Molecular mechanisms of cannabinoid addiction

Current Opinion in Neurobiology

Volumn 23, Issue 4, 2013, Pages 487-492

  Fratta, Walter ^a   Fattore, Liana ^a,b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID 1 RECEPTOR; NEUROTRANSMITTER RECEPTOR; TETRAHYDROCANNABINOLIC ACID;

BRAIN FUNCTION; BRAIN NERVE CELL; CANNABIS ADDICTION; CELL FUNCTION; CELL SURVIVAL; DISEASE ACTIVITY; DISEASE ASSOCIATION; DOWN REGULATION; GENE EXPRESSION; HUMAN; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 84881097633     PISSN: 09594388     EISSN: 18736882     Source Type: Journal    
DOI: 10.1016/j.conb.2013.02.002     Document Type: Review

References (41)

1. United Nation Office on Drugs and Crime (UNODC) World Drug Report 2012 2012, 2-3.
2. Filbey F.M., Schacht J.P., Myers U.S., Chavez R.S., Hutchison K.E. Marijuana craving in the brain. Proc Natl Acad Sci USA 2009, 106:13016-13021.
3. Weinstein A.M., Gorelick D.A. Pharmacological treatment of cannabis dependence. Curr Pharm Des 2011, 17:1351-1358.
4. Wölfling K., Flor H., Grüsser S.M. Psychophysiological responses to drug-associated stimuli in chronic heavy cannabis use. Eur J Neurosci 2008, 27:976-983.
5. Budney A.J., Hughes J.R. The cannabis withdrawal syndrome. Curr Opin Psychiatry 2006, 19:233-238.
6. Di Marzo V., Bifulco M., De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 2004, 3:771-784.
7. Piomelli D. The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 2003, 4:873-884.
8. Hoffman A.F., Lupica C.R. Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids. J Neurophysiol 2001, 85:72-83.
9. Mato S., Robbe D., Puente N., Grandes P., Manzoni O.J. Presynaptic homeostatic plasticity rescues long-term depression after chronic Delta 9-tetrahydrocannabinol exposure. J Neurosci 2005, 25:11619-11627.
10. Hoffman A.F., Riegel A.C., Lupica C.R. Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus. Eur J Neurosci 2003, 18:524-534.
11. Martin B.R., Sim-Selley L.J., Selley D.E. Signaling pathways involved in the development of cannabinoid tolerance. Trends Pharmacol Sci 2004, 25:325-330.
12. Burston J.J., Wiley J.L., Craig A.A., Selley D.E., Sim-Selley L.J. Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure. Br J Pharmacol 2010, 161:103-112.
13. Fattore L. Considering gender in cannabinoid research: a step towards personalized treatment of marijuana addicts. Drug Test Anal 2013, 5:57-61.
14. Nguyen P.T., Schmid C.L., Raehal K.M., Selley D.E., Bohn L.M., Sim-Selley L.J. β-Arrestin2 regulates cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner. Biol Psychiatry 2012, 71:714-724.
15. Oliva J.M., Ortiz S., Palomo T., Manzanares J. Spontaneous cannabinoid withdrawal produces a differential time-related responsiveness in cannabinoid CB1 receptor gene expression in the mouse brain. J Psychopharmacol 2004, 18:59-65.
16. Fattore L., Viganò D., Fadda P., Rubino T., Fratta W., Parolaro D. Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2. Eur J Neurosci 2007, 25:2191-2200.
17. Villares J. Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain. Neuroscience 2007, 145:323-334.
18. Hirvonen J., Goodwin R.S., Li C.T., Terry G.E., Zoghbi S.S., Morse C., Pike V.W., Volkow N.D., Huestis M.A., Innis R.B. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry 2012, 17:642-649.
19. Tonini R., Ciardo S., Cerovic M., Rubino T., Parolaro D., Mazzanti M., Zippel R. ERK-dependent modulation of cerebellar synaptic plasticity after chronic Delta9-tetrahydrocannabinol exposure. J Neurosci 2006, 26:5810-5818.
20. Rubino T., Forlani G., Vigano D., Zippel R., Parolaro D. Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment. Mol Cell Neurosci 2004, 25:355-362.
21. Tzavara E.T., Valjent E., Firmo C., Mas M., Beslot F., Defer N., Roques B.P., Hanoune J., Maldonado R. Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum. Eur J Neurosci 2000, 12:1038-1046.
22. Maldonado R., Rodriguez D.F. Cannabinoid addiction: behavioral models and neural correlates. J Neurosci 2002, 22:3326-3331.
23. Butovsky E., Juknat A., Goncharov I., Elbaz J., Eilam R., Zangen A., Vogel Z. In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol. J Neurochem 2005, 93:802-811.
24. Aso E., Ozaita A., Valdizán E.M., Ledent C., Pazos A., Maldonado R., Valverde O. BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice. J Neurochem 2008, 105:565-572.
25. López-Gallardo M., López-Rodríguez A.B., Llorente-Berzal Á., Rotllant D., Mackie K., Armario A., Nadal R., Viveros M.P. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion. Neuroscience 2012, 204:90-103.
26. D'Souza D.C., Pittman B., Perry E., Simen A. Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology (Berl) 2009, 202:569-578.
27. Casu M.A., Pisu C., Sanna A., Tambaro S., Spada G.P., Mongeau R., Pani L. Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study. Brain Res 2005, 1048:41-47.
28. Fan N., Yang H., Zhang J., Chen C. Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivo Delta9-THC exposure-impaired hippocampal synaptic plasticity. J Neurochem 2010, 112:691-702.
29. Nestler E.J. Is there a common molecular pathway for addiction?. Nat Neurosci 2005, 8:1445-1449.
30. Kalivas P.W. The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci 2009, 10:561-572.
31. Kauer J.A., Malenka R.C. Synaptic plasticity and addiction. Nat Rev Neurosci 2007, 8:844-858.
32. Russo S.J., Wilkinson M.B., Mazei-Robison M.S., Dietz D.M., Maze I., Krishnan V., Renthal W., Graham A., Birnbaum S.G., Green T.A., et al. Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci 2009, 29:3529-3537.
33. Le Merrer J., Befort K., Gardon O., Filliol D., Darcq E., Dembele D., Becker J.A., Kieffer B.L. Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network. Addict Biol 2012, 17:1-12.
34. Reti I.M., Han S., Miskimon M., Rosen J.B., Baraban J.M. Nicotine and Delta(9)-tetrahydrocannabinol withdrawal induce Narp in the central nucleus of the amygdala. Synapse 2009, 63:252-255.
35. Boucher A.A., Vivier L., Metna-Laurent M., Brayda-Bruno L., Mons N., Arnold J.C., Micheau J. Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. Behav Pharmacol 2009, 20:45-55.
36. Tomasiewicz H.C., Jacobs M.M., Wilkinson M.B., Wilson S.P., Nestler E.J., Hurd Y.L. Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. Biol Psychiatry 2012, 72:803-810.
37. Mateos B., Borcel E., Loriga R., Luesu W., Bini V., Llorente R., Castelli M.P., Viveros M.P. Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB(1) cannabinoid receptors. J Psychopharmacol 2011, 25:1676-1690.
38. Higuera-Matas A., Miguéns M., Coria S.M., Assis M.A., Borcel E., del Olmo N., Ambrosio E. Sex-specific disturbances of the glutamate/GABA balance in the hippocampus of adult rats subjected to adolescent cannabinoid exposure. Neuropharmacology 2012, 62:1975-1984.
39. McQueeny T., Padula C.B., Price J., Medina K.L., Logan P., Tapert S.F. Gender effects on amygdala morphometry in adolescent marijuana users. Behav Brain Res 2011, 224:128-134.
40. Medina K.L., McQueeny T., Nagel B.J., Hanson K.L., Yang T.T., Tapert S.F. Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects. Addict Biol 2009, 14:457-468.
41. Zalesky A., Solowij N., Yücel M., Lubman D.I., Takagi M., Harding I.H., Lorenzetti V., Wang R., Searle K., Pantelis C., Seal M. Effect of long-term cannabis use on axonal fibre connectivity. Brain 2012, 135:2245-2255.