Levels, metabolism, and pharmacological activity of anandamide in CB1 cannabinoid receptor knockout mice: Evidence for non-CB1, non-CB2 receptor-mediated actions of anandamide in mouse brain

Journal of Neurochemistry

Volumn 75, Issue 6, 2000, Pages 2434-2444

  Di Marzo, Vincenzo ^b   Breivogel, Chris S ^c   Tao, Qing ^c   Bridgen, David T ^c   Razdan, Raj K ^c   Zimmer, Anne M ^c   Zimmer, Andreas ^c   Martin, Billy R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b CNR   (Italy)

^c NONE

Author keywords

2 Arachidonyl glycerol; Anandamide; C57BL 6 mouse; Cannabinoid; CB1 receptor knockout; Tetrahydrocannabinol

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ANANDAMIDE; CANNABINOID; CANNABINOID RECEPTOR; DRONABINOL;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CATALEPSY; CONTROLLED STUDY; CORPUS STRIATUM; DRUG METABOLISM; ENZYME ACTIVITY; HIPPOCAMPUS; HOMOZYGOSITY; ISOTOPE DILUTION ASSAY; KNOCKOUT MOUSE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AMIDOHYDROLASES; ANIMALS; ARACHIDONIC ACIDS; BRAIN; BRAIN CHEMISTRY; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCANNABINOIDS; FEMALE; GLYCERIDES; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SPECIFICITY; POLYUNSATURATED ALKAMIDES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

ANIMALIA; MUS MUSCULUS;

EID: 0033769188     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752434.x     Document Type: Article

References (50)

1. Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain
2. An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
3. Brain regional distribution of endocannabinoids: Implications for their biosynthesis and biological function
4. Enhanced long-term potentiation in mice lacking cannabinoid CB1 receptors
5. Regional differences in cannabinoid receptor/G-protein coupling in rat brain
6. SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats
7. Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by delta 9-tetrahydrocannabinol (THC)
8. The effects of anandamide on memory consolidation in mice involve both D1 and D2 dopamine receptors
9. Long-term synaptic transformation of hippocampal CA1 gamma-aminobutyric acid synapses and the effect of anandamide
10. The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity
11. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
12. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
13. Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action
14. 9-tetrahydrocannabinol-tolerant rats
15. Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
16. A new perspective on cannabinoid signalling: Complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain
17. Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat
18. 123I-labeled AM251: A radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors
19. Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A
20. Evaluation of the cannabinoid CB2 receptor-selectiVe antagonist, SR144528: Further evidence for cannabinoid CB2 receptor absence in the rat central nervous system
21. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission
22. Cannabinoid receptor localization in brain
23. Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis
24. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
25. Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor
26. Anandamides inhibit binding to the muscarinic acetylcholine receptor
27. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
28. Effects of SR 141716A after acute or chronic cannabinoid administration in dogs
29. Molecular biology of the cannabinoid receptor
30. The pharmacohistory of Cannabis sativa
31. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
32. Molecular characterization of a peripheral receptor for cannabinoids
33. Pharmacology of cannabinoid CB1 and CB2 receptors
34. 3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice
35. Enhancement of memory in cannabinoid CB1 receptor knock-out mice
36. SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor
37. Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes
38. The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice
39. 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
40. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds
41. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells
42. Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain
43. Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system
44. Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry
45. A hydrolase enzyme inactivating endogenous ligands for cannabinoid receptors
46. Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: Blockade of delta 9-THC-induced antinociception
47. Anandamide induces overeating: Mediation by central cannabinoid (CB1) receptors
48. The biodisposition and metabolism in mice
49. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
50. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide