Zolnerciks JK, Andress EJ, Nicolaou M, Linton KJ (2011) Structure of ABC transporters. Essays Biochem 50(1):43- 61.
3. Aittoniemi J, et al. (2009) Review. SUR1: A unique ATP-binding cassette protein that functions as an ion channel regulator. Philos Trans R Soc Lond B Biol Sci 364(1514):257-267.
4. Sheppard DN, Welsh MJ (1999) Structure and function of the CFTR chloride channel. Physiol Rev 79(1, Suppl):S23-S45. (Pubitemid 29058908)
5. Gottesman MM (2002) Mechanisms of cancer drug resistance. Annu Rev Med 53:615-627.
6. Dean M, Rzhetsky A, Allikmets R (2001) The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 11(7):1156-1166. (Pubitemid 32677289)
7. Rosenberg MF, et al. (2001) Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle. EMBO J 20(20):5615-5625. (Pubitemid 33010039)
8. Aller SG, et al. (2009) Structure of P-glycoprotein reveals a molecular basis for polyspecific drug binding. Science 323(5922):1718-1722.
9. Ward A, Reyes CL, Yu J, Roth CB, Chang G (2007) Flexibility in the ABC transporter MsbA: Alternating access with a twist. Proc Natl Acad Sci USA 104(48):19005-19010.
10. Jin MS, Oldham ML, Zhang Q, Chen J (2012) Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans. Nature 490(7421):566-569.
11. Dawson RJ, Locher KP (2006) Structure of a bacterial multidrug ABC transporter. Nature 443(7108):180-185. (Pubitemid 44387602)
12. Shirihai OS, Gregory T, Yu C, Orkin SH, Weiss MJ (2000) ABC-me: A novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J 19(11):2492- 2502.
13. Zhang F, et al. (2000) M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein. FEBS Lett 478(1-2):89-94. (Pubitemid 30462264)
14. Hyde BB, et al. (2012) The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ 19(7):1117-1126.
15. Liesa M, et al. (2011) Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation 124(7):806-813.
16. Chloupková M, LeBard LS, Koeller DM (2003) MDL1 is a high copy suppressor of ATM1: Evidence for a role in resistance to oxidative stress. J Mol Biol 331(1):155-165. (Pubitemid 36870783)
17. Chen W, et al. (2009) Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci USA 106(38):16263-16268.
18. Chen W, Dailey HA, Paw BH (2010) Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood 116(4):628-630.
19. Zutz A, Gompf S, Schägger H, Tampé R (2009) Mitochondrial ABC proteins in health and disease. Biochim Biophys Acta 1787(6):681-690.
20. Young L, Leonhard K, Tatsuta T, Trowsdale J, Langer T (2001) Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science 291(5511):2135-2138.
21. Hohl M, Briand C, Grütter MG, Seeger MA (2012) Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation. Nat Struct Mol Biol 19(4):395-402.
22. Haffke M, Menzel A, Carius Y, Jahn D, Heinz DW (2010) Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides. Acta Crystallogr D Biol Crystallogr 66(Pt 9):979-987.
23. Oldham ML, Chen J (2011) Crystal structure of the maltose transporter in a pre-translocation intermediate state. Science 332(6034):1202-1205.
24. Higgins CF, Linton KJ (2004) The ATP switch model for ABC transporters. Nat Struct Mol Biol 11(10):918-926.
25. Sauna ZE, Nandigama K, Ambudkar SV (2004) Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: Effect of transport substrates and characterization of the post-hydrolysis transition state. J Biol Chem 279(47):48855-48864.
26. Kuhnke G, Neumann K, Mühlenhoff U, Lill R (2006) Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds. Mol Membr Biol 23(2):173-184.
27. Herget M, et al. (2009) Purification and reconstitution of the antigen transport complex TAP: A prerequisite for determination of peptide stoichiometry and ATP hydrolysis. J Biol Chem 284(49):33740-33749.
28. Zehnpfennig B, Urbatsch IL, Galla HJ (2009) Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry 48(20):4423-4430.
29. Schölz C, et al. (2011) Specific lipids modulate the transporter associated with antigen processing (TAP). J Biol Chem 286(15):13346- 13356.
30. Modok S, Heyward C, Callaghan R (2004) P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment. J Lipid Res 45(10): 1910-1918.
31. Takahashi K, Kimura Y, Kioka N, Matsuo M, Ueda K (2006) Purification and ATPase activity of human ABCA1. J Biol Chem 281(16):10760-10768.
32. Tombline G, et al. (2004) Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues. J Biol Chem 279(45):46518-46526.
33. Zaitseva J, Jenewein S, Jumpertz T, Holland IB, Schmitt L (2005) H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB. EMBO J 24(11):1901-1910.
34. Abele R, Tampé R (2004) The ABCs of immunology: Structure and function of TAP, the transporter associated with antigen processing. Physiology (Bethesda) 19:216-224.
35. Callaghan R, Ford RC, Kerr ID (2006) The translocation mechanism of P-glycoprotein. FEBS Lett 580(4):1056-1063.
36. Al-Shawi MK (2011) Catalytic and transport cycles of ABC exporters. Essays Biochem 50(1):63-83.
37. Uebel S, et al. (1995) Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries. J Biol Chem 270(31):18512-18516.
38. Ashkenazy H, Erez E, Martz E, Pupko T, Ben-Tal N (2010) ConSurf 2010: Calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res 38(Web Server issue):W529-W533.