메뉴 건너뛰기




Volumn 6, Issue FEB, 2015, Pages

Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies

Author keywords

cannabinoid; G protein coupled receptors; Genetically modified mice; Opioid; Reward

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CRE RECOMBINASE; DELTA OPIATE RECEPTOR; ENDOCANNABINOID; G PROTEIN COUPLED RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; OPIATE;

EID: 84926479312     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00006     Document Type: Review
Times cited : (99)

References (189)
  • 1
    • 84884934084 scopus 로고    scopus 로고
    • Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice
    • Aaltonen, N., Riera Ribas, C., Lehtonen, M., Savinainen, J. R., and Laitinen, J. T. (2014). Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice. Eur. J. Pharm. Sci. 51, 87-95. doi: 10.1016/j.ejps.2013.08.035
    • (2014) Eur. J. Pharm. Sci. , vol.51 , pp. 87-95
    • Aaltonen, N.1    Riera Ribas, C.2    Lehtonen, M.3    Savinainen, J.R.4    Laitinen, J.T.5
  • 2
    • 34347342722 scopus 로고    scopus 로고
    • Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    • Agarwal, N., Pacher, P., Tegeder, I., Amaya, F., Constantin, C. E., Brenner, G. J.,et al. (2007). Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat. Neurosci. 10, 870-879. doi: 10.1038/nn1916
    • (2007) Nat. Neurosci. , vol.10 , pp. 870-879
    • Agarwal, N.1    Pacher, P.2    Tegeder, I.3    Amaya, F.4    Constantin, C.E.5    Brenner, G.J.6
  • 3
    • 44849141696 scopus 로고    scopus 로고
    • Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
    • Ahn, K., Mckinney, M. K., and Cravatt, B. F. (2008). Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem. Rev. 108, 1687-1707. doi: 10.1021/cr0782067
    • (2008) Chem. Rev. , vol.108 , pp. 1687-1707
    • Ahn, K.1    Mckinney, M.K.2    Cravatt, B.F.3
  • 4
    • 33745960208 scopus 로고    scopus 로고
    • Antinociceptive and hypothermic effects of salvinorin a are abolished in a novel strain of kappa-opioid receptor-1 knockout mice
    • Ansonoff, M. A., Zhang, J., Czyzyk, T., Rothman, R. B., Stewart, J., Xu, H.,et al. (2006). Antinociceptive and hypothermic effects of salvinorin a are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. J. Pharmacol. Exp. Ther. 318, 641-648. doi: 10.1124/jpet.106.101998
    • (2006) J. Pharmacol. Exp. Ther. , vol.318 , pp. 641-648
    • Ansonoff, M.A.1    Zhang, J.2    Czyzyk, T.3    Rothman, R.B.4    Stewart, J.5    Xu, H.6
  • 5
    • 84886668594 scopus 로고    scopus 로고
    • Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model
    • Belin, D., and Deroche-Gamonet, V. (2012). Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model. Cold Spring Harb. Perspect. Med. 2:a011940. doi: 10.1101/cshperspect.a011940.
    • (2012) Cold Spring Harb. Perspect. Med , vol.2
    • Belin, D.1    Deroche-Gamonet, V.2
  • 6
    • 77649185404 scopus 로고    scopus 로고
    • Bimodal control of stimulated food intake by the endocannabinoid system
    • Bellocchio, L., Lafenetre, P., Cannich, A., Cota, D., Puente, N., Grandes, P.,et al. (2010). Bimodal control of stimulated food intake by the endocannabinoid system. Nat. Neurosci. 13, 281-283. doi: 10.1038/nn.2494
    • (2010) Nat. Neurosci. , vol.13 , pp. 281-283
    • Bellocchio, L.1    Lafenetre, P.2    Cannich, A.3    Cota, D.4    Puente, N.5    Grandes, P.6
  • 7
    • 84875247295 scopus 로고    scopus 로고
    • Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB(1) receptor blockade
    • Bellocchio, L., Soria-Gomez, E., Quarta, C., Metna-Laurent, M., Cardinal, P., Binder, E.,et al. (2013). Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB(1) receptor blockade. Proc. Natl. Acad. Sci. U.S.A. 110, 4786-4791. doi: 10.1073/pnas.1218573110
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 4786-4791
    • Bellocchio, L.1    Soria-Gomez, E.2    Quarta, C.3    Metna-Laurent, M.4    Cardinal, P.5    Binder, E.6
  • 8
    • 1642422411 scopus 로고    scopus 로고
    • Cannabinoid receptor and WIN 55 212-2-stimulated [35S]-GTPgammaS binding in the brain of mu-, delta-, and kappa-opioid receptor knockout mice
    • Berrendero, F., Mendizabal, V., Murtra, P., Kieffer, B. L., and Maldonado, R. (2003). Cannabinoid receptor and WIN 55 212-2-stimulated [35S]-GTPgammaS binding in the brain of mu-, delta-, and kappa-opioid receptor knockout mice. Eur. J. Neurosci. 18, 2197-2202. doi: 10.1046/j.1460-9568.2003.02951.x
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 2197-2202
    • Berrendero, F.1    Mendizabal, V.2    Murtra, P.3    Kieffer, B.L.4    Maldonado, R.5
  • 9
    • 84908519175 scopus 로고    scopus 로고
    • Endogenous opiates and behavior: 2013
    • Bodnar, R. J. (2014). Endogenous opiates and behavior: 2013. Peptides 62C, 67-136. doi: 10.1016/j.peptides.2014.09.013
    • (2014) Peptides , vol.62 C , pp. 67-136
    • Bodnar, R.J.1
  • 10
    • 0033532375 scopus 로고    scopus 로고
    • Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice
    • Brady, L. S., Herkenham, M., Rothman, R. B., Partilla, J. S., Konig, M., Zimmer, A. M.,et al. (1999). Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice. Brain Res. Mol. Brain Res. 68, 193-197. doi: 10.1016/S0169-328X(99)00090-X
    • (1999) Brain Res. Mol. Brain Res. , vol.68 , pp. 193-197
    • Brady, L.S.1    Herkenham, M.2    Rothman, R.B.3    Partilla, J.S.4    Konig, M.5    Zimmer, A.M.6
  • 11
    • 0034685707 scopus 로고    scopus 로고
    • Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor
    • Buckley, N. E., Mccoy, K. L., Mezey, E., Bonner, T., Zimmer, A., Felder, C. C.,et al. (2000). Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur. J. Pharmacol. 396, 141-149. doi: 10.1016/S0014-2999(00)00211-9
    • (2000) Eur. J. Pharmacol. , vol.396 , pp. 141-149
    • Buckley, N.E.1    Mccoy, K.L.2    Mezey, E.3    Bonner, T.4    Zimmer, A.5    Felder, C.C.6
  • 12
    • 84871343938 scopus 로고    scopus 로고
    • Dimerization with cannabinoid receptors allosterically modulates delta opioid receptor activity during neuropathic pain
    • Bushlin, I., Gupta, A., Stockton, S. D. Jr., Miller, L. K., and Devi, L. A. (2012). Dimerization with cannabinoid receptors allosterically modulates delta opioid receptor activity during neuropathic pain. PLoS ONE 7:e49789. doi: 10.1371/journal.pone.0049789
    • (2012) PLoS ONE , vol.7
    • Bushlin, I.1    Gupta, A.2    Stockton, S.D.3    Miller, L.K.4    Devi, L.A.5
  • 13
    • 0037232392 scopus 로고    scopus 로고
    • Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice
    • Castane, A., Robledo, P., Matifas, A., Kieffer, B. L., and Maldonado, R. (2003). Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice. Eur. J. Neurosci. 17, 155-159. doi: 10.1046/j.1460-9568.2003.02409.x
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 155-159
    • Castane, A.1    Robledo, P.2    Matifas, A.3    Kieffer, B.L.4    Maldonado, R.5
  • 14
    • 78649924956 scopus 로고    scopus 로고
    • Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
    • Chanda, P. K., Gao, Y., Mark, L., Btesh, J., Strassle, B. W., Lu, P.,et al. (2010). Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol. Pharmacol. 78, 996-1003. doi: 10.1124/mol.110.068304
    • (2010) Mol. Pharmacol. , vol.78 , pp. 996-1003
    • Chanda, P.K.1    Gao, Y.2    Mark, L.3    Btesh, J.4    Strassle, B.W.5    Lu, P.6
  • 15
    • 84887071742 scopus 로고    scopus 로고
    • 15 years of genetic approaches in vivo for addiction research: opioid receptor and peptide gene knockout in mouse models of drug abuse
    • Charbogne, P., Kieffer, B. L., and Befort, K. (2014). 15 years of genetic approaches in vivo for addiction research: opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology 76(Pt B), 204-217. doi: 10.1016/j.neuropharm.2013.08.028
    • (2014) Neuropharmacology , vol.76 , pp. 204-217
    • Charbogne, P.1    Kieffer, B.L.2    Befort, K.3
  • 16
    • 84922559775 scopus 로고    scopus 로고
    • A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons
    • [Epub ahead of print].
    • Chu Sin Chung, P., Keyworth, H. L., Martin-Garcia, E., Charbogne, P., Darcq, E., Bailey, A.,et al. (2014). A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons. Biol. Psychiatry doi: 10.1016/j.biopsych.2014.07.033 [Epub ahead of print].
    • (2014) Biol. Psychiatry
    • Chu Sin Chung, P.1    Keyworth, H.L.2    Martin-Garcia, E.3    Charbogne, P.4    Darcq, E.5    Bailey, A.6
  • 17
    • 18744390307 scopus 로고    scopus 로고
    • Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice
    • Clarke, S., Czyzyk, T., Ansonoff, M., Nitsche, J. F., Hsu, M. S., Nilsson, L.,et al. (2002). Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice. Eur. J. Neurosci. 16, 1705-1712. doi: 10.1046/j.1460-9568.2002.02239.x
    • (2002) Eur. J. Neurosci. , vol.16 , pp. 1705-1712
    • Clarke, S.1    Czyzyk, T.2    Ansonoff, M.3    Nitsche, J.F.4    Hsu, M.S.5    Nilsson, L.6
  • 18
    • 0242403121 scopus 로고    scopus 로고
    • Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice
    • Clarke, S., Zimmer, A., Zimmer, A. M., Hill, R. G., and Kitchen, I. (2003). Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice. Neuroscience 122, 479-489. doi: 10.1016/j.neuroscience.2003.07.011
    • (2003) Neuroscience , vol.122 , pp. 479-489
    • Clarke, S.1    Zimmer, A.2    Zimmer, A.M.3    Hill, R.G.4    Kitchen, I.5
  • 19
    • 2942577559 scopus 로고    scopus 로고
    • Mu opioid receptor: a gateway to drug addiction
    • Contet, C., Kieffer, B. L., and Befort, K. (2004). Mu opioid receptor: a gateway to drug addiction. Curr. Opin. Neurobiol. 14, 370-378. doi: 10.1016/j.conb.2004.05.005
    • (2004) Curr. Opin. Neurobiol. , vol.14 , pp. 370-378
    • Contet, C.1    Kieffer, B.L.2    Befort, K.3
  • 20
    • 0035824948 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse
    • Cossu, G., Ledent, C., Fattore, L., Imperato, A., Bohme, G. A., Parmentier, M.,et al. (2001). Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse. Behav. Brain Res. 118, 61-65. doi: 10.1016/S0166-4328(00)00311-9
    • (2001) Behav. Brain Res. , vol.118 , pp. 61-65
    • Cossu, G.1    Ledent, C.2    Fattore, L.3    Imperato, A.4    Bohme, G.A.5    Parmentier, M.6
  • 21
    • 0035979244 scopus 로고    scopus 로고
    • Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
    • Cravatt, B. F., Demarest, K., Patricelli, M. P., Bracey, M. H., Giang, D. K., Martin, B. R.,et al. (2001). Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc. Natl. Acad. Sci. U.S.A. 98, 9371-9376. doi: 10.1073/pnas.161191698
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 9371-9376
    • Cravatt, B.F.1    Demarest, K.2    Patricelli, M.P.3    Bracey, M.H.4    Giang, D.K.5    Martin, B.R.6
  • 22
    • 0029904838 scopus 로고    scopus 로고
    • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
    • Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., and Gilula, N. B. (1996). Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384, 83-87. doi: 10.1038/384083a0
    • (1996) Nature , vol.384 , pp. 83-87
    • Cravatt, B.F.1    Giang, D.K.2    Mayfield, S.P.3    Boger, D.L.4    Lerner, R.A.5    Gilula, N.B.6
  • 24
    • 84893782140 scopus 로고    scopus 로고
    • Targeted expression of mu-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
    • Cui, Y., Ostlund, S. B., James, A. S., Park, C. S., Ge, W., Roberts, K. W.,et al. (2014). Targeted expression of mu-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. Nat. Neurosci. 17, 254-261. doi: 10.1038/nn.3622
    • (2014) Nat. Neurosci. , vol.17 , pp. 254-261
    • Cui, Y.1    Ostlund, S.B.2    James, A.S.3    Park, C.S.4    Ge, W.5    Roberts, K.W.6
  • 26
    • 84909951309 scopus 로고    scopus 로고
    • Endocannabinoid 2-arachidonoylglycerol self-administration by sprague-dawley rats and stimulation of in vivo dopamine transmission in the nucleus accumbens Shell
    • De Luca, M. A., Valentini, V., Bimpisidis, Z., Cacciapaglia, F., Caboni, P., and Di Chiara, G. (2014). Endocannabinoid 2-arachidonoylglycerol self-administration by sprague-dawley rats and stimulation of in vivo dopamine transmission in the nucleus accumbens Shell. Front. Psychiatry 5:140. doi: 10.3389/fpsyt.2014.00140
    • (2014) Front. Psychiatry , vol.5 , pp. 140
    • De Luca, M.A.1    Valentini, V.2    Bimpisidis, Z.3    Cacciapaglia, F.4    Caboni, P.5    Di Chiara, G.6
  • 27
    • 77249107540 scopus 로고    scopus 로고
    • Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels
    • De Petrocellis, L., and Di Marzo, V. (2010). Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. J. Neuroimmune Pharmacol. 5, 103-121. doi: 10.1007/s11481-009-9177-z
    • (2010) J. Neuroimmune Pharmacol. , vol.5 , pp. 103-121
    • De Petrocellis, L.1    Di Marzo, V.2
  • 28
    • 84907466163 scopus 로고    scopus 로고
    • CB2 cannabinoid receptors as a therapeutic target-what does the future hold?
    • Dhopeshwarkar, A., and Mackie, K. (2014). CB2 cannabinoid receptors as a therapeutic target-what does the future hold? Mol. Pharmacol. 86, 430-437. doi: 10.1124/mol.114.094649
    • (2014) Mol. Pharmacol. , vol.86 , pp. 430-437
    • Dhopeshwarkar, A.1    Mackie, K.2
  • 29
    • 0033769188 scopus 로고    scopus 로고
    • Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain
    • Di Marzo, V., Breivogel, C. S., Tao, Q., Bridgen, D. T., Razdan, R. K., Zimmer, A. M.,et al. (2000). Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain. J. Neurochem. 75, 2434-2444. doi: 10.1046/j.1471-4159.2000.0752434.x
    • (2000) J. Neurochem. , vol.75 , pp. 2434-2444
    • Di Marzo, V.1    Breivogel, C.S.2    Tao, Q.3    Bridgen, D.T.4    Razdan, R.K.5    Zimmer, A.M.6
  • 31
    • 84857125716 scopus 로고    scopus 로고
    • Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors
    • Dubreucq, S., Kambire, S., Conforzi, M., Metna-Laurent, M., Cannich, A., Soria-Gomez, E.,et al. (2012a). Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors. Neuroscience 204, 230-244. doi: 10.1016/j.neuroscience.2011.08.049
    • (2012) Neuroscience , vol.204 , pp. 230-244
    • Dubreucq, S.1    Kambire, S.2    Conforzi, M.3    Metna-Laurent, M.4    Cannich, A.5    Soria-Gomez, E.6
  • 32
    • 84862323196 scopus 로고    scopus 로고
    • Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice
    • Dubreucq, S., Matias, I., Cardinal, P., Haring, M., Lutz, B., Marsicano, G.,et al. (2012b). Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. Neuropsychopharmacology 37, 1885-1900. doi: 10.1038/npp.2012.36
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1885-1900
    • Dubreucq, S.1    Matias, I.2    Cardinal, P.3    Haring, M.4    Lutz, B.5    Marsicano, G.6
  • 33
    • 84895775893 scopus 로고    scopus 로고
    • A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks
    • [Epub ahead of print].
    • Erbs, E., Faget, L., Scherrer, G., Matifas, A., Filliol, D., Vonesch, J. L.,et al. (2014). A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct. Funct. doi: 10.1007/s00429-014-0717-9 [Epub ahead of print].
    • (2014) Brain Struct. Funct.
    • Erbs, E.1    Faget, L.2    Scherrer, G.3    Matifas, A.4    Filliol, D.5    Vonesch, J.L.6
  • 34
    • 0027050144 scopus 로고
    • Cloning of a delta opioid receptor by functional expression
    • Evans, C. J., Keith, D. E. Jr., Morrison, H., Magendzo, K., and Edwards, R. H. (1992). Cloning of a delta opioid receptor by functional expression. Science 258, 1952-1955. doi: 10.1126/science.1335167
    • (1992) Science , vol.258 , pp. 1952-1955
    • Evans, C.J.1    Keith, D.E.2    Morrison, H.3    Magendzo, K.4    Edwards, R.H.5
  • 35
    • 27644454882 scopus 로고    scopus 로고
    • Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
    • Everitt, B. J., and Robbins, T. W. (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8, 1481-1489. doi: 10.1038/nn1579
    • (2005) Nat. Neurosci. , vol.8 , pp. 1481-1489
    • Everitt, B.J.1    Robbins, T.W.2
  • 36
    • 0034941981 scopus 로고    scopus 로고
    • Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats
    • Fattore, L., Cossu, G., Martellotta, C. M., and Fratta, W. (2001). Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats. Psychopharmacology (Berl) 156, 410-416. doi: 10.1007/s002130100734
    • (2001) Psychopharmacology (Berl) , vol.156 , pp. 410-416
    • Fattore, L.1    Cossu, G.2    Martellotta, C.M.3    Fratta, W.4
  • 38
    • 84855507862 scopus 로고    scopus 로고
    • Beyond THC: the new generation of cannabinoid designer drugs
    • Fattore, L., and Fratta, W. (2011). Beyond THC: the new generation of cannabinoid designer drugs. Front. Behav. Neurosci. 5:60. doi: 10.3389/fnbeh.2011.00060
    • (2011) Front. Behav. Neurosci , vol.5 , pp. 60
    • Fattore, L.1    Fratta, W.2
  • 39
    • 77952170829 scopus 로고    scopus 로고
    • Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders
    • Fernandez-Ruiz, J., Hernandez, M., and Ramos, J. A. (2010). Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders. CNS Neurosci. Ther. 16, e72-e91. doi: 10.1111/j.1755-5949.2010.00144.x
    • (2010) CNS Neurosci. Ther. , vol.16 , pp. e72-e91
    • Fernandez-Ruiz, J.1    Hernandez, M.2    Ramos, J.A.3
  • 40
    • 77952640781 scopus 로고    scopus 로고
    • Adenosine-cannabinoid receptor interactions. Implications for striatal function
    • Ferre, S., Lluis, C., Justinova, Z., Quiroz, C., Orru, M., Navarro, G.,et al. (2010). Adenosine-cannabinoid receptor interactions. Implications for striatal function. Br. J. Pharmacol. 160, 443-453. doi: 10.1111/j.1476-5381.2010.00723.x
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 443-453
    • Ferre, S.1    Lluis, C.2    Justinova, Z.3    Quiroz, C.4    Orru, M.5    Navarro, G.6
  • 41
    • 84871802310 scopus 로고    scopus 로고
    • Grand opening of structure-guided design for novel opioids
    • Filizola, M., and Devi, L. A. (2014). Grand opening of structure-guided design for novel opioids. Trends Pharmacol. Sci. 34, 6-12. doi: 10.1016/j.tips.2012.10.002
    • (2014) Trends Pharmacol. Sci. , vol.34 , pp. 6-12
    • Filizola, M.1    Devi, L.A.2
  • 42
    • 16744364787 scopus 로고    scopus 로고
    • Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses
    • Filliol, D., Ghozland, S., Chluba, J., Martin, M., Matthes, H. W., Simonin, F.,et al. (2000). Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat. Genet. 25, 195-200. doi: 10.1038/76061
    • (2000) Nat. Genet. , vol.25 , pp. 195-200
    • Filliol, D.1    Ghozland, S.2    Chluba, J.3    Martin, M.4    Matthes, H.W.5    Simonin, F.6
  • 43
    • 84894411984 scopus 로고    scopus 로고
    • The hypocretin/orexin receptor-1 as a novel target to modulate cannabinoid reward
    • Flores, A., Maldonado, R., and Berrendero, F. (2014). The hypocretin/orexin receptor-1 as a novel target to modulate cannabinoid reward. Biol. Psychiatry 75, 499-507. doi: 10.1016/j.biopsych.2013.06.012
    • (2014) Biol. Psychiatry , vol.75 , pp. 499-507
    • Flores, A.1    Maldonado, R.2    Berrendero, F.3
  • 44
    • 84862664017 scopus 로고    scopus 로고
    • Utility of genetically modified mice for understanding the neurobiology of substance use disorders
    • Fowler, C. D., and Kenny, P. J. (2012). Utility of genetically modified mice for understanding the neurobiology of substance use disorders. Hum. Genet. 131, 941-957. doi: 10.1007/s00439-011-1129-z
    • (2012) Hum. Genet. , vol.131 , pp. 941-957
    • Fowler, C.D.1    Kenny, P.J.2
  • 45
    • 84881097633 scopus 로고    scopus 로고
    • Molecular mechanisms of cannabinoid addiction
    • Fratta, W., and Fattore, L. (2013). Molecular mechanisms of cannabinoid addiction. Curr. Opin. Neurobiol. 23, 487-492. doi: 10.1016/j.conb.2013.02.002
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 487-492
    • Fratta, W.1    Fattore, L.2
  • 46
    • 80054109238 scopus 로고    scopus 로고
    • Key questions of endocannabinoid signalling in the CNS: which, where and when?
    • Frazier, C. J. (2011). Key questions of endocannabinoid signalling in the CNS: which, where and when? J. Physiol. 589, 4807-4808. doi: 10.1113/jphysiol.2011.219493
    • (2011) J. Physiol. , vol.589 , pp. 4807-4808
    • Frazier, C.J.1
  • 47
    • 84906834240 scopus 로고    scopus 로고
    • Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10
    • Fujita, W., Gomes, I., and Devi, L. A. (2014). Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10. Br. J. Pharmacol. 171, 4155-4176. doi: 10.1111/bph.12798
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 4155-4176
    • Fujita, W.1    Gomes, I.2    Devi, L.A.3
  • 48
    • 84877820530 scopus 로고    scopus 로고
    • Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation
    • Gaffal, E., Cron, M., Glodde, N., Bald, T., Kuner, R., Zimmer, A.,et al. (2013). Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation. J. Immunol. 190, 4929-4936. doi: 10.4049/jimmunol.1201777
    • (2013) J. Immunol. , vol.190 , pp. 4929-4936
    • Gaffal, E.1    Cron, M.2    Glodde, N.3    Bald, T.4    Kuner, R.5    Zimmer, A.6
  • 49
    • 76649137560 scopus 로고    scopus 로고
    • Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice
    • Gao, Y., Vasilyev, D. V., Goncalves, M. B., Howell, F. V., Hobbs, C., Reisenberg, M.,et al. (2010). Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J. Neurosci. 30, 2017-2024. doi: 10.1523/JNEUROSCI.5693-09.2010
    • (2010) J. Neurosci. , vol.30 , pp. 2017-2024
    • Gao, Y.1    Vasilyev, D.V.2    Goncalves, M.B.3    Howell, F.V.4    Hobbs, C.5    Reisenberg, M.6
  • 50
    • 20444398090 scopus 로고    scopus 로고
    • Endocannabinoid signaling system and brain reward: emphasis on dopamine
    • Gardner, E. L. (2005). Endocannabinoid signaling system and brain reward: emphasis on dopamine. Pharmacol. Biochem. Behav. 81, 263-284. doi: 10.1016/j.pbb.2005.01.032
    • (2005) Pharmacol. Biochem. Behav. , vol.81 , pp. 263-284
    • Gardner, E.L.1
  • 51
    • 84884187234 scopus 로고    scopus 로고
    • Opiate-induced analgesia: contributions from mu, delta and kappa opioid receptors mouse mutants
    • Gaveriaux-Ruff, C. (2013). Opiate-induced analgesia: contributions from mu, delta and kappa opioid receptors mouse mutants. Curr. Pharm. Des 19, 7373-7381. doi: 10.2174/138161281942140105163727
    • (2013) Curr. Pharm. Des , vol.19 , pp. 7373-7381
    • Gaveriaux-Ruff, C.1
  • 52
    • 79956153093 scopus 로고    scopus 로고
    • Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia
    • Gaveriaux-Ruff, C., Nozaki, C., Nadal, X., Hever, X. C., Weibel, R., Matifas, A.,et al. (2011). Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain 152, 1238-1248. doi: 10.1016/j.pain.2010.12.031
    • (2011) Pain , vol.152 , pp. 1238-1248
    • Gaveriaux-Ruff, C.1    Nozaki, C.2    Nadal, X.3    Hever, X.C.4    Weibel, R.5    Matifas, A.6
  • 53
    • 44549088448 scopus 로고    scopus 로고
    • Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex
    • Gerald, T. M., Howlett, A. C., Ward, G. R., Ho, C., and Franklin, S. O. (2008). Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex. Psychopharmacology (Berl.) 198, 497-508. doi: 10.1007/s00213-008-1141-1148
    • (2008) Psychopharmacology (Berl.) , vol.198 , pp. 497-508
    • Gerald, T.M.1    Howlett, A.C.2    Ward, G.R.3    Ho, C.4    Franklin, S.O.5
  • 54
    • 33745403776 scopus 로고    scopus 로고
    • CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression
    • Gerald, T. M., Ward, G. R., Howlett, A. C., and Franklin, S. O. (2006). CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression. Brain Res. 1093, 20-24. doi: 10.1016/j.brainres.2006.03.088
    • (2006) Brain Res. , vol.1093 , pp. 20-24
    • Gerald, T.M.1    Ward, G.R.2    Howlett, A.C.3    Franklin, S.O.4
  • 55
    • 0036470141 scopus 로고    scopus 로고
    • Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors
    • Ghozland, S., Matthes, H. W., Simonin, F., Filliol, D., Kieffer, B. L., and Maldonado, R. (2002). Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. J. Neurosci. 22, 1146-1154.
    • (2002) J. Neurosci. , vol.22 , pp. 1146-1154
    • Ghozland, S.1    Matthes, H.W.2    Simonin, F.3    Filliol, D.4    Kieffer, B.L.5    Maldonado, R.6
  • 56
    • 32844465920 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors: immunohistochemical localization in rat brain
    • Gong, J. P., Onaivi, E. S., Ishiguro, H., Liu, Q. R., Tagliaferro, P. A., Brusco, A.,et al. (2006). Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res. 1071, 10-23. doi: 10.1016/j.brainres.2005.11.035
    • (2006) Brain Res. , vol.1071 , pp. 10-23
    • Gong, J.P.1    Onaivi, E.S.2    Ishiguro, H.3    Liu, Q.R.4    Tagliaferro, P.A.5    Brusco, A.6
  • 57
    • 0037178644 scopus 로고    scopus 로고
    • Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice
    • Goody, R. J., Oakley, S. M., Filliol, D., Kieffer, B. L., and Kitchen, I. (2002). Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice. Brain Res. 945, 9-19. doi: 10.1016/S0006-8993(02)02452-6
    • (2002) Brain Res. , vol.945 , pp. 9-19
    • Goody, R.J.1    Oakley, S.M.2    Filliol, D.3    Kieffer, B.L.4    Kitchen, I.5
  • 59
    • 84936142874 scopus 로고    scopus 로고
    • Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice
    • Gutierrez-Cuesta, J., Burokas, A., Mancino, S., Kummer, S., Martin-Garcia, E., and Maldonado, R. (2014). Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice. Neuropsychopharmacology. doi: 10.1038/npp.2014.149
    • (2014) Neuropsychopharmacology.
    • Gutierrez-Cuesta, J.1    Burokas, A.2    Mancino, S.3    Kummer, S.4    Martin-Garcia, E.5    Maldonado, R.6
  • 60
    • 84863244650 scopus 로고    scopus 로고
    • Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD
    • Han, J., Kesner, P., Metna-Laurent, M., Duan, T., Xu, L., Georges, F.,et al. (2012). Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell 148, 1039-1050. doi: 10.1016/j.cell.2012.01.037
    • (2012) Cell , vol.148 , pp. 1039-1050
    • Han, J.1    Kesner, P.2    Metna-Laurent, M.3    Duan, T.4    Xu, L.5    Georges, F.6
  • 61
    • 0034644827 scopus 로고    scopus 로고
    • Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
    • Hough, L. B., Nalwalk, J. W., Chen, Y., Schuller, A., Zhu, Y., Zhang, J.,et al. (2000). Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice. Brain Res. 880, 102-108. doi: 10.1016/S0006-8993(00)02776-1
    • (2000) Brain Res. , vol.880 , pp. 102-108
    • Hough, L.B.1    Nalwalk, J.W.2    Chen, Y.3    Schuller, A.4    Zhu, Y.5    Zhang, J.6
  • 62
    • 84885406191 scopus 로고    scopus 로고
    • The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice
    • Ignatowska-Jankowska, B. M., Muldoon, P. P., Lichtman, A. H., and Damaj, M. I. (2013). The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. Psychopharmacology (Berl) 229, 591-601. doi: 10.1007/s00213-013-3117-6
    • (2013) Psychopharmacology (Berl) , vol.229 , pp. 591-601
    • Ignatowska-Jankowska, B.M.1    Muldoon, P.P.2    Lichtman, A.H.3    Damaj, M.I.4
  • 63
    • 0038845604 scopus 로고    scopus 로고
    • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    • Jarai, Z., Wagner, J. A., Varga, K., Lake, K. D., Compton, D. R., Martin, B. R.,et al. (1999). Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc. Natl. Acad. Sci. U.S.A. 96, 14136-14141. doi: 10.1073/pnas.96.24.14136
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 14136-14141
    • Jarai, Z.1    Wagner, J.A.2    Varga, K.3    Lake, K.D.4    Compton, D.R.5    Martin, B.R.6
  • 64
    • 38649114788 scopus 로고    scopus 로고
    • Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    • Jeong, W. I., Osei-Hyiaman, D., Park, O., Liu, J., Batkai, S., Mukhopadhyay, P.,et al. (2008). Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab. 7, 227-235. doi: 10.1016/j.cmet.2007.12.007
    • (2008) Cell Metab. , vol.7 , pp. 227-235
    • Jeong, W.I.1    Osei-Hyiaman, D.2    Park, O.3    Liu, J.4    Batkai, S.5    Mukhopadhyay, P.6
  • 65
    • 0029417155 scopus 로고
    • Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides
    • Kieffer, B. L. (1995). Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides. Cell Mol. Neurobiol. 15, 615-635. doi: 10.1007/BF02071128
    • (1995) Cell Mol. Neurobiol. , vol.15 , pp. 615-635
    • Kieffer, B.L.1
  • 66
    • 0027052952 scopus 로고
    • The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization
    • Kieffer, B. L., Befort, K., Gaveriaux-Ruff, C., and Hirth, C. G. (1992). The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc. Natl. Acad. Sci. U.S.A. 89, 12048-12052. doi: 10.1073/pnas.89.24.12048
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 12048-12052
    • Kieffer, B.L.1    Befort, K.2    Gaveriaux-Ruff, C.3    Hirth, C.G.4
  • 67
    • 0036095186 scopus 로고    scopus 로고
    • Exploring the opioid system by gene knockout
    • Kieffer, B. L., and Gaveriaux-Ruff, C. (2002). Exploring the opioid system by gene knockout. Prog. Neurobiol. 66, 285-306. doi: 10.1016/S0301-0082(02)00008-4
    • (2002) Prog. Neurobiol. , vol.66 , pp. 285-306
    • Kieffer, B.L.1    Gaveriaux-Ruff, C.2
  • 68
    • 0031555309 scopus 로고    scopus 로고
    • Quantitative autoradiographic mapping of mu-, delta-, and kappa-opioid receptors in knockout mice lacking the mu-opioid receptor gene
    • Kitchen, I., Slowe, S. J., Matthes, H. W., and Kieffer, B. (1997). Quantitative autoradiographic mapping of mu-, delta-, and kappa-opioid receptors in knockout mice lacking the mu-opioid receptor gene. Brain Res. 778, 73-88. doi: 10.1016/S0006-8993(97)00988-8
    • (1997) Brain Res. , vol.778 , pp. 73-88
    • Kitchen, I.1    Slowe, S.J.2    Matthes, H.W.3    Kieffer, B.4
  • 69
    • 0029957953 scopus 로고    scopus 로고
    • Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin
    • Konig, M., Zimmer, A. M., Steiner, H., Holmes, P. V., Crawley, J. N., Brownstein, M. J.,et al. (1996). Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature 383, 535-538. doi: 10.1038/383535a0
    • (1996) Nature , vol.383 , pp. 535-538
    • Konig, M.1    Zimmer, A.M.2    Steiner, H.3    Holmes, P.V.4    Crawley, J.N.5    Brownstein, M.J.6
  • 70
    • 58049147045 scopus 로고    scopus 로고
    • Neurobiological substrates for the dark side of compulsivity in addiction
    • Koob, G. F. (2009). Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology 56(Suppl. 1), 18-31. doi: 10.1016/j.neuropharm.2008.07.043
    • (2009) Neuropharmacology , vol.56 , pp. 18-31
    • Koob, G.F.1
  • 71
    • 72049098472 scopus 로고    scopus 로고
    • Neurocircuitry of addiction
    • Koob, G. F., and Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology 35, 217-238. doi: 10.1038/npp.2009.110
    • (2010) Neuropsychopharmacology , vol.35 , pp. 217-238
    • Koob, G.F.1    Volkow, N.D.2
  • 72
    • 84867164588 scopus 로고    scopus 로고
    • Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics
    • Kreek, M. J., Levran, O., Reed, B., Schlussman, S. D., Zhou, Y., and Butelman, E. R. (2012). Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. J. Clin. Invest. 122, 3387-3393. doi: 10.1172/JCI60390
    • (2012) J. Clin. Invest. , vol.122 , pp. 3387-3393
    • Kreek, M.J.1    Levran, O.2    Reed, B.3    Schlussman, S.D.4    Zhou, Y.5    Butelman, E.R.6
  • 73
    • 70349682196 scopus 로고    scopus 로고
    • Reward processing by the opioid system in the brain
    • Le Merrer, J., Becker, J. A., Befort, K., and Kieffer, B. L. (2009). Reward processing by the opioid system in the brain. Physiol. Rev. 89, 1379-1412. doi: 10.1152/physrev.00005.2009
    • (2009) Physiol. Rev. , vol.89 , pp. 1379-1412
    • Le Merrer, J.1    Becker, J.A.2    Befort, K.3    Kieffer, B.L.4
  • 74
    • 84880174862 scopus 로고    scopus 로고
    • Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance
    • Le Naour, M., Akgun, E., Yekkirala, A., Lunzer, M. M., Powers, M. D., Kalyuzhny, A. E.,et al. (2013). Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance. J. Med. Chem. 56, 5505-5513. doi: 10.1021/jm4005219
    • (2013) J. Med. Chem. , vol.56 , pp. 5505-5513
    • Le Naour, M.1    Akgun, E.2    Yekkirala, A.3    Lunzer, M.M.4    Powers, M.D.5    Kalyuzhny, A.E.6
  • 75
    • 0033555839 scopus 로고    scopus 로고
    • Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
    • Ledent, C., Valverde, O., Cossu, G., Petitet, F., Aubert, J. F., Beslot, F.,et al. (1999). Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283, 401-404. doi: 10.1126/science.283.5400.401
    • (1999) Science , vol.283 , pp. 401-404
    • Ledent, C.1    Valverde, O.2    Cossu, G.3    Petitet, F.4    Aubert, J.F.5    Beslot, F.6
  • 76
    • 0030816449 scopus 로고    scopus 로고
    • Addiction is a brain disease, and it matters
    • Leshner, A. I. (1997). Addiction is a brain disease, and it matters. Science 278, 45-47. doi: 10.1126/science.278.5335.45
    • (1997) Science , vol.278 , pp. 45-47
    • Leshner, A.I.1
  • 77
    • 33645935391 scopus 로고    scopus 로고
    • Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids
    • Leung, D., Saghatelian, A., Simon, G. M., and Cravatt, B. F. (2006). Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry 45, 4720-4726. doi: 10.1021/bi060163l
    • (2006) Biochemistry , vol.45 , pp. 4720-4726
    • Leung, D.1    Saghatelian, A.2    Simon, G.M.3    Cravatt, B.F.4
  • 78
    • 0034893982 scopus 로고    scopus 로고
    • Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice
    • Lichtman, A. H., Sheikh, S. M., Loh, H. H., and Martin, B. R. (2001). Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice. J. Pharmacol. Exp. Ther. 298, 1007-1014.
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 1007-1014
    • Lichtman, A.H.1    Sheikh, S.M.2    Loh, H.H.3    Martin, B.R.4
  • 79
    • 37349020974 scopus 로고    scopus 로고
    • Multiple pathways involved in the biosynthesis of anandamide
    • Liu, J., Wang, L., Harvey-White, J., Huang, B. X., Kim, H. Y., Luquet, S.,et al. (2008). Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology 54, 1-7. doi: 10.1016/j.neuropharm.2007.05.020
    • (2008) Neuropharmacology , vol.54 , pp. 1-7
    • Liu, J.1    Wang, L.2    Harvey-White, J.3    Huang, B.X.4    Kim, H.Y.5    Luquet, S.6
  • 80
    • 34249730845 scopus 로고    scopus 로고
    • Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors
    • Loacker, S., Sayyah, M., Wittmann, W., Herzog, H., and Schwarzer, C. (2007). Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors. Brain 130, 1017-1028. doi: 10.1093/brain/awl384
    • (2007) Brain , vol.130 , pp. 1017-1028
    • Loacker, S.1    Sayyah, M.2    Wittmann, W.3    Herzog, H.4    Schwarzer, C.5
  • 81
    • 0032031040 scopus 로고    scopus 로고
    • mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality
    • Loh, H. H., Liu, H. C., Cavalli, A., Yang, W., Chen, Y. F., and Wei, L. N. (1998). mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res. Mol. Brain Res. 54, 321-326. doi: 10.1016/S0169-328X(97)00353-7
    • (1998) Brain Res. Mol. Brain Res. , vol.54 , pp. 321-326
    • Loh, H.H.1    Liu, H.C.2    Cavalli, A.3    Yang, W.4    Chen, Y.F.5    Wei, L.N.6
  • 82
    • 77950814617 scopus 로고    scopus 로고
    • Functional interactions between endogenous cannabinoid and opioid systems: focus on alcohol, genetics and drug-addicted behaviors
    • Lopez-Moreno, J. A., Lopez-Jimenez, A., Gorriti, M. A., and De Fonseca, F. R. (2010). Functional interactions between endogenous cannabinoid and opioid systems: focus on alcohol, genetics and drug-addicted behaviors. Curr. Drug Targets 11, 406-428. doi: 10.2174/138945010790980312
    • (2010) Curr. Drug Targets , vol.11 , pp. 406-428
    • Lopez-Moreno, J.A.1    Lopez-Jimenez, A.2    Gorriti, M.A.3    De Fonseca, F.R.4
  • 83
    • 84930888521 scopus 로고    scopus 로고
    • Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence
    • Lutz, P. E., Ayranci, G., Chu-Sin-Chung, P., Matifas, A., Koebel, P., Filliol, D.,et al. (2014). Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence. Neuropsychopharmacology 39, 2694-2705. doi: 10.1038/npp.2014.126
    • (2014) Neuropsychopharmacology , vol.39 , pp. 2694-2705
    • Lutz, P.E.1    Ayranci, G.2    Chu-Sin-Chung, P.3    Matifas, A.4    Koebel, P.5    Filliol, D.6
  • 84
    • 84881022559 scopus 로고    scopus 로고
    • The multiple facets of opioid receptor function: implications for addiction
    • Lutz, P. E., and Kieffer, B. L. (2013a). The multiple facets of opioid receptor function: implications for addiction. Curr. Opin. Neurobiol. 23, 473-479. doi: 10.1016/j.conb.2013.02.005
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 473-479
    • Lutz, P.E.1    Kieffer, B.L.2
  • 85
    • 84875273292 scopus 로고    scopus 로고
    • Opioid receptors: distinct roles in mood disorders
    • Lutz, P. E., and Kieffer, B. L. (2013b). Opioid receptors: distinct roles in mood disorders. Trends Neurosci. 36, 195-206. doi: 10.1016/j.tins.2012.11.002
    • (2013) Trends Neurosci. , vol.36 , pp. 195-206
    • Lutz, P.E.1    Kieffer, B.L.2
  • 86
    • 0034924282 scopus 로고    scopus 로고
    • Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages
    • Maccarrone, M., Attina, M., Bari, M., Cartoni, A., Ledent, C., and Finazzi-Agro, A. (2001). Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages. J. Neurochem. 78, 339-348. doi: 10.1046/j.1471-4159.2001.00413.x
    • (2001) J. Neurochem. , vol.78 , pp. 339-348
    • Maccarrone, M.1    Attina, M.2    Bari, M.3    Cartoni, A.4    Ledent, C.5    Finazzi-Agro, A.6
  • 87
    • 18744396333 scopus 로고    scopus 로고
    • Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour
    • Maccarrone, M., Valverde, O., Barbaccia, M. L., Castane, A., Maldonado, R., Ledent, C.,et al. (2002). Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. Eur. J. Neurosci. 15, 1178-1186. doi: 10.1046/j.1460-9568.2002.01957.x
    • (2002) Eur. J. Neurosci. , vol.15 , pp. 1178-1186
    • Maccarrone, M.1    Valverde, O.2    Barbaccia, M.L.3    Castane, A.4    Maldonado, R.5    Ledent, C.6
  • 88
    • 33645774927 scopus 로고    scopus 로고
    • Distribution of cannabinoid receptors in the central and peripheral nervous system
    • Mackie, K. (2005). Distribution of cannabinoid receptors in the central and peripheral nervous system. Handb. Exp. Pharmacol. 299-325.
    • (2005) Handb. Exp. Pharmacol , pp. 299-325
    • Mackie, K.1
  • 89
    • 42349116262 scopus 로고    scopus 로고
    • Cannabinoid receptors: where they are and what they do
    • Mackie, K. (2008). Cannabinoid receptors: where they are and what they do. J. Neuroendocrinol. 20(Suppl. 1), 10-14. doi: 10.1111/j.1365-2826.2008.01671.x
    • (2008) J. Neuroendocrinol. , vol.20 , pp. 10-14
    • Mackie, K.1
  • 90
    • 0036669501 scopus 로고    scopus 로고
    • Study of cannabinoid dependence in animals
    • Maldonado, R. (2002). Study of cannabinoid dependence in animals. Pharmacol. Ther. 95, 153-164. doi: 10.1016/S0163-7258(02)00254-1
    • (2002) Pharmacol. Ther. , vol.95 , pp. 153-164
    • Maldonado, R.1
  • 91
    • 79953675661 scopus 로고    scopus 로고
    • Neurochemical basis of cannabis addiction
    • Maldonado, R., Berrendero, F., Ozaita, A., and Robledo, P. (2011). Neurochemical basis of cannabis addiction. Neuroscience 181, 1-17. doi: 10.1016/j.neuroscience.2011.02.035
    • (2011) Neuroscience , vol.181 , pp. 1-17
    • Maldonado, R.1    Berrendero, F.2    Ozaita, A.3    Robledo, P.4
  • 92
    • 0029764770 scopus 로고    scopus 로고
    • Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB
    • Maldonado, R., Blendy, J. A., Tzavara, E., Gass, P., Roques, B. P., Hanoune, J.,et al. (1996). Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science 273, 657-659. doi: 10.1126/science.273.5275.657
    • (1996) Science , vol.273 , pp. 657-659
    • Maldonado, R.1    Blendy, J.A.2    Tzavara, E.3    Gass, P.4    Roques, B.P.5    Hanoune, J.6
  • 93
    • 84881027576 scopus 로고    scopus 로고
    • Endocannabinoid system and drug addiction: new insights from mutant mice approaches
    • Maldonado, R., Robledo, P., and Berrendero, F. (2013). Endocannabinoid system and drug addiction: new insights from mutant mice approaches. Curr. Opin. Neurobiol. 23, 480-486. doi: 10.1016/j.conb.2013.02.004
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 480-486
    • Maldonado, R.1    Robledo, P.2    Berrendero, F.3
  • 94
    • 33645982868 scopus 로고    scopus 로고
    • Involvement of the endocannabinoid system in drug addiction
    • Maldonado, R., Valverde, O., and Berrendero, F. (2006). Involvement of the endocannabinoid system in drug addiction. Trends Neurosci. 29, 225-232. doi: 10.1016/j.tins.2006.01.008
    • (2006) Trends Neurosci. , vol.29 , pp. 225-232
    • Maldonado, R.1    Valverde, O.2    Berrendero, F.3
  • 95
    • 0028887626 scopus 로고
    • Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
    • Mansour, A., Fox, C. A., Akil, H., and Watson, S. J. (1995). Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 18, 22-29. doi: 10.1016/0166-2236(95)93946-U
    • (1995) Trends Neurosci. , vol.18 , pp. 22-29
    • Mansour, A.1    Fox, C.A.2    Akil, H.3    Watson, S.J.4
  • 97
    • 34147165471 scopus 로고    scopus 로고
    • Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
    • Maresz, K., Pryce, G., Ponomarev, E. D., Marsicano, G., Croxford, J. L., Shriver, L. P.,et al. (2007). Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat. Med. 13, 492-497. doi: 10.1038/nm1561
    • (2007) Nat. Med. , vol.13 , pp. 492-497
    • Maresz, K.1    Pryce, G.2    Ponomarev, E.D.3    Marsicano, G.4    Croxford, J.L.5    Shriver, L.P.6
  • 98
    • 0141865717 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    • Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A.,et al. (2003). CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302, 84-88. doi: 10.1126/science.1088208
    • (2003) Science , vol.302 , pp. 84-88
    • Marsicano, G.1    Goodenough, S.2    Monory, K.3    Hermann, H.4    Eder, M.5    Cannich, A.6
  • 99
    • 0036682222 scopus 로고    scopus 로고
    • The endogenous cannabinoid system controls extinction of aversive memories
    • Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G.,et al. (2002). The endogenous cannabinoid system controls extinction of aversive memories. Nature 418, 530-534. doi: 10.1038/nature00839
    • (2002) Nature , vol.418 , pp. 530-534
    • Marsicano, G.1    Wotjak, C.T.2    Azad, S.C.3    Bisogno, T.4    Rammes, G.5    Cascio, M.G.6
  • 100
    • 0032495834 scopus 로고    scopus 로고
    • Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice
    • Martellotta, M. C., Cossu, G., Fattore, L., Gessa, G. L., and Fratta, W. (1998). Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice. Neuroscience 85, 327-330. doi: 10.1016/S0306-4522(98)00052-9
    • (1998) Neuroscience , vol.85 , pp. 327-330
    • Martellotta, M.C.1    Cossu, G.2    Fattore, L.3    Gessa, G.L.4    Fratta, W.5
  • 101
    • 0033777338 scopus 로고    scopus 로고
    • Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice
    • Martin, M., Ledent, C., Parmentier, M., Maldonado, R., and Valverde, O. (2000). Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice. Eur. J. Neurosci. 12, 4038-4046. doi: 10.1046/j.1460-9568.2000.00287.x
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 4038-4046
    • Martin, M.1    Ledent, C.2    Parmentier, M.3    Maldonado, R.4    Valverde, O.5
  • 102
    • 0032786408 scopus 로고    scopus 로고
    • Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice
    • Mascia, M. S., Obinu, M. C., Ledent, C., Parmentier, M., Bohme, G. A., Imperato, A.,et al. (1999). Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice. Eur. J. Pharmacol 383, R1-R2. doi: 10.1016/S0014-2999(99)00656-1
    • (1999) Eur. J. Pharmacol , vol.383 , pp. R1-R2
    • Mascia, M.S.1    Obinu, M.C.2    Ledent, C.3    Parmentier, M.4    Bohme, G.A.5    Imperato, A.6
  • 103
    • 84920169231 scopus 로고    scopus 로고
    • In vivo opioid receptor heteromerization: where do we stand?
    • Massotte, D. (2014). In vivo opioid receptor heteromerization: where do we stand? Br. J. Pharmacol. 172, 420-434. doi: 10.1111/bph.12702
    • (2014) Br. J. Pharmacol. , vol.172 , pp. 420-434
    • Massotte, D.1
  • 104
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., and Bonner, T. I. (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564. doi: 10.1038/346561a0
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 105
    • 0029852678 scopus 로고    scopus 로고
    • Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene
    • Matthes, H. W., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I.,et al. (1996). Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 383, 819-823. doi: 10.1038/383819a0
    • (1996) Nature , vol.383 , pp. 819-823
    • Matthes, H.W.1    Maldonado, R.2    Simonin, F.3    Valverde, O.4    Slowe, S.5    Kitchen, I.6
  • 106
    • 33747333091 scopus 로고    scopus 로고
    • Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice
    • Mendizabal, V., Zimmer, A., and Maldonado, R. (2006). Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice. Neuropsychopharmacology 31, 1957-1966. doi: 10.1038/sj.npp.1300957
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1957-1966
    • Mendizabal, V.1    Zimmer, A.2    Maldonado, R.3
  • 107
    • 0028952242 scopus 로고
    • The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C
    • Mestek, A., Hurley, J. H., Bye, L. S., Campbell, A. D., Chen, Y., Tian, M.,et al. (1995). The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C. J. Neurosci. 15, 2396-2406.
    • (1995) J. Neurosci. , vol.15 , pp. 2396-2406
    • Mestek, A.1    Hurley, J.H.2    Bye, L.S.3    Campbell, A.D.4    Chen, Y.5    Tian, M.6
  • 108
    • 77957374840 scopus 로고    scopus 로고
    • Lack of a rewarding effect and a locomotor-enhancing effect of the selective mu-opioid receptor agonist amidino-TAPA
    • Mizoguchi, H., Watanabe, C., Osada, S., Yoshioka, M., Aoki, Y., Natsui, S.,et al. (2010). Lack of a rewarding effect and a locomotor-enhancing effect of the selective mu-opioid receptor agonist amidino-TAPA. Psychopharmacology (Berl) 212, 215-225. doi: 10.1007/s00213-010-1946-0
    • (2010) Psychopharmacology (Berl) , vol.212 , pp. 215-225
    • Mizoguchi, H.1    Watanabe, C.2    Osada, S.3    Yoshioka, M.4    Aoki, Y.5    Natsui, S.6
  • 109
    • 35649000942 scopus 로고    scopus 로고
    • Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice
    • Monory, K., Blaudzun, H., Massa, F., Kaiser, N., Lemberger, T., Schutz, G.,et al. (2007). Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS Biol. 5:e269. doi: 10.1371/journal.pbio.0050269
    • (2007) PLoS Biol , vol.5
    • Monory, K.1    Blaudzun, H.2    Massa, F.3    Kaiser, N.4    Lemberger, T.5    Schutz, G.6
  • 110
    • 33746913292 scopus 로고    scopus 로고
    • The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    • Monory, K., Massa, F., Egertova, M., Eder, M., Blaudzun, H., Westenbroek, R.,et al. (2006). The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51, 455-466. doi: 10.1016/j.neuron.2006.07.006
    • (2006) Neuron , vol.51 , pp. 455-466
    • Monory, K.1    Massa, F.2    Egertova, M.3    Eder, M.4    Blaudzun, H.5    Westenbroek, R.6
  • 111
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro, S., Thomas, K. L., and Abu-Shaar, M. (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365, 61-65. doi: 10.1038/365061a0
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 112
    • 84892541489 scopus 로고    scopus 로고
    • Involvement of the opioid and cannabinoid systems in pain control: new insights from knockout studies
    • Nadal, X., La Porta, C., Andreea Bura, S., and Maldonado, R. (2013). Involvement of the opioid and cannabinoid systems in pain control: new insights from knockout studies. Eur. J. Pharmacol. 716, 142-157. doi: 10.1016/j.ejphar.2013.01.077
    • (2013) Eur. J. Pharmacol. , vol.716 , pp. 142-157
    • Nadal, X.1    La Porta, C.2    Andreea Bura, S.3    Maldonado, R.4
  • 114
    • 84887080253 scopus 로고    scopus 로고
    • Epigenetic mechanisms of drug addiction
    • Nestler, E. J. (2014). Epigenetic mechanisms of drug addiction. Neuropharmacology 76 Pt B, 259-268. doi: 10.1016/j.neuropharm.2013.04.004
    • (2014) Neuropharmacology , vol.76 , pp. 259-268
    • Nestler, E.J.1
  • 115
    • 39149103043 scopus 로고    scopus 로고
    • Implication of endogenous beta-endorphin in the inhibition of the morphine-induced rewarding effect by the direct activation of spinal protein kinase C in mice
    • Niikura, K., Narita, M., Okutsu, D., Tsurukawa, Y., Nanjo, K., Kurahashi, K.,et al. (2008). Implication of endogenous beta-endorphin in the inhibition of the morphine-induced rewarding effect by the direct activation of spinal protein kinase C in mice. Neurosci. Lett. 433, 54-58. doi: 10.1016/j.neulet.2007.12.042
    • (2008) Neurosci. Lett. , vol.433 , pp. 54-58
    • Niikura, K.1    Narita, M.2    Okutsu, D.3    Tsurukawa, Y.4    Nanjo, K.5    Kurahashi, K.6
  • 117
    • 12244297090 scopus 로고    scopus 로고
    • G-protein coupling of delta-opioid receptors in brains of mu-opioid receptor knockout mice
    • Oakley, S. M., Toth, G., Borsodi, A., Kieffer, B. L., and Kitchen, I. (2003). G-protein coupling of delta-opioid receptors in brains of mu-opioid receptor knockout mice. Eur. J. Pharmacol. 466, 91-98. doi: 10.1016/S0014-2999(03)01531-0
    • (2003) Eur. J. Pharmacol. , vol.466 , pp. 91-98
    • Oakley, S.M.1    Toth, G.2    Borsodi, A.3    Kieffer, B.L.4    Kitchen, I.5
  • 118
    • 84898872648 scopus 로고    scopus 로고
    • Endocannabinoid-mediated retrograde modulation of synaptic transmission
    • Ohno-Shosaku, T., and Kano, M. (2014). Endocannabinoid-mediated retrograde modulation of synaptic transmission. Curr. Opin. Neurobiol. 29C, 1-8. doi: 10.1016/j.conb.2014.03.017
    • (2014) Curr. Opin. Neurobiol , vol.29 C , pp. 1-8
    • Ohno-Shosaku, T.1    Kano, M.2
  • 119
    • 33749544716 scopus 로고    scopus 로고
    • Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain
    • Onaivi, E. S., Ishiguro, H., Gong, J. P., Patel, S., Perchuk, A., Meozzi, P. A.,et al. (2006). Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann. N. Y. Acad. Sci. 1074, 514-536. doi: 10.1196/annals.1369.052
    • (2006) Ann. N. Y. Acad. Sci. , vol.1074 , pp. 514-536
    • Onaivi, E.S.1    Ishiguro, H.2    Gong, J.P.3    Patel, S.4    Perchuk, A.5    Meozzi, P.A.6
  • 121
    • 63849228557 scopus 로고    scopus 로고
    • Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
    • Pan, Y. X., Xu, J., Xu, M., Rossi, G. C., Matulonis, J. E., and Pasternak, G. W. (2009). Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proc. Natl. Acad. Sci. U.S.A. 106, 4917-4922. doi: 10.1073/pnas.0811586106
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 4917-4922
    • Pan, Y.X.1    Xu, J.2    Xu, M.3    Rossi, G.C.4    Matulonis, J.E.5    Pasternak, G.W.6
  • 122
    • 84922470163 scopus 로고    scopus 로고
    • Cannabinoid regulation of brain reward processing with an emphasis on the role of CB1 receptors: a step back into the future
    • Panagis, G., Mackey, B., and Vlachou, S. (2014). Cannabinoid regulation of brain reward processing with an emphasis on the role of CB1 receptors: a step back into the future. Front. Psychiatry 5:92. doi: 10.3389/fpsyt.2014.00092
    • (2014) Front. Psychiatry , vol.5 , pp. 92
    • Panagis, G.1    Mackey, B.2    Vlachou, S.3
  • 123
    • 36349011790 scopus 로고    scopus 로고
    • Self-administration of drugs in animals and humans as a model and an investigative tool
    • Panlilio, L. V., and Goldberg, S. R. (2007). Self-administration of drugs in animals and humans as a model and an investigative tool. Addiction 102, 1863-1870. doi: 10.1111/j.1360-0443.2007.02011.x
    • (2007) Addiction , vol.102 , pp. 1863-1870
    • Panlilio, L.V.1    Goldberg, S.R.2
  • 124
    • 77952616365 scopus 로고    scopus 로고
    • Animal models of cannabinoid reward
    • Panlilio, L. V., Justinova, Z., and Goldberg, S. R. (2010). Animal models of cannabinoid reward. Br. J. Pharmacol. 160, 499-510. doi: 10.1111/j.1476-5381.2010.00775.x
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 499-510
    • Panlilio, L.V.1    Justinova, Z.2    Goldberg, S.R.3
  • 125
    • 77950840678 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the interaction between cannabinoid and opioid system
    • Parolaro, D., Rubino, T., Vigano, D., Massi, P., Guidali, C., and Realini, N. (2010). Cellular mechanisms underlying the interaction between cannabinoid and opioid system. Curr. Drug Targets 11, 393-405. doi: 10.2174/138945010790980367
    • (2010) Curr. Drug Targets , vol.11 , pp. 393-405
    • Parolaro, D.1    Rubino, T.2    Vigano, D.3    Massi, P.4    Guidali, C.5    Realini, N.6
  • 126
    • 84881107392 scopus 로고    scopus 로고
    • The role of impulsivity in relapse vulnerability
    • Pattij, T., and De Vries, T. J. (2013). The role of impulsivity in relapse vulnerability. Curr. Opin. Neurobiol. 23, 700-705. doi: 10.1016/j.conb.2013.01.023
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 700-705
    • Pattij, T.1    De Vries, T.J.2
  • 127
    • 77950653576 scopus 로고    scopus 로고
    • Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists
    • Pertwee, R. G. (2010). Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists. Curr. Med. Chem 17, 1360-1381. doi: 10.2174/092986710790980050
    • (2010) Curr. Med. Chem , vol.17 , pp. 1360-1381
    • Pertwee, R.G.1
  • 128
    • 84902515498 scopus 로고    scopus 로고
    • Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol
    • Petrenko, A. B., Yamazaki, M., Sakimura, K., Kano, M., and Baba, H. (2014). Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. Behav. Brain Res. 271, 51-58. doi: 10.1016/j.bbr.2014.05.063
    • (2014) Behav. Brain Res. , vol.271 , pp. 51-58
    • Petrenko, A.B.1    Yamazaki, M.2    Sakimura, K.3    Kano, M.4    Baba, H.5
  • 129
    • 84887072489 scopus 로고    scopus 로고
    • More surprises lying ahead. The endocannabinoids keep us guessing
    • Piomelli, D. (2014). More surprises lying ahead. The endocannabinoids keep us guessing. Neuropharmacology 76 Pt B, 228-234. doi: 10.1016/j.neuropharm.2013.07.026
    • (2014) Neuropharmacology , vol.76 , pp. 228-234
    • Piomelli, D.1
  • 130
    • 30344449474 scopus 로고    scopus 로고
    • Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain
    • Pol, O., Murtra, P., Caracuel, L., Valverde, O., Puig, M. M., and Maldonado, R. (2006). Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain. Neuropharmacology 50, 123-132. doi: 10.1016/j.neuropharm.2005.11.002
    • (2006) Neuropharmacology , vol.50 , pp. 123-132
    • Pol, O.1    Murtra, P.2    Caracuel, L.3    Valverde, O.4    Puig, M.M.5    Maldonado, R.6
  • 131
    • 80051918265 scopus 로고    scopus 로고
    • The delta opioid receptor: an evolving target for the treatment of brain disorders
    • Pradhan, A. A., Befort, K., Nozaki, C., Gaveriaux-Ruff, C., and Kieffer, B. L. (2011). The delta opioid receptor: an evolving target for the treatment of brain disorders. Trends Pharmacol. Sci. 32, 581-590. doi: 10.1016/j.tips.2011.06.008
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 581-590
    • Pradhan, A.A.1    Befort, K.2    Nozaki, C.3    Gaveriaux-Ruff, C.4    Kieffer, B.L.5
  • 132
    • 84894520596 scopus 로고    scopus 로고
    • Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists
    • Pryce, G., Visintin, C., Ramagopalan, S. V., Al-Izki, S., De Faveri, L. E., Nuamah, R. A.,et al. (2014). Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists. FASEB J. 28, 117-130. doi: 10.1096/fj.13-239442
    • (2014) FASEB J. , vol.28 , pp. 117-130
    • Pryce, G.1    Visintin, C.2    Ramagopalan, S.V.3    Al-Izki, S.4    De Faveri, L.E.5    Nuamah, R.A.6
  • 133
  • 134
    • 84878576567 scopus 로고    scopus 로고
    • Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice
    • Ramesh, D., Gamage, T. F., Vanuytsel, T., Owens, R. A., Abdullah, R. A., Niphakis, M. J.,et al. (2013). Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice. Neuropsychopharmacology 38, 1039-1049. doi: 10.1038/npp.2012.269
    • (2013) Neuropsychopharmacology , vol.38 , pp. 1039-1049
    • Ramesh, D.1    Gamage, T.F.2    Vanuytsel, T.3    Owens, R.A.4    Abdullah, R.A.5    Niphakis, M.J.6
  • 135
    • 80053144160 scopus 로고    scopus 로고
    • Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice
    • Ramesh, D., Ross, G. R., Schlosburg, J. E., Owens, R. A., Abdullah, R. A., Kinsey, S. G.,et al. (2011). Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. J. Pharmacol. Exp. Ther. 339, 173-185. doi: 10.1124/jpet.111.181370
    • (2011) J. Pharmacol. Exp. Ther. , vol.339 , pp. 173-185
    • Ramesh, D.1    Ross, G.R.2    Schlosburg, J.E.3    Owens, R.A.4    Abdullah, R.A.5    Kinsey, S.G.6
  • 136
    • 0037178689 scopus 로고    scopus 로고
    • Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice
    • Rice, O. V., Gordon, N., and Gifford, A. N. (2002). Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice. Brain Res. 945, 135-138. doi: 10.1016/S0006-8993(02)02890-1
    • (2002) Brain Res. , vol.945 , pp. 135-138
    • Rice, O.V.1    Gordon, N.2    Gifford, A.N.3
  • 137
    • 0037062421 scopus 로고    scopus 로고
    • Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
    • Robbe, D., Kopf, M., Remaury, A., Bockaert, J., and Manzoni, O. J. (2002). Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens. Proc. Natl. Acad. Sci. U.S.A. 99, 8384-8388. doi: 10.1073/pnas.122149199
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 8384-8388
    • Robbe, D.1    Kopf, M.2    Remaury, A.3    Bockaert, J.4    Manzoni, O.J.5
  • 138
    • 51449093982 scopus 로고    scopus 로고
    • Review. The incentive sensitization theory of addiction: some current issues
    • Robinson, T. E., and Berridge, K. C. (2008). Review. The incentive sensitization theory of addiction: some current issues. Philos. Trans. R. Soc. Lond. B Biol. Sci. 363, 3137-3146. doi: 10.1098/rstb.2008.0093
    • (2008) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.363 , pp. 3137-3146
    • Robinson, T.E.1    Berridge, K.C.2
  • 139
    • 43749109782 scopus 로고    scopus 로고
    • Advances in the field of cannabinoid-opioid cross-talk
    • Robledo, P., Berrendero, F., Ozaita, A., and Maldonado, R. (2008). Advances in the field of cannabinoid-opioid cross-talk. Addict. Biol. 13, 213-224. doi: 10.1111/j.1369-1600.2008.00107.x
    • (2008) Addict. Biol. , vol.13 , pp. 213-224
    • Robledo, P.1    Berrendero, F.2    Ozaita, A.3    Maldonado, R.4
  • 140
    • 84859324853 scopus 로고    scopus 로고
    • Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain
    • Roques, B. P., Fournie-Zaluski, M. C., and Wurm, M. (2012). Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain. Nat. Rev. Drug Discov. 11, 292-310. doi: 10.1038/nrd3673
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 292-310
    • Roques, B.P.1    Fournie-Zaluski, M.C.2    Wurm, M.3
  • 141
    • 0029880457 scopus 로고    scopus 로고
    • Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis
    • Rubinstein, M., Mogil, J. S., Japon, M., Chan, E. C., Allen, R. G., and Low, M. J. (1996). Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 93, 3995-4000. doi: 10.1073/pnas.93.9.3995
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 3995-4000
    • Rubinstein, M.1    Mogil, J.S.2    Japon, M.3    Chan, E.C.4    Allen, R.G.5    Low, M.J.6
  • 142
    • 84879135358 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions
    • Ruehle, S., Remmers, F., Romo-Parra, H., Massa, F., Wickert, M., Wortge, S.,et al. (2013). Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions. J. Neurosci. 33, 10264-10277. doi: 10.1523/JNEUROSCI.4171-12.2013
    • (2013) J. Neurosci. , vol.33 , pp. 10264-10277
    • Ruehle, S.1    Remmers, F.2    Romo-Parra, H.3    Massa, F.4    Wickert, M.5    Wortge, S.6
  • 144
    • 33750686609 scopus 로고    scopus 로고
    • Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
    • Sanchis-Segura, C., and Spanagel, R. (2006). Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict. Biol. 11, 2-38. doi: 10.1111/j.1369-1600.2006.00012.x
    • (2006) Addict. Biol. , vol.11 , pp. 2-38
    • Sanchis-Segura, C.1    Spanagel, R.2
  • 145
    • 84888014484 scopus 로고    scopus 로고
    • Individual variation in resisting temptation: implications for addiction
    • Saunders, B. T., and Robinson, T. E. (2013). Individual variation in resisting temptation: implications for addiction. Neurosci. Biobehav. Rev. 37, 1955-1975. doi: 10.1016/j.neubiorev.2013.02.008
    • (2013) Neurosci. Biobehav. Rev. , vol.37 , pp. 1955-1975
    • Saunders, B.T.1    Robinson, T.E.2
  • 146
    • 84881367408 scopus 로고    scopus 로고
    • Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal
    • Scavone, J. L., Sterling, R. C., and Van Bockstaele, E. J. (2013). Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal. Neuroscience 248, 637-654. doi: 10.1016/j.neuroscience.2013.04.034
    • (2013) Neuroscience , vol.248 , pp. 637-654
    • Scavone, J.L.1    Sterling, R.C.2    Van Bockstaele, E.J.3
  • 147
    • 77956181836 scopus 로고    scopus 로고
    • Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
    • Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G.,et al. (2010). Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat. Neurosci. 13, 1113-1119. doi: 10.1038/nn.2616
    • (2010) Nat. Neurosci. , vol.13 , pp. 1113-1119
    • Schlosburg, J.E.1    Blankman, J.L.2    Long, J.Z.3    Nomura, D.K.4    Pan, B.5    Kinsey, S.G.6
  • 148
    • 0033366394 scopus 로고    scopus 로고
    • Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1
    • Schuller, A. G., King, M. A., Zhang, J., Bolan, E., Pan, Y. X., Morgan, D. J.,et al. (1999). Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat. Neurosci. 2, 151-156. doi: 10.1038/5706
    • (1999) Nat. Neurosci. , vol.2 , pp. 151-156
    • Schuller, A.G.1    King, M.A.2    Zhang, J.3    Bolan, E.4    Pan, Y.X.5    Morgan, D.J.6
  • 150
    • 0028670235 scopus 로고
    • The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain
    • Simonin, F., Befort, K., Gaveriaux-Ruff, C., Matthes, H., Nappey, V., Lannes, B.,et al. (1994). The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. Mol. Pharmacol. 46, 1015-1021.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 1015-1021
    • Simonin, F.1    Befort, K.2    Gaveriaux-Ruff, C.3    Matthes, H.4    Nappey, V.5    Lannes, B.6
  • 151
    • 0028983787 scopus 로고
    • kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system
    • Simonin, F., Gaveriaux-Ruff, C., Befort, K., Matthes, H., Lannes, B., Micheletti, G.,et al. (1995). kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 92, 7006-7010. doi: 10.1073/pnas.92.15.7006
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 7006-7010
    • Simonin, F.1    Gaveriaux-Ruff, C.2    Befort, K.3    Matthes, H.4    Lannes, B.5    Micheletti, G.6
  • 152
    • 0035793687 scopus 로고    scopus 로고
    • Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice
    • Simonin, F., Slowe, S., Becker, J. A., Matthes, H. W., Filliol, D., Chluba, J.,et al. (2001). Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice. Eur. J. Pharmacol. 414, 189-195. doi: 10.1016/S0014-2999(01)00822-6
    • (2001) Eur. J. Pharmacol. , vol.414 , pp. 189-195
    • Simonin, F.1    Slowe, S.2    Becker, J.A.3    Matthes, H.W.4    Filliol, D.5    Chluba, J.6
  • 153
    • 0032481350 scopus 로고    scopus 로고
    • Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal
    • Simonin, F., Valverde, O., Smadja, C., Slowe, S., Kitchen, I., Dierich, A.,et al. (1998). Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. EMBO J. 17, 886-897. doi: 10.1093/emboj/17.4.886
    • (1998) EMBO J. , vol.17 , pp. 886-897
    • Simonin, F.1    Valverde, O.2    Smadja, C.3    Slowe, S.4    Kitchen, I.5    Dierich, A.6
  • 154
    • 17144418417 scopus 로고    scopus 로고
    • Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice
    • Skoubis, P. D., Lam, H. A., Shoblock, J., Narayanan, S., and Maidment, N. T. (2005). Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice. Eur. J. Neurosci. 21, 1379-1384. doi: 10.1111/j.1460-9568.2005.03956.x
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 1379-1384
    • Skoubis, P.D.1    Lam, H.A.2    Shoblock, J.3    Narayanan, S.4    Maidment, N.T.5
  • 155
    • 0033550676 scopus 로고    scopus 로고
    • Quantitative autoradiography of mu-delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice
    • Slowe, S. J., Simonin, F., Kieffer, B., and Kitchen, I. (1999). Quantitative autoradiography of mu-delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice. Brain Res. 818, 335-345. doi: 10.1016/S0006-8993(98)01201-3
    • (1999) Brain Res. , vol.818 , pp. 335-345
    • Slowe, S.J.1    Simonin, F.2    Kieffer, B.3    Kitchen, I.4
  • 156
    • 43449127219 scopus 로고    scopus 로고
    • The endocannabinoid system in brain reward processes
    • Solinas, M., Goldberg, S. R., and Piomelli, D. (2008). The endocannabinoid system in brain reward processes. Br. J. Pharmacol. 154, 369-383. doi: 10.1038/bjp.2008.130
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 369-383
    • Solinas, M.1    Goldberg, S.R.2    Piomelli, D.3
  • 157
    • 0035010041 scopus 로고    scopus 로고
    • Mu opiate receptor gene dose effects on different morphine actions: evidence for differential in vivo mu receptor reserve
    • Sora, I., Elmer, G., Funada, M., Pieper, J., Li, X. F., Hall, F. S.,et al. (2001). Mu opiate receptor gene dose effects on different morphine actions: evidence for differential in vivo mu receptor reserve. Neuropsychopharmacology 25, 41-54. doi: 10.1016/S0893-133X(00)00252-9
    • (2001) Neuropsychopharmacology , vol.25 , pp. 41-54
    • Sora, I.1    Elmer, G.2    Funada, M.3    Pieper, J.4    Li, X.F.5    Hall, F.S.6
  • 158
    • 84892575256 scopus 로고    scopus 로고
    • Opioids, sensory systems and chronic pain
    • Stein, C. (2013). Opioids, sensory systems and chronic pain. Eur. J. Pharmacol. 716, 179-187. doi: 10.1016/j.ejphar.2013.01.076
    • (2013) Eur. J. Pharmacol. , vol.716 , pp. 179-187
    • Stein, C.1
  • 159
    • 13044311373 scopus 로고    scopus 로고
    • Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice
    • Steiner, H., Bonner, T. I., Zimmer, A. M., Kitai, S. T., and Zimmer, A. (1999). Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 96, 5786-5790. doi: 10.1073/pnas.96.10.5786
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 5786-5790
    • Steiner, H.1    Bonner, T.I.2    Zimmer, A.M.3    Kitai, S.T.4    Zimmer, A.5
  • 160
    • 59949100369 scopus 로고    scopus 로고
    • Genetic loss of faah compromises male fertility in mice
    • Sun, X., Wang, H., Okabe, M., Mackie, K., Kingsley, P. J., Marnett, L. J.,et al. (2009). Genetic loss of faah compromises male fertility in mice. Biol. Reprod. 80, 235-242. doi: 10.1095/biolreprod.108.072736
    • (2009) Biol. Reprod. , vol.80 , pp. 235-242
    • Sun, X.1    Wang, H.2    Okabe, M.3    Mackie, K.4    Kingsley, P.J.5    Marnett, L.J.6
  • 161
    • 79251472090 scopus 로고    scopus 로고
    • Individual vulnerability to addiction
    • Swendsen, J., and Le Moal, M. (2011). Individual vulnerability to addiction. Ann. N. Y. Acad. Sci. 1216, 73-85. doi: 10.1111/j.1749-6632.2010.05894.x
    • (2011) Ann. N. Y. Acad. Sci. , vol.1216 , pp. 73-85
    • Swendsen, J.1    Le Moal, M.2
  • 162
    • 84900791580 scopus 로고    scopus 로고
    • Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation
    • Szutorisz, H., Dinieri, J. A., Sweet, E., Egervari, G., Michaelides, M., Carter, J. M.,et al. (2014). Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation. Neuropsychopharmacology 39, 1315-1323. doi: 10.1038/npp.2013.352
    • (2014) Neuropsychopharmacology , vol.39 , pp. 1315-1323
    • Szutorisz, H.1    Dinieri, J.A.2    Sweet, E.3    Egervari, G.4    Michaelides, M.5    Carter, J.M.6
  • 163
    • 75949116246 scopus 로고    scopus 로고
    • The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission
    • Tanimura, A., Yamazaki, M., Hashimotodani, Y., Uchigashima, M., Kawata, S., Abe, M.,et al. (2010). The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron 65, 320-327. doi: 10.1016/j.neuron.2010.01.021
    • (2010) Neuron , vol.65 , pp. 320-327
    • Tanimura, A.1    Yamazaki, M.2    Hashimotodani, Y.3    Uchigashima, M.4    Kawata, S.5    Abe, M.6
  • 164
    • 79955958008 scopus 로고    scopus 로고
    • Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance
    • Taschler, U., Radner, F. P., Heier, C., Schreiber, R., Schweiger, M., Schoiswohl, G.,et al. (2011). Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J. Biol. Chem. 286, 17467-17477. doi: 10.1074/jbc. M110.215434
    • (2011) J. Biol. Chem. , vol.286 , pp. 17467-17477
    • Taschler, U.1    Radner, F.P.2    Heier, C.3    Schreiber, R.4    Schweiger, M.5    Schoiswohl, G.6
  • 165
    • 84866933069 scopus 로고    scopus 로고
    • Adenosine A(2A)-cannabinoid CB(1) receptor interaction: an integrative mechanism in striatal glutamatergic neurotransmission
    • Tebano, M. T., Martire, A., and Popoli, P. (2012). Adenosine A(2A)-cannabinoid CB(1) receptor interaction: an integrative mechanism in striatal glutamatergic neurotransmission. Brain Res. 1476, 108-118. doi: 10.1016/j.brainres.2012.04.051
    • (2012) Brain Res. , vol.1476 , pp. 108-118
    • Tebano, M.T.1    Martire, A.2    Popoli, P.3
  • 166
    • 0030951587 scopus 로고    scopus 로고
    • Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice
    • Tian, M., Broxmeyer, H. E., Fan, Y., Lai, Z., Zhang, S., Aronica, S.,et al. (1997). Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice. J. Exp. Med. 185, 1517-1522. doi: 10.1084/jem.185.8.1517
    • (1997) J. Exp. Med. , vol.185 , pp. 1517-1522
    • Tian, M.1    Broxmeyer, H.E.2    Fan, Y.3    Lai, Z.4    Zhang, S.5    Aronica, S.6
  • 167
    • 84867746610 scopus 로고    scopus 로고
    • Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability
    • Tomasiewicz, H. C., Jacobs, M. M., Wilkinson, M. B., Wilson, S. P., Nestler, E. J., and Hurd, Y. L. (2012). Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. Biol. Psychiatry 72, 803-810. doi: 10.1016/j.biopsych.2012.04.026
    • (2012) Biol. Psychiatry , vol.72 , pp. 803-810
    • Tomasiewicz, H.C.1    Jacobs, M.M.2    Wilkinson, M.B.3    Wilson, S.P.4    Nestler, E.J.5    Hurd, Y.L.6
  • 168
  • 169
    • 79961107765 scopus 로고    scopus 로고
    • Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways
    • Tsuboi, K., Okamoto, Y., Ikematsu, N., Inoue, M., Shimizu, Y., Uyama, T.,et al. (2011). Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. Biochim. Biophys. Acta 1811, 565-577. doi: 10.1016/j.bbalip.2011.07.009
    • (2011) Biochim. Biophys. Acta , vol.1811 , pp. 565-577
    • Tsuboi, K.1    Okamoto, Y.2    Ikematsu, N.3    Inoue, M.4    Shimizu, Y.5    Uyama, T.6
  • 170
    • 34547610708 scopus 로고    scopus 로고
    • Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
    • Tzschentke, T. M. (2007). Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade. Addict. Biol. 12, 227-462. doi: 10.1111/j.1369-1600.2007.00070.x
    • (2007) Addict. Biol. , vol.12 , pp. 227-462
    • Tzschentke, T.M.1
  • 171
    • 79957649283 scopus 로고    scopus 로고
    • Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus
    • Uchigashima, M., Yamazaki, M., Yamasaki, M., Tanimura, A., Sakimura, K., Kano, M.,et al. (2011). Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J. Neurosci. 31, 7700-7714. doi: 10.1523/JNEUROSCI.5665-10.2011
    • (2011) J. Neurosci. , vol.31 , pp. 7700-7714
    • Uchigashima, M.1    Yamazaki, M.2    Yamasaki, M.3    Tanimura, A.4    Sakimura, K.5    Kano, M.6
  • 172
    • 27644581965 scopus 로고    scopus 로고
    • Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice
    • Uriguen, L., Berrendero, F., Ledent, C., Maldonado, R., and Manzanares, J. (2005). Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice. Eur. J. Neurosci. 22, 2106-2110. doi: 10.1111/j.1460-9568.2005.04372.x
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 2106-2110
    • Uriguen, L.1    Berrendero, F.2    Ledent, C.3    Maldonado, R.4    Manzanares, J.5
  • 173
    • 0034671190 scopus 로고    scopus 로고
    • Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice
    • Valverde, O., Maldonado, R., Valjent, E., Zimmer, A. M., and Zimmer, A. (2000). Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice. J. Neurosci. 20, 9284-9289.
    • (2000) J. Neurosci. , vol.20 , pp. 9284-9289
    • Valverde, O.1    Maldonado, R.2    Valjent, E.3    Zimmer, A.M.4    Zimmer, A.5
  • 174
    • 84857128654 scopus 로고    scopus 로고
    • CB1 receptor-deficient mice as a model for depression
    • Valverde, O., and Torrens, M. (2012). CB1 receptor-deficient mice as a model for depression. Neuroscience 204, 193-206. doi: 10.1016/j.neuroscience.2011.09.031
    • (2012) Neuroscience , vol.204 , pp. 193-206
    • Valverde, O.1    Torrens, M.2
  • 175
    • 84879413396 scopus 로고    scopus 로고
    • Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity
    • Van't Veer, A., Bechtholt, A. J., Onvani, S., Potter, D., Wang, Y., Liu-Chen, L. Y.,et al. (2013). Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology 38, 1585-1597. doi: 10.1038/npp.2013.58
    • (2013) Neuropsychopharmacology , vol.38 , pp. 1585-1597
    • Van't Veer, A.1    Bechtholt, A.J.2    Onvani, S.3    Potter, D.4    Wang, Y.5    Liu-Chen, L.Y.6
  • 176
    • 72449140688 scopus 로고    scopus 로고
    • The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake
    • van Rijn, R. M., and Whistler, J. L. (2009). The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. Biol. Psychiatry 66, 777-784. doi: 10.1016/j.biopsych.2009.05.019
    • (2009) Biol. Psychiatry , vol.66 , pp. 777-784
    • van Rijn, R.M.1    Whistler, J.L.2
  • 177
    • 20444399468 scopus 로고    scopus 로고
    • Molecular and cellular basis of cannabinoid and opioid interactions
    • Vigano, D., Rubino, T., and Parolaro, D. (2005). Molecular and cellular basis of cannabinoid and opioid interactions. Pharmacol. Biochem. Behav. 81, 360-368. doi: 10.1016/j.pbb.2005.01.021
    • (2005) Pharmacol. Biochem. Behav. , vol.81 , pp. 360-368
    • Vigano, D.1    Rubino, T.2    Parolaro, D.3
  • 178
    • 37249036062 scopus 로고    scopus 로고
    • Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol
    • Vinod, K. Y., Sanguino, E., Yalamanchili, R., Manzanares, J., and Hungund, B. L. (2008). Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol. J. Neurochem. 104, 233-243. doi: 10.1111/j.1471-4159.2007.04956.x
    • (2008) J. Neurochem. , vol.104 , pp. 233-243
    • Vinod, K.Y.1    Sanguino, E.2    Yalamanchili, R.3    Manzanares, J.4    Hungund, B.L.5
  • 179
    • 84884169503 scopus 로고    scopus 로고
    • Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice
    • Weibel, R., Reiss, D., Karchewski, L., Gardon, O., Matifas, A., Filliol, D.,et al. (2013). Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice. PLoS ONE 8:e74706. doi: 10.1371/journal.pone.0074706
    • (2013) PLoS ONE , vol.8
    • Weibel, R.1    Reiss, D.2    Karchewski, L.3    Gardon, O.4    Matifas, A.5    Filliol, D.6
  • 180
    • 33846360071 scopus 로고    scopus 로고
    • Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors
    • Wise, L. E., Shelton, C. C., Cravatt, B. F., Martin, B. R., and Lichtman, A. H. (2007). Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. Eur. J. Pharmacol. 557, 44-48. doi: 10.1016/j.ejphar.2006.11.002
    • (2007) Eur. J. Pharmacol. , vol.557 , pp. 44-48
    • Wise, L.E.1    Shelton, C.C.2    Cravatt, B.F.3    Martin, B.R.4    Lichtman, A.H.5
  • 181
    • 24044458606 scopus 로고    scopus 로고
    • Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons
    • Wotherspoon, G., Fox, A., Mcintyre, P., Colley, S., Bevan, S., and Winter, J. (2005). Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons. Neuroscience 135, 235-245. doi: 10.1016/j.neuroscience.2005.06.009
    • (2005) Neuroscience , vol.135 , pp. 235-245
    • Wotherspoon, G.1    Fox, A.2    Mcintyre, P.3    Colley, S.4    Bevan, S.5    Winter, J.6
  • 182
    • 80052213796 scopus 로고    scopus 로고
    • Brain cannabinoid CB(2) receptors modulate cocaine's actions in mice
    • Xi, Z. X., Peng, X. Q., Li, X., Song, R., Zhang, H. Y., Liu, Q. R.,et al. (2011). Brain cannabinoid CB(2) receptors modulate cocaine's actions in mice. Nat. Neurosci. 14, 1160-1166. doi: 10.1038/nn.2874
    • (2011) Nat. Neurosci. , vol.14 , pp. 1160-1166
    • Xi, Z.X.1    Peng, X.Q.2    Li, X.3    Song, R.4    Zhang, H.Y.5    Liu, Q.R.6
  • 183
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen, L., Diehl, N., Brennan, M. B., and Hochgeschwender, U. (1999). Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5, 1066-1070. doi: 10.1038/12506
    • (1999) Nat. Med. , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4
  • 184
    • 80054101176 scopus 로고    scopus 로고
    • Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex
    • Yoshino, H., Miyamae, T., Hansen, G., Zambrowicz, B., Flynn, M., Pedicord, D.,et al. (2011). Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. J. Physiol. 589, 4857-4884. doi: 10.1113/jphysiol.2011.212225
    • (2011) J. Physiol. , vol.589 , pp. 4857-4884
    • Yoshino, H.1    Miyamae, T.2    Hansen, G.3    Zambrowicz, B.4    Flynn, M.5    Pedicord, D.6
  • 186
    • 84915754556 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice
    • Zhang, H. Y., Gao, M., Liu, Q. R., Bi, G. H., Li, X., Yang, H. J.,et al. (2014). Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1413210111
    • (2014) Proc. Natl. Acad. Sci. U.S.A.
    • Zhang, H.Y.1    Gao, M.2    Liu, Q.R.3    Bi, G.H.4    Li, X.5    Yang, H.J.6
  • 187
    • 0033198831 scopus 로고    scopus 로고
    • Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice
    • Zhu, Y., King, M. A., Schuller, A. G., Nitsche, J. F., Reidl, M., Elde, R. P.,et al. (1999). Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron 24, 243-252. doi: 10.1016/S0896-6273(00)80836-3
    • (1999) Neuron , vol.24 , pp. 243-252
    • Zhu, Y.1    King, M.A.2    Schuller, A.G.3    Nitsche, J.F.4    Reidl, M.5    Elde, R.P.6
  • 188
    • 0035576146 scopus 로고    scopus 로고
    • Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice
    • Zimmer, A., Valjent, E., Konig, M., Zimmer, A. M., Robledo, P., Hahn, H.,et al. (2001). Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J. Neurosci. 21, 9499-9505.
    • (2001) J. Neurosci. , vol.21 , pp. 9499-9505
    • Zimmer, A.1    Valjent, E.2    Konig, M.3    Zimmer, A.M.4    Robledo, P.5    Hahn, H.6
  • 189
    • 0033545866 scopus 로고    scopus 로고
    • Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
    • Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M., and Bonner, T. I. (1999). Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 96, 5780-5785. doi: 10.1073/pnas.96.10.5780
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 5780-5785
    • Zimmer, A.1    Zimmer, A.M.2    Hohmann, A.G.3    Herkenham, M.4    Bonner, T.I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.